Substituted Imidazoles as Glucagon Receptor Antagonists von Chang, Linda L., Sidler, Kelly L., Cascieri, Margaret A., de Laszlo, Stephen, Koch, Greg, Li, Bing, MacCoss, Malcolm, Mantlo, Nathan, O'Keefe, Stephen, Pang, Margaret, Rolando, Anna, Hagmann, William K.

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Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors von Kramer, Mark S., Cutler, Neal, Feighner, John, Shrivastava, Ram, Carman, John, Sramek, John J., Reines, Scott A., Liu, Guanghan, Snavely, Duane, Wyatt-Knowles, Edwina, Hale, Jeffrey J., Mills, Sander G., MacCoss, Malcolm, Swain, Christopher J., Harrison, Timothy, Hill, Raymond G., Hefti, Franz, Scolnick, Edward M., Cascieri, Margaret A., Chicchi, Gary G., Sadowski, Sharon, Williams, Angela R., Hewson, Louise, Smith, David, Carlson, Emma J., Hargreaves, Richard J., Nadia M. J. Rupniak

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Potent, orally absorbed glucagon receptor antagonists von de Laszlo, Stephen E., Hacker, Candice, Li, Bing, Kim, Dooseop, MacCoss, Malcolm, Mantlo, Nathan, Pivnichny, James V., Colwell, Larry, Koch, Gregory E., Cascieri, Margaret A., Hagmann, William K.

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The novel NK1 receptor antagonist MK-0869 (L-754,030) and its water soluble phosphoryl prodrug, L-758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets von TATTERSALL, F. D, RYCROFT, W, SADOWSKI, S, BER, E, CASCIERI, M, HILL, R. G, MACINTYRE, D. E, HARGREAVES, R. J, CUMBERBATCH, M, MASON, G, TYE, S, WILLIAMSON, D. J, HALE, J. J, MILLS, S. G, FINKE, P. E, MACCOSS, M

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The chemokine/chemokine-receptor family: potential and progress for therapeutic intervention von Cascieri, Margaret A, Springer, Martin S

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Receptor for Motilin Identified in the Human Gastrointestinal System von Feighner, Scott D., Tan, Carina P., McKee, Karen Kulju, Palyha, Oksana C., Hreniuk, Donna L., Pong, Sheng-Shung, Austin, Christopher P., Figueroa, David, MacNeil, Douglas, Cascieri, Margaret A., Nargund, Ravi, Bakshi, Raman, Abramovitz, Mark, Stocco, Rino, Kargman, Stacia, O'Neill, Gary, Lex H. T. Van Der Ploeg, Evans, Jilly, Patchett, Arthur A., Smith, Roy G., Howard, Andrew D.

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Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active,... von Hale, Jeffrey J, Mills, Sander G, MacCoss, Malcolm, Finke, Paul E, Cascieri, Margaret A, Sadowski, Sharon, Ber, Elzbieta, Chicchi, Gary G, Kurtz, Marc, Metzger, Joseph, Eiermann, George, Tsou, Nancy N, Tattersall, F. David, Rupniak, Nadia M. J, Williams, Angela R, Rycroft, Wayne, Hargreaves, Richard, MacIntyre, D. Euan

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Amino-aromatic interaction between histidine 197 of the neurokinin-1 receptor and CP 96345 von TUNG MING FONG, CASCIERI, M. A, HONG YU, BANSAL, A, SWAIN, C, STRADER, C. D

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Peroxisome proliferator-activated receptors gamma and alpha mediate in vivo regulation of uncoupling protein (UCP-1, UCP-2, UCP-3) gene expression von Kelly, L J, Vicario, P P, Thompson, G M, Candelore, M R, Doebber, T W, Ventre, J, Wu, M S, Meurer, R, Forrest, M J, Conner, M W, Cascieri, M A, Moller, D E

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An Orally Active, Water-Soluble Neurokinin-1 Receptor Antagonist Suitable for Both Intravenous and Oral Clinical Administration von Harrison, Timothy, Owens, Andrew P, Williams, Brian J, Swain, Christopher J, Williams, Angela, Carlson, Emma J, Rycroft, Wayne, Tattersall, F. David, Cascieri, Margaret A, Chicchi, Gary G, Sadowski, Sharon, Rupniak, Nadia M. J, Hargreaves, Richard J

