Discovery of a Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitor for the Potential Treatment of Schizophrenia von Bartolomé-Nebreda, José Manuel, Delgado, Francisca, Martín-Martín, María Luz, Martínez-Viturro, Carlos M, Pastor, Joaquín, Tong, Han Min, Iturrino, Laura, Macdonald, Gregor J, Sanderson, Wendy, Megens, Anton, Langlois, Xavier, Somers, Marijke, Vanhoof, Greet, Conde-Ceide, Susana

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Galmic, a Nonpeptide Galanin Receptor Agonist, Affects Behaviors in Seizure, Pain, and Forced-Swim Tests von Bartfai, Tamas, Lu, Xiaoying, Badie-Mahdavi, Hedieh, Barr, Alasdair M., Mazarati, Andrey, Hua, Xiao-Ying, Yaksh, Tony, Haberhauer, Gebhard, Ceide, Susana Conde, Trembleau, Laurent, Somogyi, Laszlo, Kröck, Lenz, Rebek, Julius

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Optimization of α-ketoamide based p38 inhibitors through modifications to the region that binds to the allosteric site von Montalban, Antonio Garrido, Boman, Erik, Chang, Chau-Dung, Ceide, Susana Conde, Dahl, Russell, Dalesandro, David, Delaet, Nancy G.J., Erb, Eric, Ernst, Justin T., Gibbs, Andrew, Kahl, Jeffrey, Kessler, Linda, Kucharski, Jeff, Lum, Christopher, Lundström, Jan, Miller, Stephen, Nakanishi, Hiroshi, Roberts, Edward, Saiah, Eddine, Sullivan, Robert, Urban, Jan, Wang, Zhijun, Larson, Christopher J.

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KR-003048, a potent, orally active inhibitor of p38 mitogen-activated protein kinase von Montalban, Antonio Garrido, Boman, Erik, Chang, Chau-Dung, Ceide, Susana Conde, Dahl, Russell, Dalesandro, David, Delaet, Nancy G.J., Erb, Eric, Ernst, Justin, Gibbs, Andrew, Kahl, Jeffrey, Kessler, Linda, Lundström, Jan, Miller, Stephen, Nakanishi, Hiroshi, Roberts, Edward, Saiah, Eddine, Sullivan, Robert, Wang, Zhijun, Larson, Christopher J.

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The design and synthesis of novel α-ketoamide-based p38 MAP kinase inhibitors von Montalban, Antonio Garrido, Boman, Erik, Chang, Chau-Dung, Ceide, Susana Conde, Dahl, Russell, Dalesandro, David, Delaet, Nancy G.J., Erb, Eric, Ernst, Justin T., Gibbs, Andrew, Kahl, Jeffrey, Kessler, Linda, Lundström, Jan, Miller, Stephen, Nakanishi, Hiroshi, Roberts, Edward, Saiah, Eddine, Sullivan, Robert, Wang, Zhijun, Larson, Christopher J.

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‘Reverse’ α-ketoamide-based p38 MAP kinase inhibitors von Montalban, Antonio Garrido, Boman, Erik, Chang, Chau-Dung, Ceide, Susana Conde, Dahl, Russell, Dalesandro, David, Delaet, Nancy G.J., Erb, Eric, Gibbs, Andrew, Kahl, Jeff, Kessler, Linda, Lundström, Jan, Miller, Stephen, Nakanishi, Hiroshi, Roberts, Ed, Saiah, Eddine, Sullivan, Robert, Wang, Zhijun, Larson, Christopher J.

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Synthesis of Galmic: A Nonpeptide Galanin Receptor Agonist von Ceide, Susana Conde, Trembleau, Laurent, Haberhauer, Gebhard, Somogyi, Laszlo, Lu, Xiaoying, Bartfai, Tamas, Rebek, Julius

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Inhibition of the Alanine-Serine-Cysteine‑1 Transporter by BMS-466442 von Torrecillas, Ivan R, Conde-Ceide, Susana, de Lucas, Ana Isabel, Garcı́a Molina, Aránzazu, Trabanco, Andrés A, Lavreysen, Hilde, Pardo, Leonardo, Tresadern, Gary

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Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia von Conde-Ceide, Susana, Martínez-Viturro, Carlos M., Alcázar, Jesús, Garcia-Barrantes, Pedro M., Lavreysen, Hilde, Mackie, Claire, Vinson, Paige N., Rook, Jerri M., Bridges, Thomas M., Daniels, J. Scott, Megens, Anton, Langlois, Xavier, Drinkenburg, Wilhelmus H., Ahnaou, Abdellah, Niswender, Colleen M., Jones, Carrie K., Macdonald, Gregor J., Steckler, Thomas, Conn, P. Jeffrey, Stauffer, Shaun R., Bartolomé-Nebreda, José Manuel, Lindsley, Craig W.

