Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase von Prime, Michael E, Courtney, Stephen M, Brookfield, Frederick A, Marston, Richard W, Walker, Victoria, Warne, Justin, Boyd, Andrew E, Kairies, Norman A, von der Saal, Wolfgang, Limberg, Anja, Georges, Guy, Engh, Richard A, Goller, Bernhard, Rueger, Petra, Rueth, Matthias

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Discovery and Structure–Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington’s Disease von Prime, Michael E, Andersen, Ole A, Barker, John J, Brooks, Mark A, Cheng, Robert K. Y, Toogood-Johnson, Ian, Courtney, Stephen M, Brookfield, Frederick A, Yarnold, Christopher J, Marston, Richard W, Johnson, Peter D, Johnsen, Siw F, Palfrey, Jordan J, Vaidya, Darshan, Erfan, Sayeh, Ichihara, Osamu, Felicetti, Brunella, Palan, Shilpa, Pedret-Dunn, Anna, Schaertl, Sabine, Sternberger, Ina, Ebneth, Andreas, Scheel, Andreas, Winkler, Dirk, Toledo-Sherman, Leticia, Beconi, Maria, Macdonald, Douglas, Muñoz-Sanjuan, Ignacio, Dominguez, Celia, Wityak, John

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Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies von Peterson, Luke F., Sun, Hanshi, Liu, Yihong, Potu, Harish, Kandarpa, Malathi, Ermann, Monika, Courtney, Stephen M., Young, Matthew, Showalter, Hollis D., Sun, Duxin, Jakubowiak, Andrzej, Malek, Sami N., Talpaz, Moshe, Donato, Nicholas J.

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Glyco- and Peptidomimetics from Three-Component Joullié−Ugi Coupling Show Selective Antiviral Activity von Chapman, Timothy M, Davies, Ieuan G, Gu, Baohua, Block, Timothy M, Scopes, David I. C, Hay, Philip A, Courtney, Stephen M, McNeill, Luke A, Schofield, Christopher J, Davis, Benjamin G

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Fragment‐based Identification of Hsp90 Inhibitors von Barker, John J., Barker, Oliver, Boggio, Roberto, Chauhan, Viddhata, Cheng, Robert K. Y., Corden, Vincent, Courtney, Stephen M., Edwards, Neil, Falque, Virginie M., Fusar, Fulvia, Gardiner, Mihaly, Hamelin, Estelle M. N., Hesterkamp, Thomas, Ichihara, Osamu, Jones, Richard S., Mather, Owen, Mercurio, Ciro, Minucci, Saverio, Montalbetti, Christian A. G. N., Müller, Annett, Patel, Deepti, Phillips, Banu G., Varasi, Mario, Whittaker, Mark, Winkler, Dirk, Yarnold, Christopher J.

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Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington’s Disease von Toledo-Sherman, Leticia M, Prime, Michael E, Mrzljak, Ladislav, Beconi, Maria G, Beresford, Alan, Brookfield, Frederick A, Brown, Christopher J, Cardaun, Isabell, Courtney, Stephen M, Dijkman, Ulrike, Hamelin-Flegg, Estelle, Johnson, Peter D, Kempf, Valerie, Lyons, Kathy, Matthews, Kimberly, Mitchell, William L, O’Connell, Catherine, Pena, Paula, Powell, Kendall, Rassoulpour, Arash, Reed, Laura, Reindl, Wolfgang, Selvaratnam, Suganathan, Friley, Weslyn Ward, Weddell, Derek A, Went, Naomi E, Wheelan, Patricia, Winkler, Christin, Winkler, Dirk, Wityak, John, Yarnold, Christopher J, Yates, Dawn, Munoz-Sanjuan, Ignacio, Dominguez, Celia

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Exploiting differences in caspase-2 and -3 S₂ subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhib... von Maillard, Michel C, Brookfield, Frederick A, Courtney, Stephen M, Eustache, Florence M, Gemkow, Mark J, Handel, Rebecca K, Johnson, Laura C, Johnson, Peter D, Kerry, Mark A, Krieger, Florian, Meniconi, Mirco, Muñoz-Sanjuán, Ignacio, Palfrey, Jordan J, Park, Hyunsun, Schaertl, Sabine, Taylor, Malcolm G, Weddell, Derek, Dominguez, Celia

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Allosteric Inhibition of the Neuropeptidase Neurolysin von Hines, Christina S., Ray, Kallol, Schmidt, Jack J., Xiong, Fei, Feenstra, Rolf W., Pras-Raves, Mia, de Moes, Jan Peter, Lange, Jos H.M., Melikishvili, Manana, Fried, Michael G., Mortenson, Paul, Charlton, Michael, Patel, Yogendra, Courtney, Stephen M., Kruse, Chris G., Rodgers, David W.

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Discovery of a Novel Hsp90 Inhibitor by Fragment Linking von Barker, John J., Barker, Oliver, Courtney, Stephen M., Gardiner, Mihaly, Hesterkamp, Thomas, Ichihara, Osamu, Mather, Owen, Montalbetti, Christian A. G. N., Müller, Annett, Varasi, Mario, Whittaker, Mark, Yarnold, Christopher J.

