Structure-based classification predicts drug response in EGFR-mutant NSCLC von Robichaux, Jacqulyne P., Le, Xiuning, Vijayan, R. S. K., Hicks, J. Kevin, Heeke, Simon, Elamin, Yasir Y., Lin, Heather Y., Udagawa, Hibiki, Skoulidis, Ferdinandos, Tran, Hai, Varghese, Susan, He, Junqin, Zhang, Fahao, Nilsson, Monique B., Hu, Lemei, Poteete, Alissa, Rinsurongkawong, Waree, Zhang, Xiaoshan, Ren, Chenghui, Liu, Xiaoke, Hong, Lingzhi, Zhang, Jianjun, Diao, Lixia, Madison, Russell, Schrock, Alexa B., Saam, Jennifer, Raymond, Victoria, Fang, Bingliang, Wang, Jing, Ha, Min Jin, Cross, Jason B., Gray, Jhanelle E., Heymach, John V.

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Poziotinib for EGFR exon 20-mutant NSCLC: Clinical efficacy, resistance mechanisms, and impact of insertion location on drug sensitivity von Elamin, Yasir Y., Robichaux, Jacqulyne P., Carter, Brett W., Altan, Mehmet, Tran, Hai, Gibbons, Don L., Heeke, Simon, Fossella, Frank V., Lam, Vincent K., Le, Xiuning, Negrao, Marcelo V., Nilsson, Monique B., Patel, Anisha, Vijayan, R.S.K., Cross, Jason B., Zhang, Jianjun, Byers, Lauren A., Lu, Charles, Cascone, Tina, Feng, Lei, Luthra, Rajyalakshmi, San Lucas, Francis A., Mantha, Geeta, Routbort, Mark, Blumenschein, George, Tsao, Anne S., Heymach, John V.

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Comparison of Several Molecular Docking Programs: Pose Prediction and Virtual Screening Accuracy von Cross, Jason B, Thompson, David C, Rai, Brajesh K, Baber, J. Christian, Fan, Kristi Yi, Hu, Yongbo, Humblet, Christine

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Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy von Le, Kang, Soth, Michael J., Cross, Jason B., Liu, Gang, Ray, William J., Ma, Jiacheng, Goodwani, Sunil G., Acton, Paul J., Buggia-Prevot, Virginie, Akkermans, Onno, Barker, John, Conner, Michael L., Jiang, Yongying, Liu, Zhen, McEwan, Paul, Warner-Schmidt, Jennifer, Xu, Alan, Zebisch, Matthias, Heijnen, Cobi J., Abrahams, Brett, Jones, Philip

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Identification of potent and selective MTH1 inhibitors von Petrocchi, Alessia, Leo, Elisabetta, Reyna, Naphtali J., Hamilton, Matthew M., Shi, Xi, Parker, Connor A., Mseeh, Faika, Bardenhagen, Jennifer P., Leonard, Paul, Cross, Jason B., Huang, Sha, Jiang, Yongying, Cardozo, Mario, Draetta, Giulio, Marszalek, Joseph R., Toniatti, Carlo, Jones, Philip, Lewis, Richard T.

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Screening of Hydrocarbon-Stapled Peptides for Inhibition of Calcium-Triggered Exocytosis von Lai, Ying, Tuvim, Michael J, Leitz, Jeremy, Peters, John, Pfuetzner, Richard A, Esquivies, Luis, Zhou, Qiangjun, Czako, Barbara, Cross, Jason B, Jones, Philip, Dickey, Burton F, Brunger, Axel T

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Enhancing preclinical drug discovery with artificial intelligence von Vijayan, R.S.K., Kihlberg, Jan, Cross, Jason B., Poongavanam, Vasanthanathan

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Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity von Robichaux, Jacqulyne P., Elamin, Yasir Y., Vijayan, R.S.K., Nilsson, Monique B., Hu, Lemei, He, Junqin, Zhang, Fahao, Pisegna, Marlese, Poteete, Alissa, Sun, Huiying, Li, Shuai, Chen, Ting, Han, Han, Negrao, Marcelo Vailati, Ahnert, Jordi Rodon, Diao, Lixia, Wang, Jing, Le, Xiuning, Meric-Bernstam, Funda, Routbort, Mark, Roeck, Brent, Yang, Zane, Raymond, Victoria M., Lanman, Richard B., Frampton, Garrett M., Miller, Vincent A., Schrock, Alexa B., Albacker, Lee A., Wong, Kwok-kin, Cross, Jason B., Heymach, John V.

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Methods for Virtual Screening of GPCR Targets: Approaches and Challenges von Cross, Jason B.

