Discovery of a Series of Indane-Containing NBTIs with Activity against Multidrug-Resistant Gram-Negative Pathogens von Cumming, John G., Kreis, Lukas, Kühne, Holger, Wermuth, Roger, Vercruysse, Maarten, Kramer, Christian, Rudolph, Markus G., Xu, Zhiheng

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Chemical predictive modelling to improve compound quality von Cumming, John G., Davis, Andrew M., Muresan, Sorel, Haeberlein, Markus, Chen, Hongming

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From mundane to surprising nonadditivity: drivers and impact on ML models von Guasch, Laura, Maeder, Niels, Cumming, John G., Kramer, Christian

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Novel, potent and selective anilinoquinazoline and anilinopyrimidine inhibitors of p38 MAP kinase von CUMMING, John G, MCKENZIE, Caroline L, BOWDEN, Stuart G, CAMPBELL, Douglas, MASTERS, David J, BREED, Jason, JEWSBURY, Philip J

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Novel Indane-Containing NBTIs with Potent Anti-Gram-Negative Activity and Minimal hERG Inhibition von Cumming, John G., Kreis, Lukas, Kühne, Holger, Wermuth, Roger, Vercruysse, Maarten, Cantrill, Carina, Bissantz, Caterina, Qiu, Hongxia, Kramer, Christian, Andreotti, Daniele, Fossati, Giacomo

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Better compounds faster: the development and exploitation of a desktop predictive chemistry toolkit von Cumming, John G., Winter, Jon, Poirrette, Andrew

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Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides von Cumming, John G., Cooper, Anne E., Grime, Ken, Logan, Chris J., McLaughlin, Sharon, Oldfield, John, Shaw, John S., Tucker, Howard, Winter, Jon, Whittaker, David

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Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis von Cumming, John G., Tucker, Howard, Oldfield, John, Fielding, Colin, Highton, Adrian, Faull, Alan, Wild, Martin, Brown, Dearg, Wells, Stuart, Shaw, John

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Automated QSAR with a Hierarchy of Global and Local Models von Wood, David J., Buttar, David, Cumming, John G., Davis, Andrew M., Norinder, Ulf, Rodgers, Sarah L.

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Discovery and Characterization of MAPK-activated Protein Kinase‑2 Prevention of Activation Inhibitors von Cumming, John G., Debreczeni, Judit É., Edfeldt, Fredrik, Evertsson, Emma, Harrison, Martin, Holdgate, Geoffrey A., James, Michael J., Lamont, Scott G., Oldham, Keith, Sullivan, Jane E., Wells, Stuart L.

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Beyond the Scope of Free-Wilson Analysis. 2: Can Distance Encoded R‑Group Fingerprints Provide Interpretable Nonlinear Models? von Eriksson, Mats, Chen, Hongming, Carlsson, Lars, Nissink, J. Willem M, Cumming, John G, Nilsson, Ingemar

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The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity von Cumming, John G., Bower, Justin F., Waterson, David, Faull, Alan, Poyser, Philip J., Turner, Paul, McDermott, Benjamin, Campbell, Andrew D., Hudson, Julian, James, Michael, Winter, Jon, Wood, Christine

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The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the treatment of inflam... von Brown, Dearg S., Cumming, John G., Bethel, Paul, Finlayson, Jonathan, Gerhardt, Stefan, Nash, Ian, Pauptit, Richard A., Pike, Kurt G., Reid, Alan, Snelson, Wendy, Swallow, Steve, Thompson, Caroline

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Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis von De Savi, Chris, Pape, Andrew, Sawyer, Yvonne, Milne, David, Davies, Chris, Cumming, John G., Ting, Attilla, Lamont, Scott, Smith, Peter D., Tart, Jonathon, Page, Ken, Moore, Peter

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The design and synthesis of novel N-hydroxyformamide inhibitors of ADAM-TS4 for the treatment of osteoarthritis von De Savi, Chris, Pape, Andrew, Cumming, John G., Ting, Attilla, Smith, Peter D., Burrows, Jeremy N., Mills, Mark, Davies, Chris, Lamont, Scott, Milne, David, Cook, Calum, Moore, Peter, Sawyer, Yvonne, Gerhardt, Stefan

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Stereocontrolled Assembly of Tetrasubstituted Tetrahydrofurans:  A Concise Synthesis of Virgatusin von Akindele, Tito, Marsden, Stephen P, Cumming, John G

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Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas von Burrows, Jeremy N., Cumming, John G., Fillery, Shaun M., Hamlin, Gordon A., Hudson, Julian A., Jackson, Ruth J., McLaughlin, Sharon, Shaw, John S.

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Total Synthesis of Swinholide A and Hemiswinholide A von Paterson, Ian, Yeung, Kap-Sun, Ward, Richard A, Cumming, John G, Smith, Julian D

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Dynamically resolved peri-substituted 2-formyl naphthamides: a new class of atropisomeric chiral auxiliary von Clayden, Jonathan, McCarthy, Catherine, Cumming, John G

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Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides von Cumming, John G., Brown, Simon J., Cooper, Anne E., Faull, Alan W., Flynn, Anthony P., Grime, Ken, Oldfield, John, Shaw, John S., Shepherd, Emma, Tucker, Howard, Whittaker, David

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