Discovery of the c‑Jun N‑Terminal Kinase Inhibitor CC-90001 von Nagy, Mark A, Hilgraf, Robert, Mortensen, Deborah S, Elsner, Jan, Norris, Stephen, Tikhe, Jayashree, Yoon, Won, Paisner, David, Delgado, Mercedes, Erdman, Paul, Haelewyn, Jason, Khambatta, Godrej, Xu, Li, Romanow, William J, Condroski, Kevin, Bahmanyar, Sogole, McCarrick, Meg, Benish, Brent, Blease, Kate, LeBrun, Laurie, Moghaddam, Mehran F, Apuy, Julius, Canan, Stacie S, Bennett, Brydon L, Satoh, Yoshitaka

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Systematic Study of Heteroarene Stacking Using a Congeneric Set of Molecular Glues for Procaspase‑6 von Togo, Takaya, Tram, Linh, Denton, Laura G., ElHilali-Pollard, Xochina, Gu, Jun, Jiang, Jinglei, Liu, Chenglei, Zhao, Yan, Zhao, Yanlong, Zheng, Yinzhe, Zheng, Yunping, Yang, Jingjing, Fan, Panpan, Arkin, Michelle R., Härmä, Harri, Sun, Deqian, Canan, Stacie S., Wheeler, Steven E., Renslo, Adam R.

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Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115 von Mortensen, Deborah S., Perrin-Ninkovic, Sophie M., Shevlin, Graziella, Elsner, Jan, Zhao, Jingjing, Whitefield, Brandon, Tehrani, Lida, Sapienza, John, Riggs, Jennifer R., Parnes, Jason S., Papa, Patrick, Packard, Garrick, Lee, Branden G.S., Harris, Roy, Correa, Matthew, Bahmanyar, Sogole, Richardson, Samantha J., Peng, Sophie X., Leisten, Jim, Khambatta, Godrej, Hickman, Matt, Gamez, James C., Bisonette, René R., Apuy, Julius, Cathers, Brian E., Canan, Stacie S., Moghaddam, Mehran F., Raymon, Heather K., Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E., Sankar, Sabita

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The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen von Riggs, Jennifer R, Nagy, Mark, Elsner, Jan, Erdman, Paul, Cashion, Dan, Robinson, Dale, Harris, Roy, Huang, Dehua, Tehrani, Lida, Deyanat-Yazdi, Gordafaried, Narla, Rama Krishna, Peng, Xiaohui, Tran, Tam, Barnes, Leo, Miller, Terra, Katz, Jason, Tang, Yang, Chen, Ming, Moghaddam, Mehran F, Bahmanyar, Sogole, Pagarigan, Barbra, Delker, Silvia, LeBrun, Laurie, Chamberlain, Philip P, Calabrese, Andrew, Canan, Stacie S, Leftheris, Katerina, Zhu, Dan, Boylan, John F

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Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB von Bryk, Ruslana, Mundhra, Shashirekha, Jiang, Xiuju, Wood, Madeleine, Pfau, Daniel, Weber, Elaina, Park, Suna, Zhang, Li, Wilson, Colin, Van der Westhuyzen, Renier, Street, Leslie J., Chibale, Kelly, Zimmerman, Matthew, Dartois, Veronique, Pastore, Nunzia, Ballabio, Andrea, Hawryluk, Natalie, Canan, Stacie, Khetani, Vikram, Camardo, Joseph, Nathan, Carl

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CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization von Mortensen, Deborah S, Fultz, Kimberly E, Xu, Shuichan, Xu, Weiming, Packard, Garrick, Khambatta, Godrej, Gamez, James C, Leisten, Jim, Zhao, Jingjing, Apuy, Julius, Ghoreishi, Kamran, Hickman, Matt, Narla, Rama Krishna, Bissonette, Rene, Richardson, Samantha, Peng, Sophie X, Perrin-Ninkovic, Sophie, Tran, Tam, Shi, Tao, Yang, Wen Qing, Tong, Zeen, Cathers, Brian E, Moghaddam, Mehran F, Canan, Stacie S, Worland, Peter, Sankar, Sabita, Raymon, Heather K

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Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial von Thomas, Huw D, Calabrese, Christopher R, Batey, Michael A, Canan, Stacie, Hostomsky, Zdenek, Kyle, Suzanne, Maegley, Karen A, Newell, David R, Skalitzky, Donald, Wang, Lan-Zhen, Webber, Stephen E, Curtin, Nicola J

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Collaborative virtual screening to elaborate an imidazo[1,2-]pyridine hit series for visceral leishmaniasis von Akao, Yuichiro, Canan, Stacie, Cao, Yafeng, Condroski, Kevin, Engkvist, Ola, Itono, Sachiko, Kaki, Rina, Kimura, Chiaki, Kogej, Thierry, Nagaoka, Kazuya, Naito, Akira, Nakai, Hiromi, Pairaudeau, Garry, Radu, Constantin, Roberts, Ieuan, Shimada, Mitsuyuki, Shum, David, Watanabe, Nao-aki, Xie, Huanxu, Yonezawa, Shuji, Yoshida, Osamu, Yoshida, Ryu, Mowbray, Charles, Perry, Benjamin

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Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223 von Mortensen, Deborah S, Perrin-Ninkovic, Sophie M, Shevlin, Graziella, Zhao, Jingjing, Packard, Garrick, Bahmanyar, Sogole, Correa, Matthew, Elsner, Jan, Harris, Roy, Lee, Branden G. S, Papa, Patrick, Parnes, Jason S, Riggs, Jennifer R, Sapienza, John, Tehrani, Lida, Whitefield, Brandon, Apuy, Julius, Bisonette, René R, Gamez, James C, Hickman, Matt, Khambatta, Godrej, Leisten, Jim, Peng, Sophie X, Richardson, Samantha J, Cathers, Brian E, Canan, Stacie S, Moghaddam, Mehran F, Raymon, Heather K, Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E, Sankar, Sabita

