Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation von Olson, Calla M, Jiang, Baishan, Erb, Michael A, Liang, Yanke, Doctor, Zainab M, Zhang, Zinan, Zhang, Tinghu, Kwiatkowski, Nicholas, Boukhali, Myriam, Green, Jennifer L, Haas, Wilhelm, Nomanbhoy, Tyzoon, Fischer, Eric S, Young, Richard A, Bradner, James E, Winter, Georg E, Gray, Nathanael S

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BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment von Winter, Georg E., Mayer, Andreas, Buckley, Dennis L., Erb, Michael A., Roderick, Justine E., Vittori, Sarah, Reyes, Jaime M., di Iulio, Julia, Souza, Amanda, Ott, Christopher J., Roberts, Justin M., Zeid, Rhamy, Scott, Thomas G., Paulk, Joshiawa, Lachance, Kate, Olson, Calla M., Dastjerdi, Shiva, Bauer, Sophie, Lin, Charles Y., Gray, Nathanael S., Kelliher, Michelle A., Churchman, L. Stirling, Bradner, James E.

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Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype von Olson, Calla M., Liang, Yanke, Leggett, Alan, Park, Woojun D., Li, Lianbo, Mills, Caitlin E., Elsarrag, Selma Z., Ficarro, Scott B., Zhang, Tinghu, Düster, Robert, Geyer, Matthias, Sim, Taebo, Marto, Jarrod A., Sorger, Peter K., Westover, Ken D., Lin, Charles Y., Kwiatkowski, Nicholas, Gray, Nathanael S.

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Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors von Kalan, Sampada, Amat, Ramon, Schachter, Miriam Merzel, Kwiatkowski, Nicholas, Abraham, Brian J., Liang, Yanke, Zhang, Tinghu, Olson, Calla M., Larochelle, Stéphane, Young, Richard A., Gray, Nathanael S., Fisher, Robert P.

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IRF2 is a master regulator of human keratinocyte stem cell fate von Mercado, Nicolas, Schutzius, Gabi, Kolter, Christian, Estoppey, David, Bergling, Sebastian, Roma, Guglielmo, Gubser Keller, Caroline, Nigsch, Florian, Salathe, Adrian, Terranova, Remi, Reece-Hoyes, John, Alford, John, Russ, Carsten, Knehr, Judith, Hoepfner, Dominic, Aebi, Alexandra, Ruffner, Heinz, Beck, Tanner C., Jagannathan, Sajjeev, Olson, Calla M., Sheppard, Hadley E., Elsarrag, Selma Z., Bouwmeester, Tewis, Frederiksen, Mathias, Lohmann, Felix, Lin, Charles Y., Kirkland, Susan

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Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors von Zhang, Tinghu, Kwiatkowski, Nicholas, Olson, Calla M, Dixon-Clarke, Sarah E, Abraham, Brian J, Greifenberg, Ann K, Ficarro, Scott B, Elkins, Jonathan M, Liang, Yanke, Hannett, Nancy M, Manz, Theresa, Hao, Mingfeng, Bartkowiak, Bartlomiej, Greenleaf, Arno L, Marto, Jarrod A, Geyer, Matthias, Bullock, Alex N, Young, Richard A, Gray, Nathanael S

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Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors von Zhang, Tinghu, Kwiatkowski, Nicholas, Olson, Calla M, Dixon-Clarke, Sarah E, Abraham, Brian J, Greifenberg, Ann K, Ficarro, Scott B, Elkins, Jonathan M, Liang, Yanke, Hannett, Nancy M, Manz, Theresa, Hao, Mingfeng, Bartkowiak, Bartlomiej, Greenleaf, Arno L, Marto, Jarrod A, Geyer, Matthias, Bullock, Alex N, Young, Richard A, Gray, Nathanael S

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Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer von Bowling, Elizabeth A., Wang, Jarey H., Gong, Fade, Wu, William, Neill, Nicholas J., Kim, Ik Sun, Tyagi, Siddhartha, Orellana, Mayra, Kurley, Sarah J., Dominguez-Vidaña, Rocio, Chung, Hsiang-Ching, Hsu, Tiffany Y.-T., Dubrulle, Julien, Saltzman, Alexander B., Li, Heyuan, Meena, Jitendra K., Canlas, Gino M., Chamakuri, Srinivas, Singh, Swarnima, Simon, Lukas M., Olson, Calla M., Dobrolecki, Lacey E., Lewis, Michael T., Zhang, Bing, Golding, Ido, Rosen, Jeffrey M., Young, Damian W., Malovannaya, Anna, Stossi, Fabio, Miles, George, Ellis, Matthew J., Yu, Lihua, Buonamici, Silvia, Lin, Charles Y., Karlin, Kristen L., Zhang, Xiang H.-F., Westbrook, Thomas F.

