Human cerebellar protein ligands and bifunctional compounds comprising same von DONG HANQING, SNYDER LAWRENCE B, WANG JUN, HORNBERGER KEITH R, BERLIN MICHAEL, QIAN YIMIN, ZIMMERMANN KURT, CREWS ANDREW P

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PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer von Raina, Kanak, Lu, Jing, Qian, Yimin, Altieri, Martha, Gordon, Deborah, Rossi, Ann Marie K., Wang, Jing, Chen, Xin, Dong, Hanqing, Siu, Kam, Winkler, James D., Crew, Andrew P., Crews, Craig M., Coleman, Kevin G.

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Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1 von Crew, Andrew P, Raina, Kanak, Dong, Hanqing, Qian, Yimin, Wang, Jing, Vigil, Dominico, Serebrenik, Yevgeniy V, Hamman, Brian D, Morgan, Alicia, Ferraro, Caterina, Siu, Kam, Neklesa, Taavi K, Winkler, James D, Coleman, Kevin G, Crews, Craig M

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Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance von Salami, Jemilat, Alabi, Shanique, Willard, Ryan R., Vitale, Nick J., Wang, Jing, Dong, Hanqing, Jin, Meizhong, McDonnell, Donald P., Crew, Andrew P., Neklesa, Taavi K., Crews, Craig M.

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New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race von Inker, Lesley A, Eneanya, Nwamaka D, Coresh, Josef, Tighiouart, Hocine, Wang, Dan, Sang, Yingying, Crews, Deidra C, Doria, Alessandro, Estrella, Michelle M, Froissart, Marc, Grams, Morgan E, Greene, Tom, Grubb, Anders, Gudnason, Vilmundur, Gutiérrez, Orlando M, Kalil, Roberto, Karger, Amy B, Mauer, Michael, Navis, Gerjan, Nelson, Robert G, Poggio, Emilio D, Rodby, Roger, Rossing, Peter, Rule, Andrew D, Selvin, Elizabeth, Seegmiller, Jesse C, Shlipak, Michael G, Torres, Vicente E, Yang, Wei, Ballew, Shoshana H, Couture, Sara J, Powe, Neil R, Levey, Andrew S

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Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells von Saenz, D T, Fiskus, W, Qian, Y, Manshouri, T, Rajapakshe, K, Raina, K, Coleman, K G, Crew, A P, Shen, A, Mill, C P, Sun, B, Qiu, P, Kadia, T M, Pemmaraju, N, DiNardo, C, Kim, M-S, Nowak, A J, Coarfa, C, Crews, C M, Verstovsek, S, Bhalla, K N

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RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1 von Mill, Christopher P., Fiskus, Warren, DiNardo, Courtney D., Qian, Yimin, Raina, Kanak, Rajapakshe, Kimal, Perera, Dimuthu, Coarfa, Cristian, Kadia, Tapan M., Khoury, Joseph D., Saenz, Dyana T., Saenz, David N., Illendula, Anuradha, Takahashi, Koichi, Kornblau, Steven M., Green, Michael R., Futreal, Andrew P., Bushweller, John H., Crews, Craig M., Bhalla, Kapil N.

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Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis von Wishart, Andrew L., Conner, Sydney J., Guarin, Justinne R., Fatherree, Jackson P., Peng, Yifan, McGinn, Rachel A., Crews, Rebecca, Naber, Stephen P., Hunter, Martin, Greenberg, Andrew S., Oudin, Madeleine J.

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Regulated induced proximity targeting chimeras—RIPTACs—A heterobifunctional small molecule strategy for cancer selective therapies von Raina, Kanak, Forbes, Chris D., Stronk, Rebecca, Rappi, Jonathan P., Eastman, Kyle J., Zaware, Nilesh, Yu, Xinheng, Li, Hao, Bhardwaj, Amit, Gerritz, Samuel W., Forgione, Mia, Hundt, Abigail, King, Madeline P., Posner, Zoe M., Correia, Allison D., McGovern, Andrew, Puleo, David E., Chenard, Rebekka, Mousseau, James J., Vergara, J. Ignacio, Garvin, Ethan, Macaluso, Jennifer, Martin, Michael, Bassoli, Kyle, Jones, Kelli, Garcia, Marco, Howard, Katia, Yaggi, Madeleine, Smith, Levi M., Chen, Jinshan M., Mayfield, Andrew B., De Leon, Cesar A., Hines, John, Kayser-Bricker, Katherine J., Crews, Craig M.

