Ovarian Cancer Cells in Ascites Form Aggregates That Display a Hybrid Epithelial-Mesenchymal Phenotype and Allows Survival and Proliferation of Metastasizing Cells von Capellero, Sonia, Erriquez, Jessica, Battistini, Chiara, Porporato, Roberta, Scotto, Giulia, Borella, Fulvio, Di Renzo, Maria F, Valabrega, Giorgio, Olivero, Martina

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Cancer Cells Haploinsufficient for ATM Are Sensitized to PARP Inhibitors by MET Inhibition von D'Ambrosio, Concetta, Erriquez, Jessica, Capellero, Sonia, Cignetto, Simona, Alvaro, Maria, Ciamporcero, Eric, Di Renzo, Maria Flavia, Perera, Timothy, Valabrega, Giorgio, Olivero, Martina

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PIK3R1W624R Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma von D'Ambrosio, Concetta, Erriquez, Jessica, Arigoni, Maddalena, Capellero, Sonia, Mittica, Gloria, Ghisoni, Eleonora, Borella, Fulvio, Katsaros, Dionyssios, Privitera, Silvana, Ribotta, Marisa, Maldi, Elena, Di Nardo, Giovanna, Berrino, Enrico, Venesio, Tiziana, Ponzone, Riccardo, Vaira, Marco, Hall, Douglas, Jimenez-Linan, Mercedes, Paterson, Anna L., Calogero, Raffaele A., Brenton, James D., Valabrega, Giorgio, Di Renzo, Maria Flavia, Olivero, Martina

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Three-dimensional dynamics of mesothelin-targeted CAR.CIK lymphocytes against ovarian cancer peritoneal carcinomatosis von Galvagno, Federica, Leuci, Valeria, Massa, Annamaria, Donini, Chiara, Rotolo, Ramona, Capellero, Sonia, Proment, Alessia, Vitali, Letizia, Lombardi, Andrea Maria, Tuninetti, Valentina, D’Ambrosio, Lorenzo, Merlini, Alessandra, Vigna, Elisa, Valabrega, Giorgio, Primo, Luca, Puliafito, Alberto, Sangiolo, Dario

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CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft-Tissue Sarcoma Histotypes von Leuci, Valeria, Donini, Chiara, Grignani, Giovanni, Rotolo, Ramona, Mesiano, Giulia, Fiorino, Erika, Gammaitoni, Loretta, D'Ambrosio, Lorenzo, Merlini, Alessandra, Landoni, Elisa, Medico, Enzo, Capellero, Sonia, Giraudo, Lidia, Cattaneo, Giulia, Iaia, Ilenia, Pignochino, Ymera, Basirico, Marco, Vigna, Elisa, Pisacane, Alberto, Fagioli, Franca, Ferrone, Soldano, Aglietta, Massimo, Dotti, Gianpietro, Sangiolo, Dario

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Single-Nuclei Transcriptome Profiling Reveals Intra-Tumoral Heterogeneity and Characterizes Tumor Microenvironment Architecture in a Murine Melanoma Model von Parab, Sushant, Sarlo, Valery, Capellero, Sonia, Palmiotto, Luca, Bartolini, Alice, Cantarella, Daniela, Turi, Marcello, Gullà, Annamaria, Grassi, Elena, Lazzari, Chiara, Rubatto, Marco, Gregorc, Vanesa, Carnevale-Schianca, Fabrizio, Olivero, Martina, Bussolino, Federico, Comunanza, Valentina

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Full chimaeric CAR.CIK from patients engrafted after allogeneic haematopoietic cell transplant: Feasibility, anti‐leukaemic potential and alloreactivity across major human leukocyt... von Circosta, Paola, Donini, Chiara, Gallo, Susanna, Giraudo, Lidia, Gammaitoni, Loretta, Rotolo, Ramona, Galvagno, Federica, Capellero, Sonia, Basiricò, Marco, Casucci, Monica, Aglietta, Massimo, Ferrero, Ivana, Fagioli, Franca, Cignetti, Alessandro, Carnevale‐Schianca, Fabrizio, Leuci, Valeria, Sangiolo, Dario

