LKB1 modulates lung cancer differentiation and metastasis von Castrillon, Diego H, Lindeman, Neal I, Kwiatkowski, David J, Johnson, Bruce E, Wu, Michael C, Ramsey, Matthew R, McNamara, Kate, Li, Danan, Ji, Hongbin, Kozlowski, Piotr, Sharpless, Norman E, Shapiro, Geoffrey I, Bronson, Roderick T, Bao, Lei, Naumov, George N, Bardeesy, Nabeel, Meyerson, Matthew, Koivunen, Jussi, Krishnamurthy, Janakiraman, Contreras, Cristina M, Jänne, Pasi A, Padera, Robert F, Chen, Liang, Fan, Cheng, Chirieac, Lucian R, Torrice, Chad, Shimamura, Takeshi, Lin, Xihong, Hayes, D. Neil, Perera, Samanthi A, Cai, Dongpo, Liang, Mei-Chih, Wong, Kwok-Kin, Christiani, David C

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Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis von Guo, Jianshuang, Xue, Qingqing, Liu, Kaihui, Ge, Weizhi, Liu, Wenjie, Wang, Jiyan, Zhang, Mengyi, Li, Qiu-ying, Cai, Dongpo, Shan, Changliang, Zhang, Chunze, Liu, Xinqi, Li, Jing

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Combined depletion of cell cycle and transcriptional cyclin- dependent kinase activities induces apoptosis in cancer cells von DONGPO CAI, LATHAM, Vaughan M, XINXIN ZHANG, SHAPIRO, Geoffrey I

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Proapoptotic BH3-Only BCL-2 Family Protein BIM Connects Death Signaling from Epidermal Growth Factor Receptor Inhibition to the Mitochondrion von JING DENG, SHIMAMURA, Takeshi, PERERA, Samanthi, CARLSON, Nicole E, DONGPO CAI, SHAPIRO, Geoffrey I, WONG, Kwok-Kin, LETAI, Anthony

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CTNI-29. A PHASE 2 STUDY TO EVALUATE EFFICACY AND SAFETY OF ACT001 AND TEMOZOLOMIDE COMBINATION TREATMENT IN PATIENTS WITH RECURRENT GLIOBLASTOMA MULTIFORME von Li, Wenbin, Li, Qun, Wang, Liang, Cai, Dongpo, Yang, Xunjun

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Combined Depletion of Cell Cycle and Transcriptional Cyclin-Dependent Kinase Activities Induces Apoptosis in Cancer Cells (vol 66, pg 9270, 2006) von Cai, Dongpo, Latham, Vaughan M., Zhang, Xinxin, Shapiro, Geoffrey I.

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AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter von DONGPO CAI, IYER, Anita, FELEKKIS, Kyriacos N, NEAR, Richard I, ZHIJUN LUO, CHERNOFF, Jonathan, ALBANESE, Chris, PESTELL, Richard G, LERNER, Adam

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Safety and efficacy evaluation of ACT001 and WBRT treatment in patients with solid tumor and brain metastasis von Zhang, Tian, Zhang, Wencheng, Zhang, Kunning, Chen, Xi, Cai, Dongpo, Wang, Ping, Pang, Qingsong

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Phase 1 dose-escalation study of ACT001 in patients with recurrent glioblastoma and other advanced solid tumors von Lickliter, Jason D., Jennens, Ross, Lemech, Charlotte Rose, Kichenadasse, Ganessan, Cai, Dongpo, Su, Steven Yung-Chang

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A phase I dose-escalation study to evaluate pharmacokinetics, safety and tolerability of ACT001 in patients with advanced glioma von Shi, Yehui, Bai, Guiying, Wang, Peng, Cai, Dongpo, Chen, Yue, Wang, Ping

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DIPG-08. The development of ACT001 as a novel therapeutic for diffuse intrinsic pontine gliomas von Upton, Dannielle, George, Sandra, Liu, Jie, Cai, Dongpo Doug, Su, Steven Yung-Chang, Rayner, Benjamin, Tsoli, Maria, Ziegler, David

