A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice von Escribano-Díaz, Cristina, Orthwein, Alexandre, Fradet-Turcotte, Amélie, Xing, Mengtan, Young, Jordan T.F., Tkáč, Ján, Cook, Michael A., Rosebrock, Adam P., Munro, Meagan, Canny, Marella D., Xu, Dongyi, Durocher, Daniel

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Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions von Orthwein, Alexandre, Fradet-Turcotte, Amélie, Noordermeer, Sylvie M., Canny, Marella D., Brun, Catherine M., Strecker, Jonathan, Escribano-Diaz, Cristina, Durocher, Daniel

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53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark von Fradet-Turcotte, Amélie, Canny, Marella D., Escribano-Díaz, Cristina, Orthwein, Alexandre, Leung, Charles C. Y., Huang, Hao, Landry, Marie-Claude, Kitevski-LeBlanc, Julianne, Noordermeer, Sylvie M., Sicheri, Frank, Durocher, Daniel

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Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling von Leung, Justin W, Agarwal, Poonam, Canny, Marella D, Gong, Fade, Robison, Aaron D, Finkelstein, Ilya J, Durocher, Daniel, Miller, Kyle M

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LRET-derived HADDOCK structural models describe the conformational heterogeneity required for DNA cleavage by the Mre11-Rad50 DNA damage repair complex von Canny, Marella D, Latham, Michael P

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Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency von Canny, Marella D, Moatti, Nathalie, Wan, Leo C K, Fradet-Turcotte, Amélie, Krasner, Danielle, Mateos-Gomez, Pedro A, Zimmermann, Michal, Orthwein, Alexandre, Juang, Yu-Chi, Zhang, Wei, Noordermeer, Sylvie M, Seclen, Eduardo, Wilson, Marcus D, Vorobyov, Andrew, Munro, Meagan, Ernst, Andreas, Ng, Timothy F, Cho, Tiffany, Cannon, Paula M, Sidhu, Sachdev S, Sicheri, Frank, Durocher, Daniel

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Mutation of Conserved Mre11 Residues Alter Protein Dynamics to Separate Nuclease Functions von Rahman, Samiur, Beikzadeh, Mahtab, Canny, Marella D., Kaur, Navneet, Latham, Michael P.

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Three segment ligation of a 104 kDa multi-domain protein by SrtA and OaAEP1 von Azatian, Stephan B., Canny, Marella D., Latham, Michael P.

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Adjacent mutations in the archaeal Rad50 ABC ATPase D-loop disrupt allosteric regulation of ATP hydrolysis through different mechanisms von Boswell, Zachary K, Canny, Marella D, Buschmann, Tanner A, Sang, Julie, Latham, Michael P

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A dynamic allosteric pathway underlies Rad50 ABC ATPase function in DNA repair von Boswell, Zachary K., Rahman, Samiur, Canny, Marella D., Latham, Michael P.

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Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors von Sanches, Mario, Duffy, Nicole M., Talukdar, Manisha, Thevakumaran, Nero, Chiovitti, David, Canny, Marella D., Lee, Kenneth, Kurinov, Igor, Uehling, David, Al-awar, Rima, Poda, Gennadiy, Prakesch, Michael, Wilson, Brian, Tam, Victor, Schweitzer, Colleen, Toro, Andras, Lucas, Julie L., Vuga, Danka, Lehmann, Lynn, Durocher, Daniel, Zeng, Qingping, Patterson, John B., Sicheri, Frank

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A Therapeutic Aptamer Inhibits Angiogenesis by Specifically Targeting the Heparin Binding Domain of VEGF165 von Lee, Joon-Hwa, Marella D. Canny, Andrea De Erkenez, Dominik Krilleke, Yin-Shan Ng, Shima, David T., Pardi, Arthur, Fiona Jucker

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A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex von Rahman, Samiur, Canny, Marella D., Buschmann, Tanner A., Latham, Michael P.

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Potent and Selective Inhibitors of the Inositol-requiring Enzyme 1 Endoribonuclease von Volkmann, Kori, Lucas, Julie L., Vuga, Danka, Wang, Xiaoping, Brumm, Duane, Stiles, Caryn, Kriebel, David, Der-Sarkissian, Ani, Krishnan, Kris, Schweitzer, Colleen, Liu, Zheng, Malyankar, Uriel M., Chiovitti, David, Canny, Marella, Durocher, Dan, Sicheri, Frank, Patterson, John B.

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The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage von Kitevski-LeBlanc, Julianne, Fradet-Turcotte, Amélie, Kukic, Predrag, Wilson, Marcus D, Portella, Guillem, Yuwen, Tairan, Panier, Stephanie, Duan, Shili, Canny, Marella D, van Ingen, Hugo, Arrowsmith, Cheryl H, Rubinstein, John L, Vendruscolo, Michele, Durocher, Daniel, Kay, Lewis E

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The MMS22L-TONSL Complex Mediates Recovery from Replication Stress and Homologous Recombination von O'Donnell, Lara, Panier, Stephanie, Wildenhain, Jan, Tkach, Johnny M., Al-Hakim, Abdallah, Landry, Marie-Claude, Escribano-Diaz, Cristina, Szilard, Rachel K., Young, Jordan T.F., Munro, Meagan, Canny, Marella D., Kolas, Nadine K., Zhang, Wei, Harding, Shane M., Ylanko, Jarkko, Mendez, Megan, Mullin, Michael, Sun, Thomas, Habermann, Bianca, Datti, Alessandro, Bristow, Robert G., Gingras, Anne-Claude, Tyers, Michael D., Brown, Grant W., Durocher, Daniel

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Metal ion specificities for folding and cleavage activity in the Schistosoma hammerhead ribozyme von Boots, Jennifer L, Canny, Marella D, Azimi, Ehsan, Pardi, Arthur

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Fast Cleavage Kinetics of a Natural Hammerhead Ribozyme von Canny, Marella D, Jucker, Fiona M, Kellogg, Elizabeth, Khvorova, Anastasia, Jayasena, Sumedha D, Pardi, Arthur

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Efficient Ligation of the Schistosoma Hammerhead Ribozyme von Canny, Marella D., Jucker, Fiona M., Pardi, Arthur

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Structure of the ATP‐free Mre11‐Rad50 DNA damage repair complex bound to DNA substrates von Beikzadeh, Mahtab, Canny, Marella, Latham, Michael

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