Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities von Cairns, Rob A, Mak, Tak W

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Regulation of cancer cell metabolism von Mak, Tak W, Cairns, Rob A, Harris, Isaac S

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Drivers of the Warburg phenotype von Cairns, Rob A

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The current state of cancer metabolism von Cairns, Rob A., Mak, Tak W.

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption von Papandreou, Ioanna, Cairns, Rob A., Fontana, Lucrezia, Lim, Ai Lin, Denko, Nicholas C.

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Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme von Wolf, Amparo, Agnihotri, Sameer, Micallef, Johann, Mukherjee, Joydeep, Sabha, Nesrin, Cairns, Rob, Hawkins, Cynthia, Guha, Abhijit

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D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function von Sasaki, Masato, Knobbe, Christiane B, Itsumi, Momoe, Elia, Andrew J, Harris, Isaac S, Chio, Iok In Christine, Cairns, Rob A, McCracken, Susan, Wakeham, Andrew, Haight, Jillian, Ten, Annick You, Snow, Bryan, Ueda, Takeshi, Inoue, Satoshi, Yamamoto, Kazuo, Ko, Myunggon, Rao, Anjana, Yen, Katharine E, Su, Shinsan M, Mak, Tak Wah

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Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters von Lemonnier, François, Couronné, Lucile, Parrens, Marie, Jaïs, Jean-Philippe, Travert, Marion, Lamant, Laurence, Tournillac, Olivier, Rousset, Therese, Fabiani, Bettina, Cairns, Rob A., Mak, Tak, Bastard, Christian, Bernard, Olivier A., de Leval, Laurence, Gaulard, Philippe

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IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma von Cairns, Rob A., Iqbal, Javeed, Lemonnier, François, Kucuk, Can, de Leval, Laurence, Jais, Jean-Philippe, Parrens, Marie, Martin, Antoine, Xerri, Luc, Brousset, Pierre, Chan, Li Chong, Chan, Wing-Chung, Gaulard, Philippe, Mak, Tak W.

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PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma von Agnihotri, Sameer, Golbourn, Brian, Huang, Xi, Remke, Marc, Younger, Susan, Cairns, Rob A, Chalil, Alan, Smith, Christian A, Krumholtz, Stacey-Lynn, Mackenzie, Danielle, Rakopoulos, Patricia, Ramaswamy, Vijay, Taccone, Michael S, Mischel, Paul S, Fuller, Gregory N, Hawkins, Cynthia, Stanford, William L, Taylor, Michael D, Zadeh, Gelareh, Rutka, James T

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p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression von Amelio, Ivano, Mancini, Mara, Petrova, Varvara, Cairns, Rob A., Vikhreva, Polina, Nicolai, Sara, Marini, Alberto, Antonov, Alexey A., Le Quesne, John, Baen Acevedoe, Juvenal D., Dudek, Kate, Sozzi, Gabriella, Pastorino, Ugo, Knight, Richard A., Mak, Tak W., Melino, Gerry

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Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations von Gross, Stefan, Cairns, Rob A, Minden, Mark D, Driggers, Edward M, Bittinger, Mark A, Jang, Hyun Gyung, Sasaki, Masato, Jin, Shengfang, Schenkein, David P, Su, Shinsan M, Dang, Lenny, Fantin, Valeria R, Mak, Tak W

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Overcoming Physiologic Barriers to Cancer Treatment by Molecularly Targeting the Tumor Microenvironment von Cairns, Rob, Papandreou, Ioanna, Denko, Nicholas

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Fire and water: Tumor cell adaptation to metabolic conditions von Cairns, Rob A., Mak, Tak W.

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ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis von Jin, Shengfang, Jiang Chen, Lizao Chen, Gavin Histen, Zhizhong Lin, Stefan Gross, Jeffrey Hixon, Yue Chen, Charles Kung, Yiwei Chen, Yufei Fu, Yuxuan Lu, Hui Lin, Xiujun Cai, Hua Yang, Rob A. Cairns, Marion Dorsch, Shinsan M. Su, Scott Biller, Tak W. Mak, Yong Cang

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An Alternative Sugar Fuels AML von Cairns, Rob A., Mak, Tak W.

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The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development von Lemonnier, François, Cairns, Rob A., Inoue, Satoshi, Li, Wanda Y., Dupuy, Aurelie, Broutin, Sophie, Martin, Nadine, Fataccioli, Virginie, Pelletier, Romain, Wakeham, Andrew, Snow, Bryan E., de Leval, Laurence, Pujals, Anais, Haioun, Corinne, Paci, Angelo, Tobin, Erica R., Narayanaswamy, Rohini, Yen, Katherine, Jin, Shengfang, Gaulard, Philippe, Mak, Tak W.

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Mutant IDH is sufficient to initiate enchondromatosis in mice von Hirata, Makoto, Sasaki, Masato, Cairns, Rob A, Inoue, Satoshi, Puviindran, Vijitha, Li, Wanda Y, Snow, Bryan E, Jones, Lisa D, Wei, Qingxia, Sato, Shingo, Tang, Yuning J, Nadesan, Puviindran, Rockel, Jason, Whetstone, Heather, Poon, Raymond, Weng, Angela, Gross, Stefan, Straley, Kimberly, Gliser, Camelia, Xu, Yingxia, Wunder, Jay, Mak, Tak W, Alman, Benjamin A

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Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumor... von Leung, Eric, Cairns, Rob A, Chaudary, Naz, Vellanki, Ravi N, Kalliomaki, Tuula, Moriyama, Eduardo H, Mujcic, Hilda, Wilson, Brian C, Wouters, Bradly G, Hill, Richard, Milosevic, Michael

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Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy von Cairns, Rob A, Papandreou, Ioanna, Sutphin, Patrick D, Denko, Nicholas C

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