Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies von Schaefer, Wolfgang, Regula, Jörg T, Bähner, Monika, Schanzer, Jürgen, Croasdale, Rebecca, Dürr, Harald, Gassner, Christian, Georges, Guy, Kettenberger, Hubert, Imhof-Jung, Sabine, Schwaiger, Manfred, Stubenrauch, Kay G, Sustmann, Claudio, Thomas, Markus, Scheuer, Werner, Klein, Christian

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Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies von Klein, Christian, Sustmann, Claudio, Thomas, Markus, Stubenrauch, Kay, Croasdale, Rebecca, Schanzer, Jürgen, Brinkmann, Ulrich, Kettenberger, Hubert, Regula, Jörg T., Schaefer, Wolfgang

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A Novel Glycoengineered Bispecific Antibody Format for Targeted Inhibition of Epidermal Growth Factor Receptor (EGFR) and Insulin-like Growth Factor Receptor Type I (IGF-1R) Demons... von Schanzer, Juergen M., Wartha, Katharina, Croasdale, Rebecca, Moser, Samuel, Künkele, Klaus-Peter, Ries, Carola, Scheuer, Werner, Duerr, Harald, Pompiati, Sandra, Pollman, Jan, Stracke, Jan, Lau, Wilma, Ries, Stefan, Brinkmann, Ulrich, Klein, Christian, Umana, Pablo

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Bispecific digoxigenin-binding antibodies for targeted payload delivery von Metz, Silke, Haas, Alexander K, Daub, Karin, Croasdale, Rebecca, Stracke, Jan, Lau, Wilma, Georges, Guy, Josel, Hans-Peter, Dziadek, Sebastian, Hopfner, Karl-Peter, Lammens, Alfred, Scheuer, Werner, Hoffmann, Eike, Mundigl, Olaf, Brinkmann, Ulrich

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Development of Tetravalent, Bispecific CCR5 Antibodies with Antiviral Activity against CCR5 Monoclonal Antibody-Resistant HIV-1 Strains von Schanzer, Jürgen, Jekle, Andreas, Nezu, Junichi, Lochner, Adriane, Croasdale, Rebecca, Dioszegi, Marianna, Zhang, Jun, Hoffmann, Eike, Dormeyer, Wilma, Stracke, Jan, Schäfer, Wolfgang, Ji, Changhua, Heilek, Gabrielle, Cammack, Nick, Brandt, Michael, Umana, Pablo, Brinkmann, Ulrich

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Toward enhancement of antibody thermostability and affinity by computational design in the absence of antigen von Hutchinson, Mark, Ruffolo, Jeffrey A, Haskins, Nantaporn, Iannotti, Michael, Vozza, Giuliana, Pham, Tony, Mehzabeen, Nurjahan, Shandilya, Harini, Rickert, Keith, Croasdale-Wood, Rebecca, Damschroder, Melissa, Fu, Ying, Dippel, Andrew, Gray, Jeffrey J, Kaplan, Gilad

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Targeted siRNA Delivery and mRNA Knockdown Mediated by Bispecific Digoxigenin-binding Antibodies von Schneider, Britta, Grote, Michael, John, Matthias, Haas, Alexander, Bramlage, Birgit, lckenstein, Ludger M, Jahn-Hofmann, Kerstin, Bauss, Frieder, Cheng, Weijun, Croasdale, Rebecca, Daub, Karin, Dill, Simone, Hoffmann, Eike, Lau, Wilma, Burtscher, Helmut, Ludtke, James L, Metz, Silke, Mundigl, Olaf, Neal, Zane C, Scheuer, Werner, Stracke, Jan, Herweijer, Hans, Brinkmann, Ulrjch

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p-IgGen: a paired antibody generative language model von Turnbull, Oliver M, Oglic, Dino, Croasdale-Wood, Rebecca, Deane, Charlotte M