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Filarial nematode phenotypic screening cascade to identify compounds with anti-parasitic activity for drug discovery optimization von Hawryluk, Natalie, Zhiru, Li, Carlow, Clotilde, Gokool, Suzanne, Townson, Simon, Kreiss, Tamara, Chojnowski, Agnieszka, Prorok, Monika, Siekierka, John, Ehrens, Alexandra, Koschel, Marianne, Lhermitte-Vallarino, Nathaly, Martin, Coralie, Hoerauf, Achim, Hernandez, Geraldine, Canan, Stacie, Khetani, Vikram, Zeldis, Jerome, Specht, Sabine, Hübner, Marc P., Scandale, Ivan

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Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells von CURTIN, Nicola J, WANG, Lan-Zhen, NEWELL, David R, YIAKOUVAKI, Anthie, KYLE, Suzanne, ARRIS, Christine A, CANAN-KOCH, Stacie, WEBBER, Stephen E, DURKACZ, Barbara W, CALVERT, Hilary A, HOSTOMSKY, Zdenek

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Strategies Employed for the Development of PARP Inhibitors von Canan, Stacie, Maegley, Karen, Curtin, Nicola J.

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Activation of specific RXR heterodimers by an antagonist of RXR homodimers von Lala, Deepak S, Mukherjee, Ranjan, Schulman, Ira G, Koch, Stacie S. Canan, Dardashti, Laura J, Nadzan, Alex M, Croston, Glenn E, Evans, Ronald M, Heyman, Richard A

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Collaborative Virtual Screening Identifies a 2‑Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection von Tawaraishi, Taisuke, Ochida, Atsuko, Akao, Yuichiro, Itono, Sachiko, Kamaura, Masahiro, Akther, Thamina, Shimada, Mitsuyuki, Canan, Stacie, Chowdhury, Sanjoy, Cao, Yafeng, Condroski, Kevin, Engkvist, Ola, Francisco, Amanda, Ghosh, Sunil, Kaki, Rina, Kelly, John M., Kimura, Chiaki, Kogej, Thierry, Nagaoka, Kazuya, Naito, Akira, Pairaudeau, Garry, Radu, Constantin, Roberts, Ieuan, Shum, David, Watanabe, Nao-aki, Xie, Huanxu, Yonezawa, Shuji, Yoshida, Osamu, Yoshida, Ryu, Mowbray, Charles, Perry, Benjamin

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Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection von Tawaraishi, Taisuke, Ochida, Atsuko, Akao, Yuichiro, Itono, Sachiko, Kamaura, Masahiro, Akther, Thamina, Shimada, Mitsuyuki, Canan, Stacie, Chowdhury, Sanjoy, Cao, Yafeng, Condroski, Kevin, Engkvist, Ola, Francisco, Amanda, Ghosh, Sunil, Kaki, Rina, Kelly, John M, Kimura, Chiaki, Kogej, Thierry, Nagaoka, Kazuya, Naito, Akira, Pairaudeau, Garry, Radu, Constantin, Roberts, Ieuan, Shum, David, Watanabe, Nao-Aki, Xie, Huanxu, Yonezawa, Shuji, Yoshida, Osamu, Yoshida, Ryu, Mowbray, Charles, Perry, Benjamin

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Discovery of Substituted Di(pyridin-2-yl)-1,2,4-thiadiazol-5-amines as Novel Macrofilaricidal Compounds for the Treatment of Human Filarial Infections von Hawryluk, Natalie, Robinson, Dale, Shen, Yixing, Kyne, Graham, Bedore, Matthew, Menon, Sanjay, Canan, Stacie, von Geldern, Thomas, Townson, Simon, Gokool, Suzanne, Ehrens, Alexandra, Koschel, Marianne, Lhermitte-Vallarino, Nathaly, Martin, Coralie, Hoerauf, Achim, Hernandez, Geraldine, Dalvie, Deepak, Specht, Sabine, Hübner, Marc Peter, Scandale, Ivan

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Enantioselective preparation of .beta.-alkyl-.gamma.-butyrolactones from functionalized ketene dithioacetals von Koch, Stacie S. Canan, Chamberlin, A. Richard

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Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity:  Design, Synthesis, and X-ray Cocrystal Structure von Canan Koch, Stacie S, Thoresen, Lars H, Tikhe, Jayashree G, Maegley, Karen A, Almassy, Robert J, Li, Jianke, Yu, Xiao-Hong, Zook, Scott E, Kumpf, Robert A, Zhang, Cathy, Boritzki, Theodore J, Mansour, Rena N, Zhang, Kanyin E, Ekker, Anne, Calabrese, Chris R, Curtin, Nicola J, Kyle, Suzanne, Thomas, Huw D, Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T, Griffin, Roger J, Newell, David R, Webber, Stephen E, Hostomsky, Zdenek

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Global Health Priority Box─Proactive Pandemic Preparedness von Adam, Anna, Besson, Dominique, Bryant, Rob, Rees, Sarah, Willis, Paul A., Burrows, Jeremy N., Hooft van Huisjduijnen, Rob, Laleu, Benoît, Norton, Larry, Canan, Stacie, Hawryluk, Natalie, Robinson, Dale, Palmer, Mike, Samby, Kirandeep Kaur

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Identification of the First Retinoid X Receptor Homodimer Antagonist von Canan Koch, Stacie S, Dardashti, Laura J, Hebert, Jonathan J, White, Steven K, Croston, Glenn E, Flatten, Karen S, Heyman, Richard A, Nadzan, Alex M

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