Paradigms for Precision Medicine in Epichaperome Cancer Therapy von Pillarsetty, Nagavarakishore, Jhaveri, Komal, Taldone, Tony, Caldas-Lopes, Eloisi, Punzalan, Blesida, Joshi, Suhasini, Bolaender, Alexander, Uddin, Mohammad M., Rodina, Anna, Yan, Pengrong, Ku, Anson, Ku, Thomas, Shah, Smit K., Lyashchenko, Serge, Burnazi, Eva, Wang, Tai, Lecomte, Nicolas, Janjigian, Yelena, Younes, Anas, Batlevi, Connie W., Guzman, Monica L., Roboz, Gail J., Koziorowski, Jacek, Zanzonico, Pat, Alpaugh, Mary L., Corben, Adriana, Modi, Shanu, Norton, Larry, Larson, Steven M., Lewis, Jason S., Chiosis, Gabriela, Gerecitano, John F., Dunphy, Mark P.S.

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Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models von Caldas-Lopes, Eloisi, Cerchietti, Leandro, Ahn, James H, Clement, Cristina C, Robles, Ana I, Rodina, Anna, Moulick, Kamalika, Taldone, Tony, Gozman, Alexander, Guo, Yunke, Wu, Nian, de Stanchina, Elisa, White, Julie, Gross, Steven S, Ma, Yuliang, Varticovski, Lyuba, Melnick, Ari, Chiosis, Gabriela

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HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans von Marubayashi, Sachie, Koppikar, Priya, Taldone, Tony, Abdel-Wahab, Omar, West, Nathan, Bhagwat, Neha, Caldas-Lopes, Eloisi, Ross, Kenneth N, Gönen, Mithat, Gozman, Alex, Ahn, James H, Rodina, Anna, Ouerfelli, Ouathek, Yang, Guangbin, Hedvat, Cyrus, Bradner, James E, Chiosis, Gabriela, Levine, Ross L

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Extracellular vesicles in DLBCL provide abundant clues to aberrant transcriptional programming and genomic alterations von Rutherford, Sarah C., Fachel, Angela A., Li, Sheng, Sawh, Seema, Muley, Ashlesha, Ishii, Jennifer, Saxena, Ashish, Dominguez, Pilar M., Caldas Lopes, Eloisi, Agirre, Xabier, Chambwe, Nyasha, Correa, Fabian, Jiang, Yanwen, Richards, Kristy L., Betel, Doron, Shaknovich, Rita

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Measuring the pharmacodynamic effects of a novel Hsp90 inhibitor on HER2/neu expression in mice using Zr-DFO-trastuzumab von Holland, Jason P, Caldas-Lopes, Eloisi, Divilov, Vadim, Longo, Valerie A, Taldone, Tony, Zatorska, Danuta, Chiosis, Gabriela, Lewis, Jason S

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BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy von Cerchietti, Leandro C, Hatzi, Katerina, Caldas-Lopes, Eloisi, Yang, Shao Ning, Figueroa, Maria E, Morin, Ryan D, Hirst, Martin, Mendez, Lourdes, Shaknovich, Rita, Cole, Philip A, Bhalla, Kapil, Gascoyne, Randy D, Marra, Marco, Chiosis, Gabriela, Melnick, Ari

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Targeting heat shock protein 90 with non‐quinone inhibitors: A novel chemotherapeutic approach in human hepatocellular carcinoma von Breinig, Marco, Caldas‐Lopes, Eloisi, Goeppert, Benjamin, Malz, Mona, Rieker, Ralf, Bergmann, Frank, Schirmacher, Peter, Mayer, Matthias, Chiosis, Gabriela, Kern, Michael André

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A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species von Zong, Hongliang, Gozman, Alexander, Caldas-Lopes, Eloisi, Taldone, Tony, Sturgill, Eric, Brennan, Sarah, Ochiana, Stefan O., Gomes-DaGama, Erica M., Sen, Siddhartha, Rodina, Anna, Koren, John, Becker, Michael W., Rudin, Charles M., Melnick, Ari, Levine, Ross L., Roboz, Gail J., Nimer, Stephen D., Chiosis, Gabriela, Guzman, Monica L.

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Pre-clinical efficacy of PU-H71, a novel HSP90 inhibitor, alone and in combination with bortezomib in Ewing sarcoma von Ambati, Srikanth R., Lopes, Eloisi Caldas, Kosugi, Kohji, Mony, Ullas, Zehir, Ahmet, Shah, Smit K., Taldone, Tony, Moreira, Andre L., Meyers, Paul A., Chiosis, Gabriela, Moore, Malcolm A.S.

