Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092 von Bahl, Ash, Barton, Patrick, Bowers, Keith, Caffrey, Moya V., Denton, Rebecca, Gilmour, Peter, Hawley, Shaun, Linannen, Tero, Luckhurst, Christopher A., Mochel, Tobias, Perry, Matthew W.D., Riley, Robert J., Roe, Emma, Springthorpe, Brian, Stein, Linda, Webborn, Peter

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Fused mesoionic heterocycles: synthesis of [1,2,3]triazolo[1,5- a]quinoline, [1,2,3]triazolo[1,5- a]quinazoline, [1,2,3]triazolo[1,5- a]quinoxaline and [1,2,3]triazolo[5,1- c]benzo... von Abbott, Phillip A, Bonnert, Roger V, Caffrey, Moya V, Cage, Peter A, Cooke, Andrew J, Donald, David K, Furber, Mark, Hill, Steve, Withnall, Jane

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Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X7 Receptor Antagonists/Interleukin-1β Inhibitors von Furber, Mark, Alcaraz, Lilian, Bent, Janice E, Beyerbach, Armin, Bowers, Keith, Braddock, Martin, Caffrey, Moya V, Cladingboel, David, Collington, John, Donald, David K, Fagura, Malbinder, Ince, Frank, Kinchin, Elizabeth C, Laurent, Celine, Lawson, Mandy, Luker, Timothy J, Mortimore, Michael M. P, Pimm, Austen D, Riley, Robert J, Roberts, Nicola, Robertson, Mark, Theaker, Jill, Thorne, Philip V, Weaver, Richard, Webborn, Peter, Willis, Paul

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Discovery of Potent and Selective Adamantane-Based Small-Molecule P2X 7 Receptor Antagonists/Interleukin-1β Inhibitors von Furber, Mark, Alcaraz, Lilian, Bent, Janice E., Beyerbach, Armin, Bowers, Keith, Braddock, Martin, Caffrey, Moya V., Cladingboel, David, Collington, John, Donald, David K., Fagura, Malbinder, Ince, Frank, Kinchin, Elizabeth C., Laurent, Celine, Lawson, Mandy, Luker, Timothy J., Mortimore, Michael M. P., Pimm, Austen D., Riley, Robert J., Roberts, Nicola, Robertson, Mark, Theaker, Jill, Thorne, Philip V., Weaver, Richard, Webborn, Peter, Willis, Paul

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Discovery of potent and selective adamantane-based small-molecule P2X(7) receptor antagonists/interleukin-1beta inhibitors von Furber, Mark, Alcaraz, Lilian, Bent, Janice E, Beyerbach, Armin, Bowers, Keith, Braddock, Martin, Caffrey, Moya V, Cladingboel, David, Collington, John, Donald, David K, Fagura, Malbinder, Ince, Frank, Kinchin, Elizabeth C, Laurent, Celine, Lawson, Mandy, Luker, Timothy J, Mortimore, Michael M P, Pimm, Austen D, Riley, Robert J, Roberts, Nicola, Robertson, Mark, Theaker, Jill, Thorne, Philip V, Weaver, Richard, Webborn, Peter, Willis, Paul

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Synthesis and evaluation of dual domain macrocyclic FKBP12 ligands von Caffrey, Moya V., Cladingboel, David E., Cooper, Martin E., Donald, David K., Furber, Mark, Hardern, David N., Harrison, Richard P., Stocks, Michael J., Teague, Simon J.

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Synthetic FKBP12 ligands. Design and synthesis of pyranose replacements von Birkenshaw, Timothy N., Caffrey, Moya V., Cladingboel, David E., Cooper, Martin E., Donald, David K., Furber, Mark, Hardern, David N., Harrison, Richard P., Marriott, David P., Perry, Matthew W.D., Stocks, Michael J., Teague, Simon J., Withnall, W.John

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ChemInform Abstract: Fused Mesoionic Heterocycles: Synthesis of [1,2,3]Triazolo[1,5-a]quinoline, [1,2,3]Triazolo[1,5-a]quinazoline, [1,2,3]Triazolo[1,5-a]quinoxaline and [1,2,3]Tri... von Abbott, Phillip A., Bonnert, Roger V., Caffrey, Moya V., Cage, Peter A., Cooke, Andrew J., Donald, David K., Furber, Mark, Hill, Steve, Withnall, Jane

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