Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton’s Tyrosine Kinase Inhibitor in Early Clinical Development von Crawford, James J, Johnson, Adam R, Misner, Dinah L, Belmont, Lisa D, Castanedo, Georgette, Choy, Regina, Coraggio, Melis, Dong, Liming, Eigenbrot, Charles, Erickson, Rebecca, Ghilardi, Nico, Hau, Jonathan, Katewa, Arna, Kohli, Pawan Bir, Lee, Wendy, Lubach, Joseph W, McKenzie, Brent S, Ortwine, Daniel F, Schutt, Leah, Tay, Suzanne, Wei, BinQing, Reif, Karin, Liu, Lichuan, Wong, Harvey, Young, Wendy B

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Hippo Pathway in Cancer: Aberrant Regulation and Therapeutic Opportunities von Calses, Philamer C, Crawford, James J, Lill, Jennie R, Dey, Anwesha

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Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors von Beroza, Paul, Crawford, James J., Ganichkin, Oleg, Gendelev, Leo, Harris, Seth F., Klein, Raphael, Miu, Anh, Steinbacher, Stefan, Klingler, Franca-Maria, Lemmen, Christian

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Optimized arylomycins are a new class of Gram-negative antibiotics von Smith, Peter A., Koehler, Michael F. T., Girgis, Hany S., Yan, Donghong, Chen, Yongsheng, Chen, Yuan, Crawford, James J., Durk, Matthew R., Higuchi, Robert I., Kang, Jing, Murray, Jeremy, Paraselli, Prasuna, Park, Summer, Phung, Wilson, Quinn, John G., Roberts, Tucker C., Rougé, Lionel, Schwarz, Jacob B., Skippington, Elizabeth, Wai, John, Xu, Min, Yu, Zhiyong, Zhang, Hua, Tan, Man-Wah, Heise, Christopher E.

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Alpha-2 adrenergic receptor agonists: a review of current clinical applications von Giovannitti, Jr, Joseph A, Thoms, Sean M, Crawford, James J

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Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling von Holden, Jeffrey K., Crawford, James J., Noland, Cameron L., Schmidt, Stephen, Zbieg, Jason R., Lacap, Jennifer A., Zang, Richard, Miller, Gregory M., Zhang, Yue, Beroza, Paul, Reja, Rohit, Lee, Wendy, Tom, Jeffrey Y.K., Fong, Rina, Steffek, Micah, Clausen, Saundra, Hagenbeek, Thjis J., Hu, Taishan, Zhou, Zheng, Shen, Hong C., Cunningham, Christian N.

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Learning Medicinal Chemistry Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) Rules from Cross-Company Matched Molecular Pairs Analysis (MMPA) von Kramer, Christian, Ting, Attilla, Zheng, Hao, Hert, Jérôme, Schindler, Torsten, Stahl, Martin, Robb, Graeme, Crawford, James J, Blaney, Jeff, Montague, Shane, Leach, Andrew G, Dossetter, Al G, Griffen, Ed J

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NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus von Brightbill, Hans D., Suto, Eric, Blaquiere, Nicole, Ramamoorthi, Nandhini, Sujatha-Bhaskar, Swathi, Gogol, Emily B., Castanedo, Georgette M., Jackson, Benjamin T., Kwon, Youngsu C., Haller, Susan, Lesch, Justin, Bents, Karin, Everett, Christine, Kohli, Pawan Bir, Linge, Sandra, Christian, Laura, Barrett, Kathy, Jaochico, Allan, Berezhkovskiy, Leonid M., Fan, Peter W., Modrusan, Zora, Veliz, Kelli, Townsend, Michael J., DeVoss, Jason, Johnson, Adam R., Godemann, Robert, Lee, Wyne P., Austin, Cary D., McKenzie, Brent S., Hackney, Jason A., Crawford, James J., Staben, Steven T., Alaoui Ismaili, Moulay H., Wu, Lawren C., Ghilardi, Nico

