Dissecting the treatment-naive ecosystem of human melanoma brain metastasis von Biermann, Jana, Melms, Johannes C, Amin, Amit Dipak, Wang, Yiping, Caprio, Lindsay A, Karz, Alcida, Tagore, Somnath, Barrera, Irving, Ibarra-Arellano, Miguel A, Andreatta, Massimo, Fullerton, Benjamin T, Gretarsson, Kristjan H, Sahu, Varun, Mangipudy, Vaibhav S, Nguyen, Trang T T, Nair, Ajay, Rogava, Meri, Ho, Patricia, Koch, Peter D, Banu, Matei, Humala, Nelson, Mahajan, Aayushi, Walsh, Zachary H, Shah, Shivem B, Vaccaro, Daniel H, Caldwell, Blake, Mu, Michael, Wünnemann, Florian, Chazotte, Margot, Berhe, Simon, Luoma, Adrienne M, Driver, Joseph, Ingham, Matthew, Khan, Shaheer A, Rapisuwon, Suthee, Slingluff, Jr, Craig L, Eigentler, Thomas, Röcken, Martin, Carvajal, Richard, Atkins, Michael B, Davies, Michael A, Agustinus, Albert, Bakhoum, Samuel F, Azizi, Elham, Siegelin, Markus, Lu, Chao, Carmona, Santiago J, Hibshoosh, Hanina, Ribas, Antoni, Canoll, Peter, Bruce, Jeffrey N, Bi, Wenya Linda, Agrawal, Praveen, Schapiro, Denis, Hernando, Eva, Macosko, Evan Z, Chen, Fei, Schwartz, Gary K, Izar, Benjamin

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Abstract 5944: Relief of chromosomal instability-induced cGAS-STING signaling sensitizes STK11 -mutant non-small cell lung cancer to immune checkpoint blockade von Caprio, Lindsay A., Hong, Christy, Amin, Amit Dipak, Tagore, Somnath, Melms, Johannes, Cai, Luke, Wang, Yiping, Ho, Patricia, Mu, Michael, Hibshoosh, Hanina, Henick, Brian, Wong, Kwok K., Bakhoum, Samuel F., Izar, Benjamin

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Abstract 984: Dissecting the ecosystem of treatment-naïve melanoma brain metastasis using multi-modal single-cell analysis von Melms, Johannes C., Biermann, Jana, Amin, Amit Dipak, Wang, Yiping, Tagore, Somnath, Andreatta, Massimo, Nair, Ajay, Rogava, Meri, Ho, Patricia, Caprio, Lindsay A., Walsh, Zachary H., Shah, Shivem, Vacarro, Daniel H., Caldwell, Blake, Luoma, Adrienne M., Driver, Joseph, Ingham, Matthew, Rapisuwon, Suthee, Wargo, Jennifer, Slinguff, Craig L., Macosco, Evan Z., Chen, Fei, Carvajal, Richard, Atkins, Michael B., Davies, Michael A., Azizi, Elham, Carmona, Santiago J., Hibshoosh, Hanina, Canoll, Peter D., Bruce, Jeffrey N., Bi, Wenya L., Schwartz, Gary K., Izar, Benjamin

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Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I–III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial... von Altorki, Nasser K., Walsh, Zachary H., Melms, Johannes C., Port, Jeffery L., Lee, Benjamin E., Nasar, Abu, Spinelli, Cathy, Caprio, Lindsay, Rogava, Meri, Ho, Patricia, Christos, Paul J., Saxena, Ashish, Elemento, Olivier, Bhinder, Bhavneet, Ager, Casey, Amin, Amit Dipak, Sanfilippo, Nicholas J., Mittal, Vivek, Borczuk, Alain C., Formenti, Silvia C., Izar, Benjamin, McGraw, Timothy E.

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Author Correction: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I–III non-small cell lung cancer: survival outcomes and molecular correlates of a randomi... von Altorki, Nasser K., Walsh, Zachary H., Melms, Johannes C., Port, Jeffery L., Lee, Benjamin E., Nasar, Abu, Spinelli, Cathy, Caprio, Lindsay, Rogava, Meri, Ho, Patricia, Christos, Paul J., Saxena, Ashish, Elemento, Olivier, Bhinder, Bhavneet, Ager, Casey, Amin, Amit Dipak, Sanfilippo, Nicholas J., Mittal, Vivek, Borczuk, Alain C., Formenti, Silvia C., Izar, Benjamin, McGraw, Timothy E.

