Persistent Activation of NF-κB in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage von Sau, Andrea, Lau, Rosanna, Cabrita, Miguel A., Nolan, Emma, Crooks, Peter A., Visvader, Jane E., Pratt, M.A. Christine

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Targeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells von Pei, Shanshan, Minhajuddin, Mohammad, Callahan, Kevin P., Balys, Marlene, Ashton, John M., Neering, Sarah J., Lagadinou, Eleni D., Corbett, Cheryl, Ye, Haobin, Liesveld, Jane L., O'Dwyer, Kristen M., Li, Zheng, Shi, Lei, Greninger, Patricia, Settleman, Jeffrey, Benes, Cyril, Hagen, Fred K., Munger, Joshua, Crooks, Peter A., Becker, Michael W., Jordan, Craig T.

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Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation von Bowroju, Suresh K, Mainali, Nirjal, Ayyadevara, Srinivas, Penthala, Narsimha R, Krishnamachari, Sesha, Kakraba, Samuel, Shmookler Reis, Robert J, Crooks, Peter A

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Biobanked Glioblastoma Patient-Derived Organoids as a Precision Medicine Model to Study Inhibition of Invasion von Darrigues, Emilie, Zhao, Edward H, De Loose, Annick, Lee, Madison P, Borrelli, Michael J, Eoff, Robert L, Galileo, Deni S, Penthala, Narsimha R, Crooks, Peter A, Rodriguez, Analiz

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An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells von Guzman, Monica L., Rossi, Randall M., Neelakantan, Sundar, Li, Xiaojie, Corbett, Cheryl A., Hassane, Duane C., Becker, Michael W., Bennett, John M., Sullivan, Edmund, Lachowicz, Joshua L., Vaughan, Andrew, Sweeney, Christopher J., Matthews, William, Carroll, Martin, Liesveld, Jane L., Crooks, Peter A., Jordan, Craig T.

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High flux novel polymeric membrane for renal applications von Hestekin, Christa N., Pakkaner, Efecan, Hestekin, Jamie A., De Souza, Leticia Santos, Chowdhury, Partha Pratim, Marçal, Juliana Louzada, Moore, John, Hesse, Sarah A., Takacs, Christopher J., Tassone, Christopher J., Dachavaram, Soma Shekar, Crooks, Peter A., Williams, Kate, Kurtz, Ira

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A NADPH Oxidase-Dependent Redox Signaling Pathway Mediates the Selective Radiosensitization Effect of Parthenolide in Prostate Cancer Cells von YULAN SUN, ST. CLAIR, Daret K, YONG XU, CROOKS, Peter A, ST. CLAIR, William H

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Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats von Janganati, Venumadhav, Salazar, Paloma, Parks, Brian J, Gorman, Gregory S, Prather, Paul L, Peterson, Eric C, Alund, Alexander W, Moran, Jeffery H, Crooks, Peter A, Brents, Lisa K

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Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan von Kakraba, Samuel, Ayyadevara, Srinivas, Mainali, Nirjal, Balasubramaniam, Meenakshisundaram, Bowroju, Suresh, Penthala, Narsimha Reddy, Atluri, Ramani, Barger, Steven W, Griffin, Sue T, Crooks, Peter A, Shmookler Reis, Robert J

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Cellulose sulfuric acid: An efficient biodegradable and recyclable solid acid catalyst for the one-pot synthesis of aryl-14H-dibenzo[ a.j]xanthenes under solvent-free conditions von Venu Madhav, J., Thirupathi Reddy, Y., Narsimha Reddy, P., Nikhil Reddy, M., Kuarm, Suresh, Crooks, Peter. A., Rajitha, B.

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Characterizing the Access of Cholinergic Antagonists to Efferent Synapses in the Inner Ear von Lee, Choongheon, Sinha, Anjali K, Henry, Kenneth, Walbaum, Anqi W, Crooks, Peter A, Holt, Joseph C

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Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents von Penthala, Narsimha Reddy, Madhukuri, Leena, Thakkar, Shraddha, Madadi, Nikhil Reddy, Lamture, Gauri, Eoff, Robert L, Crooks, Peter A

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Oxone ® -Mediated TEMPO-Oxidized Cellulose Nanomaterials form I and form II von Moore Ii, John P, Dachavaram, Soma Shekar, Bommagani, Shobanbabu, Penthala, Narsimha Reddy, Venkatraman, Priya, Foster, E Johan, Crooks, Peter A, A Hestekin, Jamie

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Efficient synthesis of cis-2,6-di-(2-quinolylpiperidine) von Ding, Derong, Dwoskin, Linda P., Crooks, Peter A.

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Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways von Hassane, Duane C., Sen, Siddhartha, Minhajuddin, Mohammad, Rossi, Randall M., Corbett, Cheryl A., Balys, Marlene, Wei, Liping, Crooks, Peter A., Guzman, Monica L., Jordan, Craig T.

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Parthenolide induces rapid thiol oxidation that leads to ferroptosis in hepatocellular carcinoma cells von LoBianco, Francesca V, Krager, Kimberly J, Johnson, Erica, Godwin, Christopher O, Allen, Antino R, Crooks, Peter A, Compadre, Cesar M, Borrelli, Michael J, Aykin-Burns, Nukhet

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In vitro permeation of a pegylated naltrexone prodrug across microneedle-treated skin von Milewski, Mikolaj, Yerramreddy, Thirupathi Reddy, Ghosh, Priyanka, Crooks, Peter A., Stinchcomb, Audra L.

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Targeting Nucleophosmin 1 Represents a Rational Strategy for Radiation Sensitization von Sekhar, Konjeti R., PhD, Benamar, Mouadh, BS, Venkateswaran, Amudhan, PhD, Sasi, Soumya, MS, Penthala, Narsimha R., PhD, Crooks, Peter A., PhD, DSc, Hann, Stephen R., PhD, Geng, Ling, MD, Balusu, Ramesh, PhD, Abbas, Tarek, PhD, Freeman, Michael L., PhD

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A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease von Kakraba, Samuel, Ayyadevara, Srinivas, Penthala, Narsimha Reddy, Balasubramaniam, Meenakshisundaram, Ganne, Akshatha, Liu, Ling, Alla, Ramani, Bommagani, Shoban Babu, Barger, Steven W, Griffin, W Sue T, Crooks, Peter A, Shmookler Reis, Robert J

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The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery von Papke, Roger L., Dwoskin, Linda P., Crooks, Peter A.

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