Alternatives to antibiotics—a pipeline portfolio review von Czaplewski, Lloyd, Dr, Bax, Richard, MD, Clokie, Martha, Prof, Dawson, Mike, PhD, Fairhead, Heather, PhD, Fischetti, Vincent A, Prof, Foster, Simon, Prof, Gilmore, Brendan F, Prof, Hancock, Robert E W, Prof, Harper, David, PhD, Henderson, Ian R, Prof, Hilpert, Kai, PhD, Jones, Brian V, PhD, Kadioglu, Aras, Prof, Knowles, David, PhD, Ólafsdóttir, Sigríður, PhD, Payne, David, PhD, Projan, Steve, PhD, Shaunak, Sunil, Prof, Silverman, Jared, PhD, Thomas, Christopher M, Prof, Trust, Trevor J, PhD, Warn, Peter, PhD, Rex, John H, MD

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Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability von Czaplewski, Lloyd G, Rimmer, Otis, McHale, Duncan, Laslett, Mark

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Multiple effects of benzamide antibiotics on FtsZ function von Adams, David W., Wu, Ling Juan, Czaplewski, Lloyd G., Errington, Jeff

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Letter to the Editor concerning “Prospective study using anterior approach did not show association between Modic 1 changes and low-grade infection in lumbar spine” by Rigal J, The... von Czaplewski, Lloyd G.

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Chronic low back pain, bacterial infection and treatment with antibiotics von Gilligan, Christopher J., Cohen, Steven P., Fischetti, Vincent A., Hirsch, Joshua A., Czaplewski, Lloyd G.

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An Improved Small-Molecule Inhibitor of FtsZ with Superior In Vitro Potency, Drug-Like Properties, and In Vivo Efficacy von STOKES, Neil R, BAKER, Nicola, MITCHELL, Jeffrey P, NAYAL, Narendra, YADAV, Anju, SRIVASTAVA, Anil, HAYDON, David J, BENNETT, James M, BERRY, Joanne, COLLINS, Ian, CZAPLEWSKI, Lloyd G, LOGAN, Alastair, MACDONALD, Rebecca, MACLEOD, Leanne, PEASLEY, Hilary

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Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: Structure based design, synthesis, SAR and antimicrobial activity von Yule, Ian A., Czaplewski, Lloyd G., Pommier, Stephanie, Davies, David T., Narramore, Sarah K., Fishwick, Colin W.G.

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Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity von Haydon, David J, Stokes, Neil R, Ure, Rebecca, Galbraith, Greta, Bennett, James M, Brown, David R, Baker, Patrick J, Barynin, Vladimir V, Rice, David W, Sedelnikova, Sveta E, Heal, Jonathan R, Sheridan, Joseph M, Aiwale, Sachin T, Chauhan, Pramod K, Srivastava, Anil, Taneja, Amit, Collins, Ian, Errington, Jeff, Czaplewski, Lloyd G

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Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ von Stokes, Neil R, Baker, Nicola, Bennett, James M, Chauhan, Pramod K, Collins, Ian, Davies, David T, Gavade, Maruti, Kumar, Dushyant, Lancett, Paul, Macdonald, Rebecca, Macleod, Leanne, Mahajan, Anu, Mitchell, Jeffrey P, Nayal, Narendra, Nayal, Yashodanand Nandan, Pitt, Gary R W, Singh, Mahipal, Yadav, Anju, Srivastava, Anil, Czaplewski, Lloyd G, Haydon, David J

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Reply to a letter to the editor regarding the article, “Chronic low back pain, bacterial infection and treatment with antibiotics. Gilligan CJ, Cohen SP, Fischetti VA, Hirsch JA, C... von Gilligan, Christopher J., Cohen, Steven P., Fischetti, Vincent A., Hirsch, Joshua A., Czaplewski, Lloyd G.

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Preclinical development and characterisation of PP353, a formulation of linezolid for intradiscal administration von Hagger, Graham, Guest, Sarah, Birchall, Stephen, Bradley, Alys, Brindley, Charlie, Corbett, David, Cummings, Paul J., Freire, Cristina, Harris, James, Wise, Andrew, Wood, Melanie, Czaplewski, Lloyd G.

