The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives von Pommier, Yves, Cushman, Mark

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Indenoisoquinoline Topoisomerase Inhibitors Strongly Bind and Stabilize the MYC Promoter G‑Quadruplex and Downregulate MYC von Wang, Kai-Bo, Elsayed, Mohamed S. A, Wu, Guanhui, Deng, Nanjie, Cushman, Mark, Yang, Danzhou

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Design and Synthesis of Indenoisoquinolines Targeting Topoisomerase I and Other Biological Macromolecules for Cancer Chemotherapy von Cushman, Mark

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Antibacterial Evaluation of Synthetic Thiazole Compounds In Vitro and In Vivo in a Methicillin-Resistant Staphylococcus aureus (MRSA) Skin Infection Mouse Model von Mohammad, Haroon, Cushman, Mark, Seleem, Mohamed N

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Anti-biofilm activity and synergism of novel thiazole compounds with glycopeptide antibiotics against multidrug-resistant Staphylococci von Mohammad, Haroon, Mayhoub, Abdelrahman S, Cushman, Mark, Seleem, Mohamed N

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MAIT recognition of a stimulatory bacterial antigen bound to MR1 von López-Sagaseta, Jacinto, Dulberger, Charles L, McFedries, Amanda, Cushman, Mark, Saghatelian, Alan, Adams, Erin J

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Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I−DNA Covalent Complex von Staker, Bart L, Feese, Michael D, Cushman, Mark, Pommier, Yves, Zembower, David, Stewart, Lance, Burgin, Alex B

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Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci von Mohammad, Haroon, Younis, Waleed, Chen, Lu, Peters, Christine E, Pogliano, Joe, Pogliano, Kit, Cooper, Bruce, Zhang, Jianan, Mayhoub, Abdelrahman, Oldfield, Eric, Cushman, Mark, Seleem, Mohamed N

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Selective Synthesis and Biological Evaluation of Sulfate-Conjugated Resveratrol Metabolites von Hoshino, Juma, Park, Eun-Jung, Kondratyuk, Tamara P, Marler, Laura, Pezzuto, John M, van Breemen, Richard B, Mo, Shunyan, Li, Yongchao, Cushman, Mark

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Antibacterial Characterization of Novel Synthetic Thiazole Compounds against Methicillin-Resistant Staphylococcus pseudintermedius von Mohammad, Haroon, Reddy, P V Narasimha, Monteleone, Dennis, Mayhoub, Abdelrahman S, Cushman, Mark, Hammac, G Kenitra, Seleem, Mohamed N

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Novel Fluoroindenoisoquinoline Non-Camptothecin Topoisomerase I Inhibitors von Marzi, Laetitia, Agama, Keli, Murai, Junko, Difilippantonio, Simone, James, Amy, Peer, Cody J, Figg, William D, Beck, Daniel, Elsayed, Mohamed S A, Cushman, Mark, Pommier, Yves

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Design, Synthesis, and Evaluation of Dibenzo[c,h][1,6]naphthyridines as Topoisomerase I Inhibitors and Potential Anticancer Agents von Kiselev, Evgeny, Dexheimer, Thomas S, Pommier, Yves, Cushman, Mark

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Discovery of Potent Indenoisoquinoline Topoisomerase I Poisons Lacking the 3‑Nitro Toxicophore von Beck, Daniel E, Abdelmalak, Monica, Lv, Wei, Reddy, P. V. Narasimha, Tender, Gabrielle S, O’Neill, Elizaveta, Agama, Keli, Marchand, Christophe, Pommier, Yves, Cushman, Mark

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Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1)–Topoisomerase I (Top1) Inhibitors von Nguyen, Trung Xuan, Morrell, Andrew, Conda-Sheridan, Martin, Marchand, Christophe, Agama, Keli, Bermingam, Alun, Stephen, Andrew G, Chergui, Adel, Naumova, Alena, Fisher, Robert, O’Keefe, Barry R, Pommier, Yves, Cushman, Mark

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Optimization of the Indenone Ring of Indenoisoquinoline Topoisomerase I Inhibitors von Morrell, Andrew, Placzek, Michael, Parmley, Seth, Grella, Brian, Antony, Smitha, Pommier, Yves, Cushman, Mark

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DUPA Conjugation of a Cytotoxic Indenoisoquinoline Topoisomerase I Inhibitor for Selective Prostate Cancer Cell Targeting von Roy, Jyoti, Nguyen, Trung Xuan, Kanduluru, Ananda Kumar, Venkatesh, Chelvam, Lv, Wei, Reddy, P. V. Narasimha, Low, Philip S, Cushman, Mark

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The tamoxifen metabolite norendoxifen is a potent and selective inhibitor of aromatase (CYP19) and a potential lead compound for novel therapeutic agents von Lu, Wenjie Jessie, Xu, Cong, Pei, Zifan, Mayhoub, Abdelrahman S., Cushman, Mark, Flockhart, David A.

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Design, Synthesis, and Biological Evaluation of Thiazoles Targeting Flavivirus Envelope Proteins von Mayhoub, Abdelrahman S, Khaliq, Mansoora, Kuhn, Richard J, Cushman, Mark

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Design, Synthesis, and Biological Evaluation of Antiviral Agents Targeting Flavivirus Envelope Proteins von Li, Ze, Khaliq, Mansoora, Zhou, Zhigang, Post, Carol Beth, Kuhn, Richard J, Cushman, Mark

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Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance von ANTONY, Smitha, AGAMA, Keli K, POMMIER, Yves, MIAO, Ze-Hong, TAKAGI, Kazutaka, WRIGHT, Mollie H, ROBLES, Ana I, VARTICOVSKI, Lyuba, NAGARAJAN, Muthukaman, MORRELL, Andrew, CUSHMAN, Mark

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