Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity von Kumar, Rakesh, Knick, Victoria B, Rudolph, Sharon K, Johnson, Jennifer H, Crosby, Renae M, Crouthamel, Ming-Chih, Hopper, Teresa M, Miller, Charles G, Harrington, Laura E, Onori, James A, Mullin, Robert J, Gilmer, Tona M, Truesdale, Anne T, Epperly, Andrea H, Boloor, Amogh, Stafford, Jeffrey A, Luttrell, Deirdre K, Cheung, Mui

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Discovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor R... von Harris, Philip A, Boloor, Amogh, Cheung, Mui, Kumar, Rakesh, Crosby, Renae M, Davis-Ward, Ronda G, Epperly, Andrea H, Hinkle, Kevin W, Hunter, Robert N, Johnson, Jennifer H, Knick, Victoria B, Laudeman, Christopher P, Luttrell, Deirdre K, Mook, Robert A, Nolte, Robert T, Rudolph, Sharon K, Szewczyk, Jerzy R, Truesdale, Anne T, Veal, James M, Wang, Liping, Stafford, Jeffrey A

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Rosiglitazone Induces Mitochondrial Biogenesis in Differentiated Murine 3T3-L1 and C3H/10T1/2 Adipocytes von Kashatus, Jennifer A., Remlinger, Katja S., Bing, Nan, Crosby, Renae M., Jackson, Tymissha K., Witherspoon, Sam M., Moore, John T., Ryan, Terence E., Neill, Sue D., Strum, Jay C., Rong, James X., Zhang, Vivian, Waters, K. Michelle, Johnson, Jennifer H., Klein, Jean-Louis D., Qiu, Yang, Xie, Mi

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Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase von Maynard, Andrew, Crosby, Renae M., Ellis, Byron, Hamatake, Robert, Hong, Zhi, Johns, Brian A., Kahler, Kirsten M., Koble, Cecilia, Leivers, Anna, Leivers, Martin R., Mathis, Amanda, Peat, Andrew J., Pouliot, Jeffrey J., Roberts, Christopher D., Samano, Vicente, Schmidt, Rachel M., Smith, Gary K., Spaltenstein, Andrew, Stewart, Eugene L., Thommes, Pia, Turner, Elizabeth M., Voitenleitner, Christian, Walker, Jill T., Waitt, Greg, Weatherhead, Jason, Weaver, Kurt, Williams, Shawn, Wright, Lois, Xiong, Zhiping Z., Haigh, David, Shotwell, J. Brad

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Inhibition of Colony-Stimulating-Factor-1 Signaling in vivo with the Orally Bioavailable cFMS Kinase Inhibitor GW2580 von James G. Conway, McDonald, Brad, Janet Parham, Barry Keith, David W. Rusnak, Eva Shaw, Jansen, Marilyn, Peiyuan Lin, Alan Payne, Renae M. Crosby, Jennifer H. Johnson, Lloyd Frick, Min-Hwa Jasmine Lin, Scott Depee, Sarva Tadepalli, Bart Votta, James, Ian, Karen Fuller, Timothy J. Chambers, Kull, Frederick C., Stanley D. Chamberlain, Hutchins, Jeff T., Schlessinger, Joseph

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Discovery of Novel Urea-Based Hepatitis C Protease Inhibitors with High Potency against Protease-Inhibitor-Resistant Mutants von Kazmierski, Wieslaw M, Hamatake, Robert, Duan, Maosheng, Wright, Lois L, Smith, Gary K, Jarvest, Richard L, Ji, Jing-Jing, Cooper, Joel P, Tallant, Matthew D, Crosby, Renae M, Creech, Katrina, Wang, Amy, Li, Xianfeng, Zhang, Suoming, Zhang, Yong-Kang, Liu, Yang, Ding, Charles Z, Zhou, Yasheen, Plattner, Jacob J, Baker, Stephen J, Bu, Wei, Liu, Liang