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Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets von TATTERSALL, F. D, RYCROFT, W, CASCIERI, M, BER, E, METZGER, J, MACINTYRE, D. E, HILL, R. G, HARGREAVES, R. J, FRANCIS, B, PEARCE, D, MERCHANT, K, MACLEOD, A. M, LADDUWAHETTY, T, KEOWN, L, SWAIN, C, BAKER, R

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In vitro and in vivo predictors of the anti-emetic activity of tachykinin NK1 receptor antagonists von RUPNIAK, N. M. J, TATTERSALL, F. D, MACCOSS, M, SEWARD, E, HUSCROFT, I, OWEN, S, SWAIN, C. J, HILL, R. G, HARGREAVES, R. J, WILLIAMS, A. R, RYCROFT, W, CARLSON, E. J, CASCIERI, M. A, SADOWSKI, S, BER, E, HALE, J. J, MILLS, S. G

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Characterization of the binding of a potent, selective, radioiodinated antagonist to the human neurokinin-1 receptor von Cascieri, M A, Ber, E, Fong, T M, Sadowski, S, Bansal, A, Swain, C, Seward, E, Frances, B, Burns, D, Strader, C D

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Cloning and Expression of a Novel Neuropeptide Y Receptor von Weinberg, David H., Sirinathsinghji, Dalip J.S., Tan, Carina P., Shiao, Lin-Lin, Morin, Nancy, Rigby, Michael R., Heavens, Robert H., Rapoport, Davida R., Bayne, Marvin L., Cascieri, Margaret A., Strader, Catherine D., Linemeyer, David L., MacNeil, Douglas J.

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Molecular cloning and characterization of a new receptor for galanin von Howard, Andrew D, Tan, Carina, Shiao, Lin-Lin, Palyha, Oksana C, McKee, Karen Kulju, Weinberg, David H, Feighner, Scott D, Cascieri, Margaret A, Smith, Roy G, Van Der Ploeg, Lex H.T, Sullivan, Kathleen A

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Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor von CASCIERI, M. A, MACLEOD, A. M, TUNG MING FONG, UNDERWOOD, D, LIN-LIN SHIAO, BER, E, SADOWSKI, S, HONG YU, MERCHANT, K. J, SWAIN, C. J, STRADER, C. D

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N-Heteroaryl-2-phenyl-3-(benzyloxy)piperidines:  A Novel Class of Potent Orally Active Human NK1 Antagonists von Ladduwahetty, T, Baker, R, Cascieri, M. A, Chambers, M. S, Haworth, K, Keown, L. E, MacIntyre, D. E, Metzger, J. M, Owen, S, Rycroft, W, Sadowski, S, Seward, E. M, Shepheard, S. L, Swain, C. J, Tattersall, F. D, Watt, A. P, Williamson, D. W, Hargreaves, R. J

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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs von Hale, Jeffrey J, Mills, Sander G, MacCoss, Malcolm, Dorn, Conrad P, Finke, Paul E, Budhu, Richard J, Reamer, Robert A, Huskey, Su-Er W, Luffer-Atlas, Debra, Dean, Brian J, McGowan, Erin M, Feeney, William P, Chiu, Shuet-Hing Lee, Cascieri, Margaret A, Chicchi, Gary G, Kurtz, Marc M, Sadowski, Sharon, Ber, Elzbieta, Tattersall, F. David, Rupniak, Nadia M. J, Williams, Angela R, Rycroft, Wayne, Hargreaves, Richard, Metzger, Joseph M, MacIntyre, D. Euan

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The role of histidine 265 in antagonist binding to the neurokinin-1 receptor von TUNG MING FONG, HONG YU, CASCIERI, M. A, UNDERWOOD, D, SWAIN, C. J, STRADER, C. D

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Synthesis of a Substance P Antagonist with a Somatostatin Scaffold:  Factors Affecting Agonism/Antagonism at GPCRs and the Role of Pseudosymmetry von Liu, Josephine, Underwood, Dennis J, Cascieri, Margaret A, Rohrer, Susan P, Cantin, Louis-David, Chicchi, Gary, Smith, Amos B, Hirschmann, Ralph

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