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An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance von Hagenbeek, Thijs J, Zbieg, Jason R, Hafner, Marc, Mroue, Rana, Lacap, Jennifer A, Sodir, Nicole M, Noland, Cameron L, Afghani, Shervin, Kishore, Ayush, Bhat, Kamakoti P, Yao, Xiaosai, Schmidt, Stephen, Clausen, Saundra, Steffek, Micah, Lee, Wendy, Beroza, Paul, Martin, Scott, Lin, Eva, Fong, Rina, Di Lello, Paola, Kubala, Marta H, Yang, Michelle N-Y, Lau, Jeffrey T, Chan, Emily, Arrazate, Alfonso, An, Le, Levy, Elizabeth, Lorenzo, Maria N, Lee, Ho-June, Pham, Trang H, Modrusan, Zora, Zang, Richard, Chen, Yi-Chen, Kabza, Michal, Ahmed, Musaddeque, Li, Jason, Chang, Matthew T, Maddalo, Danilo, Evangelista, Marie, Ye, Xin, Crawford, James J, Dey, Anwesha

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Potent and selective Bruton’s tyrosine kinase inhibitors: Discovery of GDC-0834 von Young, Wendy B., Barbosa, James, Blomgren, Peter, Bremer, Meire C., Crawford, James J., Dambach, Donna, Gallion, Steve, Hymowitz, Sarah G., Kropf, Jeffrey E., Lee, Seung H., Liu, Lichuan, Lubach, Joseph W., Macaluso, Jen, Maciejewski, Pat, Maurer, Brigitte, Mitchell, Scott A., Ortwine, Daniel F., Di Paolo, Julie, Reif, Karin, Scheerens, Heleen, Schmitt, Aaron, Sowell, C. Gregory, Wang, Xiaojing, Wong, Harvey, Xiong, Jin-Ming, Xu, Jianjun, Zhao, Zhongdong, Currie, Kevin S.

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Safety Considerations in the Development of Hippo Pathway Inhibitors in Cancers von Kakiuchi-Kiyota, Satoko, Schutten, Melissa M, Zhong, Yu, Crawford, James J, Dey, Anwesha

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Inhibitors of p21-activated kinases (PAKs) von Rudolph, Joachim, Crawford, James J, Hoeflich, Klaus P, Wang, Weiru

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Recent progress on nuclear receptor RORγ modulators von Cyr, Patrick, Bronner, Sarah M., Crawford, James J.

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Copper/TEMPO catalysed synthesis of nitriles from aldehydes or alcohols using aqueous ammonia and with air as the oxidant von Dornan, Laura M, Cao, Qun, Flanagan, James C A, Crawford, James J, Cook, Matthew J, Muldoon, Mark J

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LogD Contributions of Substituents Commonly Used in Medicinal Chemistry von Landry, Matthew L, Crawford, James J

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Step-Economic Synthesis of (+)-Crocacin C: A Concise Crotylboronation/[3,3]-Sigmatropic Rearrangement Approach von Pasqua, Adele E, Ferrari, Frank D, Hamman, Chris, Liu, Yanzhou, Crawford, James J, Marquez, Rodolfo

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Total Synthesis and Stereochemistry of Uncialamycin von Nicolaou, K. C., Zhang, Hongjun, Chen, Jason S., Crawford, James J., Pasunoori, Laxman

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Trust Your Gut: Strategies and Tactics for Intestinally Restricted Drugs von Dorel, Ruth, Wong, Alice R., Crawford, James J.

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Micelle‐Promoted Reductive Amination of DNA‐Conjugated Amines for DNA‐Encoded Library Synthesis von Anderson, Matthew J., Carton, Thomas P., Salvini, Catherine L. A., Crawford, James J., Pairaudeau, Garry, Waring, Michael J.

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Log D Contributions of Substituents Commonly Used in Medicinal Chemistry von Landry, Matthew L, Crawford, James J

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