CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance von Cantley, Jennifer L., Yoshimura, Toru, Camporez, Joao Paulo G., Zhang, Dongyan, Jornayvaz, Francois R., Kumashiro, Naoki, Guebre-Egziabher, Fitsum, Jurczak, Michael J., Kahn, Mario, Guigni, Bias A., Serr, Julie, Hankin, Joseph, Murphy, Robert C., Cline, Gary W., Bhanot, Sanjay, Manchem, Vara Prasad, Brown, J. Mark, Samuel, Varman T., Shulman, Gerald I.

Volltext

Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance von KUMASHIRO, Naoki, BEDDOW, Sara A, KAHN, Mario, PERLER, Bryce K, PUCHOWICZ, Michelle A, VARA PRASAD MANCHEM, BHANOT, Sanjay, STILL, Christopher D, GERHARD, Glenn S, PETERSEN, Kitt Falk, CLINE, Gary W, SHULMAN, Gerald I, VATNER, Daniel F, SAMUEL, Varman T, MAJUMDAR, Sachin K, CANTLEY, Jennifer L, GUEBRE-EGZIABHER, Fitsum, FAT, Ioana, GUIGNI, Blas, JURCZAK, Michael J, BIRKENFELD, Andreas L

Volltext

Role of patatin‐like phospholipase domain‐containing 3 on lipid‐induced hepatic steatosis and insulin resistance in rats von Kumashiro, Naoki, Yoshimura, Toru, Cantley, Jennifer L., Majumdar, Sachin K., Guebre‐Egziabher, Fitsum, Kursawe, Romy, Vatner, Daniel F., Fat, Ioana, Kahn, Mario, Erion, Derek M., Zhang, Xian‐Man, Zhang, Dongyan, Manchem, Vara Prasad, Bhanot, Sanjay, Gerhard, Glenn S., Petersen, Kitt F., Cline, Gary W., Samuel, Varman T., Shulman, Gerald I.

Volltext

Development of a Targeted Urine Proteome Assay for kidney diseases von Cantley, Lloyd G., Colangelo, Christopher M., Stone, Kathryn L., Chung, Lisa, Belcher, Justin, Abbott, Thomas, Cantley, Jennifer L., Williams, Kenneth R., Parikh, Chirag R.

Volltext

Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats von Cantley, Jennifer L, Vatner, Daniel F, Galbo, Thomas, Madiraju, Anila, Petersen, Max, Perry, Rachel J, Kumashiro, Naoki, Guebre-Egziabher, Fitsum, Gattu, Arijeet K, Stacy, Mitchel R, Dione, Donald P, Sinusas, Albert J, Ragolia, Louis, Hall, Christopher E, Manchem, Vara Prasad, Bhanot, Sanjay, Bogan, Jonathan S, Samuel, Varman T

Volltext

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF IRAK-4 von CANTLEY, Jennifer L, DONG, Hanqing, ARAUJO, Erika Marina Vieira

Volltext bestellen

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF IRAK-4 von MEDINA, Jesus Raul, CANTLEY, Jennifer L, HORNBERGER, Keith R, ARAUJO, Erika Marina Vieira

Volltext bestellen

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF IRAK-4 von MEDINA, Jesus Raul, CANTLEY, Jennifer L, HORNBERGER, Keith R, ARAUJO, Erika Marina Vieira

Volltext bestellen

Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation von Xing, Yan, Lin, Nancy U, Maurer, Matthew A, Chen, Huiqin, Mahvash, Armeen, Sahin, Aysegul, Akcakanat, Argun, Li, Yisheng, Abramson, Vandana, Litton, Jennifer, Chavez-MacGregor, Mariana, Valero, Vicente, Piha-Paul, Sarina A, Hong, David, Do, Kim-Anh, Tarco, Emily, Riall, Dianna, Eterovic, Agda Karina, Wulf, Gerburg M, Cantley, Lewis C, Mills, Gordon B, Doyle, L Austin, Winer, Eric, Hortobagyi, Gabriel N, Gonzalez-Angulo, Ana Maria, Meric-Bernstam, Funda

Volltext

Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer von Garrido-Castro, Ana C., Saura, Cristina, Barroso-Sousa, Romualdo, Guo, Hao, Ciruelos, Eva, Bermejo, Begona, Gavila, Joaquin, Serra, Violeta, Prat, Aleix, Pare, Laia, Celiz, Pamela, Villagrasa, Patricia, Li, Yisheng, Savoie, Jennifer, Xu, Zhan, Arteaga, Carlos L., Krop, Ian E., Solit, David B., Mills, Gordon B., Cantley, Lewis C., Winer, Eric P., Lin, Nancy U., Rodon, Jordi

Volltext

Somatic mutations of PIK3R1 promote gliomagenesis von Quayle, Steven N, Lee, Jennifer Y, Cheung, Lydia W T, Ding, Li, Wiedemeyer, Ruprecht, Dewan, Robert W, Huang-Hobbs, Emmet, Zhuang, Li, Wilson, Richard K, Ligon, Keith L, Mills, Gordon B, Cantley, Lewis C, Chin, Lynda

Volltext

Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers von Cantley, Jennifer, Ye, Xiaofen, Rousseau, Emma, Januario, Tom, Hamman, Brian D., Rose, Christopher M., Cheung, Tommy K., Hinkle, Trent, Soto, Leofal, Quinn, Connor, Harbin, Alicia, Bortolon, Elizabeth, Chen, Xin, Haskell, Roy, Lin, Eva, Yu, Shang-Fan, Del Rosario, Geoff, Chan, Emily, Dunlap, Debra, Koeppen, Hartmut, Martin, Scott, Merchant, Mark, Grimmer, Matt, Broccatelli, Fabio, Wang, Jing, Pizzano, Jennifer, Dragovich, Peter S., Berlin, Michael, Yauch, Robert L.