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Flavopiridol-induced apoptosis during S phase requires E2F-1 and inhibition of cyclin A-dependent kinase activity von JINGRUI JIANG, MATRANGA, Christian B, DONGPO CAI, LATHAM, Vaughan M, XINXIN ZHANG, LOWELL, April M, MARTELLI, Fabio, SHAPIRO, Geoffrey I

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Correction: Combined Depletion of Cell Cycle and Transcriptional Cyclin-Dependent Kinase Activities Induces Apoptosis in Cancer Cells von Cai, Dongpo, Latham, Jr, Vaughan M, Zhang, Xinxin, Shapiro, Geoffrey I

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Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor Veliparib (ABT-888) in Combination with Irinotecan in Patients with A... von LoRusso, Patricia M, Li, Jing, Burger, Angelika, Heilbrun, Lance K, Sausville, Edward A, Boerner, Scott A, Smith, Daryn, Pilat, Mary Jo, Zhang, Jie, Tolaney, Sara M, Cleary, James M, Chen, Alice P, Rubinstein, Lawrence, Boerner, Julie L, Bowditch, Adam, Cai, Dongpo, Bell, Tracy, Wolanski, Andrew, Marrero, Allison M, Zhang, Yiping, Ji, Jiuping, Ferry-Galow, Katherine, Kinders, Robert J, Parchment, Ralph E, Shapiro, Geoffrey I

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HGG-14. ACT001 – A PROMISING THERAPEUTIC FOR DIFFUSE INTRINSIC PONTINE GLIOMAS von Upton, Dannielle, George, Sandra, Liu, Jie, Cai, Dongpo, Su, Steven Yung-Chang, Manoharan, Neevika, Foresto, Steve, Hassall, Tim, Tsoli, Maria, Ziegler, David

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Cdk1 Participates in BRCA1-Dependent S Phase Checkpoint Control in Response to DNA Damage von Johnson, Neil, Cai, Dongpo, Kennedy, Richard D., Pathania, Shailja, Arora, Mansi, Li, Yu-Chen, D'Andrea, Alan D., Parvin, Jeffrey D., Shapiro, Geoffrey I.

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AZ703, an imidazo[1,2-a]pyridine inhibitor of cyclin-dependent kinases 1 and 2, induces E2F-1-dependent apoptosis enhanced by depletion of cyclin-dependent kinase 9 von Cai, Dongpo, Byth, Kate F, Shapiro, Geoffrey I

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Abstract CT047: Phase 1 dose-escalation study of the CDK inhibitor dinaciclib in combination with the PARP inhibitor veliparib in patients with advanced solid tumors von Shapiro, Geoffrey I., Do, Khanh T., Tolaney, Sara M., Hilton, John F., Cleary, James M., Wolanski, Andrew, Beardslee, Brian, Hassinger, Faith, Bhushan, Ketki, Cai, Dongpo, Downey, Elizabeth, Pruitt-Thompson, Solida, Barry, Suzanne M., Kochupurakkal, Bose, Geradts, Joseph, Unitt, Christine, D'Andrea, Alan D., Muzikansky, Alona, Piekarz, Richard, Doyle, L. Austin, Supko, Jeffrey

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Abstract CT325: Combination of the PARP inhibitor veliparib (ABT888) with irinotecan in patients with triple negative breast cancer: Preliminary activity and signature of response von LoRusso, Patricia M., Tolaney, Sara M., Wong, Shukmei, Parchment, Ralph E., Kinders, Robert J., Wang, Lihua, Aldrich, Jessica, Chen, Alice, Durecki, Diane, Boerner, Scott A., Guthrie, Tina, Bowditch, Adam, Heilbrun, Lance K., Pilat, Mary Jo, Craig, David, Cai, Dongpo, Bell, Tracy, Carpten, John, Shapiro, Geoffrey

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p130Cas Regulates the Activity of AND-34, a Novel Ral, Rap1, and R-Ras Guanine Nucleotide Exchange Factor von Gotoh, Takaya, Cai, Dongpo, Tian, Xuejun, Feig, Larry A., Lerner, Adam

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