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GARD: A Generally Applicable Replacement for RMSD von Baber, J. Christian, Thompson, David C, Cross, Jason B, Humblet, Christine

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Using a homology model of cytochrome P450 2D6 to predict substrate site of metabolism von Unwalla, Rayomand J., Cross, Jason B., Salaniwal, Sumeet, Shilling, Adam D., Leung, Louis, Kao, John, Humblet, Christine

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Discovery of 6‑[(3S,4S)‑4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable... von Czako, Barbara, Sun, Yuting, McAfoos, Timothy, Cross, Jason B, Leonard, Paul G, Burke, Jason P, Carroll, Christopher L, Feng, Ningping, Harris, Angela L, Jiang, Yongying, Kang, Zhijun, Kovacs, Jeffrey J, Mandal, Pijus, Meyers, Brooke A, Mseeh, Faika, Parker, Connor A, Yu, Simon S, Williams, Christopher C, Wu, Qi, Di Francesco, Maria Emilia, Draetta, Giulio, Heffernan, Timothy, Marszalek, Joseph. R, Kohl, Nancy E, Jones, Philip

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Cork-in-bottle mechanism of inhibitor binding to mammalian complex I von Chung, Injae, Serreli, Riccardo, Cross, Jason B, Di Francesco, M Emilia, Marszalek, Joseph R, Hirst, Judy

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Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme von Hamilton, Matthew M, Mseeh, Faika, McAfoos, Timothy J, Leonard, Paul G, Reyna, Naphtali J, Harris, Angela L, Xu, Alan, Han, Michelle, Soth, Michael J, Czako, Barbara, Theroff, Jay P, Mandal, Pijus K, Burke, Jason P, Virgin-Downey, Brett, Petrocchi, Alessia, Pfaffinger, Dana, Rogers, Norma E, Parker, Connor A, Yu, Simon S, Jiang, Yongying, Krapp, Stephan, Lammens, Alfred, Trevitt, Graham, Tremblay, Martin R, Mikule, Keith, Wilcoxen, Keith, Cross, Jason B, Jones, Philip, Marszalek, Joseph R, Lewis, Richard T

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The Active Site of a Zinc-Dependent Metalloproteinase Influences the Computed pKa of Ligands Coordinated to the Catalytic Zinc Ion von CROSS, Jason B., DUCA, José S., KAMINSKI, James J., MADISON, Vincent S.

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Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R von Czako, Barbara, Marszalek, Joseph. R, Burke, Jason P, Mandal, Pijus, Leonard, Paul G, Cross, Jason B, Mseeh, Faika, Jiang, Yongying, Chang, Edward Q, Suzuki, Erika, Kovacs, Jeffrey J, Feng, Ningping, Gera, Sonal, Harris, Angela L, Liu, Zhen, Mullinax, Robert A, Pang, Jihai, Parker, Connor A, Spencer, Nakia D, Yu, Simon S, Wu, Qi, Tremblay, Martin R, Mikule, Keith, Wilcoxen, Keith, Heffernan, Timothy P, Draetta, Giulio F, Jones, Philip

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Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity von Robichaux, Jacqulyne P., Elamin, Yasir Y., Vijayan, R.S.K., Nilsson, Monique B., Hu, Lemei, He, Junqin, Zhang, Fahao, Pisegna, Marlese, Poteete, Alissa, Sun, Huiying, Li, Shuai, Chen, Ting, Han, Han, Negrao, Marcelo Vailati, Ahnert, Jordi Rodon, Diao, Lixia, Wang, Jing, Le, Xiuning, Meric-Bernstam, Funda, Routbort, Mark, Roeck, Brent, Yang, Zane, Raymond, Victoria M., Lanman, Richard B., Frampton, Garrett M., Miller, Vincent A., Schrock, Alexa B., Albacker, Lee A., Wong, Kwok-kin, Cross, Jason B., Heymach, John V.

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Discovery of ART0380, a Potent and Selective ATR Kinase Inhibitor Undergoing Phase 2 Clinical Studies for the Treatment of Advanced or Metastatic Solid Cancers von Carroll, Christopher L., Johnson, Michael G., Ding, Yanbing, Kang, Zhijun, Vijayan, R. S. K., Bardenhagen, Jennifer P., Fang, Cheng, Lapointe, David, Li, Meng, Liu, Chiu-Yi, Lv, Xiaobing, Ma, XiaoYan, Pang, Jihai, Shepard, Hannah E., Suarez, Catalina, Yau, Anne Ju, Williams, Christopher C., Wu, Qi, Heald, Robert A., Robinson, Helen M. R., Smith, Graeme C. M., Cross, Jason B., Do, Mary K. Geck, Jiang, Yongying, Lively, Sarah, Yap, Timothy A., Giuliani, Virginia, Heffernan, Timothy, Jones, Philip, Di Francesco, M. Emilia

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Fragment-based discovery of DNA gyrase inhibitors targeting the ATPase subunit of GyrB von Mesleh, Michael F., Cross, Jason B., Zhang, Jing, Kahmann, Jan, Andersen, Ole A., Barker, John, Cheng, Robert K., Felicetti, Brunella, Wood, Michael, Hadfield, Andrea T., Scheich, Christoph, Moy, Terence I., Yang, Qingyi, Shotwell, Joseph, Nguyen, Kien, Lippa, Blaise, Dolle, Roland, Ryan, M. Dominic

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Discovery of Azaindole Ureas as a Novel Class of Bacterial Gyrase B Inhibitors von Zhang, Jing, Yang, Qingyi, Cross, Jason B, Romero, Jan Antoinette C, Poutsiaka, Katherine M, Epie, Felix, Bevan, Douglas, Wang, Bin, Zhang, Yanzhi, Chavan, Ajit, Zhang, Xin, Moy, Terence, Daniel, Anu, Nguyen, Kien, Chamberlain, Brian, Carter, Nicole, Shotwell, Joseph, Silverman, Jared, Metcalf, Chester A, Ryan, Dominic, Lippa, Blaise, Dolle, Roland E

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