Enhanced Efficiency of Human Pluripotent Stem Cell Genome Editing through Replacing TALENs with CRISPRs von Ding, Qiurong, Regan, Stephanie N., Xia, Yulei, Oostrom, Leoníe A., Cowan, Chad A., Musunuru, Kiran

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Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains von Ku, Manching, Koche, Richard P, Rheinbay, Esther, Mendenhall, Eric M, Endoh, Mitsuhiro, Mikkelsen, Tarjei S, Presser, Aviva, Nusbaum, Chad, Xie, Xiaohui, Chi, Andrew S, Adli, Mazhar, Kasif, Simon, Ptaszek, Leon M, Cowan, Chad A, Lander, Eric S, Koseki, Haruhiko, Bernstein, Bradley E

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Efficient Ablation of Genes in Human Hematopoietic Stem and Effector Cells using CRISPR/Cas9 von Mandal, Pankaj K., Ferreira, Leonardo M.R., Collins, Ryan, Meissner, Torsten B., Boutwell, Christian L., Friesen, Max, Vrbanac, Vladimir, Garrison, Brian S., Stortchevoi, Alexei, Bryder, David, Musunuru, Kiran, Brand, Harrison, Tager, Andrew M., Allen, Todd M., Talkowski, Michael E., Rossi, Derrick J., Cowan, Chad A.

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Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues von Zhu, Jiang, Adli, Mazhar, Zou, James Y., Verstappen, Griet, Coyne, Michael, Zhang, Xiaolan, Durham, Timothy, Miri, Mohammad, Deshpande, Vikram, De Jager, Philip L., Bennett, David A., Houmard, Joseph A., Muoio, Deborah M., Onder, Tamer T., Camahort, Ray, Cowan, Chad A., Meissner, Alexander, Epstein, Charles B., Shoresh, Noam, Bernstein, Bradley E.

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Low Incidence of Off-Target Mutations in Individual CRISPR-Cas9 and TALEN Targeted Human Stem Cell Clones Detected by Whole-Genome Sequencing von Veres, Adrian, Gosis, Bridget S., Ding, Qiurong, Collins, Ryan, Ragavendran, Ashok, Brand, Harrison, Erdin, Serkan, Cowan, Chad A., Talkowski, Michael E., Musunuru, Kiran

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GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis von Yu, Haojie, Rimbert, Antoine, Palmer, Alice E., Toyohara, Takafumi, Xia, Yulei, Xia, Fang, Ferreira, Leonardo M.R., Chen, Zhifen, Chen, Tao, Loaiza, Natalia, Horwitz, Nathaniel Brooks, Kacergis, Michael C., Zhao, Liping, Soukas, Alexander A., Kuivenhoven, Jan Albert, Kathiresan, Sekar, Cowan, Chad A.

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Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions von Hendriks, William T., Warren, Curtis R., Cowan, Chad A.

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Generation of hypoimmunogenic human pluripotent stem cells von Han, Xiao, Wang, Mengning, Duan, Songwei, Franco, Paul J., Kenty, Jennifer Hyoje-Ryu, Hedrick, Preston, Xia, Yulei, Allen, Alana, Ferreira, Leonardo M. R., Strominger, Jack L., Melton, Douglas A., Meissner, Torsten B., Cowan, Chad A.

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Rapid cellular turnover in adipose tissue von Rigamonti, Alessandra, Brennand, Kristen, Lau, Frank, Cowan, Chad A

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β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors von Roberts, Lee D., Boström, Pontus, O’Sullivan, John F., Schinzel, Robert T., Lewis, Gregory D., Dejam, Andre, Lee, Youn-Kyoung, Palma, Melinda J., Calhoun, Sondra, Georgiadi, Anastasia, Chen, Ming-Huei, Ramachandran, Vasan S., Larson, Martin G., Bouchard, Claude, Rankinen, Tuomo, Souza, Amanda L., Clish, Clary B., Wang, Thomas J., Estall, Jennifer L., Soukas, Alexander A., Cowan, Chad A., Spiegelman, Bruce M., Gerszten, Robert E.

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A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models von Ding, Qiurong, Lee, Youn-Kyoung, Schaefer, Esperance A.K., Peters, Derek T., Veres, Adrian, Kim, Kevin, Kuperwasser, Nicolas, Motola, Daniel L., Meissner, Torsten B., Hendriks, William T., Trevisan, Marta, Gupta, Rajat M., Moisan, Annie, Banks, Eric, Friesen, Max, Schinzel, Robert T., Xia, Fang, Tang, Alexander, Xia, Yulei, Figueroa, Emmanuel, Wann, Amy, Ahfeldt, Tim, Daheron, Laurence, Zhang, Feng, Rubin, Lee L., Peng, Lee F., Chung, Raymond T., Musunuru, Kiran, Cowan, Chad A.

