A Long-Acting FGF21 Molecule, PF-05231023, Decreases Body Weight and Improves Lipid Profile in Non-human Primates and Type 2 Diabetic Subjects von Talukdar, Saswata, Zhou, Yingjiang, Li, Dongmei, Rossulek, Michelle, Dong, Jennifer, Somayaji, Veena, Weng, Yan, Clark, Ronald, Lanba, Adhiraj, Owen, Bryn M., Brenner, Martin B., Trimmer, Jeffrey K., Gropp, Kathryn E., Chabot, Jeffrey R., Erion, Derek M., Rolph, Timothy P., Goodwin, Bryan, Calle, Roberto A.

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GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates von Breen, Danna M., Kim, Hanna, Bennett, Donald, Calle, Roberto A., Collins, Susie, Esquejo, Ryan M., He, Tao, Joaquim, Stephanie, Joyce, Alison, Lambert, Matthew, Lin, Laura, Pettersen, Betty, Qiao, Shuxi, Rossulek, Michelle, Weber, Gregory, Wu, Zhidan, Zhang, Bei B., Birnbaum, Morris J.

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Pharmacokinetics and pharmacodynamics of PF‐05231023, a novel long‐acting FGF21 mimetic, in a first‐in‐human study von Dong, Jennifer Q., Rossulek, Michelle, Somayaji, Veena R., Baltrukonis, Daniel, Liang, Yali, Hudson, Krischan, Hernandez‐Illas, Martha, Calle, Roberto A.

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The prevalence of low muscle mass associated with obesity in the USA von Murdock, Dana J, Wu, Ning, Grimsby, Joseph S, Calle, Roberto A, Donahue, Stephen, Glass, David J, Sleeman, Mark W, Sanchez, Robert J

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Clinical and scientific value in the pursuit of quantification of beta cells in the pancreas by PET imaging von Cline, Gary W., McCarthy, Timothy J., Carson, Richard E., Calle, Roberto A.

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The relationship between weight gain during chemotherapy and outcomes in patients with advanced non‐small cell lung cancer von Roeland, Eric J., Fintelmann, Florian J., Hilton, Fiona, Yang, Ruoyong, Whalen, Ed, Tarasenko, Lisa, Calle, Roberto A., Bonomi, Philip D.

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Investigation of pharmacokinetic drug interaction between clesacostat and DGAT2 inhibitor ervogastat in healthy adult participants von Sawant‐Basak, Aarti, Bergman, Arthur J., Mancuso, Jessica, Tripathy, Sakambari, Gosset, James R., Mendes da Costa, Laure, Esler, William P., Calle, Roberto A.

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Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a) von Deshmukh, Harshal A., Colhoun, Helen M., Johnson, Toby, McKeigue, Paul M., Betteridge, D. John, Durrington, Paul N., Fuller, John H., Livingstone, Shona, Charlton-Menys, Valentine, Neil, Andrew, Poulter, Neil, Sever, Peter, Shields, Denis C., Stanton, Alice V., Chatterjee, Aurobindo, Hyde, Craig, Calle, Roberto A., DeMicco, David A., Trompet, Stella, Postmus, Iris, Ford, Ian, Jukema, J. Wouter, Caulfield, Mark, Hitman, Graham A.

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Mechanistic investigation of the preclinical pharmacokinetics and interspecies scaling of PF-05231023, a fibroblast growth factor 21-antibody protein conjugate von Giragossian, Craig, Vage, Chandra, Li, Jun, Pelletier, Kathleen, Piché-Nicholas, Nicole, Rajadhyaksha, Manoj, Liras, Jennifer, Logan, Alison, Calle, Roberto A, Weng, Yan

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ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials von Calle, Roberto A., Amin, Neeta B., Carvajal-Gonzalez, Santos, Ross, Trenton T., Bergman, Arthur, Aggarwal, Sudeepta, Crowley, Collin, Rinaldi, Anthony, Mancuso, Jessica, Aggarwal, Naresh, Somayaji, Veena, Inglot, Malgorzata, Tuthill, Theresa A., Kou, Kou, Boucher, Magalie, Tesz, Greg, Dullea, Robert, Bence, Kendra K., Kim, Albert M., Pfefferkorn, Jeffrey A., Esler, William P.

