TLR9 activation cooperates with T cell checkpoint blockade to regress poorly immunogenic melanoma von Reilley, Matthew J., Morrow, Brittany, Ager, Casey R., Liu, Arthur, Hong, David S., Curran, Michael A.

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High potency STING agonists engage unique myeloid pathways to reverse pancreatic cancer immune privilege von Ager, Casey R, Boda, Akash, Rajapakshe, Kimal, Lea, Spencer Thomas, Di Francesco, Maria Emilia, Jayaprakash, Priyamvada, Slay, Ravaen B, Morrow, Brittany, Prasad, Rishika, Dean, Meghan A, Duffy, Colm R, Coarfa, Cristian, Jones, Philip, Curran, Michael A

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KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response von Ager, Casey R, Zhang, Mingxuan, Chaimowitz, Matthew, Bansal, Shruti, Tagore, Somnath, Obradovic, Aleksandar, Jugler, Collin, Rogava, Meri, Melms, Johannes C, McCann, Patrick, Spina, Catherine, Drake, Charles G, Dallos, Matthew C, Izar, Benjamin

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Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion von Frangieh, Chris J., Melms, Johannes C., Thakore, Pratiksha I., Geiger-Schuller, Kathryn R., Ho, Patricia, Luoma, Adrienne M., Cleary, Brian, Jerby-Arnon, Livnat, Malu, Shruti, Cuoco, Michael S., Zhao, Maryann, Ager, Casey R., Rogava, Meri, Hovey, Lila, Rotem, Asaf, Bernatchez, Chantale, Wucherpfennig, Kai W., Johnson, Bruce E., Rozenblatt-Rosen, Orit, Schadendorf, Dirk, Regev, Aviv, Izar, Benjamin

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Intratumoral STING Activation with T-cell Checkpoint Modulation Generates Systemic Antitumor Immunity von Ager, Casey R, Reilley, Matthew J, Nicholas, Courtney, Bartkowiak, Todd, Jaiswal, Ashvin R, Curran, Michael A

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Blocking IL1 Beta Promotes Tumor Regression and Remodeling of the Myeloid Compartment in a Renal Cell Carcinoma Model: Multidimensional Analyses von Aggen, David H., Ager, Casey R., Obradovic, Aleksandar Z., Chowdhury, Nivedita, Ghasemzadeh, Ali, Mao, Wendy, Chaimowitz, Matthew G., Lopez-Bujanda, Zoila A., Spina, Catherine S., Hawley, Jessica E., Dallos, Matthew C., Zhang, Cheng, Wang, Vinson, Li, Hu, Guo, Xinzheng, Drake, Charles G.

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Discovery of IACS-8803 and IACS-8779, potent agonists of stimulator of interferon genes (STING) with robust systemic antitumor efficacy von Ager, Casey R., Zhang, Huaping, Wei, Zhanlei, Jones, Philip, Curran, Michael A., Di Francesco, M. Emilia

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Activation of 4-1BB on Liver Myeloid Cells Triggers Hepatitis via an Interleukin-27-Dependent Pathway von Bartkowiak, Todd, Jaiswal, Ashvin R, Ager, Casey R, Chin, Renee, Chen, Chao-Hsien, Budhani, Pratha, Ai, Midan, Reilley, Matthew J, Sebastian, Manu M, Hong, David S, Curran, Michael A

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The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity von Ho, Patricia, Melms, Johannes C., Rogava, Meri, Frangieh, Chris J., Poźniak, Joanna, Shah, Shivem B., Walsh, Zachary, Kyrysyuk, Oleksandr, Amin, Amit Dipak, Caprio, Lindsay, Fullerton, Benjamin T., Soni, Rajesh Kumar, Ager, Casey R., Biermann, Jana, Wang, Yiping, Khosravi-Maharlooei, Mohsen, Zanetti, Giorgia, Mu, Michael, Fatima, Hijab, Moore, Emily K., Vasan, Neil, Bakhoum, Samuel F., Reiner, Steven L., Bernatchez, Chantale, Sykes, Megan, Mace, Emily M., Wucherpfennig, Kai W., Schadendorf, Dirk, Bechter, Oliver, Shah, Parin, Schwartz, Gary K., Marine, Jean-Christophe, Izar, Benjamin

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Anti-PD-1 immunotherapy with androgen deprivation therapy induces robust immune infiltration in metastatic castration-sensitive prostate cancer von Hawley, Jessica E, Obradovic, Aleksandar Z, Dallos, Matthew C, Lim, Emerson A, Runcie, Karie, Ager, Casey R, McKiernan, James, Anderson, Christopher B, Decastro, Guarionex J, Weintraub, Joshua, Virk, Renu, Lowy, Israel, Hu, Jianhua, Chaimowitz, Matthew G, Guo, Xinzheng V, Zhang, Ya, Haffner, Michael C, Worley, Jeremy, Stein, Mark N, Califano, Andrea, Drake, Charles G

