Practical Synthesis of a S1P Receptor 1 Agonist via a Guareschi–Thorpe Reaction von Schmidt, Gunther, Bolli, Martin H, Lescop, Cyrille, Abele, Stefan

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Discovery of the Novel, Orally Active, and Selective LPA1 Receptor Antagonist ACT-1016-0707 as a Preclinical Candidate for the Treatment of Fibrotic Diseases von Lescop, Cyrille, Birker, Magdalena, Brotschi, Christine, Bürki, Cédric, Morrison, Keith, Froidevaux, Sylvie, Delahaye, Stéphane, Nayler, Oliver, Bolli, Martin H.

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Discovery of a Novel Orally Active, Selective LPA Receptor Type 1 Antagonist, 4‑(4-(2-Isopropylphenyl)-4-((2-methoxy-4-methylphenyl)carbamoyl)piperidin-1-yl)-4-oxobutanoic Acid, wi... von Lescop, Cyrille, Brotschi, Christine, Williams, Jodi T., Sager, Christoph P., Birker, Magdalena, Morrison, Keith, Froidevaux, Sylvie, Delahaye, Stéphane, Nayler, Oliver, Bolli, Martin H.

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A New Synthesis of 2-Azabicyclo[2.1.1]hexanes von Lescop, Cyrille, Mévellec, Laurence, Huet, François

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S1P1 Modulator-Induced Gαi Signaling and β-Arrestin Recruitment Are Both Necessary to Induce Rapid and Efficient Reduction of Blood Lymphocyte Count In Vivo von Birker-Robaczewska, Magdalena, Bolli, Martin, Rey, Markus, de Kanter, Ruben, Kohl, Christopher, Lescop, Cyrille, Boucher, Maxime, Poirey, Sylvie, Steiner, Beat, Nayler, Oliver

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S1P 1 Modulator-Induced G α i Signaling and β -Arrestin Recruitment Are Both Necessary to Induce Rapid and Efficient Reduction of Blood Lymphocyte Count In Vivo von Birker-Robaczewska, Magdalena, Bolli, Martin, Rey, Markus, de Kanter, Ruben, Kohl, Christopher, Lescop, Cyrille, Boucher, Maxime, Poirey, Sylvie, Steiner, Beat, Nayler, Oliver

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A New Synthesis of cis-Cyclobut-3-ene-1,2-dicarboxylic Anhydride von Gauvry, Noëlle, Comoy, Corinne, Lescop, Cyrille, Huet, François

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Substituted Cyclobutenes, Their Preparation, and Their Versatility in Synthesis von Gauvry, Noëlle, Lescop, Cyrille, Huet, François

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Novel S1P1 receptor agonists – Part 5: From amino-to alkoxy-pyridines von Bolli, Martin H., Lescop, Cyrille, Birker, Magdalena, de Kanter, Ruben, Hess, Patrick, Kohl, Christopher, Nayler, Oliver, Rey, Markus, Sieber, Patrick, Velker, Jörg, Weller, Thomas, Steiner, Beat

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Crystalline form of the compound (s)-3-{ 4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy} -propane-1,2-diol von Lescop, Cyrille

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Novel S1P 1 receptor agonists – Part 4: Alkylaminomethyl substituted aryl head groups von Lescop, Cyrille, Müller, Claus, Mathys, Boris, Birker, Magdalena, de Kanter, Ruben, Kohl, Christopher, Hess, Patrick, Nayler, Oliver, Rey, Markus, Sieber, Patrick, Steiner, Beat, Weller, Thomas, Bolli, Martin H.

