Targeting MYCN in Pediatric and Adult Cancers von Liu, Zhihui, Chen, Samuel S, Clarke, Saki, Veschi, Veronica, Thiele, Carol J

Volltext

Cancer Stem Cells and Neuroblastoma: Characteristics and Therapeutic Targeting Options von Veschi, Veronica, Verona, Francesco, Thiele, Carol J

Volltext

MYCN drives oncogenesis by cooperating with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription von Liu, Zhihui, Zhang, Xiyuan, Xu, Man, Hong, Jason J, Ciardiello, Amanda, Lei, Haiyan, Shern, Jack F, Thiele, Carol J

Volltext

Lineage specific transcription factor waves reprogram neuroblastoma from self-renewal to differentiation von Banerjee, Deblina, Bagchi, Sukriti, Liu, Zhihui, Chou, Hsien-Chao, Xu, Man, Sun, Ming, Aloisi, Sara, Vaksman, Zalman, Diskin, Sharon J., Zimmerman, Mark, Khan, Javed, Gryder, Berkley, Thiele, Carol J.

Volltext

Combining selinexor with alisertib to target the p53 pathway in neuroblastoma von Nguyen, Rosa, Wang, Hong, Sun, Ming, Lee, Dong Geun, Peng, Junmin, Thiele, Carol J.

Volltext

Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma von Veschi, Veronica, Liu, Zhihui, Voss, Ty C., Ozbun, Laurent, Gryder, Berkley, Yan, Chunhua, Hu, Ying, Ma, Anqi, Jin, Jian, Mazur, Sharlyn J., Lam, Norris, Souza, Barbara K., Giannini, Giuseppe, Hager, Gordon L., Arrowsmith, Cheryl H., Khan, Javed, Appella, Ettore, Thiele, Carol J.

Volltext

CASZ1 induces skeletal muscle and rhabdomyosarcoma differentiation through a feed-forward loop with MYOD and MYOG von Liu, Zhihui, Zhang, Xiyuan, Lei, Haiyan, Lam, Norris, Carter, Sakereh, Yockey, Oliver, Xu, Max, Mendoza, Arnulfo, Hernandez, Edjay R., Wei, Jun S., Khan, Javed, Yohe, Marielle E., Shern, Jack F., Thiele, Carol J.

Volltext

EZH2 Mediates Epigenetic Silencing of Neuroblastoma Suppressor Genes CASZ1, CLU, RUNX3, and NGFR von CHUNXI WANG, ZHIHUI LIU, KAI GE, THIELE, Carol J, WOO, Chan-Wook, ZHIJIE LI, LIFENG WANG, WEI, Jun S, MARQUEZ, Victor E, BATES, Susan E, QIHUANG JIN, KHAN, Javed

Volltext

Corrigendum: Combination of rapamycin and MK-2206 induced cell death via autophagy and necroptosis in MYCN-amplified neuroblastoma cell lines von Dong, Yudi, Gong, Wei, Hua, Zhongyan, Chen, Bo, Zhao, Guifeng, Liu, Zhihui, Thiele, Carol J, Li, Zhijie

Volltext

Loss of CASZ1 tumor suppressor linked to oncogenic subversion of neuroblastoma core regulatory circuitry von Liu, Zhihui, Zhang, Xiyuan, Xu, Man, Lei, Haiyan, Shern, Jack F., Thiele, Carol J.

Volltext

The anti-tumor growth effect of a novel agent DMAMCL in rhabdomyosarcoma in vitro and in vivo von Xu, Ning, Hua, Zhongyan, Ba, Gen, Zhang, Simeng, Liu, Zhihui, Thiele, Carol J, Li, Zhijie

Volltext

Essential Role of the Zinc Finger Transcription Factor Casz1 for Mammalian Cardiac Morphogenesis and Development von Liu, Zhihui, Li, Wenling, Ma, Xuefei, Ding, Nancy, Spallotta, Francesco, Southon, Eileen, Tessarollo, Lino, Gaetano, Carlo, Mukouyama, Yoh-suke, Thiele, Carol J.

Volltext

PI3K and MAPK pathways mediate the BDNF/TrkB-increased metastasis in neuroblastoma von Hua, Zhongyan, Gu, Xiao, Dong, Yudi, Tan, Fei, Liu, Zhihui, Thiele, Carol J., Li, Zhijie

Volltext

Combination of Rapamycin and MK-2206 Induced Cell Death via Autophagy and Necroptosis in MYCN-Amplified Neuroblastoma Cell Lines von Dong, Yudi, Gong, Wei, Hua, Zhongyan, Chen, Bo, Zhao, Guifeng, Liu, Zhihui, Thiele, Carol J, Li, Zhijie

Volltext

CASZ1b, the short isoform of CASZ1 gene, coexpresses with CASZ1a during neurogenesis and suppresses neuroblastoma cell growth von Liu, Zhihui, Naranjo, Arlene, Thiele, Carol J

Volltext

Corrigendum: Downregulation of ATXN3 enhances the sensitivity to AKT inhibitors (Perifosine or MK-2206), but decreases the sensitivity to chemotherapeutic drugs (etoposide or cispl... von Gong, Baocheng, Zhang, Jinhua, Hua, Zhongyan, Liu, Zhihui, Thiele, Carol J., Li, Zhijie

Volltext

Downregulation of ATXN3 Enhances the Sensitivity to AKT Inhibitors (Perifosine or MK-2206), but Decreases the Sensitivity to Chemotherapeutic Drugs (Etoposide or Cisplatin) in Neur... von Gong, Baocheng, Zhang, Jinhua, Hua, Zhongyan, Liu, Zhihui, Thiele, Carol J., Li, Zhijie

Volltext

Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma von Sun, Ming, Cao, Yingying, Okada, Reona, Reyes-González, Jeyshka M, Stack, Hannah G, Qin, Haiying, Li, Nan, Seibert, Charlie, Kelly, Michael C, Ruppin, Eytan, Ho, Mitchell, Thiele, Carol J, Nguyen, Rosa

Volltext

Antitumor effects of the small molecule DMAMCL in neuroblastoma via suppressing aerobic glycolysis and targeting PFKL von Zhang, Simeng, Hua, Zhongyan, Ba, Gen, Xu, Ning, Miao, Jianing, Zhao, Guifeng, Gong, Wei, Liu, Zhihui, Thiele, Carol J., Li, Zhijie

Volltext

Perifosine‐induced inhibition of akt attenuates brain‐derived neurotrophic factor/TrkB‐induced chemoresistance in neuroblastoma in vivo von Li, Zhijie, Oh, Doo‐Yi, Nakamura, Katsuya, Thiele, Carol J.

Volltext