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TetraMabs: simultaneous targeting of four oncogenic receptor tyrosine kinases for tumor growth inhibition in heterogeneous tumor cell populations von Castoldi, Raffaella, Schanzer, Jürgen, Panke, Christian, Jucknischke, Ute, Neubert, Natalie J., Croasdale, Rebecca, Scheuer, Werner, Auer, Johannes, Klein, Christian, Niederfellner, Gerhard, Kobold, Sebastian, Sustmann, Claudio

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Development of tetravalent IgG1 dual targeting IGF-1R–EGFR antibodies with potent tumor inhibition von Croasdale, Rebecca, Wartha, Katharina, Schanzer, Juergen M., Kuenkele, Klaus-Peter, Ries, Carola, Mayer, Klaus, Gassner, Christian, Wagner, Martina, Dimoudis, Nikolaos, Herter, Sylvia, Jaeger, Christiane, Ferrara, Claudia, Hoffmann, Eike, Kling, Lothar, Lau, Wilma, Staack, Roland F., Heinrich, Julia, Scheuer, Werner, Stracke, Jan, Gerdes, Christian, Brinkmann, Ulrich, Umana, Pablo, Klein, Christian

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XGFR, a novel affinity-matured bispecific antibody targeting IGF-1R and EGFR with combined signaling inhibition and enhanced immune activation for the treatment of pancreatic cance... von Schanzer, Juergen M, Wartha, Katharina, Moessner, Ekkehard, Hosse, Ralf J, Moser, Samuel, Croasdale, Rebecca, Trochanowska, Halina, Shao, Cuiying, Wang, Peng, Shi, Lei, Weinzierl, Tina, Rieder, Natascha, Bacac, Marina, Ries, Carola H, Kettenberger, Hubert, Schlothauer, Tilman, Friess, Thomas, Umana, Pablo, Klein, Christian

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An undecided coiled coil: the leucine zipper of Nek2 kinase exhibits atypical conformational exchange dynamics von Croasdale, Rebecca, Ivins, Frank J, Muskett, Fred, Daviter, Tina, Scott, David J, Hardy, Tara, Smerdon, Steven J, Fry, Andrew M, Pfuhl, Mark

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Bispecific antibody derivatives with restricted binding functionalities that are activated by proteolytic processing von Metz, Silke, Panke, Christian, Haas, Alexander K., Schanzer, Jürgen, Lau, Wilma, Croasdale, Rebecca, Hoffmann, Eike, Schneider, Britta, Auer, Johannes, Gassner, Christian, Bossenmaier, Birgit, Umana, Pablo, Sustmann, Claudio, Brinkmann, Ulrich

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AIntibody: an experimentally validated in silico antibody discovery design challenge von Erasmus, M. Frank, Spector, Laura, Ferrara, Fortunato, DiNiro, Roberto, Pohl, Thomas J., Perea-Schmittle, Katheryn, Wang, Wei, Tessier, Peter M., Richardson, Crystal, Turner, Laure, Kumar, Sumit, Bedinger, Daniel, Sormanni, Pietro, Fernández-Quintero, Monica L., Ward, Andrew B., Loeffler, Johannes R., Swanson, Olivia M., Deane, Charlotte M., Raybould, Matthew I. J., Evers, Andreas, Sellmann, Carolin, Bachas, Sharrol, Ruffolo, Jeff, Nastri, Horacio G., Ramesh, Karthik, Sørensen, Jesper, Croasdale-Wood, Rebecca, Hijano, Oliver, Leal-Lopes, Camila, Shahsavarian, Melody, Qiu, Yu, Marcatili, Paolo, Vernet, Erik, Akbar, Rahmad, Friedensohn, Simon, Wagner, Rick, Kurella, Vinodh babu, Malhotra, Shipra, Kumar, Satyendra, Kidger, Patrick, Almagro, Juan C., Furfine, Eric, Stanton, Marty, Graff, Christilyn P., Villalba, Santiago David, Tomszak, Florian, Teixeira, Andre A. R., Hopkins, Elizabeth, Dovner, Molly, D’Angelo, Sara, Bradbury, Andrew R. M.