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Melanoma Evolves Complete Immunotherapy Resistance through the Acquisition of a Hypermetabolic Phenotype von Jaiswal, Ashvin R., Liu, Arthur J., Pudakalakatti, Shivanand, Dutta, Prasanta, Jayaprakash, Priyamvada, Bartkowiak, Todd, Ager, Casey R., Wang, Zhi-Qiang, Reuben, Alexandre, Cooper, Zachary A., Ivan, Cristina, Ju, Zhenlin, Nwajei, Felix, Wang, Jing, Davies, Michael A., Davis, R. Eric, Wargo, Jennifer A., Bhattacharya, Pratip K., Hong, David S., Curran, Michael A.

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Longitudinal Immune Profiling Reveals Unique Myeloid and T-cell Phenotypes Associated with Spontaneous Immunoediting in a Prostate Tumor Model von Ager, Casey R., Obradovic, Aleksandar Z., Arriaga, Juan M., Chaimowitz, Matthew G., Califano, Andrea, Abate-Shen, Cory, Drake, Charles G.

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Hypoxia-activated prodrug and antiangiogenic therapies cooperatively treat pancreatic cancer but elicit immunosuppressive G-MDSC infiltration von Liu, Arthur, Gammon, Seth T, Pisaneschi, Federica, Boda, Akash, Ager, Casey R, Piwnica-Worms, David, Hong, David S, Curran, Michael A

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Identification of Nonfunctional Alternatively Spliced Isoforms of STING in Human Acute Myeloid Leukemia von Boda, Akash R, Liu, Arthur J, Castro-Pando, Susana, Whitfield, Benjamin T, Molldrem, Jeffrey J, Al-Atrash, Gheath, Di Francesco, Maria Emilia, Jones, Philip, Ager, Casey R, Curran, Michael A

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High-potency synthetic STING agonists rewire myeloid stroma in the tumour microenvironment to amplify immune checkpoint blockade efficacy in refractory pancreatic cancer von Boda, Akash R, Ager, Casey R, Rajapakshe, Kimal, Lea, Spencer T, Curran, Michael A

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Abstract PR-005: Adenosine signaling and radiation-induced immunosuppressive changes to the tumor microenvironment von Bansal, Shruti, Chaimowitz, Mathew, Ager, Casey R., Obradovic, Aleksandar A., Drake, Charles G., Spina, Catherine S.

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Abstract B52: Effects of tissue site and antigenicity on KPC-derived pancreatic tumor growth and response to combination immunotherapy von Ager, Casey R., Curran, Michael A.

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The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity von Ho, Patricia, Melms, Johannes C, Rogava, Meri, Frangieh, Chris J, Pozniak, Joanna, Shah, Shivem B, Walsh, Zachary, Kyrysyuk, Oleksandr, Amin, Amit Dipak, Caprio, Lindsay, Fullerton, Benjamin T, Soni, Rajesh Kumar, Ager, Casey R, Biermann, Jana, Wang, Yiping, Khosravi-Maharlooei, Mohsen, Zanetti, Giorgia, Mu, Michael, Fatima, Hijab, Moore, Emily K, Vasan, Neil, Bakhoum, Samuel F, Reiner, Steven L, Bernatchez, Chantale, Sykes, Megan, Mace, Emily M, Wucherpfennig, Kai W, Schadendorf, Dirk, Bechter, Oliver, Shah, Parin, Schwartz, Gary K, Marine, Jean-Christophe, Izar, Benjamin

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Multi-modal pooled Perturb-CITE-Seq screens in patient models define novel mechanisms of cancer immune evasion von Frangieh, Chris J., Melms, Johannes C., Thakore, Pratiksha I., Geiger-Schuller, Kathryn R., Ho, Patricia, Luoma, Adrienne M., Cleary, Brian, Jerby-Arnon, Livnat, Malu, Shruti, Cuoco, Michael S., Zhao, Maryann, Ager, Casey R., Rogava, Meri, Hovey, Lila, Rotem, Asaf, Bernatchez, Chantale, Wucherpfennig, Kai W., Johnson, Bruce E., Rozenblatt-Rosen, Orit, Schadendorf, Dirk, Regev, Aviv, Izar, Benjamin

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Abstract 3612: Elucidating and targeting master regulators of tumor infiltrating regulatory T cells von Ager, Casey R., Obradovic, Aleksandar, Turunen, Mikko, Khosravi-Maharlooei, Mohsen, Karan, Charles, Califano, Andrea, Drake, Charles G.

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