Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells von MacLeod, Graham, Bozek, Danielle A., Rajakulendran, Nishani, Monteiro, Vernon, Ahmadi, Moloud, Steinhart, Zachary, Kushida, Michelle M., Yu, Helen, Coutinho, Fiona J., Cavalli, Florence M.G., Restall, Ian, Hao, Xiaoguang, Hart, Traver, Luchman, H. Artee, Weiss, Samuel, Dirks, Peter B., Angers, Stephane

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ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells von Park, Nicole I., Guilhamon, Paul, Desai, Kinjal, McAdam, Rochelle F., Langille, Ellen, O’Connor, Madlen, Lan, Xiaoyang, Whetstone, Heather, Coutinho, Fiona J., Vanner, Robert J., Ling, Erick, Prinos, Panagiotis, Lee, Lilian, Selvadurai, Hayden, Atwal, Gurnit, Kushida, Michelle, Clarke, Ian D., Voisin, Veronique, Cusimano, Michael D., Bernstein, Mark, Das, Sunit, Bader, Gary, Arrowsmith, Cheryl H., Angers, Stephane, Huang, Xi, Lupien, Mathieu, Dirks, Peter B.

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High-resolution structural genomics reveals new therapeutic vulnerabilities in glioblastoma von Johnston, Michael J, Nikolic, Ana, Ninkovic, Nicoletta, Guilhamon, Paul, Cavalli, Florence M G, Seaman, Steven, Zemp, Franz J, Lee, John, Abdelkareem, Aly, Ellestad, Katrina, Murison, Alex, Kushida, Michelle M, Coutinho, Fiona J, Ma, Yussanne, Mungall, Andrew J, Moore, Richard, Marra, Marco A, Taylor, Michael D, Dirks, Peter B, Pugh, Trevor J, Morrissy, Sorana, St Croix, Bradley, Mahoney, Douglas J, Lupien, Mathieu, Gallo, Marco

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A Tumorigenic MLL-Homeobox Network in Human Glioblastoma Stem Cells von GALLO, Marco, HO, Jenny, COUTINHO, Fiona J, VANNER, Robert, LEE, Lilian, HEAD, Renee, LING, Erick K. M, CLARKE, Ian D, DIRKS, Peter B

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Pan-cancer analysis of non-coding transcripts reveals the prognostic onco-lncRNA HOXA10-AS in gliomas von Isaev, Keren, Jiang, Lingyan, Wu, Shuai, Lee, Christian A., Watters, Valérie, Fort, Victoire, Tsai, Ricky, Coutinho, Fiona J., Hussein, Samer M.I., Zhang, Jie, Wu, Jinsong, Dirks, Peter B., Schramek, Daniel, Reimand, Jüri

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ASCL1 Reorganizes Chromatin to Direct Neuronal Fate and Suppress Tumorigenicity of Glioblastoma Stem Cells von Park, Nicole I., Guilhamon, Paul, Desai, Kinjal, McAdam, Rochelle F., Langille, Ellen, O’Connor, Madlen, Lan, Xiaoyang, Whetstone, Heather, Coutinho, Fiona J., Vanner, Robert J., Ling, Erick, Prinos, Panagiotis, Lee, Lilian, Selvadurai, Hayden, Atwal, Gurnit, Kushida, Michelle, Clarke, Ian D., Voisin, Veronique, Cusimano, Michael D., Bernstein, Mark, Das, Sunit, Bader, Gary, Arrowsmith, Cheryl H., Angers, Stephane, Huang, Xi, Lupien, Mathieu, Dirks, Peter B.

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Characterization of blaSHV Genes on Plasmids from Escherichia coli and Salmonella enterica Isolates from Canadian Food Animals (2006-2007) von Pouget, Jennie G, Coutinho, Fiona J, Reid-Smith, Richard J, Boerlin, Patrick

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A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression von Chen, Xin, Wanggou, Siyi, Bodalia, Ankur, Zhu, Min, Dong, Weifan, Fan, Jerry J., Yin, Wen Chi, Min, Hyun-Kee, Hu, Malini, Draghici, Diana, Dou, Wenkun, Li, Feng, Coutinho, Fiona J., Whetstone, Heather, Kushida, Michelle M., Dirks, Peter B., Song, Yuanquan, Hui, Chi-chung, Sun, Yu, Wang, Lu-Yang, Li, Xuejun, Huang, Xi