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Diagnostic performance of circulating biomarkers for non-alcoholic steatohepatitis von Sanyal, Arun J., Shankar, Sudha S., Yates, Katherine P., Bolognese, James, Daly, Erika, Dehn, Clayton A., Neuschwander-Tetri, Brent, Kowdley, Kris, Vuppalanchi, Raj, Behling, Cynthia, Tonascia, James, Samir, Anthony, Sirlin, Claude, Sherlock, Sarah P., Fowler, Kathryn, Heymann, Helen, Kamphaus, Tania N., Loomba, Rohit, Calle, Roberto A.

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Non-Invasive Biomarkers of Nonalcoholic Steatohepatitis: the FNIH NIMBLE project von Sanyal, Arun J., Shankar, Sudha S., Calle, Roberto A., Samir, Anthony E., Sirlin, Claude B., Sherlock, Sarah P., Loomba, Rohit, Fowler, Kathryn J., Dehn, Clayton A., Heymann, Helen, Kamphaus, Tania N.

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Once‐weekly administration of a long‐acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people... von Kim, Albert M., Somayaji, Veena R., Dong, Jennifer Q., Rolph, Timothy P., Weng, Yan, Chabot, Jeffrey R., Gropp, Kathryn E., Talukdar, Saswata, Calle, Roberto A.

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The effects of ertugliflozin on β‐cell function: Pooled analysis from four phase 3 randomized controlled studies von Gallo, Silvina, Raji, Annaswamy, Calle, Roberto A., Pong, Annpey, Meyer, Christian

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1200-P: The Prevalence of Obesity-Associated Loss of Lean Muscle Mass von MURDOCK, DANA J., WU, NING, GLASS, DAVID J., GRIMSBY, JOSEPH S., CALLE, ROBERTO A., DONAHUE, STEPHEN, SLEEMAN, MARK, SANCHEZ, ROBERT J.

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Efficacy and safety of the glucagon receptor antagonist PF‐06291874: A 12‐week, randomized, dose‐response study in patients with type 2 diabetes mellitus on background metformin th... von Kazierad, David J., Chidsey, Kristin, Somayaji, Veena R., Bergman, Arthur J., Calle, Roberto A.

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Repeatability of MRI Biomarkers in Nonalcoholic Fatty Liver Disease: The NIMBLE Consortium von Fowler, Kathryn J, Venkatesh, Sudhakar K, Obuchowski, Nancy, Middleton, Michael S, Chen, Jun, Pepin, Kay, Magnuson, Jessica, Brown, Kathy J, Batakis, Danielle, Henderson, Walter C, Shankar, Sudha S, Kamphaus, Tania N, Pasek, Alex, Calle, Roberto A, Sanyal, Arun J, Loomba, Rohit, Ehman, Richard, Samir, Anthony E, Sirlin, Claude B, Sherlock, Sarah P

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Decreased VMAT2 in the pancreas of humans with type 2 diabetes mellitus measured in vivo by PET imaging von Cline, Gary W., Naganawa, Mika, Chen, Laigao, Chidsey, Kristin, Carvajal-Gonzalez, Santos, Pawlak, Sylvester, Rossulek, Michelle, Zhang, Yanwei, Bini, Jason, McCarthy, Timothy J., Carson, Richard E., Calle, Roberto A.

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Inhibition of ketohexokinase in adults with NAFLD reduces liver fat and inflammatory markers: A randomized phase 2 trial von Kazierad, David J., Chidsey, Kristin, Somayaji, Veena R., Bergman, Arthur J., Birnbaum, Morris J., Calle, Roberto A.

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Standardized Mixed-Meal Tolerance and Arginine Stimulation Tests Provide Reproducible and Complementary Measures of β-Cell Function: Results From the Foundation for the National In... von Shankar, Sudha S, Vella, Adrian, Raymond, Ralph H, Staten, Myrlene A, Calle, Roberto A, Bergman, Richard N, Cao, Charlie, Chen, Danny, Cobelli, Claudio, Dalla Man, Chiara, Deeg, Mark, Dong, Jennifer Q, Lee, Douglas S, Polidori, David, Robertson, R Paul, Ruetten, Hartmut, Stefanovski, Darko, Vassileva, Maria T, Weir, Gordon C, Fryburg, David A

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