Exendin-4, a glucagon-like peptide 1 receptor agonist, protects cholangiocytes from apoptosis von Marzioni, M, Alpini, G, Saccomanno, S, Candelaresi, C, Venter, J, Rychlicki, C, Fava, G, Francis, H, Trozzi, L, Benedetti, A

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Role of endogenous opioids in modulating HSC activity in vitro and liver fibrosis in vivo von De Minicis, S, Candelaresi, C, Marzioni, M, Saccomano, S, Roskams, T, Casini, A, Risaliti, A, Salzano, R, Cautero, N, di Francesco, F, Benedetti, A, Svegliati-Baroni, G

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P353 ACTIVATION OF THE DEVELOPMENTAL PATHWAY Ngn-3/miR-7a REGULATES CHOLANGIOCYTES PROLIFERATION IN RESPONSE TO INJURY von Marzioni, M, Agostinelli, L, Candelaresi, C, Saccomanno, S, De Minicis, S, Maroni, L, Rychlicki, C, Mingarelli, E, Trozzi, L, Benedetti, A, Baroni, G. Svegliati

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Selective inhibition of ion transport mechanisms regulating intracellular pH reduces proliferation and induces apoptosis in cholangiocarcinoma cells von Di Sario, A, Bendia, E, Omenetti, A, De Minicis, S, Marzioni, M, Kleemann, H.W, Candelaresi, C, Saccomanno, S, Alpini, G, Benedetti, A

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Gut-stimulated inflammasome activation drives progression of liver injury in NASH von Gemini, S, Agostinelli, L, Rychlicki, C, De Minicis, S, Faraci, M.G, Candelaresi, C, Traini, S, Saccomanno, S, Pinto, C, Surace, G, Capretti, F, Marzioni, M, Svegliati Baroni, G

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OC-08 Dysbiosis contributes to liver fibrosis through bacterial translocation and elevated endotoxemia by increasing Gram– abundance von De Minicis, S, Rychlicki, C, Agostinelli, L, Saccomanno, S, Candelaresi, C, Trozzi, L, Marzioni, M, Benedetti, A, Svegliati Baroni, G

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Activation of the developmental pathway Ngn-3/miR-7a regulates cholangiocytes proliferation in response to injury von Marzioni, M, Agostinelli, L, Candelaresi, C, Saccomanno, S, De Minicis, S, Maroni, L, Rychlicki, C, Mingarelli, E, Trozzi, L, Benedetti, A, Svegliati Baroni, G

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Hepatoprotective and antifibrotic effect of a new silybin–phosphatidylcholine–Vitamin E complex in rats von Di Sario, A., Bendia, E., Taffetani, S., Omenetti, A., Candelaresi, C., Marzioni, M., De Minicis, S., Benedetti, A.

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36 PDX-1/HES-1 INTERACTIONS DETERMINE CHOLANGIOCYTE PROLIFERATIVE RESPONSE TO INJURY: THE SIGNIFICANCE FOR SCLEROSING CHOLANGITIS von Marzioni, M, Saccomanno, S, Agostinelli, L, Rychlicki, C, Pierantonelli, I, Trauner, M, Fickert, P, Müller, T, Shanmukhappa, K, Alpini, G, Trozzi, L, De Minicis, S, Candelaresi, C, Baroni, G. Svegliati, Benedetti, A

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The anti-fibrotic effect of pirfenidone in rat liver fibrosis is mediated by downregulation of procollagen α1(I), TIMP-1 and MMP-2 von Di Sario, A., Bendia, E., Macarri, G., Candelaresi, C., Taffetani, S., Marzioni, M., Omenetti, A., Minicis, S. De, Trozzi, L., Benedetti, A.

