Discovery and Development of Simeprevir (TMC435), a HCV NS3/4A Protease Inhibitor von Rosenquist, Åsa, Samuelsson, Bertil, Johansson, Per-Ola, Cummings, Maxwell D., Lenz, Oliver, Raboisson, Pierre, Simmen, Kenny, Vendeville, Sandrine, de Kock, Herman, Nilsson, Magnus, Horvath, Andras, Kalmeijer, Ronald, de la Rosa, Guy, Beumont-Mauviel, Maria

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Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance von Hare, Stephen, Vos, Ann M., Clayton, Reginald F., Thuring, Jan W., Cummings, Maxwell D., Cherepanov, Peter, Coffin, John M.

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Structure-Based Macrocycle Design in Small-Molecule Drug Discovery and Simple Metrics To Identify Opportunities for Macrocyclization of Small-Molecule Ligands von Cummings, Maxwell D, Sekharan, Sivakumar

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In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435 von LENZ, Oliver, VERBINNEN, Thierry, VERMEIREN, Katrien, IVENS, Tania, RABOISSON, Pierre, EDLUND, Michael, STORM, Susan, VRANG, Lotta, DE KOCK, Herman, FANNING, Gregory C, SIMMEN, Kenneth A, LIN, Tse-I, VIJGEN, Leen, CUMMINGS, Maxwell D, LINDBERG, Jimmy, MARTIN BERKE, Jan, DEHERTOGH, Pascale, FRANSEN, Els, SCHOLLIERS, Annick

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Conformational Sampling of Macrocyclic Drugs in Different Environments: Can We Find the Relevant Conformations? von Poongavanam, Vasanthanathan, Danelius, Emma, Peintner, Stefan, Alcaraz, Lilian, Caron, Giulia, Cummings, Maxwell D, Wlodek, Stanislaw, Erdelyi, Mate, Hawkins, Paul C. D, Ermondi, Giuseppe, Kihlberg, Jan

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Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target von Cummings, Maxwell D, Lindberg, Jimmy, Lin, Tse -I, de Kock, Herman, Lenz, Oliver, Lilja, Elisabet, Felländer, Sara, Baraznenok, Vera, Nyström, Susanne, Nilsson, Magnus, Vrang, Lotta, Edlund, Michael, Rosenquist, Åsa, Samuelsson, Bertil, Raboisson, Pierre, Simmen, Kenneth

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Structure-Based Site of Metabolism Prediction for Cytochrome P450 2D6 von Moors, Samuel L. C, Vos, Ann M, Cummings, Maxwell D, Van Vlijmen, Herman, Ceulemans, Arnout

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Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein von Roymans, Dirk, De Bondt, Hendrik L, Arnoult, Eric, Geluykens, Peggy, Gevers, Tom, Van Ginderen, Marcia, Verheyen, Nick, Kim, Hidong, Willebrords, Rudy, Bonfanti, Jean-François, Bruinzeel, Wouter, Cummings, Maxwell D, van Vlijmen, Herman, Andries, Koen

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TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage von DEVOGELAERE, Benoit, BERKE, Jan Martin, LENZ, Oliver, CUMMINGS, Maxwell D, CLAYTON, Reginald F, VENDEVILLE, Sandrine, RABOISSON, Pierre, SIMMEN, Kenneth A, FANNING, Gregory C, LIN, Tse-I, VIJGEN, Leen, DEHERTOGH, Pascale, FRANSEN, Els, CLEIREN, Erna, VAN DER HELM, Liesbet, NYANGUILE, Origène, TAHRI, Abdellah, AMSSOMS, Katie

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Structure-Based Design of a Benzodiazepine Scaffold Yields a Potent Allosteric Inhibitor of Hepatitis C NS5B RNA Polymerase von Vandyck, Koen, Cummings, Maxwell D, Nyanguile, Origène, Boutton, Carlo W, Vendeville, Sandrine, McGowan, David, Devogelaere, Benoit, Amssoms, Katie, Last, Stefaan, Rombauts, Klara, Tahri, Abdellah, Lory, Pedro, Hu, Lili, Beauchamp, Derek A, Simmen, Kenny, Raboisson, Pierre

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Targeting Enteropeptidase with Reversible Covalent Inhibitors To Achieve Metabolic Benefits von Sun, Weimei, Zhang, Xuqing, Cummings, Maxwell D., Albarazanji, Kamal, Wu, Jiejun, Wang, Mina, Alexander, Richard, Zhu, Bin, Zhang, YueMei, Leonard, James, Lanter, James, Lenhard, James

