Concordance of blood- and tumor-based detection of RAS mutations to guide anti-EGFR therapy in metastatic colorectal cancer von Grasselli, J., Elez, E., Caratù, G., Matito, J., Santos, C., Macarulla, T., Vidal, J., Garcia, M., Viéitez, J.M., Paéz, D., Falcó, E., Lopez Lopez, C., Aranda, E., Jones, F., Sikri, V., Nuciforo, P., Fasani, R., Tabernero, J., Montagut, C., Azuara, D., Dienstmann, R., Salazar, R., Vivancos, A.

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Early evolutionary divergence between papillary and anaplastic thyroid cancers von Capdevila, J., Mayor, R., Mancuso, F.M., Iglesias, C., Caratù, G., Matos, I., Zafón, C., Hernando, J., Petit, A., Nuciforo, P., Cameselle-Teijeiro, J.M., Álvarez, C., Recio, J.A., Tabernero, J., Matias-Guiu, X., Vivancos, A., Seoane, J.

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RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer von Cruz, C., Castroviejo-Bermejo, M., Gutiérrez-Enríquez, S., Llop-Guevara, A., Ibrahim, Y.H., Gris-Oliver, A., Bonache, S., Morancho, B., Bruna, A., Rueda, O.M., Lai, Z., Polanska, U.M., Jones, G.N., Kristel, P., de Bustos, L., Guzman, M., Rodríguez, O., Grueso, J., Montalban, G., Caratú, G., Mancuso, F., Fasani, R., Jiménez, J., Howat, W.J., Dougherty, B., Vivancos, A., Nuciforo, P., Serres-Créixams, X., Rubio, I.T., Oaknin, A., Cadogan, E., Barrett, J.C., Caldas, C., Baselga, J., Saura, C., Cortés, J., Arribas, J., Jonkers, J., Díez, O., O’Connor, M.J., Balmaña, J., Serra, V.

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Early evolutionary divergence between papillary and anaplastic thyroid cancers von Capdevila, J., Mayor, R., Mancuso, F.M., Iglesias, C., Caratú, G., Matos, I., Zafón, C., Hernando, J., Petit, A., Nuciforo, P., Cameselle-Teijeiro, J.M., Álvarez, C.V., Recio, J.A., Tabernero, J., Matias-Guiu, X., Vivancos, A., Seoane, J.

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2027P - VHIO-300 and a thousand and one nights: A tale of precision medicine von Caratù, G., Mancuso, F.M., Sansó, M., Matito, J., Fasani, R., Oaknin, A., Alsina Maqueda, M., Capdevila, J., Elez Fernández, E., Macarulla Mercade, T., Carles, J., Saura, C., Rodon, J.A., Dienstmann, R., Nuciforo, P.G., Garralda, E., Felip, E., Tabernero, J., Vivancos, A.

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VHIO-300 and a thousand and one nights: A tale of precision medicine von Caratù, G., Mancuso, F.M., Sansó, M., Matito, J., Fasani, R., Oaknin, A., Alsina Maqueda, M., Capdevila, J., Elez Fernández, E., Macarulla Mercade, T., Carles, J., Saura, C., Rodon, J.A., Dienstmann, R., Nuciforo, P.G., Garralda, E., Felip, E., Tabernero, J., Vivancos, A.

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575PRAS mutant allele fraction in plasma predicts benefit to anti-angiogenic based first-line treatment in metastatic colorectal cancer von Martini, G, Elez, E, Mancuso, F M, España, M A Gomez, Caratù, G, Matito, J, Martinez, G Argiles, Margalef, N Mulet, Morales, M J Ortiz, Montana, F J Ros, Garcia, A, Comas, R, Vivas, C Santos, Perez-Lopez, R, Nuciforo, P G, Casanovas, O, Dienstmann, R, Tabernero, J, Aguilar, E Aranda, Vivancos, A

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RAS mutant allele fraction in plasma predicts benefit to anti-angiogenic based first-line treatment in metastatic colorectal cancer von Martini, G., Elez, E., Mancuso, F.M., España, M A Gomez, Caratù, G., Matito, J., Martinez, G Argiles, Margalef, N Mulet, Morales, M J Ortiz, Montana, F J Ros, Garcia, A., Comas, R., Vivas, C Santos, Perez-Lopez, R., Nuciforo, P.G., Casanovas, O., Dienstmann, R., Tabernero, J., Aguilar, E Aranda, Vivancos, A.

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575P - RAS mutant allele fraction in plasma predicts benefit to anti-angiogenic based first-line treatment in metastatic colorectal cancer von Martini, G., Elez, E., Mancuso, F.M., España, M A Gomez, Caratù, G., Matito, J., Martinez, G Argiles, Margalef, N Mulet, Morales, M J Ortiz, Montana, F J Ros, Garcia, A., Comas, R., Vivas, C Santos, Perez-Lopez, R., Nuciforo, P.G., Casanovas, O., Dienstmann, R., Tabernero, J., Aguilar, E Aranda, Vivancos, A.

