PD-1- CD45RA+ effector-memory CD8 T cells and CXCL10+ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma von Cappuyns, Sarah, Philips, Gino, Vandecaveye, Vincent, Boeckx, Bram, Schepers, Rogier, Van Brussel, Thomas, Arijs, Ingrid, Mechels, Aurelie, Bassez, Ayse, Lodi, Francesca, Jaekers, Joris, Topal, Halit, Topal, Baki, Bricard, Orian, Qian, Junbin, Van Cutsem, Eric, Verslype, Chris, Lambrechts, Diether, Dekervel, Jeroen

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Combination Therapies for Advanced Hepatocellular Carcinoma: Biomarkers and Unmet Needs von Cappuyns, Sarah, Llovet, Josep M

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Oncogenic role of PMEPA1 and its association with immune exhaustion and TGF-β activation in HCC von Piqué-Gili, Marta, Andreu-Oller, Carmen, Mesropian, Agavni, Esteban-Fabró, Roger, Bárcena-Varela, Marina, Ruiz de Galarreta, Marina, Montironi, Carla, Martinez-Quetglas, Iris, Cappuyns, Sarah, Peix, Judit, Keraite, Ieva, Gris-Oliver, Albert, Fernández-Martínez, Elisa, Mauro, Ezequiel, Torres-Martin, Miguel, Abril-Fornaguera, Jordi, Lindblad, Katherine E., Lambrechts, Diether, Dekervel, Jeroen, Thung, Swan N., Sia, Daniela, Lujambio, Amaia, Pinyol, Roser, Llovet, Josep M.

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Combination Therapies for Advanced Hepatocellular Carcinoma: Biomarkers and Unmet Needs von Cappuyns, Sarah, Llovet, Josep M

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The ongoing search for biomarkers of response to systemic therapy in advanced hepatocellular carcinoma von Cappuyns, Sarah

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Pre-treatment cross-talk between the tumoural and peripheral immune system predicts response to checkpoint inhibition in advanced HCC: a single-cell study von Cappuyns, Sarah, Philips, Gino, Vandecaveye, Vincent, Verslype, Chris, Van Cutsem, Eric, Lambrechts, Diether, Dekervel, Jeroen

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Unraveling the Synergy between Atezolizumab and Bevacizumab for the Treatment of Hepatocellular Carcinoma von Brackenier, Cedric, Kinget, Lisa, Cappuyns, Sarah, Verslype, Chris, Beuselinck, Benoit, Dekervel, Jeroen

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DNA methylation-driven EMT is a common mechanism of resistance to various therapeutic agents in cancer von Galle, Eva, Thienpont, Bernard, Cappuyns, Sarah, Venken, Tom, Busschaert, Pieter, Van Haele, Matthias, Van Cutsem, Eric, Roskams, Tania, van Pelt, Jos, Verslype, Chris, Dekervel, Jeroen, Lambrechts, Diether

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Critical Appraisal of Guideline Recommendations on Systemic Therapies for Advanced Hepatocellular Carcinoma A Review von Cappuyns, Sarah, Corbett, Virginia, Yarchoan, Mark, Finn, Richard S, Llovet, Josep M

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PD-1- CD45RA+ effector-memory CD8 T cells and CXCL10+ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma von Cappuyns, Sarah, Philips, Gino, Vandecaveye, Vincent, Boeckx, Bram, Schepers, Rogier, Van Brussel, Thomas, Arijs, Ingrid, Mechels, Aurelie, Bassez, Ayse, Lodi, Francesca, Jaekers, Joris, Topal, Halit, Topal, Baki, Bricard, Orian, Qian, Junbin, Van Cutsem, Eric, Verslype, Chris, Lambrechts, Diether, Dekervel, Jeroen

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Unraveling the Synergy between Atezolizumab and Bevacizumab for the Treatment of Hepatocellular Carcinoma von Brackenier, Cedric, Kinget, Lisa, Cappuyns, Sarah, Verslype, Chris, Beuselinck, Benoit, Dekervel, Jeroen