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Full chimaeric CAR . CIK from patients engrafted after allogeneic haematopoietic cell transplant: Feasibility, anti‐leukaemic potential and alloreactivity across major human leukoc... von Circosta, Paola, Donini, Chiara, Gallo, Susanna, Giraudo, Lidia, Gammaitoni, Loretta, Rotolo, Ramona, Galvagno, Federica, Capellero, Sonia, Basiricò, Marco, Casucci, Monica, Aglietta, Massimo, Ferrero, Ivana, Fagioli, Franca, Cignetti, Alessandro, Carnevale‐Schianca, Fabrizio, Leuci, Valeria, Sangiolo, Dario

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Adoptive immunotherapy against ovarian cancer von Mittica, Gloria, Capellero, Sonia, Genta, Sofia, Cagnazzo, Celeste, Aglietta, Massimo, Sangiolo, Dario, Valabrega, Giorgio

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Abstract GMM-023: PATIENT DERIVED XENOGRAFTS (PDXS) AND PDX DERIVED TUMOR CELLS (PDTC) ALLOW THE IDENTIFICATION OF ACTIONABLE CANCER GENES AND TREATMENT OPTIONS FOR PLATINUM REFRAC... von Olivero, Martina, Erriquez, Jessica, Arigoni, Maddalena, Capellero, Sonia, D'Ambrosio, Concetta, Mittica, Gloria, Borella, Fulvio, Katsaros, Dionyssios, Privitera, Silvana, Berrino, Enrico, Venesio, Tiziana, Valabrega, Giorgio, Calogero, Raffaele, Renzo, Maria Flavia Di

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Abstract 1677: Assays of conventional chemotherapeutics and targeted drugs for ovarian cancer using patient derived models von D'Ambrosio, Concetta, Erriquez, Jessica, Arigoni, Maddalena, Capellero, Sonia, Mittica, Gloria, Ghisoni, Eleonora, Borella, Fulvio, Katsaros, Dionyssios, Privitera, Silvana, Ribotta, Marisa, Maldi, Elena, Nardo, Giovanna Di, Berrino, Enrico, Venesio, Tiziana, Ponzone, Riccardo, Vaira, Marco, Hall, Douglas, Jimenez-Linan, Mercedes, Paterson, Anna, Valabrega, Giorgio, Calogero, Raffaele, Brenton, James, Di Renzo, Mariaflavia, Olivero, Martina

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Abstract 3102: Identification of actionable cancer genes and treatment options for metastatic ovarian carcinomas using patient-derived xenografts and PDX-derived tumor cells von Olivero, Martina, Erriquez, Jessica, Arigoni, Maddalena, Capellero, Sonia, D'Ambrosio, Concetta, Mittica, Gloria, Borella, Fulvio, Katsaros, Dionyssios, Privitera, Silvana, Berrino, Enrico, Venesio, Tiziana, Valabrega, Giorgio, Calogero, Raffaele, Renzo, Maria Flavia Di

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Abstract 3194: Anti-mesothelin CAR.CIK lymphocytes are effective against ovarian cancer in 3D models of peritoneal carcinomatosis von Galvagno, Federica, Leuci, Valeria, Donini, Chiara, Massa, Annamaria, Rotolo, Ramona, Capellero, Sonia, Proment, Alessia, Vitali, Letizia, Tuninetti, Valentina, Olivero, Martina, Vigna, Elisa, Valabrega, Giorgio, Primo, Luca, Puliafito, Alberto, Sangiolo, Dario