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Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity von Richards, Laura M, Whitley, Owen K N, MacLeod, Graham, Cavalli, Florence M G, Coutinho, Fiona J, Jaramillo, Julia E, Svergun, Nataliia, Riverin, Mazdak, Croucher, Danielle C, Kushida, Michelle, Yu, Kenny, Guilhamon, Paul, Rastegar, Naghmeh, Ahmadi, Moloud, Bhatti, Jasmine K, Bozek, Danielle A, Li, Naijin, Lee, Lilian, Che, Clare, Luis, Erika, Park, Nicole I, Xu, Zhiyu, Ketela, Troy, Moore, Richard A, Marra, Marco A, Spears, Julian, Cusimano, Michael D, Das, Sunit, Bernstein, Mark, Haibe-Kains, Benjamin, Lupien, Mathieu, Luchman, H Artee, Weiss, Samuel, Angers, Stephane, Dirks, Peter B, Bader, Gary D, Pugh, Trevor J

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Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival von Guilhamon, Paul, Chesnelong, Charles, Kushida, Michelle M, Nikolic, Ana, Singhal, Divya, MacLeod, Graham, Madani Tonekaboni, Seyed Ali, Cavalli, Florence Mg, Arlidge, Christopher, Rajakulendran, Nishani, Rastegar, Naghmeh, Hao, Xiaoguang, Hassam, Rozina, Smith, Laura J, Whetstone, Heather, Coutinho, Fiona J, Nadorp, Bettina, Ellestad, Katrina I, Luchman, H Artee, Chan, Jennifer Ai-Wen, Shoichet, Molly S, Taylor, Michael D, Haibe-Kains, Benjamin, Weiss, Samuel, Angers, Stephane, Gallo, Marco, Dirks, Peter B, Lupien, Mathieu

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Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma von Hoffman, Mary, Gillmor, Aaron H, Kunz, Daniel J, Johnston, Michael J, Nikolic, Ana, Narta, Kiran, Zarrei, Mehdi, King, Jennifer, Ellestad, Katrina, Dang, Ngoc Ha, Cavalli, Florence M G, Kushida, Michelle M, Coutinho, Fiona J, Zhu, Yuankun, Luu, Betty, Ma, Yussanne, Mungall, Andrew J, Moore, Richard, Marra, Marco A, Taylor, Michael D, Pugh, Trevor J, Dirks, Peter B, Strother, Douglas, Lafay-Cousin, Lucie, Resnick, Adam C, Scherer, Stephen, Senger, Donna L, Simons, Benjamin D, Chan, Jennifer A, Morrissy, A Sorana, Gallo, Marco

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Characterization of bla(SHV) genes on plasmids from Escherichia coli and Salmonella enterica isolates from Canadian food animals (2006-2007) von Pouget, Jennie G, Coutinho, Fiona J, Reid-Smith, Richard J, Boerlin, Patrick

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Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy von Lan, Xiaoyang, Jörg, David J., Cavalli, Florence M. G., Richards, Laura M., Nguyen, Long V., Vanner, Robert J., Guilhamon, Paul, Lee, Lilian, Kushida, Michelle M., Pellacani, Davide, Park, Nicole I., Coutinho, Fiona J., Whetstone, Heather, Selvadurai, Hayden J., Che, Clare, Luu, Betty, Carles, Annaick, Moksa, Michelle, Rastegar, Naghmeh, Head, Renee, Dolma, Sonam, Prinos, Panagiotis, Cusimano, Michael D., Das, Sunit, Bernstein, Mark, Arrowsmith, Cheryl H., Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Gallo, Marco, Lupien, Mathieu, Pugh, Trevor J., Taylor, Michael D., Hirst, Martin, Eaves, Connie J., Simons, Benjamin D., Dirks, Peter B.

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Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma von Michealraj, Kulandaimanuvel Antony, Kumar, Sachin A., Kim, Leo J.Y., Cavalli, Florence M.G., Przelicki, David, Wojcik, John B., Delaidelli, Alberto, Bajic, Andrea, Saulnier, Olivier, MacLeod, Graham, Vellanki, Ravi N., Vladoiu, Maria C., Guilhamon, Paul, Ong, Winnie, Lee, John J.Y., Jiang, Yanqing, Holgado, Borja L., Rasnitsyn, Alex, Malik, Ahmad A., Tsai, Ricky, Richman, Cory M., Juraschka, Kyle, Haapasalo, Joonas, Wang, Evan Y., De Antonellis, Pasqualino, Suzuki, Hiromichi, Farooq, Hamza, Balin, Polina, Kharas, Kaitlin, Van Ommeren, Randy, Sirbu, Olga, Rastan, Avesta, Krumholtz, Stacey L., Ly, Michelle, Ahmadi, Moloud, Deblois, Geneviève, Srikanthan, Dilakshan, Luu, Betty, Loukides, James, Wu, Xiaochong, Garzia, Livia, Ramaswamy, Vijay, Kanshin, Evgeny, Sánchez-Osuna, María, El-Hamamy, Ibrahim, Coutinho, Fiona J., Prinos, Panagiotis, Singh, Sheila, Donovan, Laura K., Daniels, Craig, Schramek, Daniel, Tyers, Mike, Weiss, Samuel, Stein, Lincoln D., Lupien, Mathieu, Wouters, Bradly G., Garcia, Benjamin A., Arrowsmith, Cheryl H., Sorensen, Poul H., Angers, Stephane, Jabado, Nada, Dirks, Peter B., Mack, Stephen C., Agnihotri, Sameer, Rich, Jeremy N., Taylor, Michael D.

