SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis von Jacobs, Robert T, Nare, Bakela, Wring, Stephen A, Orr, Matthew D, Chen, Daitao, Sligar, Jessica M, Jenks, Matthew X, Noe, Robert A, Bowling, Tana S, Mercer, Luke T, Rewerts, Cindy, Gaukel, Eric, Owens, Jennifer, Parham, Robin, Randolph, Ryan, Beaudet, Beth, Bacchi, Cyrus J, Yarlett, Nigel, Plattner, Jacob J, Freund, Yvonne, Ding, Charles, Akama, Tsutomu, Zhang, Y-K, Brun, Reto, Kaiser, Marcel, Scandale, Ivan, Don, Robert

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Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides von Thompson, Andrew M., Marshall, Andrew J., Maes, Louis, Yarlett, Nigel, Bacchi, Cyrus J., Gaukel, Eric, Wring, Stephen A., Launay, Delphine, Braillard, Stephanie, Chatelain, Eric, Mowbray, Charles E., Denny, William A.

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In Memoriam: Michael Levandowsky (1935–2016) von Bacchi, Cyrus J., Gorrell, Thomas, McManus, George, Yarlett, Nigel

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Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin von Vujcic, Slavoljub, Diegelman, Paula, Bacchi, Cyrus J, Kramer, Debora L, Porter, Carl W

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Dibenzosuberyl substituted polyamines and analogs of clomipramine as effective inhibitors of trypanothione reductase; molecular docking, and assessment of trypanocidal activities von O’Sullivan, Mary C., Durham, Timothy B., Valdes, Hannah E., Dauer, Kelly L., Karney, Nicholas J., Forrestel, Andrew C., Bacchi, Cyrus J., Baker, Jerome F.

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Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis von NARE, Bakela, WRING, Stephen, HUSSAIN, Ali, JARNAGIN, Kurt, JENKS, Matthew, KAISER, Marcel, MERCER, Luke, MEJIA, Elena, NOE, Andy, ORR, Matt, PARHAM, Robin, PLATTNER, Jacob, BACCHI, Cyrus, RANDOLPH, Ryan, RATTENDI, Donna, REWERTS, Cindy, SLIGAR, Jessica, YARLETT, Nigel, DON, Robert, JACOBS, Robert, BEAUDET, Beth, BOWLING, Tana, BRUN, Reto, DAITAO CHEN, DING, Charles, FREUND, Yvonne, GAUKEL, Eric

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Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents von Vanden Eynde, Jean J, Mayence, Annie, Mottamal, Madhusoodanan, Bacchi, Cyrus J, Yarlett, Nigel, Kaiser, Marcel, Brun, Reto, Huang, Tien L

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Pharmacokinetics and pharmacodynamics utilizing unbound target tissue exposure as part of a disposition-based rationale for lead optimization of benzoxaboroles in the treatment of... von WRING, STEPHEN, GAUKEL, ERIC, NARE, BAKELA, JACOBS, ROBERT, BEAUDET, BETH, BOWLING, TANA, MERCER, LUKE, BACCHI, CYRUS, YARLETT, NIGEL, RANDOLPH, RYAN, PARHAM, ROBIN, REWERTS, CINDY, PLATNER, JACOB, DON, ROBERT

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Trypanocidal Activity of 8-Methyl-5′-{[(Z)-4-Aminobut-2-enyl]-(Methylamino)}Adenosine (Genz-644131), an Adenosylmethionine Decarboxylase Inhibitor von BACCHI, Cyrus J, BARKER, Robert H, RODRIGUEZ, Aixa, HIRTH, Bradford, RATTENDI, Donna, YARLETT, Nigel, HENDRICK, Clifford L, SYBERTZ, Edmund

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Novel S-Adenosylmethionine Decarboxylase Inhibitors for the Treatment of Human African Trypanosomiasis von BARKER, Robert H, HANLAN LIU, RODRIGUEZ, Aixa, YARLETT, Nigel, KLINGER, Jeffrey D, SYBERTZ, Edmund, HIRTH, Bradford, CELATKA, Cassandra A, FITZPATRICK, Richard, YIBIN XIANG, WILLERT, Erin K, PHILLIPS, Margaret A, KAISER, Marcel, BACCHI, Cyrus J

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Discovery of Novel Benzoxaborole-Based Potent Antitrypanosomal Agents von Ding, Dazhong, Zhao, Yaxue, Meng, Qingqing, Xie, Dongsheng, Nare, Bakela, Chen, Daitao, Bacchi, Cyrus J, Yarlett, Nigel, Zhang, Yong-Kang, Hernandez, Vincent, Xia, Yi, Freund, Yvonne, Abdulla, Maha, Ang, Kean-Hooi, Ratnam, Joseline, McKerrow, James H, Jacobs, Robert T, Zhou, Huchen, Plattner, Jacob J

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2,4-Diaminopyrimidines as potent inhibitors of Trypanosoma brucei and identification of molecular targets by a chemical proteomics approach von Mercer, Luke, Bowling, Tana, Perales, Joe, Freeman, Jennifer, Nguyen, Tien, Bacchi, Cyrus, Yarlett, Nigel, Don, Robert, Jacobs, Robert, Nare, Bakela

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Novel alkylpolyaminoguanidines and alkylpolyaminobiguanides with potent antitrypanosomal activity von Bi, Xiangdong, Lopez, Christina, Bacchi, Cyrus J., Rattendi, Donna, Woster, Patrick M.

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Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity von Huang, Tien L., Eynde, Jean Jacques Vanden, Mayence, Annie, Collins, Margaret S., Cushion, Melanie T., Rattendi, Donna, Londono, Indira, Mazumder, Lakshman, Bacchi, Cyrus J., Yarlett, Nigel

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Metabolism of an Alkyl Polyamine Analog by a Polyamine Oxidase from the Microsporidian Encephalitozoon cuniculi von BACCHI, Cyrus J, YARLETT, Nigel, FACIANE, Evangeline, XIANGDONG BI, RATTENDI, Donna, WEISS, Louis M, WOSTER, Patrick M

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Multiple Triclosan Targets in Trypanosoma brucei von Paul, Kimberly S, Bacchi, Cyrus J, Englund, Paul T

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Selective Antimicrotubule Activity of N1-Phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (GB-II-5) against Kinetoplastid Parasites von Werbovetz, Karl A, Sackett, Dan L, Delfín, Dawn, Bhattacharya, Gautam, Salem, Manar, Obrzut, Tomasz, Rattendi, Donna, Bacchi, Cyrus

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Chemotherapy of Human African Trypanosomiasis von Bacchi, Cyrus J.

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Novel Trypanocidal Analogs of 5′-(Methylthio)-Adenosine von SUFRIN, Janice R, SPIESS, Arthur J, MARASCO, Canio J, RATTENDI, Donna, BACCHI, Cyrus J

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SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei von Perales, Joe B., Freeman, Jennifer, Bacchi, Cyrus J., Bowling, Tana, Don, Robert, Gaukel, Eric, Mercer, Luke, Moore III, Joseph A., Nare, Bakela, Nguyen, Tien M., Noe, Robert A., Randolph, Ryan, Rewerts, Cindy, Wring, Stephen A., Yarlett, Nigel, Jacobs, Robert T.

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