Inhibition of NAE‐dependent protein hyper‐NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease von Lee‐Law, Pui Y., Olaizola, Paula, Caballero‐Camino, Francisco J., Izquierdo‐Sanchez, Laura, Rodrigues, Pedro M., Perugorria, Maria J., Azkargorta, Mikel, Elortza, Felix, Martinez‐Chantar, Maria L., Aspichueta, Patricia, Marzioni, Marco, Bujanda, Luis, Drenth, Joost P. H., Banales, Jesus M.

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Synthetic Conjugates of Ursodeoxycholic Acid Inhibit Cystogenesis in Experimental Models of Polycystic Liver Disease von Caballero‐Camino, Francisco J., Rivilla, Ivan, Herraez, Elisa, Briz, Oscar, Santos‐Laso, Alvaro, Izquierdo‐Sanchez, Laura, Lee‐Law, Pui Y., Rodrigues, Pedro M., Munoz‐Garrido, Patricia, Jin, Sujeong, Peixoto, Estanislao, Richard, Seth, Gradilone, Sergio A., Perugorria, Maria J., Esteller, Manel, Bujanda, Luis, Marin, Jose J.G., Banales, Jesus M., Cossío, Fernando P.

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A3907, a systemic ASBT inhibitor, improves cholestasis in mice by multiorgan activity and shows translational relevance to humans von Caballero-Camino, Francisco J, Rodrigues, Pedro M, Wångsell, Fredrik, Agirre-Lizaso, Aloña, Olaizola, Paula, Izquierdo-Sanchez, Laura, Perugorria, Maria J, Bujanda, Luis, Angelin, Bo, Straniero, Sara, Wallebäck, Anna, Starke, Ingemar, Gillberg, Per-Göran, Strängberg, Ellen, Bonn, Britta, Mattsson, Jan P, Madsen, Martin R, Hansen, Henrik H, Lindström, Erik, Åkerblad, Peter, Banales, Jesus M

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Genetics, pathobiology and therapeutic opportunities of polycystic liver disease von Olaizola, Paula, Rodrigues, Pedro M., Caballero-Camino, Francisco J., Izquierdo-Sanchez, Laura, Aspichueta, Patricia, Bujanda, Luis, Larusso, Nicholas F., Drenth, Joost P. H., Perugorria, Maria J., Banales, Jesus M.

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Targeting UBC9-mediated protein hyper-SUMOylation in cystic cholangiocytes halts polycystic liver disease in experimental models von Lee-Law, Pui Y., Olaizola, Paula, Caballero-Camino, Francisco J., Izquierdo-Sanchez, Laura, Rodrigues, Pedro M., Santos-Laso, Alvaro, Azkargorta, Mikel, Elortza, Felix, Martinez-Chantar, Maria L., Perugorria, Maria J., Aspichueta, Patricia, Marzioni, Marco, LaRusso, Nicholas F., Bujanda, Luis, Drenth, Joost P.H., Banales, Jesus M.

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Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models von Olaizola, Paula, Lee-Law, Pui Yuen, Fernandez-Barrena, Maite G., Alvarez, Laura, Cadamuro, Massimiliano, Azkargorta, Mikel, O’Rourke, Colm J., Caballero-Camino, Francisco J., Olaizola, Irene, Macias, Rocio I.R., Marin, Jose J.G., Serrano-Maciá, Marina, Martinez-Chantar, Maria L., Avila, Matias A., Aspichueta, Patricia, Calvisi, Diego F., Evert, Matthias, Fabris, Luca, Castro, Rui E., Elortza, Felix, Andersen, Jesper B., Bujanda, Luis, Rodrigues, Pedro M., Perugorria, Maria J., Banales, Jesus M.

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Proteostasis disturbances and endoplasmic reticulum stress contribute to polycystic liver disease: New therapeutic targets von Santos‐Laso, Alvaro, Izquierdo‐Sanchez, Laura, Rodrigues, Pedro M., Huang, Bing Q., Azkargorta, Mikel, Lapitz, Ainhoa, Munoz‐Garrido, Patricia, Arbelaiz, Ander, Caballero-Camino, Francisco J., Fernández‐Barrena, Maite G., Jimenez‐Agüero, Raul, Argemi, Josepmaria, Aragon, Tomas, Elortza, Felix, Marzioni, Marco, Drenth, Joost P. H., LaRusso, Nicholas F., Bujanda, Luis, Perugorria, Maria J., Banales, Jesus M., Andersson, Emma

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Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models von Olaizola, Paula, Lee-Law, Pui Yuen, Fernandez-Barrena, Maite G, Alvarez, Laura, Cadamuro, Massimiliano, Azkargorta, Mikel, O'Rourke, Colm J, Caballero-Camino, Francisco J, Olaizola, Irene, Macias, Rocio I R, Marin, Jose J G, Serrano-Maciá, Marina, Martinez-Chantar, Maria L, Avila, Matias A, Aspichueta, Patricia, Calvisi, Diego F, Evert, Matthias, Fabris, Luca, Castro, Rui E, Elortza, Felix, Andersen, Jesper B, Bujanda, Luis, Rodrigues, Pedro M, Perugorria, Maria J, Banales, Jesus M

