De novo design of picomolar SARS-CoV-2 miniprotein inhibitors von Cao, Longxing, Goreshnik, Inna, Coventry, Brian, Case, James Brett, Miller, Lauren, Kozodoy, Lisa, Chen, Rita E., Carter, Lauren, Walls, Alexandra C., Park, Young-Jun, Strauch, Eva-Maria, Stewart, Lance, Diamond, Michael S., Veesler, David, Baker, David

Volltext

De novo design of luciferases using deep learning von Yeh, Andy Hsien-Wei, Norn, Christoffer, Kipnis, Yakov, Tischer, Doug, Pellock, Samuel J., Evans, Declan, Ma, Pengchen, Lee, Gyu Rie, Zhang, Jason Z., Anishchenko, Ivan, Coventry, Brian, Cao, Longxing, Dauparas, Justas, Halabiya, Samer, DeWitt, Michelle, Carter, Lauren, Houk, K. N., Baker, David

Volltext

De novo design of miniprotein antagonists of cytokine storm inducers von Huang, Buwei, Coventry, Brian, Borowska, Marta T., Arhontoulis, Dimitrios C., Exposit, Marc, Abedi, Mohamad, Jude, Kevin M., Halabiya, Samer F., Allen, Aza, Cordray, Cami, Goreshnik, Inna, Ahlrichs, Maggie, Chan, Sidney, Tunggal, Hillary, DeWitt, Michelle, Hyams, Nathaniel, Carter, Lauren, Stewart, Lance, Fuller, Deborah H., Mei, Ying, Garcia, K. Christopher, Baker, David

Volltext

Computational design of a neutralizing antibody with picomolar binding affinity for all concerning SARS-CoV-2 variants von Jeong, Bo-Seong, Cha, Jeong Seok, Hwang, Insu, Kim, Uijin, Adolf-Bryfogle, Jared, Coventry, Brian, Cho, Hyun-Soo, Kim, Kyun-Do, Oh, Byung-Ha

Volltext

Macromolecular modeling and design in Rosetta: recent methods and frameworks von Leman, Julia Koehler, Weitzner, Brian D., Lewis, Steven M., Adolf-Bryfogle, Jared, Alam, Nawsad, Alford, Rebecca F., Aprahamian, Melanie, Baker, David, Barlow, Kyle A., Basanta, Benjamin, Bender, Brian J., Blacklock, Kristin, Bonet, Jaume, Boyken, Scott E., Bradley, Phil, Bystroff, Chris, Conway, Patrick, Cooper, Seth, Correia, Bruno E., Coventry, Brian, Das, Rhiju, DiMaio, Frank, Dsilva, Lorna, Dunbrack, Roland, Ford, Alexander S., Fu, Darwin Y., Geniesse, Caleb, Goldschmidt, Lukasz, Gowthaman, Ragul, Gray, Jeffrey J., Gront, Dominik, Guffy, Sharon, Huang, Po-Ssu, Jacobs, Tim M., Jeliazkov, Jeliazko R., Johnson, David K., Kappel, Kalli, Karanicolas, John, Khakzad, Hamed, Khar, Karen R., Khare, Sagar D., Khatib, Firas, Khramushin, Alisa, King, Indigo C., Kleffner, Robert, Koepnick, Brian, Kortemme, Tanja, Kuenze, Georg, Kuhlman, Brian, Kuroda, Daisuke, Labonte, Jason W., Lai, Jason K., Lapidoth, Gideon, Leaver-Fay, Andrew, Lindert, Steffen, Linsky, Thomas, London, Nir, Lubin, Joseph H., Lyskov, Sergey, Maguire, Jack, Malmström, Lars, Marcos, Enrique, Marcu, Orly, Marze, Nicholas A., Meiler, Jens, Moretti, Rocco, Mulligan, Vikram Khipple, Nerli, Santrupti, Norn, Christoffer, Ollikainen, Noah, Ovchinnikov, Sergey, Pacella, Michael S., Pan, Xingjie, Park, Hahnbeom, Pavlovicz, Ryan E., Pethe, Manasi, Pilla, Kala Bharath, Raveh, Barak, Renfrew, P. Douglas, Burman, Shourya S. Roy, Rubenstein, Aliza, Sauer, Marion F., Scheck, Andreas, Schief, William, Schueler-Furman, Ora, Sedan, Yuval, Sevy, Alexander M., Sgourakis, Nikolaos G., Shi, Lei, Siegel, Justin B., Silva, Daniel-Adriano, Smith, Shannon, Song, Yifan, Stein, Amelie, Szegedy, Maria, Teets, Frank D., Thyme, Summer B., Wang, Ray Yu-Ruei, Watkins, Andrew, Zimmerman, Lior

