Mechanisms of Beta-Cell Apoptosis in Type 2 Diabetes-Prone Situations and Potential Protection by GLP-1-Based Therapies von Costes, Safia, Bertrand, Gyslaine, Ravier, Magalie A.

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GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function von Zaïmia, Nour, Obeid, Joelle, Varrault, Annie, Sabatier, Julia, Broca, Christophe, Gilon, Patrick, Costes, Safia, Bertrand, Gyslaine, Ravier, Magalie A.

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The nuclear receptor REV-ERBα is implicated in the alteration of β-cell autophagy and survival under diabetogenic conditions von Brown, Matthew R., Laouteouet, Damien, Delobel, Morgane, Villard, Orianne, Broca, Christophe, Bertrand, Gyslaine, Wojtusciszyn, Anne, Dalle, Stéphane, Ravier, Magalie A., Matveyenko, Aleksey V., Costes, Safia

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Targeting protein misfolding to protect pancreatic beta-cells in type 2 diabetes von Costes, Safia

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The CDK4–pRB–E2F1 pathway controls insulin secretion von Annicotte, Jean-Sébastien, Blanchet, Emilie, Chavey, Carine, Iankova, Irena, Costes, Safia, Assou, Said, Teyssier, Jacques, Dalle, Stéphane, Sardet, Claude, Fajas, Lluis

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Calcium-activated Calpain-2 Is a Mediator of Beta Cell Dysfunction and Apoptosis in Type 2 Diabetes von Huang, Chang-jiang, Gurlo, Tatyana, Haataja, Leena, Costes, Safia, Daval, Marie, Ryazantsev, Sergey, Wu, Xiuji, Butler, Alexandra E., Butler, Peter C.

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Insulin-Degrading Enzyme Inhibition, a Novel Therapy for Type 2 Diabetes? von Costes, Safia, Butler, Peter C.

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Degradation of cAMP-Responsive Element–Binding Protein by the Ubiquitin-Proteasome Pathway Contributes to Glucotoxicity in β-Cells and Human Pancreatic Islets von COSTES, Safia, VANDEWALLE, Brigitte, DALLE, Stéphane, TOURREL-CUZIN, Cécile, BROCA, Christophe, LINCK, Nathalie, BERTRAND, Gyslaine, KERR-CONTE, Julie, PORTHA, Bernard, PATTOU, François, BOCKAERT, Joel

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Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity von Rivera, Jacqueline F, Costes, Safia, Gurlo, Tatyana, Glabe, Charles G, Butler, Peter C

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Activation of Melatonin Signaling Promotes β-Cell Survival and Function von Costes, Safia, Boss, Marti, Thomas, Anthony P, Matveyenko, Aleksey V

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β-Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few? von COSTES, Safia, LANGEN, Ralf, GURLO, Tatyana, MATVEYENKO, Aleksey V, BUTLER, Peter C

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UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: Evidence of interplay between the ubiquitin/proteasome system and autophagy von Costes, Safia, Gurlo, Tatyana, Rivera, Jacqueline F, Butler, Peter C

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Erratum. β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide–Induced UCH-L1 Deficiency. Diabetes 2011;60:227–238 von Costes, Safia, Huang, Chang-jiang, Gurlo, Tatyana, Daval, Marie, Matveyenko, Aleksey V., Rizza, Robert A., Butler, Alexandra E., Butler, Peter C.

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GLP-1 Mediates Antiapoptotic Effect by Phosphorylating Bad through a β-Arrestin 1-mediated ERK1/2 Activation in Pancreatic β-Cells von Quoyer, Julie, Longuet, Christine, Broca, Christophe, Linck, Nathalie, Costes, Safia, Varin, Elodie, Bockaert, Joël, Bertrand, Gyslaine, Dalle, Stéphane

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325-LB: Circadian Clock Nuclear Receptor REV-ERBa Is a Novel Regulator of Beta-Cell Function, Survival, and Autophagy under Diabetogenic Conditions von COSTES, SAFIA, LAOUTEOUET, DAMIEN, RAVIER, MAGALIE A., DELOBEL, MORGANE, BERTRAND, GYSLAINE, DALLE, STéPHANE, MATVEYENKO, ALEKSEY

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β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide-Induced UCH-L1 Deficiency von COSTES, Safia, HUANG, Chang-Jiang, GURLO, Tatyana, DAVAL, Marie, MATVEYENKO, Aleksey V, RIZZA, Robert A, BUTLER, Alexandra E, BUTLER, Peter C

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Glucagon Promotes cAMP-response Element-binding Protein Phosphorylation via Activation of ERK1/2 in MIN6 Cell Line and Isolated Islets of Langerhans von Dalle, Stéphane, Longuet, Christine, Costes, Safia, Broca, Christophe, Faruque, Omar, Fontés, Ghislaine, Hani, El Habib, Bataille, Dominique

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ERK1/2 Control Phosphorylation and Protein Level of cAMP-Responsive Element–Binding Protein von Costes, Safia, Broca, Christophe, Bertrand, Gyslaine, Lajoix, Anne-Dominique, Bataille, Dominique, Bockaert, Joel, Dalle, Stéphane

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Cyclin-Dependent Kinase 5 Promotes Pancreatic β-Cell Survival via Fak-Akt Signaling Pathways von DAVAL, Marie, GURLO, Tatyana, COSTES, Safia, HUANG, Chang-Jiang, BUTLER, Peter C

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ERK1 is dispensable for mouse pancreatic beta cell function but is necessary for glucose-induced full activation of MSK1 and CREB von Leduc, Michele, Richard, Joy, Costes, Safia, Muller, Dany, Varrault, Annie, Compan, Vincent, Mathieu, Julia, Tanti, Jean-François, Pagès, Gilles, Pouyssegur, Jacques, Bertrand, Gyslaine, Dalle, Stéphane, Ravier, Magalie A.

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