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SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease von Wityak, John, Prime, Michael E, Brookfield, Frederick A, Courtney, Stephen M, Erfan, Sayeh, Johnsen, Siw, Johnson, Peter D, Li, Marie, Marston, Richard W, Reed, Laura, Vaidya, Darshan, Schaertl, Sabine, Pedret-Dunn, Anna, Beconi, Maria, Macdonald, Douglas, Muñoz-Sanjuan, Ignacio, Dominguez, Celia

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Chiral Resolution and Pharmacological Characterization of the Enantiomers of the Hsp90 Inhibitor 2-Amino-7-[4-fluoro-2-(3-pyridyl)phenyl]-4-methyl-7,8-dihydro-6H-quinazolin-5-one O... von Amici, Raffaella, Bigogno, Chiara, Boggio, Roberto, Colombo, Andrea, Courtney, Stephen M., Dal Zuffo, Roberto, Dondio, Giulio, Fusar, Fulvia, Gagliardi, Stefania, Minucci, Saverio, Molteni, Marco, Montalbetti, Christian A. G. N., Mortoni, Annalisa, Varasi, Mario, Vultaggio, Stefania, Mercurio, Ciro

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Irreversible 4‑Aminopiperidine Transglutaminase 2 Inhibitors for Huntington's Disease von Prime, Michael E, Brookfield, Frederick A, Courtney, Stephen M, Gaines, Simon, Marston, Richard W, Ichihara, Osamu, Li, Marie, Vaidya, Darshan, Williams, Helen, Pedret-Dunn, Anna, Reed, Laura, Schaertl, Sabine, Toledo-Sherman, Leticia, Beconi, Maria, Macdonald, Douglas, Muñoz-Sanjuan, Ignacio, Dominguez, Celia, Wityak, John

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Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: novel classes of heparanase inhibitor von Courtney, Stephen M., Hay, Philip A., Buck, Richard T., Colville, Claire S., Phillips, David J., Scopes, David I.C., Pollard, Faye C., Page, Martin J., Bennett, James M., Hircock, Margaret L., McKenzie, Edward A., Bhaman, Maina, Felix, Robert, Stubberfield, Colin R., Turner, Paul R.

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2,3-Dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid derivatives: a novel class of small molecule heparanase inhibitors von COURTNEY, Stephen M, HAY, Philip A, MCKENZIE, Edward A, STUBBERFIELD, Colin R, TURNER, Paul R, BUCK, Richard T, COLVILLE, Claire S, PORTER, David W, SCOPES, David I. C, POLLARD, Faye C, PAGE, Martin J, BENNETT, James M, HIRCOCK, Margaret L

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Exploiting differences in caspase-2 and -3 S 2 subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhi... von Maillard, Michel C., Brookfield, Frederick A., Courtney, Stephen M., Eustache, Florence M., Gemkow, Mark J., Handel, Rebecca K., Johnson, Laura C., Johnson, Peter D., Kerry, Mark A., Krieger, Florian, Meniconi, Mirco, Muñoz-Sanjuán, Ignacio, Palfrey, Jordan J., Park, Hyunsun, Schaertl, Sabine, Taylor, Malcolm G., Weddell, Derek, Dominguez, Celia

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Chiral Resolution and Pharmacological Characterization of the Enantiomers of the Hsp90 Inhibitor 2‐Amino‐7‐[4‐fluoro‐2‐(3‐pyridyl)phenyl]‐4‐methyl‐7,8‐dihydro‐6 H ‐quinazolin‐5‐one... von Amici, Raffaella, Bigogno, Chiara, Boggio, Roberto, Colombo, Andrea, Courtney, Stephen M., Dal Zuffo, Roberto, Dondio, Giulio, Fusar, Fulvia, Gagliardi, Stefania, Minucci, Saverio, Molteni, Marco, Montalbetti, Christian A. G. N., Mortoni, Annalisa, Varasi, Mario, Vultaggio, Stefania, Mercurio, Ciro

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Exploiting differences in caspase-2 and -3 S sub(2 subsites for selectivity: Structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2... von Maillard, Michel C, Brookfield, Frederick A, Courtney, Stephen M, Eustache, Florence M, Gemkow, Mark J, Handel, Rebecca K, Johnson, Laura C, Johnson, Peter D, Kerry, Mark A, Krieger, Florian, Meniconi, Mirco, Munoz-Sanjuan, Ignacio, Palfrey, Jordan J, Park, Hyunsun, Schaertl, Sabine, Taylor, Malcolm G, Weddell, Derek, Dominguez, Celia

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2,3-Dihydro-1,3-dioxo-1 H-isoindole-5-carboxylic acid derivatives: a novel class of small molecule heparanase inhibitors von Courtney, Stephen M., Hay, Philip A., Buck, Richard T., Colville, Claire S., Porter, David W., Scopes, David I.C., Pollard, Faye C., Page, Martin J., Bennett, James M., Hircock, Margaret L., McKenzie, Edward A., Stubberfield, Colin R., Turner, Paul R.

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A new convenient procedure for the synthesis of pyrrolo[2,1- c][l,4]benzodiazepines von Courtney, Stephen M., Thurston, David E.

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PYRAZOLONE DERIVATIVES AS NITROXYL DONORS von COURTNEY, STEPHEN, M, BROOKFIELD, FREDERICK, A, FROST, LISA, M, TOSCANO, JOHN, P, GUTHRIE, DARYL, A, KALISH, VINCENT, J, NORTH, CARL, L

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