Volltext

Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists von Glögl, Matthias, Krishnakumar, Aditya, Ragotte, Robert J, Goreshnik, Inna, Coventry, Brian, Bera, Asim K, Kang, Alex, Joyce, Emily, Ahn, Green, Huang, Buwei, Yang, Wei, Chen, Wei, Sanchez, Mariana Garcia, Koepnick, Brian, Baker, David

Volltext

Accurate de novo design of heterochiral protein–protein interactions von Sun, Ke, Li, Sicong, Zheng, Bowen, Zhu, Yanlei, Wang, Tongyue, Liang, Mingfu, Yao, Yue, Zhang, Kairan, Zhang, Jizhong, Li, Hongyong, Han, Dongyang, Zheng, Jishen, Coventry, Brian, Cao, Longxing, Baker, David, Liu, Lei, Lu, Peilong

Volltext

Improving de novo protein binder design with deep learning von Bennett, Nathaniel R, Coventry, Brian, Goreshnik, Inna, Huang, Buwei, Allen, Aza, Vafeados, Dionne, Peng, Ying Po, Dauparas, Justas, Baek, Minkyung, Stewart, Lance, DiMaio, Frank, De Munck, Steven, Savvides, Savvas, Baker, David

Volltext

Blueprinting extendable nanomaterials with standardized protein blocks von Huddy, Timothy F., Hsia, Yang, Kibler, Ryan D., Xu, Jinwei, Bethel, Neville, Nagarajan, Deepesh, Redler, Rachel, Leung, Philip J. Y., Weidle, Connor, Courbet, Alexis, Yang, Erin C., Bera, Asim K., Coudray, Nicolas, Calise, S. John, Davila-Hernandez, Fatima A., Han, Hannah L., Carr, Kenneth D., Li, Zhe, McHugh, Ryan, Reggiano, Gabriella, Kang, Alex, Sankaran, Banumathi, Dickinson, Miles S., Coventry, Brian, Brunette, T. J., Liu, Yulai, Dauparas, Justas, Borst, Andrew J., Ekiert, Damian, Kollman, Justin M., Bhabha, Gira, Baker, David

Volltext

Protein-binding proteins designed from target structural information von DeBouver, Nicholas, Cao, Longxing, Coventry, Brian, Bera, Asim, Yang, Wei, Bernard, Steffen, Stewart, Lance, Wilson, Ian, Ruohola-Baker, Hannele, Schlessinger, Joseph, Lee, Sangwon, Savvides, Savvas, Garcia, K. Christopher

Volltext

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies von Edman, Natasha I., Phal, Ashish, Redler, Rachel L., Schlichthaerle, Thomas, Srivatsan, Sanjay R., Ehnes, Devon Duron, Etemadi, Ali, An, Seong J., Favor, Andrew, Li, Zhe, Praetorius, Florian, Gordon, Max, Vincent, Thomas, Marchiano, Silvia, Blakely, Leslie, Lin, Chuwei, Yang, Wei, Coventry, Brian, Hicks, Derrick R., Cao, Longxing, Bethel, Neville, Heine, Piper, Murray, Analisa, Gerben, Stacey, Carter, Lauren, Miranda, Marcos, Negahdari, Babak, Lee, Sangwon, Trapnell, Cole, Zheng, Ying, Murry, Charles E., Schweppe, Devin K., Freedman, Benjamin S., Stewart, Lance, Ekiert, Damian C., Schlessinger, Joseph, Shendure, Jay, Bhabha, Gira, Ruohola-Baker, Hannele, Baker, David

Volltext

Binding and sensing diverse small molecules using shape-complementary pseudocycles von An, Linna, Said, Meerit, Tran, Long, Majumder, Sagardip, Goreshnik, Inna, Lee, Gyu Rie, Juergens, David, Dauparas, Justas, Anishchenko, Ivan, Coventry, Brian, Bera, Asim K, Kang, Alex, Levine, Paul M, Alvarez, Valentina, Pillai, Arvind, Norn, Christoffer, Feldman, David, Zorine, Dmitri, Hicks, Derrick R, Li, Xinting, Sanchez, Mariana Garcia, Vafeados, Dionne K, Salveson, Patrick J, Vorobieva, Anastassia A, Baker, David