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End-of-Life Care Transitions in Assisted Living: Associations With State Staffing and Training Regulations von Guo, Wenhan, Cai, Shubing, Caprio, Thomas, Schwartz, Lindsay, Temkin-Greener, Helena

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Abstract 6157: Hypoxia increases motility of neuroblastoma cells induced by the neuropeptide Y/Y5 receptor pathway and exacerbates their metastatic potential von Abualsaud, Nouran, Caprio, Lindsay, Hong, Sung Hyeok, Galli, Susana, Kitlinska, Joanna

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Association of circulating CD103 + T cells with major pathological response in a randomized phase 2 trial of neoadjuvant durvalumab with or without stereotactic body radiotherapy i... von Walsh, Zachary, Melms, Johannes C, Rogava, Meri, Caprio, Lindsay, Ager, Casey, Amin, Amit Dipak, Ho, Patricia, Malbari, Murtaza, Mittal, Vivek, McGraw, Timothy, Altorki, Nasser K., Izar, Benjamin

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The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity von Ho, Patricia, Melms, Johannes C., Rogava, Meri, Frangieh, Chris J., Poźniak, Joanna, Shah, Shivem B., Walsh, Zachary, Kyrysyuk, Oleksandr, Amin, Amit Dipak, Caprio, Lindsay, Fullerton, Benjamin T., Soni, Rajesh Kumar, Ager, Casey R., Biermann, Jana, Wang, Yiping, Khosravi-Maharlooei, Mohsen, Zanetti, Giorgia, Mu, Michael, Fatima, Hijab, Moore, Emily K., Vasan, Neil, Bakhoum, Samuel F., Reiner, Steven L., Bernatchez, Chantale, Sykes, Megan, Mace, Emily M., Wucherpfennig, Kai W., Schadendorf, Dirk, Bechter, Oliver, Shah, Parin, Schwartz, Gary K., Marine, Jean-Christophe, Izar, Benjamin

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Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens von Wang, Yiping, Fan, Joy Linyue, Melms, Johannes C., Amin, Amit Dipak, Georgis, Yohanna, Barrera, Irving, Ho, Patricia, Tagore, Somnath, Abril-Rodríguez, Gabriel, He, Siyu, Jin, Yinuo, Biermann, Jana, Hofree, Matan, Caprio, Lindsay, Berhe, Simon, Khan, Shaheer A., Henick, Brian S., Ribas, Antoni, Macosko, Evan Z., Chen, Fei, Taylor, Alison M., Schwartz, Gary K., Carvajal, Richard D., Azizi, Elham, Izar, Benjamin

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Neuropeptide Y/Y5 Receptor Pathway Stimulates Neuroblastoma Cell Motility Through RhoA Activation von Abualsaud, Nouran, Caprio, Lindsay, Galli, Susana, Krawczyk, Ewa, Alamri, Lamia, Zhu, Shiya, Gallicano, G Ian, Kitlinska, Joanna

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Abstract 3663: Neuropeptide Y stimulates neuroblastoma cell migration via Y5R/RhoA pathway von Abualsaud, Nouran, Caprio, Lindsay, Bakr, Abrar, Alamri, Lamia, Krawczyk, Ewa, Galli, Susana, Hong, Sung Hyeok, Kitlinska, Joanna

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Multi-modal single-cell and whole-genome sequencing of small, frozen clinical specimens von Wang, Yiping, Fan, Joy Linyue, Melms, Johannes C., Amin, Amit Dipak, Georgis, Yohanna, Barrera, Irving, Ho, Patricia, Tagore, Somnath, Abril-Rodríguez, Gabriel, He, Siyu, Jin, Yinuo, Biermann, Jana, Hofree, Matan, Caprio, Lindsay, Berhe, Simon, Khan, Shaheer A., Henick, Brian S., Ribas, Antoni, Macosko, Evan Z., Chen, Fei, Taylor, Alison M., Schwartz, Gary K., Carvajal, Richard D., Azizi, Elham, Izar, Benjamin

