Robust Classification of Small-Molecule Mechanism of Action Using a Minimalist High-Content Microscopy Screen and Multidimensional Phenotypic Trajectory Analysis von Twarog, Nathaniel R, Low, Jonathan A, Currier, Duane G, Miller, Greg, Chen, Taosheng, Shelat, Anang A

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Identification of an Inhibitor of the EWS-FLI1 Oncogenic Transcription Factor by High-Throughput Screening von Grohar, Patrick J., Woldemichael, Girma M., Griffin, Laurie B., Mendoza, Arnulfo, Chen, Qing-Rong, Yeung, Choh, Currier, Duane G., Davis, Sean, Khanna, Chand, Khan, Javed, McMahon, James B., Helman, Lee J.

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A high-content screen of FDA approved drugs to enhance CAR T cell function: ingenol-3-angelate improves B7-H3-CAR T cell activity by upregulating B7-H3 on the target cell surface v... von Lee, Ha Won, O'Reilly, Carla, Beckett, Alex N, Currier, Duane G, Chen, Taosheng, DeRenzo, Christopher

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CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss von Teitz, Tal, Fang, Jie, Goktug, Asli N, Bonga, Justine D, Diao, Shiyong, Hazlitt, Robert A, Iconaru, Luigi, Morfouace, Marie, Currier, Duane, Zhou, Yinmei, Umans, Robyn A, Taylor, Michael R, Cheng, Cheng, Min, Jaeki, Freeman, Burgess, Peng, Junmin, Roussel, Martine F, Kriwacki, Richard, Guy, R Kiplin, Chen, Taosheng, Zuo, Jian

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Development of Second-Generation CDK2 Inhibitors for the Prevention of Cisplatin-Induced Hearing Loss von Hazlitt, Robert A, Teitz, Tal, Bonga, Justine D, Fang, Jie, Diao, Shiyong, Iconaru, Luigi, Yang, Lei, Goktug, Asli N, Currier, Duane G, Chen, Taosheng, Rankovic, Zoran, Min, Jaeki, Zuo, Jian

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A CRISPR-drug perturbational map for identifying compounds to combine with commonly used chemotherapeutics von Lee, Hyeong-Min, Wright, William C., Pan, Min, Low, Jonathan, Currier, Duane, Fang, Jie, Singh, Shivendra, Nance, Stephanie, Delahunty, Ian, Kim, Yuna, Chapple, Richard H., Zhang, Yinwen, Liu, Xueying, Steele, Jacob A., Qi, Jun, Pruett-Miller, Shondra M., Easton, John, Chen, Taosheng, Yang, Jun, Durbin, Adam D., Geeleher, Paul

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Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia von Kamens, Jennifer L., Nance, Stephanie, Koss, Cary, Xu, Beisi, Cotton, Anitria, Lam, Jeannie W., Garfinkle, Elizabeth A. R., Nallagatla, Pratima, Smith, Amelia M. R., Mitchell, Sharnise, Ma, Jing, Currier, Duane, Wright, William C., Kavdia, Kanisha, Pagala, Vishwajeeth R., Kim, Wonil, Wallace, LaShanale M., Cho, Ji-Hoon, Fan, Yiping, Seth, Aman, Twarog, Nathaniel, Choi, John K., Obeng, Esther A., Hatley, Mark E., Metzger, Monika L., Inaba, Hiroto, Jeha, Sima, Rubnitz, Jeffrey E., Peng, Junmin, Chen, Taosheng, Shelat, Anang A., Guy, R. Kiplin, Gruber, Tanja A.

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Sonic hedgehog regulates presynaptic terminal size, ultrastructure and function in hippocampal neurons von Mitchell, Nicholas, Petralia, Ronald S, Currier, Duane G, Wang, Ya-Xian, Kim, Alvin, Mattson, Mark P, Yao, Pamela J

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Addiction to Elevated Insulin-like Growth Factor I Receptor and Initial Modulation of the AKT Pathway Define the Responsiveness of Rhabdomyosarcoma to the Targeting Antibody von LIANG CAO, YUNKAI YU, DARKO, Isaac, CURRIER, Duane, MAYEENUDDIN, Linnia H, XIAOLIN WAN, KHANNA, Chand, HELMAN, Lee J

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High-Throughput Screening Identifies 1,4,5-Substituted 1,2,3-Triazole Analogs as Potent and Specific Antagonists of Pregnane X Receptor von Lin, Wenwei, Goktug, Asli N, Wu, Jing, Currier, Duane G, Chen, Taosheng

