Revisiting the BRCA-pathway through the lens of replication gap suppression: "Gaps determine therapy response in BRCA mutant cancer" von Cantor, Sharon B

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Exploiting replication gaps for cancer therapy von Cong, Ke, Cantor, Sharon B

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Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling von Lee, Wei Ting C., Yin, Yandong, Morten, Michael J., Tonzi, Peter, Gwo, Pam Pam, Odermatt, Diana C., Modesti, Mauro, Cantor, Sharon B., Gari, Kerstin, Huang, Tony T., Rothenberg, Eli

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Positioning loss of PARP1 activity as the central toxic event in BRCA-deficient cancer von MacGilvary, Nathan, Cantor, Sharon B.

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Replication fork stability confers chemoresistance in BRCA-deficient cells von Ray Chaudhuri, Arnab, Callen, Elsa, Ding, Xia, Gogola, Ewa, Duarte, Alexandra A., Lee, Ji-Eun, Wong, Nancy, Lafarga, Vanessa, Calvo, Jennifer A., Panzarino, Nicholas J., John, Sam, Day, Amanda, Crespo, Anna Vidal, Shen, Binghui, Starnes, Linda M., Ruiter, Julian R. de, Daniel, Jeremy A., Konstantinopoulos, Panagiotis A., Cortez, David, Cantor, Sharon B., Fernandez-Capetillo, Oscar, Ge, Kai, Jonkers, Jos, Rottenberg, Sven, Sharan, Shyam K., Nussenzweig, André

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Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency von Cong, Ke, Peng, Min, Kousholt, Arne Nedergaard, Lee, Wei Ting C., Lee, Silviana, Nayak, Sumeet, Krais, John, VanderVere-Carozza, Pamela S., Pawelczak, Katherine S., Calvo, Jennifer, Panzarino, Nicholas J., Turchi, John J., Johnson, Neil, Jonkers, Jos, Rothenberg, Eli, Cantor, Sharon B.

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Replication Gaps Underlie BRCA Deficiency and Therapy Response von Panzarino, Nicholas J, Krais, John J, Cong, Ke, Peng, Min, Mosqueda, Michelle, Nayak, Sumeet U, Bond, Samuel M, Calvo, Jennifer A, Doshi, Mihir B, Bere, Matt, Ou, Jianhong, Deng, Bin, Zhu, Lihua J, Johnson, Neil, Cantor, Sharon B

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Unveiling the toxicity of single-stranded DNA gaps through a yeast model von Whalen, Jenna M., Cantor, Sharon B.

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Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency von Cong, Ke, Peng, Min, Kousholt, Arne Nedergaard, Lee, Wei Ting C, Lee, Silviana, Nayak, Sumeet, Krais, John, VanderVere-Carozza, Pamela S, Pawelczak, Katherine S, Calvo, Jennifer, Panzarino, Nicholas J, Turchi, John J, Johnson, Neil, Jonkers, Jos, Rothenberg, Eli, Cantor, Sharon B

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Resistance to therapy in BRCA2 mutant cells due to loss of the nucleosome remodeling factor CHD4 von Guillemette, Shawna, Serra, Ryan W, Peng, Min, Hayes, Janelle A, Konstantinopoulos, Panagiotis A, Green, Michael R, Cantor, Sharon B

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FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells von Cong, Ke, MacGilvary, Nathan, Lee, Silviana, MacLeod, Shannon G., Calvo, Jennifer, Peng, Min, Nedergaard Kousholt, Arne, Day, Tovah A., Cantor, Sharon B.

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Opposing Roles of FANCJ and HLTF Protect Forks and Restrain Replication during Stress von Peng, Min, Cong, Ke, Panzarino, Nicholas J., Nayak, Sumeet, Calvo, Jennifer, Deng, Bin, Zhu, Lihua Julie, Morocz, Monika, Hegedus, Lili, Haracska, Lajos, Cantor, Sharon B.

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Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses von Peng, Min, Xie, Jenny, Ucher, Anna, Stavnezer, Janet, Cantor, Sharon B

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David Livingston (1941-2021) von Cantor, Sharon B, Sellers, William R, Pathania, Shailja, Greenberg, Roger A

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Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability von Nayak, Sumeet, Calvo, Jennifer A, Cong, Ke, Peng, Min, Berthiaume, Emily, Jackson, Jessica, Zaino, Angela M, Vindigni, Alessandro, Hadden, M Kyle, Cantor, Sharon B

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RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination von Barber, Louise J., Youds, Jillian L., Ward, Jordan D., McIlwraith, Michael J., O'Neil, Nigel J., Petalcorin, Mark I.R., Martin, Julie S., Collis, Spencer J., Cantor, Sharon B., Auclair, Melissa, Tissenbaum, Heidi, West, Stephen C., Rose, Ann M., Boulton, Simon J.

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Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes von Greenberg, Roger A, Sobhian, Bijan, Pathania, Shailja, Cantor, Sharon B, Nakatani, Yoshihiro, Livingston, David M

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Molecular and cellular functions of the FANCJ DNA helicase defective in cancer and in Fanconi anemia von Brosh, Jr, Robert M, Cantor, Sharon B

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Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1 von Calvo, Jennifer A, Fritchman, Briana, Hernandez, Desiree, Persky, Nicole S, Johannessen, Cory M, Piccioni, Federica, Kelch, Brian A, Cantor, Sharon B

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Lead compound profiling for small molecule inhibitors of the REV1-CT/RIR Translesion synthesis Protein-Protein interaction von Zaino, Angela M., Dash, Radha Charan, James, Stephy J., MacGilvary, Nathan, Crompton, Andrew, McPherson, Kerry S., Stanzione, Marcello, Korzhnev, Dmitry M., Dyson, Nicholas J., Chatterjee, Nimrat, Cantor, Sharon B., Hadden, M. Kyle

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