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Novel S1P(1) receptor agonists--part 3: from thiophenes to pyridines von Bolli, Martin H, Abele, Stefan, Birker, Magdalena, Bravo, Roberto, Bur, Daniel, de Kanter, Ruben, Kohl, Christopher, Grimont, Julien, Hess, Patrick, Lescop, Cyrille, Mathys, Boris, Müller, Claus, Nayler, Oliver, Rey, Markus, Scherz, Michael, Schmidt, Gunther, Seifert, Jürgen, Steiner, Beat, Velker, Jörg, Weller, Thomas

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Novel S1P1 receptor agonists – Part 4: Alkylaminomethyl substituted aryl head groups von Lescop, Cyrille, Müller, Claus, Mathys, Boris, Birker, Magdalena, de Kanter, Ruben, Kohl, Christopher, Hess, Patrick, Nayler, Oliver, Rey, Markus, Sieber, Patrick, Steiner, Beat, Weller, Thomas, Bolli, Martin H.

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Cenerimod, a novel selective S1P1 receptor modulator with unique signaling properties von Piali, Luca, Birker‐Robaczewska, Magdalena, Lescop, Cyrille, Froidevaux, Sylvie, Schmitz, Nicole, Morrison, Keith, Kohl, Christopher, Rey, Markus, Studer, Rolf, Vezzali, Enrico, Hess, Patrick, Clozel, Martine, Steiner, Beat, Bolli, Martin H., Nayler, Oliver

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Novel S1P1 Receptor Agonists − Part 3: From Thiophenes to Pyridines von Bolli, Martin H, Abele, Stefan, Birker, Magdalena, Bravo, Roberto, Bur, Daniel, de Kanter, Ruben, Kohl, Christopher, Grimont, Julien, Hess, Patrick, Lescop, Cyrille, Mathys, Boris, Müller, Claus, Nayler, Oliver, Rey, Markus, Scherz, Michael, Schmidt, Gunther, Seifert, Jürgen, Steiner, Beat, Velker, Jörg, Weller, Thomas

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CRYSTALLINE FORM OF THE COMPOUND (S)-3-{4-[5-(2-CYCLOPENTYL-6-METHOXY-PYRIDIN-4-YL)-[1,2,4]OXADIAZOL-3-YL]-2-ETHYL-6-METHYL-PHENOXY}-PROPANE-1,2-DIOL von LESCOP, CYRILLE

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Effect of calpain and proteasome inhibition on Ca²⁺-dependent proteolysis and muscle histopathology in the mdx mouse von Briguet, Alexandre, Erb, Michael, Courdier-Fruh, Isabelle, Barzaghi, Patrizia, Santos, Gesa, Herzner, Holger, Lescop, Cyrille, Siendt, Hervé, Henneboehle, Marco, Weyermann, Philipp, Magyar, Josef P, Dubach-Powell, Judith, Metz, Günther, Meier, Thomas

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CRYSTALLINE FORM OF THE COMPOUND (S)-3-{4-[5-(2-CYCLOPENTYL-6-METHOXY-PYRIDIN-4-YL)-[1,2,4]OXADIAZOL-3-YL]-2-ETHYL-6-METHYL-PHENOXY}-PROPANE-1,2-DIOL von LESCOP, CYRILLE

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Novel S1P 1 Receptor Agonists − Part 3: From Thiophenes to Pyridines von Bolli, Martin H., Abele, Stefan, Birker, Magdalena, Bravo, Roberto, Bur, Daniel, de Kanter, Ruben, Kohl, Christopher, Grimont, Julien, Hess, Patrick, Lescop, Cyrille, Mathys, Boris, Müller, Claus, Nayler, Oliver, Rey, Markus, Scherz, Michael, Schmidt, Gunther, Seifert, Jürgen, Steiner, Beat, Velker, Jörg, Weller, Thomas

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CRYSTALLINE FORM OF THE COMPOUND (S)-3-{4-[5-(2-CYCLOPENTYL-6-METHOXY-PYRIDIN-4-YL)-[1,2,4]OXADIAZOL-3-YL]-2-ETHYL-6-METHYL-PHENOXY}-PROPANE-1,2-DIOL von LESCOP, Cyrille

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