Volltext

Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial von Konstantinopoulos, Panagiotis A, Barry, William T, Birrer, Michael, Westin, Shannon N, Cadoo, Karen A, Shapiro, Geoffrey I, Mayer, Erica L, O'Cearbhaill, Roisin E, Coleman, Robert L, Kochupurakkal, Bose, Whalen, Christin, Curtis, Jennifer, Farooq, Sarah, Luo, Weixiu, Eismann, Julia, Buss, Mary K, Aghajanian, Carol, Mills, Gordon B, Palakurthi, Sangeetha, Kirschmeier, Paul, Liu, Joyce, Cantley, Lewis C, Kaufmann, Scott H, Swisher, Elizabeth M, D'Andrea, Alan D, Winer, Eric, Wulf, Gerburg M, Matulonis, Ursula A

Volltext

Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9 von Gallop, Jennifer L., Walrant, Astrid, Cantley, Lewis C., Kirschner, Marc W.

Volltext

The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor von Gozani, Or, Karuman, Philip, Jones, David R., Ivanov, Dmitri, Cha, James, Lugovskoy, Alexey A., Baird, Cheryl L., Zhu, Hong, Field, Seth J., Lessnick, Stephen L., Villasenor, Jennifer, Mehrotra, Bharat, Chen, Jian, Rao, Vikram R., Brugge, Joan S., Ferguson, Colin G., Payrastre, Bernard, Myszka, David G., Cantley, Lewis C., Wagner, Gerhard, Divecha, Nullin, Prestwich, Glenn D., Yuan, Junying

Volltext

Incidental Detection of Classical Galactosemia through Newborn Screening for Phenylketonuria: A 10-Year Retrospective Audit to Determine the Efficacy of This Approach von Cantley, Nathan W P, Barski, Robert, Kemp, Helena, Hogg, Sarah L, Wu, Hoi Yee Teresa, Bowron, Ann, Collingwood, Catherine, Cundick, Jennifer, Hart, Claire, Shakespeare, Lynette, Preece, Mary Anne, Aitkenhead, Helen, Smith, Sarah, Carling, Rachel S, Moat, Stuart J

Volltext

Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer von Klomp, Jennifer E, Diehl, J Nathaniel, Klomp, Jeffrey A, Edwards, A Cole, Yang, Runying, Morales, Alexis J, Taylor, Khalilah E, Drizyte-Miller, Kristina, Bryant, Kirsten L, Schaefer, Antje, Johnson, Jared L, Huntsman, Emily M, Yaron, Tomer M, Pierobon, Mariaelena, Baldelli, Elisa, Prevatte, Alex W, Barker, Natalie K, Herring, Laura E, Petricoin, 3rd, Emanuel F, Graves, Lee M, Cantley, Lewis C, Cox, Adrienne D, Der, Channing J, Stalnecker, Clint A

Volltext

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus von Kathiresan, Sekar, Rader, Daniel J, Musunuru, Kiran, Strong, Alanna, Frank-Kamenetsky, Maria, Lee, Noemi E, Ahfeldt, Tim, Sachs, Katherine V, Li, Xiaoyu, Li, Hui, Kuperwasser, Nicolas, Ruda, Vera M, Pirruccello, James P, Muchmore, Brian, Prokunina-Olsson, Ludmila, Hall, Jennifer L, Schadt, Eric E, Morales, Carlos R, Lund-Katz, Sissel, Phillips, Michael C, Wong, Jamie, Cantley, William, Racie, Timothy, Ejebe, Kenechi G, Orho-Melander, Marju, Melander, Olle, Koteliansky, Victor, Fitzgerald, Kevin, Krauss, Ronald M, Cowan, Chad A

Volltext

Vascular Dysmorphogenesis Caused by an Activating Mutation in the Receptor Tyrosine Kinase TIE2 von Vikkula, Miikka, Boon, Laurence M, Iii, Kermit L.Carraway, Calvert, Jennifer T, Diamonti, A.John, Goumnerov, Boyan, Pasyk, Krystyna A, Marchuk, Douglas A, Warman, Matthew L, Cantley, Lewis C, Mulliken, John B, Olsen, Bjorn R

Volltext

Human primary immunodeficiency caused by expression of a kinase-dead p110δ mutant von Cohen, Sarah Beaussant, Bainter, Wayne, Johnson, Jared L., Lin, Ting-Yu, Wong, Jenny C.Y., Wallace, Jacqueline G., Jones, Jennifer, Qureshi, Sonia, Mir, Fatima, Qamar, Farah, Cantley, Lewis C., Geha, Raif S., Chou, Janet

Volltext