The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment von Santucci, Matteo, Vignudelli, Tatiana, Ferrari, Stefania, Mor, Marco, Scalvini, Laura, Bolognesi, Maria Laura, Uliassi, Elisa, Costi, Maria Paola

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Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Va... von Pozzi, Cecilia, Ferrari, Stefania, Luciani, Rosaria, Tassone, Giusy, Costi, Maria Paola, Mangani, Stefano

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Intrinsic Fluorescence of the Active and the Inactive Functional Forms of Human Thymidylate Synthase von Vitiello, Simone, Caselli, Monica, Pavesi, Giorgia, Santucci, Matteo, Ferrari, Stefania, Paola Costi, Maria, Ponterini, Glauco

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Intersite communication in dimeric enzymes highlighted by structural and thermodynamic analysis of didansyltyrosine binding to thymidylate synthases von Venturelli, Alberto, Guaitoli, Giambattista, Vanossi, Davide, Saitta, Francesca, Fessas, Dimitrios, Vitiello, Simone, Malpezzi, Giulia, Aiello, Daniele, Ferrari, Stefania, Tondi, Donatella, Ponterini, Glauco, Paola Costi, Maria

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Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors von Panecka-Hofman, Joanna, Pöhner, Ina, Spyrakis, Francesca, Zeppelin, Talia, Di Pisa, Flavio, Dello Iacono, Lucia, Bonucci, Alessio, Quotadamo, Antonio, Venturelli, Alberto, Mangani, Stefano, Costi, Maria Paola, Wade, Rebecca C.

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Biochemical characterization of the feedforward loop between CDK1 and FOXM1 in epidermal stem cells von Polito, Maria Pia, Romaldini, Alessio, Tagliazucchi, Lorenzo, Marini, Grazia, Radice, Federica, Gozza, Gaia Andrea, Bergamini, Giulia, Costi, Maria Paola, Enzo, Elena

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Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors von Pozzi, Cecilia, Ferrari, Stefania, Luciani, Rosaria, Costi, Maria Paola, Mangani, Stefano

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Enhanced anticancer effect of thymidylate synthase dimer disrupters by promoting intracellular accumulation von Marverti, Gaetano, Moschella, Maria Gaetana, Belardo, Alice, Lamesta, Michele, Mercanile, Giada, Tagliazucchi, Lorenzo, Aiello, Daniele, Venturelli, Alberto, Illuminati, Davide, Guerrini, Remo, Losi, Lorena, Ponterini, Glauco, Costi, Maria Paola, D'Arca, Domenico

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Discovery of a benzothiophene-flavonol halting miltefosine and antimonial drug resistance in Leishmania parasites through the application of medicinal chemistry, screening and geno... von Borsari, Chiara, Jiménez-Antón, María Dolores, Eick, Julia, Bifeld, Eugenia, Torrado, Juan José, Olías-Molero, Ana Isabel, Corral, María Jesús, Santarem, Nuno, Baptista, Catarina, Severi, Leda, Gul, Sheraz, Wolf, Markus, Kuzikov, Maria, Ellinger, Bernhard, Reinshagen, Jeanette, Witt, Gesa, Linciano, Pasquale, Tait, Annalisa, Costantino, Luca, Luciani, Rosaria, Tejera Nevado, Paloma, Zander-Dinse, Dorothea, Franco, Caio H., Ferrari, Stefania, Moraes, Carolina B., Cordeiro-da-Silva, Anabela, Ponterini, Glauco, Clos, Joachim, Alunda, José María, Costi, Maria Paola

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Current Treatments to Control African Trypanosomiasis and One Health Perspective von Venturelli, Alberto, Tagliazucchi, Lorenzo, Lima, Clara, Venuti, Federica, Malpezzi, Giulia, Magoulas, George E, Santarem, Nuno, Calogeropoulou, Theodora, Cordeiro-da-Silva, Anabela, Costi, Maria Paola

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Intrinsic Fluorometric Reporters of Pteridine Reductase 1, a Target for Antiparasitic Agents von Ferrari, Stefania, Costi, Maria Paola, Ponterini, Glauco

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Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase von Tassone, Giusy, Landi, Giacomo, Linciano, Pasquale, Francesconi, Valeria, Tonelli, Michele, Tagliazucchi, Lorenzo, Costi, Maria Paola, Mangani, Stefano, Pozzi, Cecilia