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Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement von Chopra, Ian, Prof, Schofield, Christopher, Prof, Everett, Martin, PhD, O'Neill, Alex, PhD, Miller, Keith, PhD, Wilcox, Mark, Prof, Frère, Jean-Marie, Prof, Dawson, Mike, PhD, Czaplewski, Lloyd, PhD, Urleb, Uros, PhD, Courvalin, Patrice, Prof

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Biological Evaluation of Benzothiazole Ethyl Urea Inhibitors of Bacterial Type II Topoisomerases von STOKES, Neil R, THOMAIDES-BREARS, Helena B, LUNNISS, Christopher J, PEASLEY, Hilary, POMMIER, Stéphanie, PRICE, Daniel, SMEE, Carol, HAYDON, David J, BARKER, Stephanie, BENNETT, James M, BERRY, Joanne, COLLINS, Ian, CZAPLEWSKI, Lloyd G, GAMBLE, Vicki, LANCETT, Paul, LOGAN, Alastair

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Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ von Czaplewski, Lloyd G., Collins, Ian, Boyd, E. Andrew, Brown, David, East, Stephen P., Gardiner, Mihaly, Fletcher, Rowena, Haydon, David J., Henstock, Vincent, Ingram, Peter, Jones, Clare, Noula, Caterina, Kennison, Leanne, Rockley, Chris, Rose, Valerie, Thomaides-Brears, Helena B., Ure, Rebecca, Whittaker, Mark, Stokes, Neil R.

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Pharmacokinetics of PP353, a formulation of linezolid for intervertebral disc administration, in patients with chronic low back pain and Modic change Type 1: A first‐in‐human, Phas... von Tripathi, Shiva S., Sneath, Robert, Golash, Aprajay, Desai, Parag, McHale, Duncan, Guest, Sarah, Brindley, Charlie, Cummings, Paul, Smith, Shane, Stroud, Conrad, Scott, Graham, Ruston, Steve, Czaplewski, Lloyd

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Novel Inhibitors of Bacterial Cytokinesis Identified by a Cell-based Antibiotic Screening Assay von Stokes, Neil R., Sievers, Jörg, Barker, Stephanie, Bennett, James M., Brown, David R., Collins, Ian, Errington, Veronica M., Foulger, David, Hall, Michelle, Halsey, Rowena, Johnson, Hazel, Rose, Valerie, Thomaides, Helena B., Haydon, David J., Czaplewski, Lloyd G., Errington, Jeff

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Discovery and development of new antibacterial drugs: learning from experience? von Jackson, Nicole, Czaplewski, Lloyd, Piddock, Laura J V

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Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors von Axford, Lorraine C., Agarwal, Piyush K., Anderson, Kelly H., Andrau, Laura N., Atherall, John, Barker, Stephanie, Bennett, James M., Blair, Michael, Collins, Ian, Czaplewski, Lloyd G., Davies, David T., Gannon, Carlie T., Kumar, Dushyant, Lancett, Paul, Logan, Alastair, Lunniss, Christopher J., Mitchell, Dale R., Offermann, Daniel A., Palmer, James T., Palmer, Nicholas, Pitt, Gary R.W., Pommier, Stéphanie, Price, Daniel, Narasinga Rao, B., Saxena, Rashmi, Shukla, Tarun, Singh, Amit K., Singh, Mahipal, Srivastava, Anil, Steele, Christopher, Stokes, Neil R., Thomaides-Brears, Helena B., Tyndall, Edward M., Watson, David, Haydon, David J.

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DNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity von East, Stephen P., White, Clara Bantry, Barker, Oliver, Barker, Stephanie, Bennett, James, Brown, David, Boyd, E. Andrew, Brennan, Christopher, Chowdhury, Chandana, Collins, Ian, Convers-Reignier, Emmanuelle, Dymock, Brian W., Fletcher, Rowena, Haydon, David J., Gardiner, Mihaly, Hatcher, Stuart, Ingram, Peter, Lancett, Paul, Mortenson, Paul, Papadopoulos, Konstantinos, Smee, Carol, Thomaides-Brears, Helena B., Tye, Heather, Workman, James, Czaplewski, Lloyd G.

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Analysis of the Clinical Pipeline of Treatments for Drug-Resistant Bacterial Infections: Despite Progress, More Action Is Needed von Butler, Mark S, Gigante, Valeria, Sati, Hatim, Paulin, Sarah, Al-Sulaiman, Laila, Rex, John H, Fernandes, Prabhavathi, Arias, Cesar A, Paul, Mical, Thwaites, Guy E, Czaplewski, Lloyd, Alm, Richard A, Lienhardt, Christian, Spigelman, Melvin, Silver, Lynn L, Ohmagari, Norio, Kozlov, Roman, Harbarth, Stephan, Beyer, Peter

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