A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress von Egger, Tom, Bordignon, Benoît, Coquelle, Arnaud

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Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription von Tuduri, Sandie, Crabbé, Laure, Conti, Chiara, Tourrière, Hélène, Holtgreve-Grez, Heidi, Jauch, Anna, Pantesco, Véronique, De Vos, John, Thomas, Aubin, Theillet, Charles, Pommier, Yves, Tazi, Jamal, Coquelle, Arnaud, Pasero, Philippe

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Inhibition of Ataxia-Telangiectasia Mutated and RAD3-Related ( ATR ) Overcomes Oxaliplatin Resistance and Promotes Antitumor Immunity in Colorectal Cancer von Combès, Eve, Andrade, Augusto F, Tosi, Diego, Michaud, Henri-Alexandre, Coquel, Flavie, Garambois, Veronique, Desigaud, Delphine, Jarlier, Marta, Coquelle, Arnaud, Pasero, Philippe, Bonnefoy, Nathalie, Moreaux, Jerome, Martineau, Pierre, Del Rio, Maguy, Beijersbergen, Roderick L, Vezzio-Vie, Nadia, Gongora, Celine

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MAPK14/p38α confers irinotecan resistance to TP53-defective cells by inducing survival autophagy von Paillas, Salome, Causse, Annick, Marzi, Laetitia, de Medina, Philippe, Poirot, Marc, Denis, Vincent, Vezzio-Vie, Nadia, Espert, Lucile, Arzouk, Hayat, Coquelle, Arnaud, Martineau, Pierre, Del Rio, Maguy, Pattingre, Sophie, Gongora, Céline

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New Topoisomerase I mutations are associated with resistance to camptothecin von Gongora, Céline, Vezzio-Vie, Nadia, Tuduri, Sandie, Denis, Vincent, Causse, Annick, Auzanneau, Céline, Collod-Beroud, Gwenaëlle, Coquelle, Arnaud, Pasero, Philippe, Pourquier, Philippe, Martineau, Pierre, Del Rio, Maguy

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Tax impairs DNA replication forks and increases DNA breaks in specific oncogenic genome regions von Chaib-Mezrag, Hassiba, Lemaçon, Delphine, Fontaine, Hélène, Bellon, Marcia, Bai, Xue Tao, Drac, Marjorie, Coquelle, Arnaud, Nicot, Christophe

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Does interference between replication and transcription contribute to genomic instability in cancer cells? von Tuduri, Sandie, Crabbe, Laure, Tourrière, Hélène, Coquelle, Arnaud, Pasero, Philippe

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Expression of Fragile Sites Triggers Intrachromosomal Mammalian Gene Amplification and Sets Boundaries to Early Amplicons von Coquelle, Arnaud, Pipiras, Eva, Toledo, Franck, Buttin, Gérard, Debatisse, Michelle

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Dicer prevents genome instability in response to replication stress von Fragkos, Michalis, Barra, Viviana, Egger, Tom, Bordignon, Benoit, Lemacon, Delphine, Naim, Valeria, Coquelle, Arnaud

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Patients With Colorectal Tumors With Microsatellite Instability and Large Deletions in HSP110 T17 Have Improved Response to 5-Fluorouracil–Based Chemotherapy von Collura, Ada, Lagrange, Anaïs, Svrcek, Magali, Marisa, Laetitia, Buhard, Olivier, Guilloux, Agathe, Wanherdrick, Kristell, Dorard, Coralie, Taieb, Anna, Saget, Arnaud, Loh, Marie, Soong, Richie, Zeps, Nikolajs, Platell, Cameron, Mews, Andrew, Iacopetta, Barry, De Thonel, Aurélie, Seigneuric, Renaud, Marcion, Guillaume, Chapusot, Caroline, Lepage, Come, Bouvier, Anne–Marie, Gaub, Marie–Pierre, Milano, Gérard, Selves, Janick, Senet, Patrick, Delarue, Patrice, Arzouk, Hayat, Lacoste, Claire, Coquelle, Arnaud, Bengrine–Lefèvre, Leila, Tournigand, Christophe, Lefèvre, Jérémie H, Parc, Yann, Biard, Denis S, Fléjou, Jean–François, Garrido, Carmen, Duval, Alex