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A high-throughput screening identifies histone deacetylase inhibitors as therapeutic agents against medulloblastoma von Zhang, Shanshan, Gong, Zhaojian, Oladimeji, Peter O, Currier, Duane G, Deng, Qipan, Liu, Ming, Chen, Taosheng, Li, Yong

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Author Correction: Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia von Kamens, Jennifer L., Nance, Stephanie, Koss, Cary, Xu, Beisi, Cotton, Anitria, Lam, Jeannie W., Garfinkle, Elizabeth A. R., Nallagatla, Pratima, Smith, Amelia M. R., Mitchell, Sharnise, Ma, Jing, Currier, Duane, Wright, William C., Kavdia, Kanisha, Pagala, Vishwajeeth R., Kim, Wonil, Wallace, LaShanale M., Cho, Ji-Hoon, Fan, Yiping, Seth, Aman, Twarog, Nathaniel, Choi, John K., Obeng, Esther A., Hatley, Mark E., Metzger, Monika L., Inaba, Hiroto, Jeha, Sima, Rubnitz, Jeffrey E., Peng, Junmin, Chen, Taosheng, Shelat, Anang A., Guy, R. Kiplin, Gruber, Tanja A.

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Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma von He, Chen, Xu, Ke, Zhu, Xiaoyan, Dunphy, Paige S., Gudenas, Brian, Lin, Wenwei, Twarog, Nathaniel, Hover, Laura D., Kwon, Chang-Hyuk, Kasper, Lawryn H., Zhang, Junyuan, Li, Xiaoyu, Dalton, James, Jonchere, Barbara, Mercer, Kimberly S., Currier, Duane G., Caufield, William, Wang, Yingzhe, Xie, Jia, Broniscer, Alberto, Wetmore, Cynthia, Upadhyaya, Santhosh A., Qaddoumi, Ibrahim, Klimo, Paul, Boop, Frederick, Gajjar, Amar, Zhang, Jinghui, Orr, Brent A., Robinson, Giles W., Monje, Michelle, Freeman III, Burgess B., Roussel, Martine F., Northcott, Paul A., Chen, Taosheng, Rankovic, Zoran, Wu, Gang, Chiang, Jason, Tinkle, Christopher L., Shelat, Anang A., Baker, Suzanne J.

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Oseltamivir (Tamiflu), a commonly prescribed antiviral drug, mitigates hearing loss in mice von Sailor‐Longsworth, Emma J., Lutze, Richard D., Ingersoll, Matthew A., Kelmann, Regina G., Ly, Kristina, Currier, Duane, Chen, Taosheng, Zuo, Jian, Teitz, Tal

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Increased Skin Tumor Incidence and Keratinocyte Hyper-Proliferation in a Mouse Model of Down Syndrome von Yang, Annan, Currier, Duane, Poitras, Jennifer L, Reeves, Roger H

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17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma von Singh, Shivendra, Abu-Zaid, Ahmed, Lin, Wenwei, Low, Jonathan, Abdolvahabi, Alireza, Jin, Hongjian, Wu, Qiong, Cooke, Bailey, Fang, Jie, Bowling, John, Vaithiyalingam, Sivaraja, Currier, Duane, Yun, Mi-Kyung, Fernando, Dinesh M., Maier, Julie, Tillman, Heather, Bulsara, Purva, Lu, Zhaohua, Das, Sourav, Shelat, Anang, Li, Zhenmei, Young, Brandon, Lee, Richard, Rankovic, Zoran, Murphy, Andrew J., White, Stephen W., Davidoff, Andrew M., Chen, Taosheng, Yang, Jun

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Locations and patterns of meiotic recombination in two-generation pedigrees von Ting, Jason C, Roberson, Elisha D O, Currier, Duane G, Pevsner, Jonathan

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A high-content screen of FDA approved drugs to enhance CAR T cell function: ingenol-3-angelate improves B7-H3-CAR T cell activity by upregulating B7-H3 on the target cell surface v... von Lee, Ha Won, O'Reilly, Carla, Beckett, Alex N, Currier, Duane G, Chen, Taosheng, DeRenzo, Christopher

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BRAF inhibition protects against hearing loss in mice von Ingersoll, Matthew A, Malloy, Emma A, Caster, Lauryn E, Holland, Eva M, Xu, Zhenhang, Zallocchi, Marisa, Currier, Duane, Liu, Huizhan, He, David Z Z, Min, Jaeki, Chen, Taosheng, Zuo, Jian, Teitz, Tal

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Abstract 1907: Combocat: A high-throughput framework for drug combination studies von Wright, William C., Pan, Min, Lee, Hyeong-Min, Phelps, Gregory A., Low, Jonathan, Currier, Duane, Lee, Richard E., Chen, Taosheng, Geeleher, Paul

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