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A structural and functional dissection of the cardiac stress response factor MS1 von Fogl, Claudia, Puckey, Loretto, Hinssen, Ulrike, Zaleska, Mariola, El-Mezgueldi, Mohammed, Croasdale, Rebecca, Bowman, Andrew, Matsukawa, Akira, Samani, Nilesh J., Savva, Renos, Pfuhl, Mark

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An Undecided Coiled Coil von Croasdale, Rebecca, Ivins, Frank J., Muskett, Fred, Daviter, Tina, Scott, David J., Hardy, Tara, Smerdon, Steven J., Fry, Andrew M., Pfuhl, Mark

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Abstract LB-212: XGFR, an Fc-engineered dual signaling inhibitor targeting IGF-1R and EGFR von Wartha, Katharina, Croasdale, Rebecca, Schanzer, Juergen, Brinkmann, Ulrich, Hofmann, Marco H., Ries, Carola, Rieder, Natascha, Hoelzlwimmer, Gabriele, Freytag, Olivier, Herter, Sylvia, Gerdes, Christian, Kuenkele, Klaus-Peter, Klein, Christian

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Abstract 3285: Ang-2-VEGF CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 function mediates potent anti-tumoral and anti-angiogenic efficacy von Thomas, Markus, Scheuer, Werner, Regula, Jörg Thomas, Bähner, Monika, Schanzer, Jürgen Michael, Croasdale, Rebecca, Gassner, Christian, Georges, Guy, Kettenberger, Hubert, Dürr, Harald, Imhof-Jung, Sabine, Schwaiger, Manfred, Stubenrauch, Kay-Gunnar, Weidner, Michael K., Schäfer, Wolfgang, Klein, Christian

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Abstract 2970: Overcoming mechanisms of escape from treatments for multiple myeloma with ISB 2001, a potential first-in-class trispecific BCMA and CD38 targeted T cell engager von Pihlgren, Maria, Carretero, Laura, Berret, Jeremy, Hall, Olivia, Estoppey, Carole, Drake, Adam, Pais, Daniela, Macoin, Julie, Chimen, Myriam, Suere, Perrine, Nallet, Emily, Pouleau, Blandine, Stainnack, Elodie, Loyau, Jeremy, Monney, Thierry, Delachat, Aurore, Dreyfus, Cyrille, Blein, Stan, Kaya, Zeynep, Matthes, Thomas, Croasdale-wood, Rebecca, Edwards, James, Edwards, Claire, Mbow, Lamine, Dyson, Michael, Konto, Cyril, Srivastava, Ankita, Zhukovshy, Eugene, Perro, Mario

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ISB 2001 trispecific T cell engager shows strong tumor cytotoxicity and overcomes immune escape mechanisms of multiple myeloma cells von Carretero-Iglesia, Laura, Hall, Olivia J., Berret, Jérémy, Pais, Daniela, Estoppey, Carole, Chimen, Myriam, Monney, Thierry, Loyau, Jeremy, Dreyfus, Cyrille, Macoin, Julie, Perez, Cynthia, Menon, Vinu, Gruber, Isabelle, Laurendon, Amélie, Caro, Lydia N., Gudi, Girish S., Matsuura, Tomomi, van der Graaf, Piet H., Blein, Stanislas, Mbow, M. Lamine, Croasdale-Wood, Rebecca, Srivastava, Ankita, Dyson, Michael R., Matthes, Thomas, Kaya, Zeynep, Edwards, Claire M., Edwards, James R., Maiga, Sophie, Pellat-Deceunynck, Catherine, Touzeau, Cyrille, Moreau, Philippe, Konto, Cyril, Drake, Adam, Zhukovsky, Eugene A., Perro, Mario, Pihlgren, Maria

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