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Effect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Resp... von McNamee, James J, Gillies, Michael A, Barrett, Nicholas A, Perkins, Gavin D, Tunnicliffe, William, Young, Duncan, Bentley, Andrew, Harrison, David A, Brodie, Daniel, Boyle, Andrew J, Millar, Jonathan E, Szakmany, Tamas, Bannard-Smith, Jonathan, Tully, Redmond P, Agus, Ashley, McDowell, Clíona, Jackson, Colette, McAuley, Daniel F

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Beyond cyclosporine A: conformation-dependent passive membrane permeabilities of cyclic peptide natural products von Ahlbach, Christopher L, Lexa, Katrina W, Bockus, Andrew T, Chen, Valerie, Crews, Phillip, Jacobson, Matthew P, Lokey, R Scott

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The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study von Burslem, George M., Smith, Blake E., Lai, Ashton C., Jaime-Figueroa, Saul, McQuaid, Daniel C., Bondeson, Daniel P., Toure, Momar, Dong, Hanqing, Qian, Yimin, Wang, Jing, Crew, Andrew P., Hines, John, Crews, Craig M.

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Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4 von Lu, Jing, Qian, Yimin, Altieri, Martha, Dong, Hanqing, Wang, Jing, Raina, Kanak, Hines, John, Winkler, James D., Crew, Andrew P., Coleman, Kevin, Crews, Craig M.

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The genomic landscape of pediatric acute lymphoblastic leukemia von Brady, Samuel W., Roberts, Kathryn G., Gu, Zhaohui, Shi, Lei, Pounds, Stanley, Pei, Deqing, Cheng, Cheng, Dai, Yunfeng, Devidas, Meenakshi, Qu, Chunxu, Hill, Ashley N., Payne-Turner, Debbie, Ma, Xiaotu, Iacobucci, Ilaria, Baviskar, Pradyuamna, Wei, Lei, Arunachalam, Sasi, Hagiwara, Kohei, Liu, Yanling, Flasch, Diane A., Liu, Yu, Parker, Matthew, Chen, Xiaolong, Elsayed, Abdelrahman H., Pathak, Omkar, Li, Yongjin, Fan, Yiping, Michael, J. Robert, Rusch, Michael, Wilkinson, Mark R., Foy, Scott, Hedges, Dale J., Newman, Scott, Zhou, Xin, Wang, Jian, Reilly, Colleen, Sioson, Edgar, Rice, Stephen V., Pastor Loyola, Victor, Wu, Gang, Rampersaud, Evadnie, Reshmi, Shalini C., Gastier-Foster, Julie, Guidry Auvil, Jaime M., Gesuwan, Patee, Smith, Malcolm A., Winick, Naomi, Carroll, Andrew J., Heerema, Nyla A., Harvey, Richard C., Willman, Cheryl L., Larsen, Eric, Raetz, Elizabeth A., Borowitz, Michael J., Wood, Brent L., Carroll, William L., Zweidler-McKay, Patrick A., Rabin, Karen R., Mattano, Leonard A., Maloney, Kelly W., Winter, Stuart S., Burke, Michael J., Salzer, Wanda, Dunsmore, Kimberly P., Angiolillo, Anne L., Crews, Kristine R., Downing, James R., Jeha, Sima, Pui, Ching-Hon, Evans, William E., Yang, Jun J., Relling, Mary V., Gerhard, Daniela S., Loh, Mignon L., Hunger, Stephen P., Zhang, Jinghui, Mullighan, Charles G.

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A Neutralizing Monoclonal Antibody for Hospitalized Patients with Covid-19 von Lundgren, Jens D, Grund, Birgit, Barkauskas, Christina E, Holland, Thomas L, Gottlieb, Robert L, Sandkovsky, Uriel, Brown, Samuel M, Knowlton, Kirk U, Self, Wesley H, Files, D Clark, Jain, Mamta K, Benfield, Thomas, Bowdish, Michael E, Leshnower, Bradley G, Baker, Jason V, Jensen, Jens-Ulrik, Gardner, Edward M, Ginde, Adit A, Harris, Estelle S, Johansen, Isik S, Markowitz, Norman, Matthay, Michael A, Østergaard, Lars, Chang, Christina C, Davey, Victoria J, Goodman, Anna, Higgs, Elizabeth S, Murray, Daniel D, Murray, Thomas A, Paredes, Roger, Parmar, Mahesh K B, Phillips, Andrew N, Reilly, Cavan, Sharma, Shweta, Dewar, Robin L, Teitelbaum, Marc, Wentworth, Deborah, Cao, Huyen, Klekotka, Paul, Babiker, Abdel G, Gelijns, Annetine C, Kan, Virginia L, Polizzotto, Mark N, Thompson, B Taylor, Lane, H Clifford, Neaton, James D

