RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL von Lawlor, Kate E., Khan, Nufail, Mildenhall, Alison, Gerlic, Motti, Croker, Ben A., D’Cruz, Akshay A., Hall, Cathrine, Kaur Spall, Sukhdeep, Anderton, Holly, Masters, Seth L., Rashidi, Maryam, Wicks, Ian P., Alexander, Warren S., Mitsuuchi, Yasuhiro, Benetatos, Christopher A., Condon, Stephen M., Wong, W. Wei-Lynn, Silke, John, Vaux, David L., Vince, James E.

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Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics von Lalaoui, Najoua, Hänggi, Kay, Brumatti, Gabriela, Chau, Diep, Nguyen, Nhu-Y.N., Vasilikos, Lazaros, Spilgies, Lisanne M., Heckmann, Denise A., Ma, Chunyan, Ghisi, Margherita, Salmon, Jessica M., Matthews, Geoffrey M., de Valle, Elisha, Moujalled, Donia M., Menon, Manoj B., Spall, Sukhdeep Kaur, Glaser, Stefan P., Richmond, Jennifer, Lock, Richard B., Condon, Stephen M., Gugasyan, Raffi, Gaestel, Matthias, Guthridge, Mark, Johnstone, Ricky W., Munoz, Lenka, Wei, Andrew, Ekert, Paul G., Vaux, David L., Wong, W. Wei-Lynn, Silke, John

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Smac Mimetics Activate the E3 Ligase Activity of cIAP1 Protein by Promoting RING Domain Dimerization von Feltham, Rebecca, Bettjeman, Bodhi, Budhidarmo, Rhesa, Mace, Peter D., Shirley, Sarah, Condon, Stephen M., Chunduru, Srinivas K., McKinlay, Mark A., Vaux, David L., Silke, John, Day, Catherine L.

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Bivalent IAP antagonists inhibit TRAF2-bound cIAPs and limit TNF-mediated NF-κB signaling von Condon, Stephen M

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Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase von Nakatani, Yoshio, Kleffmann, Torsten, Linke, Katrin, Condon, Stephen M, Hinds, Mark G, Day, Catherine L

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Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies von Condon, Stephen M, Mitsuuchi, Yasuhiro, Deng, Yijun, LaPorte, Matthew G, Rippin, Susan R, Haimowitz, Thomas, Alexander, Matthew D, Kumar, Pavan Tirunahari, Hendi, Mukta S, Lee, Yu-Hua, Benetatos, Christopher A, Yu, Guangyao, Kapoor, Gurpreet Singh, Neiman, Eric, Seipel, Martin E, Burns, Jennifer M, Graham, Martin A, McKinlay, Mark A, Li, Xiaochun, Wang, Jiawei, Shi, Yigong, Feltham, Rebecca, Bettjeman, Bodhi, Cumming, Mathew H, Vince, James E, Khan, Nufail, Silke, John, Day, Catherine L, Chunduru, Srinivas K

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TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFα von Vince, James E, Chau, Diep, Callus, Bernard, Wong, W. Wei-Lynn, Hawkins, Christine J, Schneider, Pascal, McKinlay, Mark, Benetatos, Christopher A, Condon, Stephen M, Chunduru, Srinivas K, Yeoh, George, Brink, Robert, Vaux, David L, Silke, John

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Combination of IAP antagonist and IFNγ activates novel caspase-10- and RIPK1-dependent cell death pathways von Tanzer, Maria C, Khan, Nufail, Rickard, James A, Etemadi, Nima, Lalaoui, Najoua, Spall, Sukhdeep Kaur, Hildebrand, Joanne M, Segal, David, Miasari, Maria, Chau, Diep, Wong, WendyWei-Lynn, McKinlay, Mark, Chunduru, Srinivas K, Benetatos, Christopher A, Condon, Stephen M, Vince, James E, Herold, Marco J, Silke, John

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Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics von Lalaoui, Najoua, Hänggi, Kay, Brumatti, Gabriela, Chau, Diep, Nguyen, Nhu-Y.N., Vasilikos, Lazaros, Spilgies, Lisanne M., Heckmann, Denise A., Ma, Chunyan, Ghisi, Margherita, Salmon, Jessica M., Matthews, Geoffrey M., de Valle, Elisha, Moujalled, Donia M., Menon, Manoj B., Spall, Sukhdeep Kaur, Glaser, Stefan P., Richmond, Jennifer, Lock, Richard B., Condon, Stephen M., Gugasyan, Raffi, Gaestel, Matthias, Guthridge, Mark, Johnstone, Ricky W., Munoz, Lenka, Wei, Andrew, Ekert, Paul G., Vaux, David L., Wong, W. Wei-Lynn, Silke, John

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Process Development of the Soft Histone Deacetylate Enzyme Inhibitor SHP-141: Acylation of Methyl Paraben and Suberyl Hydroxamic Acid Formation von Deng, Yijun, Ng DiMarco, Christina, Vakhilt, Tanya, Jonas, Marco, White, Jaclyn, Arefyev, Dennis, Tokala, Ramachandar, Akhtar, Parveen, Zhu, Lei, Sun, Xufeng, Haimowitz, Thomas, Condon, Stephen M

