SillyPutty: Improved clustering by optimizing the silhouette width von Bombina, Polina, Tally, Dwayne, Abrams, Zachary B, Coombes, Kevin R

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A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition von Mak, Milena P, Tong, Pan, Diao, Lixia, Cardnell, Robert J, Gibbons, Don L, William, William N, Skoulidis, Ferdinandos, Parra, Edwin R, Rodriguez-Canales, Jaime, Wistuba, Ignacio I, Heymach, John V, Weinstein, John N, Coombes, Kevin R, Wang, Jing, Byers, Lauren Averett

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Human papillomavirus and the landscape of secondary genetic alterations in oral cancers von Gillison, Maura L, Akagi, Keiko, Xiao, Weihong, Jiang, Bo, Pickard, Robert K L, Li, Jingfeng, Swanson, Benjamin J, Agrawal, Amit D, Zucker, Mark, Stache-Crain, Birgit, Emde, Anne-Katrin, Geiger, Heather M, Robine, Nicolas, Coombes, Kevin R, Symer, David E

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Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus von James, Michael A, Wen, Weidong, Wang, Yian, Byers, Lauren A, Heymach, John V, Coombes, Kevin R, Girard, Luc, Minna, John, You, Ming

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Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia von Shojaee, Seyedmehdi, Caeser, Rebecca, Buchner, Maike, Park, Eugene, Swaminathan, Srividya, Hurtz, Christian, Geng, Huimin, Chan, Lai N., Klemm, Lars, Hofmann, Wolf-Karsten, Qiu, Yi Hua, Zhang, Nianxiang, Coombes, Kevin R., Paietta, Elisabeth, Molkentin, Jeffery, Koeffler, H. Phillip, Willman, Cheryl L., Hunger, Stephen P., Melnick, Ari, Kornblau, Steven M., Müschen, Markus

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Mercator: a pipeline for multi-method, unsupervised visualization and distance generation von Abrams, Zachary B., Coombes, Caitlin E., Li, Suli, Coombes, Kevin R.

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A novel model to label delirium in an intensive care unit from clinician actions von Coombes, Caitlin E, Coombes, Kevin R, Fareed, Naleef

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Preclinical Evaluation of the Novel BTK Inhibitor Acalabrutinib in Canine Models of B-Cell Non-Hodgkin Lymphoma von Harrington, Bonnie K, Gardner, Heather L, Izumi, Raquel, Hamdy, Ahmed, Rothbaum, Wayne, Coombes, Kevin R, Covey, Todd, Kaptein, Allard, Gulrajani, Michael, Van Lith, Bart, Krejsa, Cecile, Coss, Christopher C, Russell, Duncan S, Zhang, Xiaoli, Urie, Bridget K, London, Cheryl A, Byrd, John C, Johnson, Amy J, Kisseberth, William C

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Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells von Sun, Michael, Estrov, Zeev, Ji, Yuan, Coombes, Kevin R, Harris, David H, Kurzrock, Razelle

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Thresher: determining the number of clusters while removing outliers von Wang, Min, Abrams, Zachary B, Kornblau, Steven M, Coombes, Kevin R

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Sequences of Events from the Electronic Medical Record and the Onset of Infection von Coombes, Caitlin E., Coombes, Kevin R., Fareed, Naleef

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Unsupervised machine learning and prognostic factors of survival in chronic lymphocytic leukemia von Coombes, Caitlin E, Abrams, Zachary B, Li, Suli, Abruzzo, Lynne V, Coombes, Kevin R

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Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1 von Byers, Lauren Averett, Wang, Jing, Nilsson, Monique B, Fujimoto, Junya, Saintigny, Pierre, Yordy, John, Giri, Uma, Peyton, Michael, Fan, You Hong, Diao, Lixia, Masrorpour, Fatemeh, Shen, Li, Liu, Wenbin, Duchemann, Boris, Tumula, Praveen, Bhardwaj, Vikas, Welsh, James, Weber, Stephanie, Glisson, Bonnie S, Kalhor, Neda, Wistuba, Ignacio I, Girard, Luc, Lippman, Scott M, Mills, Gordon B, Coombes, Kevin R, Weinstein, John N, Minna, John D, Heymach, John V

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Prognostic biomarkers for esophageal adenocarcinoma identified by analysis of tumor transcriptome von Kim, Soo Mi, Park, Yun-Yong, Park, Eun Sung, Cho, Jae Yong, Izzo, Julie G, Zhang, Di, Kim, Sang-Bae, Lee, Jeffrey H, Bhutani, Manoop S, Swisher, Stephen G, Wu, Xifeng, Coombes, Kevin R, Maru, Dipen, Wang, Kenneth K, Buttar, Navtej S, Ajani, Jaffer A, Lee, Ju-Seog

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Prognostic impact and targeting of CRM1 in acute myeloid leukemia von Kojima, Kensuke, Kornblau, Steven M., Ruvolo, Vivian, Dilip, Archana, Duvvuri, Seshagiri, Davis, R. Eric, Zhang, Min, Wang, Zhiqiang, Coombes, Kevin R., Zhang, Nianxiang, Qiu, Yi Hua, Burks, Jared K., Kantarjian, Hagop, Shacham, Sharon, Kauffman, Michael, Andreeff, Michael

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Effect of KRAS Oncogene Substitutions on Protein Behavior: Implications for Signaling and Clinical Outcome von Ihle, Nathan T., Byers, Lauren A., Kim, Edward S., Saintigny, Pierre, Lee, J. Jack, Blumenschein, George R., Tsao, Anne, Liu, Suyu, Larsen, Jill E., Wang, Jing, Diao, Lixia, Coombes, Kevin R., Chen, Lu, Zhang, Shuxing, Abdelmelek, Mena F., Tang, Ximing, Papadimitrakopoulou, Vassiliki, Minna, John D., Lippman, Scott M., Hong, Waun K., Herbst, Roy S., Wistuba, Ignacio I., Heymach, John V., Powis, Garth

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A protocol to evaluate RNA sequencing normalization methods von Abrams, Zachary B, Johnson, Travis S, Huang, Kun, Payne, Philip R O, Coombes, Kevin

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Proteomic profiling identifies distinct protein patterns in acute myelogenous leukemia CD34+CD38- stem-like cells von Kornblau, Steven M, Qutub, Amina, Yao, Hui, York, Heather, Qiu, Yi Hua, Graber, David, Ravandi, Farhad, Cortes, Jorge, Andreeff, Michael, Zhang, Nianxiang, Coombes, Kevin R

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Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities von Skoulidis, Ferdinandos, Byers, Lauren A, Diao, Lixia, Papadimitrakopoulou, Vassiliki A, Tong, Pan, Izzo, Julie, Behrens, Carmen, Kadara, Humam, Parra, Edwin R, Canales, Jaime Rodriguez, Zhang, Jianjun, Giri, Uma, Gudikote, Jayanthi, Cortez, Maria A, Yang, Chao, Fan, Youhong, Peyton, Michael, Girard, Luc, Coombes, Kevin R, Toniatti, Carlo, Heffernan, Timothy P, Choi, Murim, Frampton, Garrett M, Miller, Vincent, Weinstein, John N, Herbst, Roy S, Wong, Kwok-Kin, Zhang, Jianhua, Sharma, Padmanee, Mills, Gordon B, Hong, Waun K, Minna, John D, Allison, James P, Futreal, Andrew, Wang, Jing, Wistuba, Ignacio I, Heymach, John V

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Simulation-derived best practices for clustering clinical data von Coombes, Caitlin E., Liu, Xin, Abrams, Zachary B., Coombes, Kevin R., Brock, Guy

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