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OC.03.4 DYSBIOSIS CONTRIBUTES TO LIVER FIBROSIS THROUGH BACTERIAL TRANSLOCATION AND ELEVATED ENDOTOXEMIA BY INCREASING GRAM– ABUNDANCE von De Minicis, S, Rychlicki, C, Agostinelli, L, Saccomanno, S, Candelaresi, C, Trozzi, L, Marzioni, M, Schiadà, L, Kostandini, A, Benedetti, A, Baroni, G. Svegliati

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PC.01.2 PDX-1 MRNA EXPRESSION IN ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE CYTOASPIRATE AS A NEW MARKER FOR IMPROVING THE DIAGNOSIS OF PANCREATIC CANCER von Marzioni, M, Germani, U, Agostinelli, L, Bedogni, G, Marini, F, Bellentani, S, De Minicis, S, Rychlicki, C, Saccomanno, S, Candelaresi, C, Trozzi, L, Surace, G, Traini, S, Benedetti, A, Caletti, G, Lorenzini, I, Fusaroli, P

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238 AN ESTROGEN RECEPTOR ß SELECTIVE AGONIST EXERTS SPECIFIC PRO-APOPTOTIC EFFECTS AND PROMOTES TUMOR REGRESSION IN A RAT MODEL OF INTRA-HEPATIC CHOLANGIOCARCINOMA von Marzioni, M, Torrice, A, Rychlicki, C, Agostinelli, L, Pierantonelli, I, Rhönnstad, P, Trozzi, L, Saccomanno, S, Apelqvist, T, Gentile, R, Candelaresi, C, Fava, G, Benedetti, A, Gaudio, E, De Minicis, S, Kallin, E, Alvaro, D, Nilsson, S

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OC-1 PDX-1/Hes-1 interactions determine cholangiocyte proliferative response to injury: the significance for sclerosing cholangitis von Marzioni, M, Saccomanno, S, Agostinelli, L, Rychlicki, C, Pierantonelli, I, Trauner, M, Fickert, P, Müller, T, Shanmukhappa, K, Alpini, G, Trozzi, L, De Minicis, S, Candelaresi, C, Baroni, G. Svegliati, Benedetti, A

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Human cholangiocarcinoma development is associated with dysregulation of opioidergic modulation of cholangiocyte growth von Marzioni, M, Invernizzi, P, Candelaresi, C, Maggioni, M, Saccomanno, S, Selmi, C, Rychlicki, C, Agostinelli, L, Cassani, B, Miozzo, M, Pasini, S, Fava, G, Alpini, G, Benedetti, A

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96 SEMAPHORIN7A, A NEW PLAYER IN HEPATIC FIBROSIS: AN IN VITRO AND IN VIVO STUDY von De Minicis, S, Rychlicki, C, Agostinelli, L, Trozzi, L, Candelaresi, C, Saccomanno, S, Bataller, R, Juez, E, Marzioni, M, Benedetti, A, Svegliati-Baroni, G

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880 ESTROGEN RECEPTOR β SELECTIVE AGONISTS EXERT ANTI-CANCER ACTIVITY ON EXPERIMENTAL INTRA-HEPATIC CHOLANGIOCARCINOMA: AN IN VITRO AND IN VIVO STUDY von Marzioni, M, Saccomanno, S, Torrice, A, Rychlicki, C, Agostinelli, L, Rhönnstad, P, Trozzi, L, Apelqvist, T, Candelaresi, C, Fava, G, Benedetti, A, Gaudio, E, Kallin, E, Alvaro, D, Nilsson, S

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73 PANCREATIC DUODENAL HOMEOBOX GENE-1 (PDX-1) PROTEIN DE NOVO EXPRESSION IN REACTIVE CHOLANGIOCYTES DRIVES THEIR PHENOTYPICAL CHANGES IN RESPONSE TO INJURY von Marzioni, M, Saccomanno, S, Candelaresi, C, Rychlicki, C, Agostinelli, L, Shanmukhappa, K, Trozzi, L, De Minicis, S, Benedetti, A

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OC.05.5 PDX-1/HES-1 INTERACTIONS DETERMINE CHOLANGIOCYTE PROLIFERATIVE RESPONSE TO INJURY: THE SIGNIFICANCE FOR SCLEROSING CHOLANGITIS von Maezioni, M, Saccomanno, S, Agostinelli, L, Rychlicki, C, Pierantonelli, I, Trauner, M, Fickert, P, Müller, T, Shanmukhappa, K, Alpini, G, Trozzi, L, De Minicis, S, Candelaresi, C, Falcioni, G, Rossetti, P, Svegliati-Baroni, G, Benedetti, A

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296 PDGFβ AND TGFβ1 STIMULATES HEPATIC STELLATE CELLS THROUGH C-ABL ACTIVATION von Candelaresi, C, Saccomanno, S, Marra, F, De Minicis, S, Agostinelli, L, Benedetti, A, Svegliati-Baroni, G

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