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Process Development and Synthesis of Birinapant: Large Scale Preparation and Acid-Mediated Dimerization of the Key Indole Intermediate von Deng, Yijun, Xie, Qiuzhe, LaPorte, Matthew G, Chasnoff, Anna T. A, Mortensen, Mark A, Patra, Debasis, Putrelo, Seth A, Antonovich, Robert S, Cao, Hong, Yan, Jun, Cooper, Arthur J, Rippin, Susan R, Alexander, Matthew D, Kumar, Pavan Tirunahari, Hendi, Mukta S, Lee, Yu-Hua, Haimowitz, Thomas, Condon, Stephen M

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The discovery and structure–activity relationships of pyrano[3,4- b]indole-based inhibitors of hepatitis C virus NS5B polymerase von Jackson, Randy W., LaPorte, Matthew G., Herbertz, Torsten, Draper, Tandy L., Gaboury, Janet A., Rippin, Susan R., Patel, Ravi, Chunduru, Srinivas K., Benetatos, Christopher A., Young, Dorothy C., Burns, Christopher J., Condon, Stephen M.

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Electrophilic Oxidation and [1,2]-Rearrangement of the Biindole Core of Birinapant von Deng, Yijun, Haimowitz, Thomas, LaPorte, Matthew G, Rippin, Susan R, Alexander, Matthew D, Kumar, Pavan Tirunahari, Hendi, Mukta S, Lee, Yu-Hua, Condon, Stephen M

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The discovery and structure–activity relationships of pyrano[3,4- b]indole based inhibitors of hepatitis C virus NS5B polymerase von LaPorte, Matthew G., Draper, Tandy L., Miller, Lori E., Blackledge, Charles W., Leister, Lara K., Amparo, Eugene, Hussey, Alison R., Young, Dorothy C., Chunduru, Srinivas K., Benetatos, Christopher A., Rhodes, Gerry, Gopalsamy, Ariamala, Herbertz, Torsten, Burns, Christopher J., Condon, Stephen M.

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Identification and characterization of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones as inhibitors of the fatty acid transporter FATP4 von Blackburn, Christopher, Guan, Bing, Brown, James, Cullis, Courtney, Condon, Stephen M., Jenkins, Tracy J., Peluso, Stephane, Ye, Yingchun, Gimeno, Ruth E., Punreddy, Sandhya, Sun, Ying, Wu, Hui, Hubbard, Brian, Kaushik, Virendar, Tummino, Peter, Sanchetti, Praveen, Yu Sun, Dong, Daniels, Tom, Tozzo, Effie, Balani, Suresh K., Raman, Prakash

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Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models von Benetatos, Christopher A, Mitsuuchi, Yasuhiro, Burns, Jennifer M, Neiman, Eric M, Condon, Stephen M, Yu, Guangyao, Seipel, Martin E, Kapoor, Gurpreet S, Laporte, Matthew G, Rippin, Susan R, Deng, Yijun, Hendi, Mukta S, Tirunahari, Pavan K, Lee, Yu-Hua, Haimowitz, Thomas, Alexander, Matthew D, Graham, Martin A, Weng, David, Shi, Yigong, McKinlay, Mark A, Chunduru, Srinivas K

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IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis von Vince, James E., Wong, W. Wei-Lynn, Khan, Nufail, Feltham, Rebecca, Chau, Diep, Ahmed, Afsar U., Benetatos, Christopher A., Chunduru, Srinivas K., Condon, Stephen M., McKinlay, Mark, Brink, Robert, Leverkus, Martin, Tergaonkar, Vinay, Schneider, Pascal, Callus, Bernard A., Koentgen, Frank, Vaux, David L., Silke, John

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Bivalent IAP antagonists inhibit TRAF2-bound cIAPs and limit TNF-mediated NF-[kappa]B signaling von Condon, Stephen M

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The Discovery of Pyrano[3,4-b]indole-Based Allosteric Inhibitors of HCV NS5B Polymerase with In Vivo Activity von LaPorte, Matthew G., Jackson, Randy W., Draper, Tandy L., Gaboury, Janet A., Galie, Kristin, Herbertz, Torsten, Hussey, Alison R., Rippin, Susan R., Benetatos, Christopher A., Chunduru, Srinivas K., Christensen, Joel S., Coburn, Glen A., Rizzo, Christopher J., Rhodes, Gerry, O'Connell, John, Howe, Anita Y. M., Mansour, Tarek S., Collett, Marc S., Pevear, Daniel C., Young, Dorothy C., Gao, Tiejun, Tyrrell , D. Lorne J., Kneteman, Norman M., Burns, Christopher J., Condon, Stephen M.

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A Unified Total Synthesis of the Immunomodulators (−)-Rapamycin and (−)-27-Demethoxyrapamycin:  Construction of the C(21−42) Perimeters von Smith, Amos B, Condon, Stephen M, McCauley, John A, Leazer, Johnnie L, Leahy, James W, Maleczka, Robert E

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