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Discovery and Evaluation of 2-Anilino-5-aryloxazoles as a Novel Class of VEGFR2 Kinase Inhibitors von Harris, Philip A, Cheung, Mui, Hunter, Robert N, Brown, Matthew L, Veal, James M, Nolte, Robert T, Wang, Liping, Liu, Wendy, Crosby, Renae M, Johnson, Jennifer H, Epperly, Andrea H, Kumar, Rakesh, Luttrell, Deirdre K, Stafford, Jeffrey A

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Synthesis and SAR of acyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties von Li, Xianfeng, Zhang, Suoming, Zhang, Yong-Kang, Liu, Yang, Ding, Charles Z., Zhou, Yasheen, Plattner, Jacob J., Baker, Stephen J., Bu, Wei, Liu, Liang, Kazmierski, Wieslaw M., Duan, Maosheng, Grimes, Richard M., Wright, Lois L., Smith, Gary K., Jarvest, Richard L., Ji, Jing-Jing, Cooper, Joel P., Tallant, Matthew D., Crosby, Renae M., Creech, Katrina, Ni, Zhi-Jie, Zou, Wuxin, Wright, Jon

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Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease von Ding, Charles Z., Zhang, Yong-Kang, Li, Xianfeng, Liu, Yang, Zhang, Suoming, Zhou, Yasheen, Plattner, Jacob J., Baker, Stephen J., Liu, Liang, Duan, Maosheng, Jarvest, Richard L., Ji, Jingjing, Kazmierski, Wieslaw M., Tallant, Matthew D., Wright, Lois L., Smith, Gary K., Crosby, Renae M., Wang, Amy A., Ni, Zhi-Jie, Zou, Wuxin, Wright, Jon

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Imidazo[1,2-a]pyridines That Directly Interact with Hepatitis C NS4B: Initial Preclinical Characterization von Shotwell, J. Brad, Baskaran, Subramanian, Chong, Pek, Creech, Katrina L, Crosby, Renae M, Dickson, Hamilton, Fang, Jing, Garrido, Dulce, Mathis, Amanda, Maung, Jack, Parks, Derek J, Pouliot, Jeffrey J, Price, Daniel J, Rai, Roopa, Seal, John W, Schmitz, Uli, Tai, Vincent W. F, Thomson, Michael, Xie, Mi, Xiong, Zhiping Z, Peat, Andrew J

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Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates von Li, Xianfeng, Zhang, Yong-Kang, Liu, Yang, Ding, Charles Z., Zhou, Yasheen, Li, Qun, Plattner, Jacob J., Baker, Stephen J., Zhang, Suoming, Kazmierski, Wieslaw M., Wright, Lois L., Smith, Gary K., Grimes, Richard M., Crosby, Renae M., Creech, Katrina L., Carballo, Luz H., Slater, Martin J., Jarvest, Richard L., Thommes, Pia, Hubbard, Julia A., Convery, Maire A., Nassau, Pamela M., McDowell, William, Skarzynski, Tadeusz J., Qian, Xuelei, Fan, Dazhong, Liao, Liang, Ni, Zhi-Jie, Pennicott, Lewis E., Zou, Wuxin, Wright, Jon

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Synthesis of new acylsulfamoyl benzoxaboroles as potent inhibitors of HCV NS3 protease von Li, Xianfeng, Zhang, Yong-Kang, Liu, Yang, Zhang, Suoming, Ding, Charles Z., Zhou, Yasheen, Plattner, Jacob J., Baker, Stephen J., Liu, Liang, Bu, Wei, Kazmierski, Wieslaw M., Wright, Lois L., Smith, Gary K., Jarvest, Richard L., Duan, Maosheng, Ji, Jing-Jing, Cooper, Joel P., Tallant, Matthew D., Crosby, Renae M., Creech, Katrina, Ni, Zhi-Jie, Zou, Wuxin, Wright, Jon

