Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis von Jaffe, Andrew E., Straub, Richard E., Shin, Joo Heon, Tao, Ran, Gao, Yuan, Collado-Torres, Leonardo, Kam-Thong, Tony, Xi, Hualin S., Quan, Jie, Chen, Qiang, Colantuoni, Carlo, Ulrich, William S., Maher, Brady J., Deep-Soboslay, Amy, Cross, Alan J., Brandon, Nicholas J., Leek, Jeffrey T., Hyde, Thomas M., Kleinman, Joel E., Weinberger, Daniel R.

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Comprehensive assessment of multiple biases in small RNA sequencing reveals significant differences in the performance of widely used methods von Wright, Carrie, Rajpurohit, Anandita, Burke, Emily E, Williams, Courtney, Collado-Torres, Leonardo, Kimos, Martha, Brandon, Nicholas J, Cross, Alan J, Jaffe, Andrew E, Weinberger, Daniel R, Shin, Joo Heon

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Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19) von Ma, Liang, Semick, Stephen A., Chen, Qiang, Li, Chao, Tao, Ran, Price, Amanda J., Shin, Joo Heon, Jia, Yankai, Brandon, Nicholas J., Cross, Alan J., Hyde, Thomas M., Kleinman, Joel E., Jaffe, Andrew E., Weinberger, Daniel R., Straub, Richard E.

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Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates von Micali, Nicola, Kim, Suel-Kee, Diaz-Bustamante, Marcelo, Stein-O’Brien, Genevieve, Seo, Seungmae, Shin, Joo-Heon, Rash, Brian G., Ma, Shaojie, Wang, Yanhong, Olivares, Nicolas A., Arellano, Jon I., Maynard, Kristen R., Fertig, Elana J., Cross, Alan J., Bürli, Roland W., Brandon, Nicholas J., Weinberger, Daniel R., Chenoweth, Joshua G., Hoeppner, Daniel J., Sestan, Nenad, Rakic, Pasko, Colantuoni, Carlo, McKay, Ronald D.

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Metabotropic Glutamate Receptors 2 and 3 as Targets for Treating Nicotine Addiction von Cross, Alan J., Anthenelli, Robert, Li, Xia

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Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs von Burke, Emily E., Chenoweth, Joshua G., Shin, Joo Heon, Collado-Torres, Leonardo, Kim, Suel-Kee, Micali, Nicola, Wang, Yanhong, Colantuoni, Carlo, Straub, Richard E., Hoeppner, Daniel J., Chen, Huei-Ying, Sellers, Alana, Shibbani, Kamel, Hamersky, Gregory R., Diaz Bustamante, Marcelo, Phan, BaDoi N., Ulrich, William S., Valencia, Cristian, Jaishankar, Amritha, Price, Amanda J., Rajpurohit, Anandita, Semick, Stephen A., Bürli, Roland W., Barrow, James C., Hiler, Daniel J., Page, Stephanie C., Martinowich, Keri, Hyde, Thomas M., Kleinman, Joel E., Berman, Karen F., Apud, Jose A., Cross, Alan J., Brandon, Nicholas J., Weinberger, Daniel R., Maher, Brady J., McKay, Ronald D. G., Jaffe, Andrew E.

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From bench to bedside: mGluR2 positive allosteric modulators as medications to treat substance use disorders von Acri, Jane B., Cross, Alan J., Skolnick, Phil

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The mGluR2 Positive Allosteric Modulator, AZD8529, and Cue-Induced Relapse to Alcohol Seeking in Rats von Augier, Eric, Dulman, Russell S, Rauffenbart, Caroline, Augier, Gaëlle, Cross, Alan J, Heilig, Markus

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Effect of mGluR2 positive allosteric modulation on frontostriatal working memory activation in schizophrenia von Wolf, Daniel H., Zheng, David, Kohler, Christian, Turetsky, Bruce I., Ruparel, Kosha, Satterthwaite, Theodore D., Elliott, Mark A., March, Mary E., Cross, Alan J., Smith, Mark A., Zukin, Stephen R., Gur, Ruben C., Gur, Raquel E.