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1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside Inhibitors von NYANGUILE, Origene, PAUWELS, Frederik, DEHERTOGH, Pascale, CUMMINGS, Maxwell D, BONFANTI, Jean-Francois, SIMMEN, Kenneth A, RABOISSON, Pierre, VAN DEN BROECK, Walter, BOUTTON, Carlo W, QUIRYNEN, Ludo, IVENS, Tania, VAN DER HELM, Liesbet, VANDERCRUYSSEN, Geneviève, MOSTMANS, Wendy, DELOUVROY, Frédéric

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1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus von NYANGUILE, Origène, DEVOGELAERE, Benoit, VANDERCRUYSSEN, Geneviève, VERMEIREN, Katrien, MOSTMANS, Wendy, DEHERTOGH, Pascale, DELOUVROY, Frédéric, VENDEVILLE, Sandrine, VANDYCK, Koen, DOCKX, Koen, CLEIREN, Ema, RABOISSON, Pierre, VIJGEN, Leen, SIMMEN, Kenneth A, FANNING, Gregory C, VAN DEN BROECK, Walter, PAUWELS, Frederik, CUMMINGS, Maxwell D, DE BONDT, Hendrik L, VOS, Ann M, BERKE, Jan M, LENZ, Oliver

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Virologic response and characterisation of HCV genotype 2–6 in patients receiving TMC435 monotherapy (study TMC435-C202) von Lenz, Oliver, Vijgen, Leen, Berke, Jan Martin, Cummings, Maxwell D, Fevery, Bart, Peeters, Monika, Smedt, Goedele De, Moreno, Christophe, Picchio, Gaston

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Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation von Soroosh, Pejman, Wu, Jiejun, Xue, Xiaohua, Song, Jiao, Sutton, Steven W., Sablad, Marciano, Yu, Jingxue, Nelen, Marina I., Liu, Xuejun, Castro, Glenda, Luna, Rosa, Crawford, Shelby, Banie, Homayon, Dandridge, Rose A., Deng, Xiaohu, Bittner, Anton, Kuei, Chester, Tootoonchi, Mandana, Rozenkrants, Natasha, Herman, Krystal, Gao, Jingjin, Yang, Xia V., Sachen, Kacey, Ngo, Karen, Fung-Leung, Wai-Ping, Nguyen, Steven, de Leon-Tabaldo, Aimee, Blevitt, Jonathan, Zhang, Yan, Cummings, Maxwell D., Rao, Tadimeti, Mani, Neelakandha S., Liu, Changlu, McKinnon, Murray, Milla, Marcos E., Fourie, Anne M., Sun, Siquan

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Structure of the C-terminally truncated human ProMMP9, a gelatin-binding matrix metalloproteinase von Elkins, Patricia A., Ho, Yen Sen, Smith, Ward W., Janson, Cheryl A., D'Alessio, Karla J., McQueney, Michael S., Cummings, Maxwell D., Romanic, Anne M.

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Discovery and optimization of a series of small-molecule allosteric inhibitors of MALT1 protease von Lu, Tianbao, Connolly, Peter J., Philippar, Ulrike, Sun, Weimei, Cummings, Maxwell D., Barbay, Kent, Gys, Luc, Van Nuffel, Luc, Austin, Nigel, Bekkers, Mariette, Shen, Fang, Cai, Ann, Attar, Ricardo, Meerpoel, Lieven, Edwards, James

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Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy von Lu, Tianbao, Schubert, Carsten, Cummings, Maxwell D., Bignan, Gilles, Connolly, Peter J., Smans, Karine, Ludovici, Donald, Parker, Michael H., Meyer, Christophe, Rocaboy, Christian, Alexander, Richard, Grasberger, Bruce, De Breucker, Sabine, Esser, Norbert, Fraiponts, Erwin, Gilissen, Ron, Janssens, Boudewijn, Peeters, Danielle, Van Nuffel, Luc, Vermeulen, Peter, Bischoff, James, Meerpoel, Lieven

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Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt von Gege, Christian, Albers, Michael, Kinzel, Olaf, Kleymann, Gerald, Schlüter, Thomas, Steeneck, Christoph, Hoffmann, Thomas, Xue, Xiaohua, Cummings, Maxwell D., Spurlino, John, Milligan, Cynthia, Fourie, Anne M., Edwards, James P., Leonard, Kristi, Coe, Kevin, Scott, Brian, Pippel, Dan, Goldberg, Steven D.

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Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach von Steeneck, Christoph, Gege, Christian, Kinzel, Olaf, Albers, Michael, Kleymann, Gerald, Schlüter, Thomas, Schulz, Andreas, Xue, Xiaohua, Cummings, Maxwell D., Fourie, Anne M., Leonard, Kristi A., Scott, Brian, Edwards, James P., Hoffmann, Thomas, Goldberg, Steven D.

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