TH1 signatures are present in the lower airways of children with severe asthma, regardless of allergic status von Wisniewski, Julia A., Muehling, Lyndsey M., Eccles, Jacob D., Capaldo, Brian J., Agrawal, Rachana, Shirley, Debbie-Ann, Patrie, James T., Workman, Lisa J., Schuyler, Alexander J., Lawrence, Monica G., Teague, W. Gerald, Woodfolk, Judith A.

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Nascent Prostate Cancer Heterogeneity Drives Evolution and Resistance to Intense Hormonal Therapy von Wilkinson, Scott, Ye, Huihui, Karzai, Fatima, Harmon, Stephanie A., Terrigino, Nicholas T., VanderWeele, David J., Bright, John R., Atway, Rayann, Trostel, Shana Y., Carrabba, Nicole V., Whitlock, Nichelle C., Walker, Stephanie M., Lis, Rosina T., Abdul Sater, Houssein, Capaldo, Brian J., Madan, Ravi A., Gulley, James L., Chun, Guinevere, Merino, Maria J., Pinto, Peter A., Salles, Daniela C., Kaur, Harsimar B., Lotan, Tamara L., Venzon, David J., Choyke, Peter L., Turkbey, Baris, Dahut, William L., Sowalsky, Adam G.

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Human TH1 and TH2 cells targeting rhinovirus and allergen coordinately promote allergic asthma von Muehling, Lyndsey M., Heymann, Peter W., Wright, Paul W., Eccles, Jacob D., Agrawal, Rachana, Carper, Holliday T., Murphy, Deborah D., Workman, Lisa J., Word, Carolyn R., Ratcliffe, Sarah J., Capaldo, Brian J., Platts-Mills, Thomas A.E., Turner, Ronald B., Kwok, William W., Woodfolk, Judith A.

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Stem cell dynamics and cellular heterogeneity across lineage subtypes of castrate-resistant prostate cancer von Beshiri, Michael L, Capaldo, Brian J, Lake, Ross, Ku, Anson T, Burner, Danielle, Tice, Caitlin M, Tran, Crystal, Kostas, Julianna, Alilin, Aian Neil, Yin, JuanJuan, Agarwal, Supreet, Morris, Samantha A, Karzai, Fatima H, Lotan, Tamara L, Dahut, William L, Sowalsky, Adam G, Kelly, Kathleen

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RUNX3 levels in human hematopoietic progenitors are regulated by aging and dictate erythroid-myeloid balance von Balogh, Peter, Adelman, Emmalee R., Pluvinage, John, Capaldo, Brian J., Freeman, Katie C., Singh, Sandeep, Elagib, Kamaleldin E., Nakamura, Yukio, Kurita, Ryo, Sashida, Goro, Zunder, Eli R., Li, Hui, Gru, Alejandro A., Price, Elizabeth A., Schrier, Stanley L., Weissman, Irving L., Figueroa, Maria E., Pang, Wendy W., Goldfarb, Adam N.

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Tumor-derived biomarkers predict efficacy of B7H3 antibody-drug conjugate treatment in metastatic prostate cancer models von Agarwal, Supreet, Fang, Lei, McGowen, Kerry, Yin, JuanJuan, Bowman, Joel, Ku, Anson T, Alilin, Aian Neil, Corey, Eva, Roudier, Martine P, True, Lawrence D, Dumpit, Ruth, Coleman, Ilsa, Lee, John K, Nelson, Peter S, Capaldo, Brian J, Mariani, Aida, Hoover, Clare, Senatorov, Ilya S, Beshiri, Michael, Sowalsky, Adam G, Hurt, Elaine M, Kelly, Kathleen

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MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity von Whitlock, Nichelle C., Trostel, Shana Y., Wilkinson, Scott, Terrigino, Nicholas T., Hennigan, S. Thomas, Lake, Ross, Carrabba, Nicole V., Atway, Rayann, Walton, Elizabeth D., Gryder, Berkley E., Capaldo, Brian J., Ye, Huihui, Sowalsky, Adam G.

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Microenvironmental agonists generate de novo phenotypic resistance to combined ibrutinib plus venetoclax in CLL and MCL von Jayappa, Kallesh D., Portell, Craig A., Gordon, Vicki L., Capaldo, Brian J., Bekiranov, Stefan, Axelrod, Mark J., Brett, L. Kyle, Wulfkuhle, Julia D., Gallagher, Rosa I., Petricoin, Emanuel F., Bender, Timothy P., Williams, Michael E., Weber, Michael J.

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Synthetic lethal screening with small-molecule inhibitors provides a pathway to rational combination therapies for melanoma von Roller, Devin G, Axelrod, Mark, Capaldo, Brian J, Jensen, Karin, Mackey, Aaron, Weber, Michael J, Gioeli, Daniel

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Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma von Capaldo, Brian J, Roller, Devin, Axelrod, Mark J, Koeppel, Alex F, Petricoin, Emanuel F, Slingluff, Jr, Craig L, Weber, Michael J, Mackey, Aaron J, Gioeli, Daniel, Bekiranov, Stefan

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Isolated BAL Neutrophilia and Unimodal Airway Epithelial IL-13 Inducible Gene Signatures Characterize Children with Treatment-Resistant Asthma von Borish, Larry, MD, FAAAAI, Braciale, Thomas J., MD, PhD, Shirley, Debbie-Ann, MD, Steinke, John W., PhD, FAAAAI, Williams, Sandford, MS, Pollack, Karlyn, BS, Capaldo, Brian J., PhD, Teague, W. Gerald, MD

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An integrated framework using high‐dimensional mass cytometry and fluorescent flow cytometry identifies discrete B cell subsets in patients with red meat allergy von Cox, Kelly M., Commins, Scott P., Capaldo, Brian J., Workman, Lisa J., Platts‐Mills, Thomas A. E., Amir, El‐ad D., Lannigan, Josephine A., Schuyler, Alexander J., Erickson, Loren D.