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Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial von Benavente, O R, Coffey, C S, Conwit, R, Hart, R G, McClure, L A, Pearce, L A, Pergola, P E, Szychowski, J M

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Harmonizing Clinical Sequencing and Interpretation for the eMERGE III Network von Venner, Eric, Muzny, Donna M., Abrams, Debra, Albertson-Junkans, Ladia, Ames, Darren C., Aronson, Samuel, Babb, Lawrence J., Balasubramanian, Adithya, Bastarache, Lisa, Behr, Meckenzie, Blout, Carrie, Bowser, Mark, Brilliant, Murray, Brodeur, Wendy, Caraballo, Pedro, Castro, Victor, Chisholm, Rex L., Chung, Wendy, Chute, Christopher G., City, Brittany, Connolly, John J., Crane, Paul, Crew, Katherine, De Andrade, Mariza, Denson, Shawn, Denny, Josh, DeSmet, Tim, Dikilitas, Ozan, Fullerton, Stephanie M., Gabriel, Stacey, Gainer, Vivian, Gharavi, Ali, Glazer, Andrew M., Goehringer, Jessica, Gordon, Adam S., Graham, Chet, Dayal, Jyoti, Hakonarson, Hakon, Harden, Maegan V., Harr, Margaret, Hayes, M. Geoffrey, Henrikson, Nora, Howell, Kayla M., Jiang, Yunyun, Joo, Yoonjung Yoonie, Justice, Anne E., Kalla, Sara E., Kalra, Divya, Kelly, Melissa A., Key, Dustin, Kiryluk, Krzysztof, Kullo, Iftikhar J., Larson, Eric B., Lin, Chiao-Feng, Linder, Jodell, Macbeth, Alyssa, Dinsmore, Michael J., Dodge, Sheila, Fasel, David, Fedotov, Alex, Feng, Qiping, McGowan, Michelle L., Meldrim, Jim, Mosley, Jonathan, Muniz, Jesse, Murdock, David R., Murugan, Mullai, Myers, Melanie F., Namjou, Bahram, Ni, Yizhao, Obeng, Aniwaa Owusu, Taylor, Casey Overby, Peterson, Josh F., Pratap, Siddharth, Prows, Cynthia A., Ralston, James D., Ramaprasan, Arvind, Rasmussen-Torvik, Laura, Schaid, Dan, Sengupta, Soumitra, Singh, Rajbir, Sleiman, Patrick M.A., Smoller, Jordan W., Stanaway, Ian B., Stroud, Mary, Tolwinski, Kasia, Van Driest, Sara L., Veenstra, David, Vicente, Gina, Wagner, Michael, Walunas, Theresa, Wells, Quinn, White, Peter S., Wiley, Ken L., Wilson, Michael W., Woolf, Betty, Yi, Victoria, Zhang, Ge, Zhang, Lan, Gibbs, Richard A.

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Roll-Back Eradication of Bovine Tuberculosis (TB) From Wildlife in New Zealand: Concepts, Evolving Approaches, and Progress von Nugent, Graham, Gormley, Andrew M, Anderson, Dean P, Crews, Kevin

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Abstract 43: Discovery of ARV-110, a first in class androgen receptor degrading PROTAC for the treatment of men with metastatic castration resistant prostate cancer von Snyder, Lawrence B., Neklesa, Taavi K., Chen, Xin, Dong, Hanqing, Ferraro, Caterina, Gordon, Deborah A., Macaluso, Jennifer, Pizzano, Jennifer, Wang, Jing, Willard, Ryan R., Vitale, Nicholas, Peck, Ron, Moore, Marcia Dougan, Crews, Craig M., Houston, John, Crew, Andrew P., Taylor, Ian

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Abstract 44: The discovery of ARV-471, an orally bioavailable estrogen receptor degrading PROTAC for the treatment of patients with breast cancer von Snyder, Lawrence B., Flanagan, John J., Qian, Yimin, Gough, Sheryl M., Andreoli, Monica, Bookbinder, Mark, Cadelina, Gregory, Bradley, John, Rousseau, Emma, Chandler, Julian, Willard, Ryan, Pizzano, Jennifer, Crews, Craig M., Crew, Andrew P., Houston, John, Moore, Marcia Dougan, Peck, Ron, Taylor, Ian

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