Dual Targeting of Histone Deacetylase and Topoisomerase II with Novel Bifunctional Inhibitors von Guerrant, William, Patil, Vishal, Canzoneri, Joshua C, Oyelere, Adegboyega K

Volltext

Dual-acting histone deacetylase-topoisomerase I inhibitors von Guerrant, William, Patil, Vishal, Canzoneri, Joshua C., Yao, Li-Pan, Hood, Rebecca, Oyelere, Adegboyega K.

Volltext

Interaction of anthracyclines with iron responsive element mRNAs von Canzoneri, Joshua C, Oyelere, Adegboyega K

Volltext

Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity von Awadallah, Fadi M., Piazza, Gary A., Gary, Bernard D., Keeton, Adam B., Canzoneri, Joshua C.

Volltext

Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling von Zhu, Bing, Lindsey, Ashley, Li, Nan, Lee, Kevin, Ramirez-Alcantara, Veronica, Canzoneri, Joshua C, Fajardo, Alexandra, Madeira da Silva, Luciana, Thomas, Meagan, Piazza, John T, Yet, Larry, Eberhardt, Brian T, Gurpinar, Evrim, Otali, Dennis, Grizzle, William, Valiyaveettil, Jacob, Chen, Xi, Keeton, Adam B, Piazza, Gary A

Volltext

Suppression of β-catenin/TCF transcriptional activity and colon tumor cell growth by dual inhibition of PDE5 and 10 von Li, Nan, Chen, Xi, Zhu, Bing, Ramírez-Alcántara, Verónica, Canzoneri, Joshua C, Lee, Kevin, Sigler, Sara, Gary, Bernard, Li, Yonghe, Zhang, Wei, Moyer, Mary P, Salter, E Alan, Wierzbicki, Andrzej, Keeton, Adam B, Piazza, Gary A

Volltext

Abstract 326: Discovery and in vitro and in vivo characterization of a novel, small-molecule Ras inhibitor class von Keeton, Adam B., Zhu, Bing, Lee, Kevin J., Canzoneri, Joshua C., Sigler, Sara C., Lindsey, Ashley S., Ramirez-Alcantara, Veronica, Barnes, Luciana, Mattox, Tyler E., McConnell, Kate, Berry, Kristy L., Valiyaveettil, Jacob, Chen, Xi, Boyd, Michael R., Piazza, Gary A.

Volltext

Structure-Based Design of Novel Tetrahydro-Beta-Carboline Derivatives with a Hydrophilic Side Chain as Potential Phosphodiesterase Inhibitors von Elhady, Ahmed K, Sigler, Sara C, Noureldin, Nazih, Canzoneri, Joshua C, Ahmed, Nermin S, Piazza, Gary A, Abadi, Ashraf H

Volltext

Novel Quinazolin-4(3H)-one/Schiff Base Hybrids as Antiproliferative and Phosphodiesterase 4 Inhibitors: Design, Synthesis, and Docking Studies von Abdel-Rahman, Hamdy M., Abdel-Aziz, Mohamed, Canzoneri, Joshua C., Gary, Bernard D., Piazza, Gary A.

Volltext

Design and Synthesis of Substituted Pyridazinone-1-Acetylhydrazones as Novel Phosphodiesterase 4 Inhibitors von Abdel-Rahman, Hamdy M., Abdel-Aziz, Mohamed, Tinsley, Heather N., Gary, Bernard D., Canzoneri, Joshua C., Piazza, Gary A.

Volltext

Macrolide-Peptide Conjugates as Probes of the Path of Travel of the Nascent Peptides through the Ribosome von Washington, Arren Z., Benicewicz, Derek B., Canzoneri, Joshua C., Fagan, Crystal E., Mwakwari, Sandra C., Maehigashi, Tatsuya, Dunham, Christine M., Oyelere, Adegboyega K.

Volltext

Design and synthesis of novel histone deacetylase inhibitor derived from nuclear localization signal peptide von Canzoneri, Joshua C., Chen, Po C., Oyelere, Adegboyega K.

Volltext

Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity von Li, N, Lee, K, Xi, Y, Zhu, B, Gary, B D, Ramírez-Alcántara, V, Gurpinar, E, Canzoneri, J C, Fajardo, A, Sigler, S, Piazza, J T, Chen, X, Andrews, J, Thomas, M, Lu, W, Li, Y, Laan, D J, Moyer, M P, Russo, S, Eberhardt, B T, Yet, L, Keeton, A B, Grizzle, W E, Piazza, G A

Volltext

Upregulation of cellular protective mechanisms against oxidative damage via pharmacological intervention von Allani, Shailaja Kesaraju, Chen, Xi, Ramirez‐Alcántara, Verónica, Canzoneri, Joshua, Prentice, Howard, Huang, Xupei, Piazza, Gary, Weissbach, Herbert

Volltext

A novel sulindac derivative protects against oxidative damage by a cyclooxygenase-independent mechanism von Allani, Shailaja Kesaraju, Rayala, Ramanjaneyulu, Rivera, Oscar, Prentice, Howard M, Chen, Xi, Ramírez-Alcántara, Veronica, Canzoneri, Joshua, Menzie-Suderam, Janet, Huang, Xupei, Georgescu, Constantin, Wren, Jonathan D, Piazza, Gary A, Weissbach, Herbert

Volltext

Abstract 4972: Novel Ras inhibitor DC070-547 potently and selectively blocks Ras-RBD binding, EGFR binding to Ras signaling complex, EGFR activation of Ras signaling, and growth of... von Zhu, Bing, Chen, Xi, Valiyaveettil, Jacob, Canzoneri, Joshua, Lee, Kevin, Saville, Kate, Berry, Kristy, Barnes, Luciana, Maddox, Tyler, Lindsey, Ashley, Ward, Antonio, Ramirez-Alcantara, Veronica, Keeton, Adam, Boyd, Michael, Piazza, Gary

Volltext

Abstract B23: DC070-547, a novel Ras inhibitor potently and selectivity inhibits colon tumor growth in vitro and in vivo von Ramirez-Alcantara, Veronica, Keeton, Adam B., Zhu, Bing, Lee, Kevin J., Canzoneri, Joshua, Lindsey, Ashley S., Barnes, Luciana Madeira da Silva, Berry, Kristy, Valiyaveettil, Jacob, Chen, Xi, Boyd, Michael R., Piazza, Gary

Volltext

Abstract 701: A novel class of Ras selective inhibitors von Canzoneri, Joshua C., Chen, Xi, Keeton, Adam B., Lee, Kevin, Gary, Bernard, Butler, Ethan B., Grizzle, William E., Wilson, Landon, Barnes, Stephen, Boyd, Michael R., Piazza, Gary A.

Volltext

Abstract 4372: Phosphodiesterase 10A inhibition suppresses lung tumor cell growth by activating PKG to inhibit ras and Wnt signaling von Zhu, Bing, Lee, Kevin, Canzoneri, Joshua, Ramirez-Alcantara, Veronica, Sigler, Sara, Gary, Bernard, Butler, Ethan, Keeton, Adam, Chen, Xi, Boyd, Michael, Piazza, Gary

Volltext

Abstract 1238: A novel Ras inhibitor potently and selectively suppresses lung tumor cell growth by blocking Ras-Raf binding von Zhu, Bing, Chen, Xi, Ramirez-Alcantara, Veronica, Lee, Kevin, Valiyaveettil, Jacob, Canzoneri, Joshua, Sigler, Sara, Berry, Kristy, Lindsey, Ashley, Keeton, Adam, Boyd, Michael R., Piazza, Gary A.

Volltext