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HER2-positive breast cancer cells resistant to trastuzumab and lapatinib lose reliance upon HER2 and are sensitive to the multitargeted kinase inhibitor sorafenib von Valabrega, Giorgio, Capellero, Sonia, Cavalloni, Giuliana, Zaccarello, Gianluca, Petrelli, Annalisa, Migliardi, Giorgia, Milani, Andrea, Peraldo-Neia, Caterina, Gammaitoni, Loretta, Sapino, Anna, Pecchioni, Carla, Moggio, Aldo, Giordano, Silvia, Aglietta, Massimo, Montemurro, Filippo

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Transient proteasome inhibition as a strategy to enhance lentiviral transduction of hematopoietic CD34 + cells and T lymphocytes: Implications for the use of low viral doses and la... von Leuci, Valeria, Mesiano, Giulia, Gammaitoni, Loretta, Cammarata, Cristina, Capellero, Sonia, Todorovic, Maja, Jordaney, Noela, Circosta, Paola, Elia, Angela, Lesnikova, Marina, Georges, George E., Piacibello, Wanda, Fagioli, Franca, Cignetti, Alessandro, Aglietta, Massimo, Sangiolo, Dario

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PIK3R1 W624R Is an Actionable Mutation in High Grade Serous Ovarian Carcinoma von D'Ambrosio, Concetta, Erriquez, Jessica, Arigoni, Maddalena, Capellero, Sonia, Mittica, Gloria, Ghisoni, Eleonora, Borella, Fulvio, Katsaros, Dionyssios, Privitera, Silvana, Ribotta, Marisa, Maldi, Elena, Di Nardo, Giovanna, Berrino, Enrico, Venesio, Tiziana, Ponzone, Riccardo, Vaira, Marco, Hall, Douglas, Jimenez-Linan, Mercedes, Paterson, Anna L, Calogero, Raffaele A, Brenton, James D, Valabrega, Giorgio, Di Renzo, Maria Flavia, Olivero, Martina

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Efficient Transcriptional Targeting of Human Hematopoietic Stem Cells and Blood Cell Lineages by Lentiviral Vectors Containing the Regulatory Element of the Wiskott‐Aldrich Syndrom... von Leuci, Valeria, Gammaitoni, Loretta, Capellero, Sonia, Sangiolo, Dario, Mesuraca, Maria, Bond, Heather M., Migliardi, Giorgia, Cammarata, Cristina, Aglietta, Massimo, Morrone, Giovanni, Piacibello, Wanda

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Sustained Long‐Term Engraftment and Transgene Expression of Peripheral Blood CD34+ Cells Transduced with Third‐Generation Lentiviral Vectors von Tesio, Melania, Gammaitoni, Loretta, Gunetti, Monica, Leuci, Valeria, Pignochino, Ymera, Jordaney, Noela, Capellero, Sonia, Cammarata, Cristina, Caione, Luisa, Migliaretti, Giuseppe, Fagioli, Franca, Tabilio, Antonio, Aglietta, Massimo, Piacibello, Wanda

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MIC A/B Protein Expression Associates with Trastuzumab-Resistant Breast Cancer Cells Leading to Effective Immunotherapy by Cytokine Induced Killer Cells von Sangiolo, Dario, Valabrega, Giorgio, Cavalloni, Giuliana, Capellero, Sonia, Mesiano, Giulia, Todorovic, Maja, Cammarata, Cristina, Neia, Caterina Peraldo, Piacibello, Wanda, Cignetti, Alessandro, Aglietta, Massimo

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Abstract A82: HHER2-positive breast cancer cells resistant to trastuzumab and lapatinib lose reliance upon HER2 and become sensitive to the multitargeted kinase inhibitor sorafenib von Capellero, Sonia, Valabrega, Giorgio, Cavalloni, Giuliana, Zaccarello, Gianluca, Petrelli, Annalisa, Migliardi, Giorgia, Milani, Andrea, Neia, Caterina Peraldo, Gammaitoni, Loretta, Favero, Francesco, Moggio, Aldo, Giordano, Silvia, Aglietta, Massimo, Montemurro, Filippo

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