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PRMT5 inhibition disrupts splicing and stemness in glioblastoma von Sachamitr, Patty, Ho, Jolene C., Ciamponi, Felipe E., Ba-Alawi, Wail, Coutinho, Fiona J., Guilhamon, Paul, Kushida, Michelle M., Cavalli, Florence M. G., Lee, Lilian, Rastegar, Naghmeh, Vu, Victoria, Sánchez-Osuna, María, Coulombe-Huntington, Jasmin, Kanshin, Evgeny, Whetstone, Heather, Durand, Mathieu, Thibault, Philippe, Hart, Kirsten, Mangos, Maria, Veyhl, Joseph, Chen, Wenjun, Tran, Nhat, Duong, Bang-Chi, Aman, Ahmed M., Che, Xinghui, Lan, Xiaoyang, Whitley, Owen, Zaslaver, Olga, Barsyte-Lovejoy, Dalia, Richards, Laura M., Restall, Ian, Caudy, Amy, Röst, Hannes L., Bonday, Zahid Quyoom, Bernstein, Mark, Das, Sunit, Cusimano, Michael D., Spears, Julian, Bader, Gary D., Pugh, Trevor J., Tyers, Mike, Lupien, Mathieu, Haibe-Kains, Benjamin, Artee Luchman, H., Weiss, Samuel, Massirer, Katlin B., Prinos, Panagiotis, Arrowsmith, Cheryl H., Dirks, Peter B.

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MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin von Gallo, Marco, Coutinho, Fiona J., Vanner, Robert J., Gayden, Tenzin, Mack, Stephen C., Murison, Alex, Remke, Marc, Li, Ren, Takayama, Naoya, Desai, Kinjal, Lee, Lilian, Lan, Xiaoyang, Park, Nicole I., Barsyte-Lovejoy, Dalia, Smil, David, Sturm, Dominik, Kushida, Michelle M., Head, Renee, Cusimano, Michael D., Bernstein, Mark, Clarke, Ian D., Dick, John E., Pfister, Stefan M., Rich, Jeremy N., Arrowsmith, Cheryl H., Taylor, Michael D., Jabado, Nada, Bazett-Jones, David P., Lupien, Mathieu, Dirks, Peter B.

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Characterization of bla SHV Genes on Plasmids from Escherichia coli and Salmonella enterica Isolates from Canadian Food Animals (2006-2007) von Pouget, Jennie G., Coutinho, Fiona J., Reid-Smith, Richard J., Boerlin, Patrick

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Characterization of bla^sub SHV^ Genes on Plasmids from Escherichia coli and Salmonella enterica Isolates from Canadian Food Animals (2006-2007) von Pouget, Jennie G, Coutinho, Fiona J, Reid-Smith, Richard J, Boerlin, Patrick

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Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma von Hoffman, Mary, Gillmor, Aaron H, Kunz, Daniel J, Johnston, Michael J, Nikolic, Ana, Narta, Kiran, Zarrei, Mehdi, King, Jennifer, Ellestad, Katrina, Dang, Ngoc Ha, Cavalli, Florence MG, Kushida, Michelle M, Coutinho, Fiona J, Zhu, Yuankun, Luu, Betty, Ma, Yussanne, Mungall, Andrew J, Moore, Richard, Marra, Marco A, Taylor, Michael D, Pugh, Trevor J, Dirks, Peter B, Strother, Douglas, Lafay-Cousin, Lucie, Resnick, Adam C, Scherer, Stephen, Senger, Donna L, Simons, Benjamin D, Chan, Jennifer A, Morrissy, A Sorana, Gallo, Marco

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How nature can exploit nonspecific catalytic and carbohydrate binding modules to create enzymatic specificity von Cuskin, Fiona, Flint, James E., Gloster, Tracey M., Morland, Carl, Baslé, Arnaud, Henrissat, Bernard, Coutinho, Pedro M., Strazzulli, Andrea, Solovyova, Alexandra S., Davies, Gideon J., Gilbert, Harry J.

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