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Formation and phenotypic characterization of CD49a, CD49b and CD103 expressing CD8 T cell populations in human metastatic melanoma von Melssen, Marit M., Olson, Walter, Wages, Nolan A., Capaldo, Brian J., Mauldin, Ileana S., Mahmutovic, Adela, Hutchison, Ciara, Melief, Cornelis J.M., Bullock, Timothy N., Engelhard, Victor H., Slingluff, Craig L.

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Progression of prostate cancer reprograms MYC-mediated lipid metabolism via lysine methyltransferase 2A von Whitlock, Nichelle C., White, Margaret E., Capaldo, Brian J., Ku, Anson T., Agarwal, Supreet, Fang, Lei, Wilkinson, Scott, Trostel, Shana Y., Shi, Zhen-Dan, Basuli, Falguni, Wong, Karen, Jagoda, Elaine M., Kelly, Kathleen, Choyke, Peter L., Sowalsky, Adam G.

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Identification of a new target of miR-16, Vacuolar Protein Sorting 4a von Adhikari, Neeta, Guan, Weihua, Capaldo, Brian, Mackey, Aaron J, Carlson, Marjorie, Ramakrishnan, Sundaram, Walek, Dinesha, Gupta, Manu, Mitchell, Adam, Eckman, Peter, John, Ranjit, Ashley, Euan, Barton, Paul J, Hall, Jennifer L

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Cardiac resynchronization therapy reduces expression of inflammation-promoting genes related to interleukin-1β in heart failure von Bilchick, Kenneth, Kothari, Hema, Narayan, Aditya, Garmey, James, Omar, Abdullah, Capaldo, Brian, McNamara, Coleen

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TMPRSS2-ERG promotes the initiation of prostate cancer by suppressing oncogene-induced senescence von Fang, Lei, Li, Dongmei, Yin, JuanJuan, Pan, Hong, Ye, Huihui, Bowman, Joel, Capaldo, Brian, Kelly, Kathleen

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Total Synthesis of a Functional Designer Eukaryotic Chromosome von Annaluru, Narayana, Muller, Héloïse, Mitchell, Leslie A., Ramalingam, Sivaprakash, Stracquadanio, Giovanni, Richardson, Sarah M., Dymond, Jessica S., Kuang, Zheng, Scheifele, Lisa Z., Cooper, Eric M., Cai, Yizhi, Zeller, Karen, Agmon, Neta, Han, Jeffrey S., Hadjithomas, Michalis, Tullman, Jennifer, Caravelli, Katrina, Cirelli, Kimberly, Guo, Zheyuan, London, Viktoriya, Yeluru, Apurva, Murugan, Sindurathy, Kandavelou, Karthikeyan, Agier, Nicolas, Fischer, Gilles, Yang, Kun, Martin, Andrew, Bilgel, Murat, Bohutski, Pavlo, Boulier, Kristin M., Capaldo, Brian J., Chang, Joy, Charoen, Kristie, Choi, Woo Jin, Deng, Peter, DiCarlo, James E., Doong, Judy, Dunn, Jessilyn, Feinberg, Jason I., Fernandez, Christopher, Floria, Charlotte E., Gladowski, David, Hadidi, Pasha, Ishizuka, Isabel, Jabbari, Javaneh, Lau, Calvin Y. L., Lee, Pablo A., Li, Sean, Lin, Denise, Linder, Matthias E., Ling, Jonathan, Liu, Jaime, Liu, Jonathan, London, Mariya, Ma, Henry, Mao, Jessica, McDade, Jessica E., McMillan, Alexandra, Moore, Aaron M., Oh, Won Chan, Ouyang, Yu, Patel, Ruchi, Paul, Marina, Paulsen, Laura C., Qiu, Judy, Rhee, Alex, Rubashkin, Matthew G., Soh, Ina Y., Sotuyo, Nathaniel E., Srinivas, Venkatesh, Suarez, Allison, Wong, Andy, Wong, Remus, Xie, Wei Rose, Xu, Yijie, Yu, Allen T., Koszul, Romain, Bader, Joel S., Boeke, Jef D., Chandrasegaran, Srinivasan

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Abstract A066: Molecular phenotyping in single cell RNA sequencing allows for identification of common populations across studies and platforms von Capaldo, Brian, Beshiri, Michael, Yin, Juan, Kelly, Kathy

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Human T(H)1 and T(H)2 cells targeting rhinovirus and allergen coordinately promote allergic asthma von Muehling, Lyndsey M., Heymann, Peter W., Wright, Paul W., Eccles, Jacob D., Agrawal, Rachana, Carper, Holliday T., Murphy, Deborah D., Workman, Lisa J., Word, Carolyn R., Ratcliffe, Sarah J., Capaldo, Brian J., Platts-Mills, Thomas A. E., Turner, Ronald B., Kwok, William W., Woodfolk, Judith A.

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