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Adipocyte Metabolism and Insulin Signaling Perturbations: Insights from Genetics von Friesen, Max, Cowan, Chad A.

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A comparison of non-integrating reprogramming methods von Schlaeger, Thorsten M, Daheron, Laurence, Brickler, Thomas R, Entwisle, Samuel, Chan, Karrie, Cianci, Amelia, DeVine, Alexander, Ettenger, Andrew, Fitzgerald, Kelly, Godfrey, Michelle, Gupta, Dipti, McPherson, Jade, Malwadkar, Prerana, Gupta, Manav, Bell, Blair, Doi, Akiko, Jung, Namyoung, Li, Xin, Lynes, Maureen S, Brookes, Emily, Cherry, Anne B C, Demirbas, Didem, Tsankov, Alexander M, Zon, Leonard I, Rubin, Lee L, Feinberg, Andrew P, Meissner, Alexander, Cowan, Chad A, Daley, George Q

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Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells von Patsch, Christoph, Challet-Meylan, Ludivine, Thoma, Eva C., Urich, Eduard, Heckel, Tobias, O’Sullivan, John F., Grainger, Stephanie J., Kapp, Friedrich G., Sun, Lin, Christensen, Klaus, Xia, Yulei, Florido, Mary H. C., He, Wei, Pan, Wei, Prummer, Michael, Warren, Curtis R., Jakob-Roetne, Roland, Certa, Ulrich, Jagasia, Ravi, Freskgård, Per-Ola, Adatto, Isaac, Kling, Dorothee, Huang, Paul, Zon, Leonard I., Chaikof, Elliot L., Gerszten, Robert E., Graf, Martin, Iacone, Roberto, Cowan, Chad A.

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Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing von Ding, Qiurong, Strong, Alanna, Patel, Kevin M, Ng, Sze-Ling, Gosis, Bridget S, Regan, Stephanie N, Cowan, Chad A, Rader, Daniel J, Musunuru, Kiran

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Microenvironmental Control of Adipocyte Fate and Function von Pope, Benjamin D, Warren, Curtis R, Parker, Kevin Kit, Cowan, Chad A

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From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus von Kathiresan, Sekar, Rader, Daniel J, Musunuru, Kiran, Strong, Alanna, Frank-Kamenetsky, Maria, Lee, Noemi E, Ahfeldt, Tim, Sachs, Katherine V, Li, Xiaoyu, Li, Hui, Kuperwasser, Nicolas, Ruda, Vera M, Pirruccello, James P, Muchmore, Brian, Prokunina-Olsson, Ludmila, Hall, Jennifer L, Schadt, Eric E, Morales, Carlos R, Lund-Katz, Sissel, Phillips, Michael C, Wong, Jamie, Cantley, William, Racie, Timothy, Ejebe, Kenechi G, Orho-Melander, Marju, Melander, Olle, Koteliansky, Victor, Fitzgerald, Kevin, Krauss, Ronald M, Cowan, Chad A

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Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease von Warren, Curtis R., O’Sullivan, John F., Friesen, Max, Becker, Caroline E., Zhang, Xiaoling, Liu, Poching, Wakabayashi, Yoshiyuki, Morningstar, Jordan E., Shi, Xu, Choi, Jihoon, Xia, Fang, Peters, Derek T., Florido, Mary H.C., Tsankov, Alexander M., Duberow, Eilene, Comisar, Lauren, Shay, Jennifer, Jiang, Xin, Meissner, Alexander, Musunuru, Kiran, Kathiresan, Sekar, Daheron, Laurence, Zhu, Jun, Gerszten, Robert E., Deo, Rahul C., Vasan, Ramachandran S., O’Donnell, Christopher J., Cowan, Chad A.

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Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci von Forrest, Marc P., Zhang, Hanwen, Moy, Winton, McGowan, Heather, Leites, Catherine, Dionisio, Leonardo E., Xu, Zihui, Shi, Jianxin, Sanders, Alan R., Greenleaf, William J., Cowan, Chad A., Pang, Zhiping P., Gejman, Pablo V., Penzes, Peter, Duan, Jubao

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Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells von Mae, Shin-Ichi, Shono, Akemi, Shiota, Fumihiko, Yasuno, Tetsuhiko, Kajiwara, Masatoshi, Gotoda-Nishimura, Nanaka, Arai, Sayaka, Sato-Otubo, Aiko, Toyoda, Taro, Takahashi, Kazutoshi, Nakayama, Naoki, Cowan, Chad A., Aoi, Takashi, Ogawa, Seishi, McMahon, Andrew P., Yamanaka, Shinya, Osafune, Kenji

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