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The insulin receptor cellular IRES confers resistance to eIF4A inhibition von Olson, Calla M, Donovan, Marissa R, Spellberg, Michael J, Marr, 2nd, Michael T

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Development and Characterization of a Wee1 Kinase Degrader von Li, Zhengnian, Pinch, Benika J., Olson, Calla M., Donovan, Katherine A., Nowak, Radosław P., Mills, Caitlin E., Scott, David A., Doctor, Zainab M., Eleuteri, Nicholas A., Chung, Mirra, Sorger, Peter K., Fischer, Eric S., Gray, Nathanael S.

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Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13 von Liu, Yao, Hao, Mingfeng, Leggett, Alan L, Gao, Yang, Ficarro, Scott B, Che, Jianwei, He, Zhixiang, Olson, Calla M, Marto, Jarrod A, Kwiatkowski, Nicholas P, Zhang, Tinghu, Gray, Nathanael S

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A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation von de Wispelaere, Mélissanne, Carocci, Margot, Burri, Dominique J., Neidermyer, William J., Olson, Calla M., Roggenbach, Imme, Liang, Yanke, Wang, Jinhua, Whelan, Sean P.J., Gray, Nathanael S., Yang, Priscilla L.

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Determinants at the N- and C-termini of Gα12 required for activation of Rho-mediated signaling von Ritchie, Benjamin J, Smolski, William C, Montgomery, Ellyn R, Fisher, Elizabeth S, Choi, Tina Y, Olson, Calla M, Foster, Lori A, Meigs, Thomas E

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Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors von Richters, André, Doyle, Shelby K., Freeman, David B., Lee, Christina, Leifer, Becky S., Jagannathan, Sajjeev, Kabinger, Florian, Koren, Jošt Vrabič, Struntz, Nicholas B., Urgiles, Julie, Stagg, Ryan A., Curtin, Brice H., Chatterjee, Deep, Mathea, Sebastian, Mikochik, Peter J., Hopkins, Tamara D., Gao, Hua, Branch, Jonathan R., Xin, Hong, Westover, Lori, Bignan, Gilles C., Rupnow, Brent A., Karlin, Kristen L., Olson, Calla M., Westbrook, Thomas F., Vacca, Joseph, Wilfong, Chris M., Trotter, B. Wesley, Saffran, Douglas C., Bischofberger, Norbert, Knapp, Stefan, Russo, Joshua W., Hickson, Ian, Bischoff, James R., Gottardis, Marco M., Balk, Steven P., Lin, Charles Y., Pop, Marius S., Koehler, Angela N.

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MODL-12. REPURPOSING SSRI/SNRI TARGETING NEUROTRANSMITTER SIGNALING TO SENSITIZE DMG TO CDK9 INHIBITORS von Murdaugh, Rebecca L, Eberl, Brittany R, Richard, Rosemary U, Tremblay, Jack R, Dei-Ampeh, Alfred, Olson, Calla M, Anastas, Jamie N

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Abstract 1771: Targeting oncogenic transcription in prostate cancer with a novel, oral bioavailable, and ultra-selective CDK9 inhibitor von Richters, André, Freeman, David, Lee, Christina, Kabinger, Florian, Doyle, Shelby, Leifer, Becky, Mikochik, Peter, Jagannathan, Sajjeev, Koren, Jost Vrabic, Karlin, Kristen, Olson, Calla M., Wilfong, Christopher, Lin, Charles Y., Saffran, Doug, Vacca, Joseph, Bischofberger, Norbert, Pop, Marius, Koehler, Angela N.

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Covalent targeting of remote cysteine residues to develop CDK12 and 13 inhibitors von Zhang, Tinghu, Kwiatkowski, Nicholas, Olson, Calla M, Dixon-Clarke, Sarah E, Abraham, Brian J, Greifenberg, Ann K, Ficarro, Scott B, Elkins, Jonathan M, Liang, Yanke, Hannett, Nancy M, Manz, Theresa, Hao, Mingfeng, Bartkowiak, Bartlomiej, Greenleaf, Arno L, Marto, Jarrod A, Geyer, Matthias, Bullock, Alex N, Young, Richard A, Gray, Nathanael S

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A broad-spectrum antiviral molecule, QL47, selectively inhibits eukaryotic translation von de Wispelaere, Mélissanne, Carocci, Margot, Burri, Dominique J, Neidermyer, Jr, William J, Olson, Calla M, Roggenbach, Imme, Liang, Yanke, Wang, Jinhua, Whelan, Sean P J, Gray, Nathanael S, Yang, Priscilla L

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Determinants at the N- and C-termini of G[alpha].sub.12 required for activation of Rho-mediated signaling von Ritchie, Benjamin J, Smolski, William C, Montgomery, Ellyn R, Fisher, Elizabeth S, Choi, Tina Y, Olson, Calla M, Foster, Lori A, Meigs, Thomas E

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Determinants at the N- and C-termini of G[alpha]12 required for activation of Rho-mediated signaling von Ritchie, Benjamin J, Smolski, William C, Montgomery, Ellyn R, Fisher, Elizabeth S, Choi, Tina Y, Olson, Calla M, Foster, Lori A, Meigs, Thomas E

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