Volltext

Designed endocytosis-inducing proteins degrade targets and amplify signals von Huang, Buwei, Abedi, Mohamad, Ahn, Green, Coventry, Brian, Sappington, Isaac, Tang, Cong, Wang, Rong, Schlichthaerle, Thomas, Zhang, Jason Z, Wang, Yujia, Goreshnik, Inna, Chiu, Ching Wen, Chazin-Gray, Adam, Chan, Sidney, Gerben, Stacey, Murray, Analisa, Wang, Shunzhi, O'Neill, Jason, Yi, Li, Yeh, Ronald, Misquith, Ayesha, Wolf, Anitra, Tomasovic, Luke M, Piraner, Dan I, Duran Gonzalez, Maria J, Bennett, Nathaniel R, Venkatesh, Preetham, Ahlrichs, Maggie, Dobbins, Craig, Yang, Wei, Wang, Xinru, Sahtoe, Danny D, Vafeados, Dionne, Mout, Rubul, Shivaei, Shirin, Cao, Longxing, Carter, Lauren, Stewart, Lance, Spangler, Jamie B, Roybal, Kole T, Greisen, Per Jr, Li, Xiaochun, Bernardes, Gonçalo J L, Bertozzi, Carolyn R, Baker, David

Volltext

DE NOVO DESIGNED HIGH AFFINITY PROTEIN BINDERS TO CONVEX PROTEIN TARGET SITES ON TGFBRII, CTLA-4 AND PD-L1 von COVENTRY, Brian, HICKS, Derrick, BAKER, David, GORESHNIK, Inna, YANG, Wei

Volltext bestellen

DE NOVO DESIGNED HIGH AFFINITY PROTEIN BINDERS TO CONVEX PROTEIN TARGET SITES ON TGFBRII, CTLA-4 AND PD-L1 von COVENTRY, Brian, HICKS, Derrick, BAKER, David, GORESHNIK, Inna, YANG, Wei

Volltext bestellen

Designed endocytosis-inducing proteins degrade targets and amplify signals von Huang, Buwei, Abedi, Mohamad, Ahn, Green, Coventry, Brian, Sappington, Isaac, Tang, Cong, Wang, Rong, Schlichthaerle, Thomas, Zhang, Jason Z, Wang, Yujia, Goreshnik, Inna, Chiu, Ching Wen, Chazin-Gray, Adam, Chan, Sidney, Gerben, Stacey, Murray, Analisa, Wang, Shunzhi, O'Neill, Jason, Yi, Li, Yeh, Ronald, Misquith, Ayesha, Wolf, Anitra, Tomasovic, Luke M, Piraner, Dan I, Duran Gonzalez, Maria J, Bennett, Nathaniel R, Venkatesh, Preetham, Ahlrichs, Maggie, Dobbins, Craig, Yang, Wei, Wang, Xinru, Sahtoe, Danny D, Vafeados, Dionne, Mout, Rubul, Shivaei, Shirin, Cao, Longxing, Carter, Lauren, Stewart, Lance, Spangler, Jamie B, Roybal, Kole T, Greisen, Per Jr, Li, Xiaochun, Bernardes, Gonçalo JL, Bertozzi, Carolyn R, Baker, David

Volltext bestellen

MULTIPLE DE NOVO DESIGNED PROTEIN BINDING PROTEINS von COVENTRY, Brian, STEWART, Lansing Joseph, BAKER, David, HUANG, Buwei, BENNETT, Nathaniel, GORESHNIK, Inna, SCHLICHTHAERLE, Thomas, CAO, Longxing, STRAUCH, Eva-Maria

Volltext bestellen

DE NOVO DESIGNED BINDERS TARGETING HUMAN EPCAM AND PDL1 RECEPTORS von WANG, Jue, COVENTRY, Brian, HICKS, Derrick, PENG, Vanessa, BAKER, David, SILVA MANZANO, Daniel, HALABIYA, Samer, GORESHNIK, Inna, PERKINS, Jilliane

Volltext bestellen

DE NOVO DESIGNED BINDERS TARGETING HUMAN EPCAM AND PDL1 RECEPTORS von COVENTRY, Brian, WANG, Jue, HICKS, Derrick, PENG, Vanessa, BAKER, David, SILVA MANZANO, Daniel, GORESHNIK, Inna, HALABIYA, Samer, PERKINS, Jilliane

Volltext bestellen

DE NOVO DESIGNED CYCLIC OLIGOMERIC PROTEINS von FAVOR, Andrew, RUOHOLA-BAKER, Hannele, REDLER, Rachel, BAKER, David, COVENTRY, Brian, EDMAN, Natasha, ETEMADI, Ali, HICKS, Derrick, EKIERT, Damian, BHABHA, Gira, SCHLICHTHAERLE, Thomas, YANG, Wei, STEWART, Lance Joseph, PHAL, Ashish

Volltext bestellen