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Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups von Li, Xianfeng, Liu, Yang, Zhang, Yong-Kang, Plattner, Jacob J., Baker, Stephen J., Bu, Wei, Liu, Liang, Zhou, Yasheen, Ding, Charles Z., Zhang, Suoming, Kazmierski, Wieslaw M., Hamatake, Robert, Duan, Maosheng, Wright, Lois L., Smith, Gary K., Jarvest, Richard L., Ji, Jing-Jing, Cooper, Joel P., Tallant, Matthew D., Crosby, Renae M., Creech, Katrina, Wang, Amy

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The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: Potential therapy for cancer von RUSNAK, David W, AFFLECK, Karen, JOWETT, Amanda, STABLES, Jeremy, TOPLEY, Peter, WOOD, Edgar R, BRIGNOLA, Perry S, KADWELL, Sue H, REEP, Bryan R, MULLIN, Robert J, ALLIGOOD, Krystal J, KEITH, Barry R, COCKERILL, Stuart G, CROSBY, Renae M, MURRAY, Doris M, KNIGHT, W. Blaine, GILMER, Tona M, LACKEY, Karen, STUBBERFIELD, Colin, HARRIS, Robert, PAGE, Martin, SMITH, Kathryn J, GUNTRIP, Stephen B, CARTER, Malcolm C, SHAW, Robert J

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Potent Dipeptide Inhibitors of the pp60 c - src SH2 Domain von Pacofsky, Gregory J, Lackey, Karen, Alligood, Krystal J, Berman, Judd, Charifson, Paul S, Crosby, Renae M, Dorsey, George F, Feldman, Paul L, Gilmer, Tona M, Hummel, Conrad W, Jordan, Steven R, Mohr, Christopher, Shewchuk, Lisa M, Sternbach, Daniel D, Rodriguez, Marc

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Bovine DNA contains a single major family of interspersed repetitive sequences von Richardson, K.K, Crosby, R.M, Good, P.J, Rosen, N.L, Mayfield, J.E

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The cloning, expression, and nucleotide sequence of a gene coding for an immunogenic Brucella abortus protein von Mayfield, John E., Bricker, Betsy J., Godfrey, Holly, Crosby, Renae M., Knight, David J., Hailing, Shirley M., Balinsky, Doris, Tabatabai, Louisa B.

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Potent Dipeptide Inhibitors of the pp60c-src SH2 Domain von PACOFSKY, Gregory J., LACKEY, Karen, ALLIGOOD, Krystal J., BERMAN, Judd, CHARIFSON, Paul S., CROSBY, Renae M., DORSEY, George F., FELDMAN, Paul L., GILMER, Tona M., HUMMEL, Conrad W., JORDAN, Steven R., MOHR, Christopher, SHEWCHUK, Lisa M., STERNBACH, Daniel D., RODRIGUEZ, Marc

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Design of N‑Benzoxaborole Benzofuran GSK8175Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor von Chong, Pek Y, Shotwell, J. Brad, Miller, John, Price, Daniel J, Maynard, Andy, Voitenleitner, Christian, Mathis, Amanda, Williams, Shawn, Pouliot, Jeffrey J, Creech, Katrina, Wang, Feng, Fang, Jing, Zhang, Huichang, Tai, Vincent W.-F, Turner, Elizabeth, Kahler, Kirsten M, Crosby, Renae, Peat, Andrew J

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GSK2818713, a Novel Biphenylene Scaffold-Based Hepatitis C NS5A Replication Complex Inhibitor with Broad Genotype Coverage von Kazmierski, Wieslaw M, Baskaran, Sam, Walker, Jill T, Miriyala, Nagaraju, Meesala, Ramu, Beesu, Mallesh, Adjabeng, George, Grimes, Richard M, Hamatake, Robert, Leivers, Martin R, Crosby, Renae, Xia, Bing, Remlinger, Katja

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