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The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity von Ho, Patricia, Melms, Johannes C, Rogava, Meri, Frangieh, Chris J, Pozniak, Joanna, Shah, Shivem B, Walsh, Zachary, Kyrysyuk, Oleksandr, Amin, Amit Dipak, Caprio, Lindsay, Fullerton, Benjamin T, Soni, Rajesh Kumar, Ager, Casey R, Biermann, Jana, Wang, Yiping, Khosravi-Maharlooei, Mohsen, Zanetti, Giorgia, Mu, Michael, Fatima, Hijab, Moore, Emily K, Vasan, Neil, Bakhoum, Samuel F, Reiner, Steven L, Bernatchez, Chantale, Sykes, Megan, Mace, Emily M, Wucherpfennig, Kai W, Schadendorf, Dirk, Bechter, Oliver, Shah, Parin, Schwartz, Gary K, Marine, Jean-Christophe, Izar, Benjamin

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Abstract 4143: The role of neuropeptide Y and its Y5 receptor in RhoA-mediated regulation of cytokinesis and cell motility von Abualsaud, Nouran, Lu, Congyi, Mahajan, Akanksha, Bakr, Abrar, Zhu, Shiya, Caprio, Lindsay, Hong, Sung Hyeok, Kitlinska, Joanna

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Introduction Of A High-fat/sucrose Diet Modulates Voluntary Wheel Running Activity In Adult Female Rats: 1559 Board #234 June 1 8 00 AM - 9 30 AM von Hyatt, Jon-Philippe K., Caprio, Lindsay, Bienenstock, Elisa J., Kim, Jung A., McCall, Gary E.

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A Tumor Cell-Selective Inhibitor of Mitogen-Activated Protein Kinase Phosphatases Sensitizes Breast Cancer Cells to Lymphokine-Activated Killer Cell Activity von Kaltenmeier, Christof T., Vollmer, Laura L., Vernetti, Lawrence A., Caprio, Lindsay, Davis, Keanu, Korotchenko, Vasiliy N., Day, Billy W., Tsang, Michael, Hulkower, Keren I., Lotze, Michael T., Vogt, Andreas

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Abstract PR018: Neuropeptide Y as a metastatic factor von Adnani, Mina, Hong, Sung-Hyeok, Galli, Susana, Mahajan, Akanksha, Abualsaud, Nouran, Caprio, Lindsay, Tilan, Jason U., Rodriguez, Olga, Wang, Hingkun, Albanese, Christopher, Cavalli, Luciane R., Kitlinska, Joanna

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Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation von Rogava, Meri, Aprati, Tyler J, Chi, Wei-Yu, Melms, Johannes C, Hug, Clemens, Davis, Stephanie H, Earlie, Ethan M, Chung, Charlie, Deshmukh, Sachin K, Wu, Sharon, Sledge, George, Tang, Stephen, Ho, Patricia, Amin, Amit Dipak, Caprio, Lindsay, Gurjao, Carino, Tagore, Somnath, Ngo, Bryan, Lee, Michael J, Zanetti, Giorgia, Wang, Yiping, Chen, Sean, Ge, William, Melo, Luiza Martins Nascentes, Allies, Gabriele, Rösler, Jonas, Gibney, Goeffrey T, Schmitz, Oliver J, Sykes, Megan, Creusot, Rémi J, Tüting, Thomas, Schadendorf, Dirk, Röcken, Martin, Eigentler, Thomas K, Molotkov, Andrei, Mintz, Akiva, Bakhoum, Samuel F, Beyaz, Semir, Cantley, Lewis C, Sorger, Peter K, Meckelmann, Sven W, Tasdogan, Alpaslan, Liu, David, Laughney, Ashley M, Izar, Benjamin

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Abstract 3517: Multi-modal single-cell and spatial genomics reveals genomic, adaptive and microenvironmental features of human non-small cell lung cancer brain metastasis von Tagore, Somnath, Caprio, Lindsay, Amin, Amit Dipak, Barrera, Irving, Melms, Johannes, Luthria, Karan, Wang, Yiping, Georgis, Yohanna, Jaiswal, Abhi, Lagos, Galina G., Walsh, Zachary, Shah, Parin, Biermann, Jana, Sheikh, Neha, Ramaradj, Priyanka, Anandasabapathy, Niroshana, Hibshoosh, Hanina, Schwartz, Gary, Henick, Brian, Taylor, Alison, Chen, Fei, Izar, Benjamin

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