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The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys von Justinova, Zuzana, Panlilio, Leigh V, Secci, Maria E, Redhi, Godfrey H, Schindler, Charles W, Cross, Alan J, Mrzljak, Ladislav, Medd, Amy, Shaham, Yavin, Goldberg, Steven R

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Differential Pharmacology and Binding of mGlu2 Receptor Allosteric Modulators von O’Brien, Daniel E., Shaw, Douglas M., Cho, Hyekyung P., Cross, Alan J., Wesolowski, Steven S., Felts, Andrew S., Bergare, Jonas, Elmore, Charles S., Lindsley, Craig W., Niswender, Colleen M., Conn, P. Jeffrey

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BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders von Schubert, Christian R., O’Donnell, Patricio, Quan, Jie, Wendland, Jens R., Xi, Hualin S., Winslow, Ashley R., Domenici, Enrico, Essioux, Laurent, Kam-Thong, Tony, Airey, David C., Calley, John N., Collier, David A., Wang, Hong, Eastwood, Brian, Ebert, Philip, Liu, Yushi, Nisenbaum, Laura, Ruble, Cara, Scherschel, James E., Smith, Ryan Matthew, Qian, Hui-Rong, Merchant, Kalpana, Didriksen, Michael, Matsumoto, Mitsuyuki, Saito, Takeshi, Brandon, Nicholas J., Cross, Alan J., Wang, Qi, Manji, Husseini, Kolb, Hartmuth, Furey, Maura, Drevets, Wayne C., Shin, Joo Heon, Jaffe, Andrew E., Jia, Yankai, Straub, Richard E., Deep-Soboslay, Amy, Hyde, Thomas M., Kleinman, Joel E., Weinberger, Daniel R.

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Derisking Psychiatric Drug Development: The NIMH's Fast Fail Program, A Novel Precompetitive Model von Grabb, Margaret C, Cross, Alan J, Potter, William Z, McCracken, James T

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The central nervous system effects of the partial GABA‐Aα2,3‐selective receptor modulator AZD7325 in comparison with lorazepam in healthy males von Chen, Xia, Jacobs, Gabriël, Kam, Marieke, Jaeger, Judith, Lappalainen, Jaakko, Maruff, Paul, Smith, Mark A., Cross, Alan J., Cohen, Adam, Gerven, Joop

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Individual variation in the emergence of anterior-to-posterior neural fates from human pluripotent stem cells von Kim, Suel-Kee, Seo, Seungmae, Stein-O’Brien, Genevieve, Jaishankar, Amritha, Ogawa, Kazuya, Micali, Nicola, Luria, Victor, Karger, Amir, Wang, Yanhong, Kim, Hyojin, Hyde, Thomas M., Kleinman, Joel E., Voss, Ty, Fertig, Elana J., Shin, Joo-Heon, Bürli, Roland, Cross, Alan J., Brandon, Nicholas J., Weinberger, Daniel R., Chenoweth, Joshua G., Hoeppner, Daniel J., Sestan, Nenad, Colantuoni, Carlo, McKay, Ronald D.

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Novel inhibitors of As(III) S-adenosylmethionine methyltransferase (AS3MT) identified by virtual screening von Bürli, Roland W., Wei, Huijun, Ernst, Glen, Mariga, Abigail, Hardern, Ian M., Herlihy, Kara, Cross, Alan J., Wesolowski, Steven S., Chen, Hongming, McKay, Ronald D.G., Weinberger, Daniel R., Brandon, Nicholas J., Barrow, James C.

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Alzheimer's disease research and development: a call for a new research roadmap von Feldman, Howard H., Haas, Magali, Gandy, Sam, Schoepp, Darryle D., Cross, Alan J., Mayeux, Richard, Sperling, Reisa A., Fillit, Howard, van de Hoef, Diana L., Dougal, Sonya, Nye, Jeffrey S.

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AZD6280, a novel partial γ-aminobutyric acid A receptor modulator, demonstrates a pharmacodynamically selective effect profile in healthy male volunteers von Chen, Xia, Jacobs, Gabriel, de Kam, Marieke L, Jaeger, Judith, Lappalainen, Jaakko, Maruff, Paul, Smith, Mark A, Cross, Alan J, Cohen, Adam, van Gerven, Joop

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Differential Pharmacology and Binding of mGlu 2 Receptor Allosteric Modulators von O'Brien, Daniel E, Shaw, Douglas M, Cho, Hyekyung P, Cross, Alan J, Wesolowski, Steven S, Felts, Andrew S, Bergare, Jonas, Elmore, Charles S, Lindsley, Craig W, Niswender, Colleen M, Conn, P Jeffrey

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Quantification of the interrelationships of receptor pharmacologies within a tricyclic privileged structural scaffold through application of modified forward selection von Wood, Michael W., Wesolowski, Steven S., Widzowski, Daniel V., Cross, Alan J.

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