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Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells von MARVERTI, GAETANO, LIGABUE, ALESSIO, LOMBARDI, PAOLO, FERRARI, STEFANIA, MONTI, MARIA GIUSEPPINA, FRASSINETI, CHIARA, COSTI, MARIA PAOLA

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Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development von Cavazzuti, Antonio, Paglietti, Giuseppe, Hunter, William N, Gamarro, Francisco, Piras, Sandra, Loriga, Mario, Allecca, Sergio, Corona, Paola, McLuskey, Karen, Tulloch, Lindsay, Gibellini, Federica, Ferrari, Stefania, Costi, Maria Paola

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Design, Synthesis and Antiparasitic Evaluation of Click Phospholipids von Magoulas, George E, Afroudakis, Pantelis, Georgikopoulou, Kalliopi, Roussaki, Marina, Borsari, Chiara, Fotopoulou, Theano, Santarem, Nuno, Barrias, Emile, Tejera Nevado, Paloma, Hachenberg, Julia, Bifeld, Eugenia, Ellinger, Bernhard, Kuzikov, Maria, Fragiadaki, Irini, Scoulica, Effie, Clos, Joachim, Gul, Sheraz, Costi, Maria Paola, de Souza, Wanderley, Prousis, Kyriakos C, Cordeiro da Silva, Anabela, Calogeropoulou, Theodora

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Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth von Costantino, Luca, Ferrari, Stefania, Santucci, Matteo, Salo-Ahen, Outi M H, Carosati, Emanuele, Franchini, Silvia, Lauriola, Angela, Pozzi, Cecilia, Trande, Matteo, Gozzi, Gaia, Saxena, Puneet, Cannazza, Giuseppe, Losi, Lorena, Cardinale, Daniela, Venturelli, Alberto, Quotadamo, Antonio, Linciano, Pasquale, Tagliazucchi, Lorenzo, Moschella, Maria Gaetana, Guerrini, Remo, Pacifico, Salvatore, Luciani, Rosaria, Genovese, Filippo, Henrich, Stefan, Alboni, Silvia, Santarem, Nuno, da Silva Cordeiro, Anabela, Giovannetti, Elisa, Peters, Godefridus J, Pinton, Paolo, Rimessi, Alessandro, Cruciani, Gabriele, Stroud, Robert M, Wade, Rebecca C, Mangani, Stefano, Marverti, Gaetano, D'Arca, Domenico, Ponterini, Glauco, Costi, Maria Paola

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Cyclic Peptides Acting as Allosteric Inhibitors of Human Thymidylate Synthase and Cancer Cell Growth von Pacifico, Salvatore, Santucci, Matteo, Luciani, Rosaria, Saxena, Puneet, Linciano, Pasquale, Ponterini, Glauco, Lauriola, Angela, D'Arca, Domenico, Marverti, Gaetano, Guerrini, Remo, Costi, Maria Paola

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Oxaliplatin plus leucovorin and 5-fluorouracil (FOLFOX-4) as a salvage chemotherapy in heavily-pretreated platinum-resistant ovarian cancer von Conteduca, Vincenza, Gurioli, Giorgia, Rossi, Lorena, Scarpi, Emanuela, Lolli, Cristian, Schepisi, Giuseppe, Farolfi, Alberto, De Lisi, Delia, Gallà, Valentina, Burgio, Salvatore Luca, Menna, Cecilia, Amadori, Andrea, Losi, Lorena, Amadori, Dino, Costi, Maria Paola, De Giorgi, Ugo

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Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases von Santucci, Matteo, Luciani, Rosaria, Gianquinto, Eleonora, Pozzi, Cecilia, Pisa, Flavio di, Dello Iacono, Lucia, Landi, Giacomo, Tagliazucchi, Lorenzo, Mangani, Stefano, Spyrakis, Francesca, Costi, Maria Paola

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Environmental impacts of drugs against parasitic vector-borne diseases and the need to integrate sustainability into their development and use von Lima, Clara M., Uliassi, Elisa, Thoré, Eli S.J., Bertram, Michael G., Cardoso, Luis, Cordeiro da Silva, Anabela, Costi, Maria Paola, de Koning, Harry P.

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