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Synthetic conjugates of ursodeoxycholic acid inhibit cystogenesis in experimental models of polycystic liver disease von Caballero-Camino, Francisco J, Rivilla, Iván, Herraez, Elisa, Briz, Oscar, Santos-Laso, Álvaro, Izquierdo-Sanchez, Laura, Lee-Law, Pui Y, Rodrigues, Pedro M, Muñoz-Garrido, Patricia, Jin, Sujeong, Peixoto, Estanislao, Richard, Seth, Gradilone, Sergio A, Perugorria, Maria J, Esteller, Manel, Bujanda, Luis, Marín, José J. G, Banales, Jesús M, Cossio, Fernando P

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177 - NOVEL PLATINUM-BASED CHEMOTHERAPEUTIC AGENTS HALT CHOLANGIOCARCINOMA PROGRESSION THROUGH THE INDUCTION OF INTERSTRAND DNA BREAKS, PREVENTING DNA REPAIR MECHANISMS von Olaizola, Irene, Odriozola, Mikel, Asensio, Maitane, Olaizola, Paula, Rivilla, Iván, Guimaraes, Amanda, Caballero-Camino, Francisco J., Herráez, Elisa, Briz, Óscar, Rodrigues, Pedro M., Perugorria, Maria J., Bujanda, Luis, Garcia-Marin, Jose J., Cossio, Fernando, Banales, Jesus M.

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Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma von Lapitz, Ainhoa, Azkargorta, Mikel, Milkiewicz, Piotr, Olaizola, Paula, Zhuravleva, Ekaterina, Grimsrud, Marit M., Schramm, Christoph, Arbelaiz, Ander, O'Rourke, Colm J., La Casta, Adelaida, Milkiewicz, Malgorzata, Pastor, Tania, Vesterhus, Mette, Jimenez-Agüero, Raul, Dill, Michael T., Lamarca, Angela, Valle, Juan W., Macias, Rocio I.R., Izquierdo-Sanchez, Laura, Pérez Castaño, Ylenia, Caballero-Camino, Francisco Javier, Riaño, Ioana, Krawczyk, Marcin, Ibarra, Cesar, Bustamante, Javier, Nova-Camacho, Luiz M., Falcon-Perez, Juan M., Elortza, Felix, Perugorria, Maria J., Andersen, Jesper B., Bujanda, Luis, Karlsen, Tom H., Folseraas, Trine, Rodrigues, Pedro M., Banales, Jesus M.

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Liquid biopsy-based protein biomarkers for risk prediction, early diagnosis, and prognostication of cholangiocarcinoma von Lapitz, Ainhoa, Azkargorta, Mikel, Milkiewicz, Piotr, Olaizola, Paula, Zhuravleva, Ekaterina, Grimsrud, Marit Mæhle, Schramm, Christoph, Arbelaiz, Ander, O'Rourke, Colm J, La Casta, Adelaida, Milkiewicz, Malgorzata, Pastor, Tania, Vesterhus, Mette Nåmdal, Jimenez-Agüero, Raul, Dill, Michael T, Lamarca, Angela, Valle, Juan W, Macias, Rocio I.R, Izquierdo-Sanchez, Laura, Pérez Castaño, Ylenia, Caballero-Camino, Francisco Javier, Riaño, Ioana, Krawczyk, Marcin, Ibarra, Cesar, Bustamante, Javier, Nova-Camacho, Luiz M, Falcon-Perez, Juan M, Elortza, Felix, Perugorria, Maria J, Andersen, Jesper B, Bujanda, Luis, Karlsen, Tom Hemming, Folseraas, Trine, Rodrigues, Pedro M, Banales, Jesus M

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LIQUID BIOPSY PROTEINS AS PSC-SPECIFIC AND PAN-CCA BIOMARKERS OF CANCER RISK, EARLY DIAGNOSIS AND SURVIVAL MIRRORING TUMOR CELLS von Lapitz, Ainhoa, Azkargorta, Mikel, Milkiewicz, Piotr, Olaizola, Paula, Zhuravleva, Ekaterina, Grimsrud, Marit M., Schramm, Christoph, Arbelaiz, Ander, O’Rourke, Colm J., Casta, Adelaida La, Milkiewicz, Malgorzata, Pastor, Tania, Vesterhus, Mette, Jiménez-Agüero, Raul, Dill, Michael T., Lamarca, Angela, Valle, Juan W., Macias, Rocio I.R., Izquierdo-Sánchez, Laura, Castaño, Ylenia Pérez, Camino, Francisco Javier Caballero, Riano, Ioana, Krawczyk, Marcin, Ibarra, Cesar, Bustamante, Javier, Camacho, Luiz Miguel Nova, Falcon-Pérez, Juan M., Elortza, Felix, Perugorria, Maria J., Andersen, Jesper B., Bujanda, Luis, Karlsen, Tom H., Folseraas, Trine, Rodrigues, Pedro M., Banales, Jesus M.

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