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Predicting response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma using single-cell RNA-sequencing-derived gene signatures von Cappuyns, Sarah, Piqué-Gili, Marta, Esteban-Fabró, Roger, Philips, Gino, Pinyol, Roser, Vandecaveye, Vincent, Abril-Fornaguera, Jordi, Haber, Philipp, Verslype, Chris, Van Cutsem, Eric, Lambrechts, Diether, Villanueva, Augusto, Dekervel, Jeroen, Llovet, Josep

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OS-059-YI - Predicting response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma using single-cell RNA-sequencing-derived gene signatures von Cappuyns, Sarah, Piqué-Gili, Marta, Esteban-Fabró, Roger, Philips, Gino, Pinyol, Roser, Vandecaveye, Vincent, Abril-Fornaguera, Jordi, Haber, Philipp, Verslype, Chris, Van Cutsem, Eric, Lambrechts, Diether, Villanueva, Augusto, Dekervel, Jeroen, Llovet, Josep

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TOP-066 - PD1-negative CD45RA effector-memory CD8 T-cells are essential for response to checkpoint inhibition in advanced hepatocellular carcinoma von Cappuyns, Sarah, Philips, Gino, Vandecaveye, Vincent, Boeckx, Bram, Schepers, Rogier, Van Brussel, Thomas, Arijs, Ingrid, Mechels, Aurelie, Bassez, Ayse, Lodi, Francesca, Jaekers, Joris, Topal, Halit, Topal, Baki, Bricard, Orian, Qian, Junbin, Van Cutsem, Eric, Verslype, Chris, Lambrechts, Diether, Dekervel, Jeroen

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PD1-negative CD45RA effector-memory CD8 T-cells are essential for response to checkpoint inhibition in advanced hepatocellular carcinoma von Cappuyns, Sarah, Philips, Gino, Vandecaveye, Vincent, Boeckx, Bram, Schepers, Rogier, Van Brussel, Thomas, Arijs, Ingrid, Mechels, Aurelie, Bassez, Ayse, Lodi, Francesca, Jaekers, Joris, Topal, Halit, Topal, Baki, Bricard, Orian, Qian, Junbin, Van Cutsem, Eric, Verslype, Chris, Lambrechts, Diether, Dekervel, Jeroen

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Applications of single-cell multi-omics in liver cancer von Peeters, Frederik, Cappuyns, Sarah, Pique-Gili, Marta, Phillips, Gino, Verslype, Chris, Lambrechts, Diether, Dekervel, Jeroen

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Applications of single-cell multi-omics in liver cancerKey points von Frederik Peeters, Sarah Cappuyns, Marta Piqué-Gili, Gino Phillips, Chris Verslype, Diether Lambrechts, Jeroen Dekervel

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Applications of single-cell multi-omics in liver cancer von Peeters, Frederik, Cappuyns, Sarah, Piqué-Gili, Marta, Phillips, Gino, Verslype, Chris, Lambrechts, Diether, Dekervel, Jeroen

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TOP-507-YI Single-cell RNA sequencing-derived gene signatures reveal distinct response mechanisms to atezolizumab + bevacizumab in advanced hepatocellular carcinoma von Cappuyns, Sarah, Piqué-Gili, Marta, Esteban-Fabró, Roger, Philips, Gino, Pinyol, Roser, Gris-Oliver, Albert, Vandecaveye, Vincent, Abril-Fornaguera, Jordi, Montironi, Carla, Bassaganyas, Laia, Peix, Judit, Zeitlhoefler, Marcus, Mesropian, Agavni, Huguet-Pradell, Júlia, Haber, Philipp, Mohr, Raphael, Meyer, Tim, Reeves, Helen Louise, Edeline, Julien, Finkelmeier, Fabian, Trojan, Jörg, Galle, Peter R., Foerster, Friedrich, Minguez, Beatriz, Montal, Robert, Heikenwälder, Mathias, Verslype, Chris, Van Cutsem, Eric, Lambrechts, Diether, Villanueva, Augusto, Dekervel, Jeroen, Llovet, Josep

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Abstract PR03: Pretreatment immune cell composition and checkpoint ligand expression define the response to immunotherapy in advanced HCC: a study using single-cell sequencing von Cappuyns, Sarah, Philips, Gino, Vandecaveye, Vincent, Verslype, Chris, Van Cutsem, Eric, Lambrechts, Diether, Derkervel, Jeroen

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