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Disruption of mitochondrial membrane potential during apoptosis induced by PSC 833 and CsA in multidrug-resistant lymphoid leukemia von Bustamante, Juanita, Caldas Lopes, Eloisi, Garcia, Mariana, Di Libero, Eugenia, Alvarez, Elida, Hajos, Silvia E

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Qpctl Inhibition, By Targeting the Inflammatory Tumor Microenvironment, Constitutes a Novel Therapeutic Approach for Diffuse Large B-Cell Lymphoma von Di Siervi, Nicolas, Mullender, Jasper, Revuelta, María Victoria, Zamponi, Nahuel, Caldas-Lopes, Eloisi, Isshiki, Yusuke, Béguelin, Wendy, Scheepstra, Marcel, Evers, Bastiaan, Wuerthner, Jens, Cerchietti, Leandro

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The epichaperome is an integrated chaperome network that facilitates tumour survival von Rodina, Anna, Wang, Tai, Yan, Pengrong, Gomes, Erica DaGama, Dunphy, Mark P. S., Pillarsetty, Nagavarakishore, Koren, John, Gerecitano, John F., Taldone, Tony, Zong, Hongliang, Caldas-Lopes, Eloisi, Alpaugh, Mary, Corben, Adriana, Riolo, Matthew, Beattie, Brad, Pressl, Christina, Peter, Radu I., Xu, Chao, Trondl, Robert, Patel, Hardik J., Shimizu, Fumiko, Bolaender, Alexander, Yang, Chenghua, Panchal, Palak, Farooq, Mohammad F., Kishinevsky, Sarah, Modi, Shanu, Lin, Oscar, Chu, Feixia, Patil, Sujata, Erdjument-Bromage, Hediye, Zanzonico, Pat, Hudis, Clifford, Studer, Lorenz, Roboz, Gail J., Cesarman, Ethel, Cerchietti, Leandro, Levine, Ross, Melnick, Ari, Larson, Steven M., Lewis, Jason S., Guzman, Monica L., Chiosis, Gabriela

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A novel tetrazole analogue of resveratrol is a potent anticancer agent von Bommagani, Shobanbabu, Penthala, Narsimha Reddy, Balasubramaniam, Meenakshisundaram, Kuravi, Sudhakiranmayi, Caldas-Lopes, Eloisi, Guzman, Monica L., Balusu, Ramesh, Crooks, Peter A.

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Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90 von Moulick, Kamalika, Ahn, James H, Zong, Hongliang, Rodina, Anna, Cerchietti, Leandro, Gomes DaGama, Erica M, Caldas-Lopes, Eloisi, Beebe, Kristin, Perna, Fabiana, Hatzi, Katerina, Vu, Ly P, Zhao, Xinyang, Zatorska, Danuta, Taldone, Tony, Smith-Jones, Peter, Alpaugh, Mary, Gross, Steven S, Pillarsetty, Nagavarakishore, Ku, Thomas, Lewis, Jason S, Larson, Steven M, Levine, Ross, Erdjument-Bromage, Hediye, Guzman, Monica L, Nimer, Stephen D, Melnick, Ari, Neckers, Len, Chiosis, Gabriela

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Harnessing the Epichaperome As a Therapeutic Approach in Multiple Myeloma von Caldas Lopes, Eloisi, Wang, Tai, Jayabalan, David S, Taldone, Tony, Monge, Jorge, Contreras, Jorge, Winnie, Yip, Trujillo, Vicenta, Palak, Panchal, Lombardi, Nicholas, Sahil, Sharma, Chander, Digwal, Coleman, Morton, Chiosis, Gabriela, Niesvizky, Ruben, Guzman, Monica L.

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Ligaria cuneifolia flavonoid fractions modulate cell growth of normal lymphocytes and tumor cells as well as multidrug resistant cells von Cerdá Zolezzi, Paula, Fernández, Teresa, Aulicino, Paula, Cavaliere, Victoria, Greczanik, Sofía, Caldas Lopes, Eloisi, Wagner, Marcelo, Ricco, Rafael, Gurni, Alberto, Hajos, Silvia, Álvarez, Elida

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Abstract 5155: Orally bioavailable aurora-kinase B inhibitor (MK7) as a potential therapeutic approach in multiple myeloma von Contreras, Jorge, Lopes, Eloisi Caldas, Monge, Jorge, Jayabalan, David, Gunaganti, Naresh, Frett, Brendan, Li, Hong-yu, Coleman, Morton, Niesvizky, Ruben, Guzman, Monica L.

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Targeting Aurora-kinase B with the novel Aurora Kinase B inhibitor MK7 in multiple myeloma von Contreras, Jorge, Caldas-Lopes, Eloisi, Jayabalan, David, Monge, Jorge, Lombardi, Nicholas, Li, Hong-yu, Gunaganti, Naresh, Niesvizky, Ruben, Guzman, Monica

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Novel Alkylating Agent, Ureidomustine Exhibit Pre-Clinical Efficacy in B-Cell Lymphoma with Minimal Dose-Limiting Myelotoxicity von Caldas Lopes, Eloisi, Jae-Hung, Shieh, Ambati, Srikanth, Tsann-Long, Su, Correa, Fabian, Peguero, Elizabeth, Moore, Malcolm A.S.

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Daratumumab in Patients with Multiple Myeloma and Renal Impairment - Real-World Data from a Single-Center Institution von Monge, Jorge, Solomon, Robin S., Flicker, Kari, Jayabalan, David S, Guo, Jin, Contreras, Jorge, Pogonowski, Kathleen, Agudo, Natalie, Guarneri, Danielle, Liotta, Brielle, Lopes, Eloisi Caldas, Pearse, Roger, Coleman, Morton, Niesvizky, Ruben, Rossi, Adriana C.

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