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2027PVHIO-300 and a thousand and one nights: A tale of precision medicine von Caratù, G, Mancuso, F M, Sansó, M, Matito, J, Fasani, R, Oaknin, A, Alsina Maqueda, M, Capdevila, J, Elez Fernández, E, Macarulla Mercade, T, Carles, J, Saura, C, Rodon, J A, Dienstmann, R, Nuciforo, P G, Garralda, E, Felip, E, Tabernero, J, Vivancos, A

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Establishment of patient-derived tumor organoids to functionally inform treatment decisions in metastatic colorectal cancer von Martini, G., Belli, V., Napolitano, S., Ciaramella, V., Ciardiello, D., Belli, A., Izzo, F., Avallone, A., Selvaggi, F., Menegon Tasselli, F., Santaniello, W., Franco, R., Puig, I., Ramirez, L., Chicote, I., Mancuso, F., Caratu, G., Serres, X., Fasani, R., Jimenez, J., Ros, J., Baraibar, I., Mulet, N., Della Corte, C.M., Troiani, T., Vivancos, A., Dienstmann, R., Elez, E., Palmer, H.G., Tabernero, J., Martinelli, E., Ciardiello, F., Argilés, G.

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O-024 Circulating tumor DNA extended RAS mutational analysis as a surrogate of mutational status of tumor samples in metastatic colorectal cancer and its impact on patient selectio... von Grasselli, J., Elez, E., Caratù, G., Matito, J., Santos, C., Macarulla, T., Vidal, J., Garcia, M., Viéitez, J.M., Paéz, D., Falcó, E., Lopez, C. Lopez, Aranda, E., Jones, F., Sikri, V., Nuciforo, P., Dienstmann, R., Montagut, C., Tabernero, J., Azuara, D., Salazar, R., Vivancos, A.

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561P Liquid biopsy tracking of immunotherapy-induced T cell dynamics in MSS colorectal and endometrial tumors von Heyn, H., Melero, J.L., Deuner, G., Argota, I. Baraibar, Grzelak, M., Caratu, G., Duran, C. Garcia, Béjar, J.F. Grau, Illescas, D.G., Madrid, L. Fariñas, Nieto, P., Morabito, S., Rotem, A., Casbas-Hernandez, P., Gros, A., Tabernero, J., Oaknin, A., Sachica, J.N., Borcherding, N., Fernandez, M.E. Elez

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487P Use of patient-derived tumour organoids to identify acquired treatment resistance and determine optimal post-progression combinations in metastatic colorectal cancer von Martini, G., Borreil, I. Puig, Ramirez, L., Chicote, I., Mancuso, F.M., Caratu, G., Serres-Créixams, X., Fasani, R., Jimenez, J., Montañá, F.J. Ros, Argota, I. Baraibar, Ciardiello, D., Margalef, N. Mulet, Dienstmann, R., Vivancos, A., Elez, E., Palmer, H., Tabernero, J., Martinez, G. Argiles

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Lurbinectedin (PM01183) exhibits antitumor activity in PARP-inhibitor resistant germline BRCA PDX and lacks cross-resistance with cisplatin von Cruz, C., Caratu, G., Llop-Guevara, A., Castroviejo, M., Gutierrez-Enriquez, S., Morancho, B., Campa, E. Álvarezdela, Prudkin, L., Nuciforo, P., Arribas, J., Vivancos, A., Cruz, Xdela, Galmarini, C., Avilés, P.M., Saura, C., Díez, O., Serra, V., Balmaña, J.

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O-024Circulating tumor DNA extended RAS mutational analysis as a surrogate of mutational status of tumor samples in metastatic colorectal cancer and its impact on patient selection... von Grasselli, J, Elez, E, Caratu, G, Matito, J, Santos, C, Macarulla, T, Vidal, J, Garcia, M, Vieitez, J M, Paez, D, Falco, E, Lopez, C Lopez, Aranda, E, Jones, F, Sikri, V, Nuciforo, P, Dienstmann, R, Montagut, C, Tabernero, J, Azuara, D, Salazar, R, Vivancos, A

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Abstract P4-07-05: PARP inhibition in breast and ovarian patient-derived tumor xenografts (PDX) harboring germline BRCA1/2 mutations unveils mechanisms of primary and acquired resi... von Cruz, C, Bustos, Ld, Gris, A, Palafox, M, Castroviejo, M, Llop, A, Morancho, B, Diez, O, Gutiérrez, S, Caratú, G, Prudkin, L, Bruna, A, Caldas, C, O'Connor, MJ, Rubio, IT, Arribas, J, Baselga, J, Cortes, J, Serra, V, Balmaña, J

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Early evolutionary divergence between papillary and anaplastic thyroid cancers von Capdevila, J, Mayor, R, Mancuso, F M, Iglesias, C, Caratú, G, Matos, I, Zafón, C, Hernando, J, Petit, A, Nuciforo, P, Cameselle-Teijeiro, J M, Álvarez, C V, Recio, J A, Tabernero, J, Matias-Guiu, X, Vivancos, A, Seoane, J

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1656P - Breast Cancer (BC) and the Study of Intratumoral Heterogeneity through PI3K Pathway-Biomarkers von De Mattos-Arruda, L., Cortes, J., Aura, C.M., Gregori, J., Caratú, G., Saura, C., Oliveira, M., Tabernero, J., Seoane, J., Vivancos, A.

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Breast Cancer (BC) and the Study of Intratumoral Heterogeneity through PI3K Pathway-Biomarkers von De Mattos-Arruda, L., Cortes, J., Aura, C.M., Gregori, J., Caratú, G., Saura, C., Oliveira, M., Tabernero, J., Seoane, J., Vivancos, A.

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