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Induction of multiple double-strand breaks within an hsr by meganucleaseI-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rear... von Coquelle, Arnaud, Rozier, Lorène, Dutrillaux, Bernard, Debatisse, Michelle

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Synergistic efficacy of 3n-butyrate and 5-fluorouracil in human colorectal cancer xenografts via modulation of DNA synthesis von Bras–Gonçalves, Rui Alberto, Pocard, Marc, Poirson–Bichat, Florence, de Pinieux, Gonzague, Pandrea, Ivona, Arvelo, Francisco, Ronco, Gino, Villa, Pierre, Coquelle, Arnaud, Milano, Gérard, Dutrillaux, Bernard, Poupon, Marie–France, Formento, Jean–Louis, Lesuffleur, Thécla

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NF-κB constitutes a potential therapeutic target in high-risk myelodysplastic syndrome von Braun, Thorsten, Carvalho, Gabrielle, Coquelle, Arnaud, Vozenin, Marie-Catherine, Lepelley, Pascale, Hirsch, François, Kiladjian, Jean-Jacques, Ribrag, Vincent, Fenaux, Pierre, Kroemer, Guido

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Apoptosis regulation in tetraploid cancer cells von Castedo, Maria, Coquelle, Arnaud, Vivet, Sonia, Vitale, Ilio, Kauffmann, Audrey, Dessen, Philippe, Pequignot, Marie O, Casares, Noelia, Valent, Alexandre, Mouhamad, Shahul, Schmitt, Elise, Modjtahedi, Nazanine, Vainchenker, William, Zitvogel, Laurence, Lazar, Vladimir, Garrido, Carmen, Kroemer, Guido

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Abstract A147: Synthetic lethality screening reveals ATR as responsible for oxaliplatin resistance in colorectal cancer cells von Combes, Eve, Faria Andrade, Augusto, Tosi, Diego, Coquel, Flavie, Désigaud, Delphine, Garambois, Veronique, Coquelle, Arnaud, Martineau, Pierre, Del Rio, Maguy, Pasero, Philippe, Moreaux, Jerome, Beijersbergen, Roderick, Vie, Nadia, Gongora, Céline

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Selective Resistance of Tetraploid Cancer Cells against DNA Damage-Induced Apoptosis von CASTEDO, MARIA, COQUELLE, ARNAUD, VITALE, ILIO, VIVET, SONIA, MOUHAMAD, SHAHUL, VIAUD, SOPHIE, ZITVOGEL, LAURENCE, KROEMER, GUIDO

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Non-homologous end-joining genes are not inactivated in human radiation-induced sarcomas with genomic instability von Lefèvre, Sandrine H, Coquelle, Arnaud, Gonin-Laurent, Nathalie, Cör, Andrej, Vogt, Nicolas, Chauveinc, Laurent, Anract, Philippe, Dutrillaux, Bernard, Chevillard, Sylvie, Malfoy, Bernard

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A New Role for Hypoxia in Tumor Progression: Induction of Fragile Site Triggering Genomic Rearrangements and Formation of Complex DMs and HSRs von Coquelle, Arnaud, Toledo, Franck, Stern, Sabine, Bieth, Anne, Debatisse, Michelle

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Induction of multiple double-strand breaks within an hsr by meganuclease I-SceI expression or fragile site activation leads to formation of double minutes and other chromosomal rea... von COQUELLE, Arnaud, ROZIER, Lorène, DUTRILLAUX, Bernard, DEBATISSE, Michelle

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Tax impairs DNA replication forks and increases DNA breaks in specific oncogenic genome regions von Chaib-Mezrag, Hassiba, Lemaçon, Delphine, Fontaine, Hélène, Bellon, Marcia, Tao Bai, Xue, Drac, Marjorie, Coquelle, Arnaud, Nicot, Christophe

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