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Identification of a Novel Orally Bioavailable Phosphodiesterase 10A (PDE10A) Inhibitor with Efficacy in Animal Models of Schizophrenia von Bartolomé-Nebreda, José Manuel, Alonso de Diego, Sergio A, Artola, Marta, Delgado, Francisca, Delgado, Óscar, Martín-Martín, María Luz, Martínez-Viturro, Carlos M, Pena, Miguel Ángel, Tong, Han Min, Van Gool, Michiel, Alonso, José Manuel, Fontana, Alberto, Macdonald, Gregor J, Megens, Anton, Langlois, Xavier, Somers, Marijke, Vanhoof, Greet, Conde-Ceide, Susana

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Dihydrothiazolopyridone Derivatives as a Novel Family of Positive Allosteric Modulators of the Metabotropic Glutamate 5 (mGlu5) Receptor von Bartolomé-Nebreda, José Manuel, Conde-Ceide, Susana, Delgado, Francisca, Iturrino, Laura, Pastor, Joaquín, Pena, Miguel Ángel, Trabanco, Andrés A, Tresadern, Gary, Wassvik, Carola M, Stauffer, Shaun R, Jadhav, Satyawan, Gogi, Kiran, Vinson, Paige N, Noetzel, Meredith J, Days, Emily, Weaver, C. David, Lindsley, Craig W, Niswender, Colleen M, Jones, Carrie K, Conn, P. Jeffrey, Rombouts, Frederik, Lavreysen, Hilde, Macdonald, Gregor J, Mackie, Claire, Steckler, Thomas

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Further optimization of the mGlu5 PAM clinical candidate VU0409551/JNJ-46778212: Progress and challenges towards a back-up compound von Zhou, Ya, Malosh, Chrysa, Conde-Ceide, Susana, Martínez-Viturro, Carlos Manuel, Alcázar, Jesus, Lavreysen, Hilde, Mackie, Claire, Bridges, Thomas M., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Macdonald, Gregor J., Steckler, Thomas, Conn, P. Jeffrey, Stauffer, Shaun R., Bartolomé-Nebreda, José Manuel, Lindsley, Craig W.

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Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical mod... von Conde-Ceide, Susana, Alcázar, Jesús, Alonso de Diego, Sergio A., López, Silvia, Martín-Martín, María Luz, Martínez-Viturro, Carlos M., Pena, Miguel-Angel, Tong, Han Min, Lavreysen, Hilde, Mackie, Claire, Bridges, Thomas M., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Macdonald, Gregor J., Steckler, Thomas, Conn, P. Jeffrey, Stauffer, Shaun R., Lindsley, Craig W., Bartolomé-Nebreda, José Manuel

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Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu5) von Turlington, Mark, Malosh, Chrysa, Jacobs, Jon, Manka, Jason T, Noetzel, Meredith J, Vinson, Paige N, Jadhav, Satyawan, Herman, Elizabeth J, Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M, Conde-Ceide, Susana, Martín-Martín, M. Luz, Tong, Han Min, López, Silvia, MacDonald, Gregor J, Steckler, Thomas, Daniels, J. Scott, Weaver, C. David, Niswender, Colleen M, Jones, Carrie K, Conn, P. Jeffrey, Lindsley, Craig W, Stauffer, Shaun R

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Preliminary investigation of 6,7-dihydropyrazolo[1,5- a ]pyrazin-4-one derivatives as a novel series of mGlu 5 receptor positive allosteric modulators with efficacy in preclinical... von Conde-Ceide, Susana, Alcázar, Jesús, Alonso de Diego, Sergio A., López, Silvia, Martín-Martín, María Luz, Martínez-Viturro, Carlos M., Pena, Miguel-Angel, Tong, Han Min, Lavreysen, Hilde, Mackie, Claire, Bridges, Thomas M., Daniels, J. Scott, Niswender, Colleen M., Jones, Carrie K., Macdonald, Gregor J., Steckler, Thomas, Conn, P. Jeffrey, Stauffer, Shaun R., Lindsley, Craig W., Bartolomé-Nebreda, José Manuel

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Discovery and SAR of novel series of imidazopyrimidinones and dihydroimidazopyrimidinones as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5) von Martín-Martín, María Luz, Bartolomé-Nebreda, José Manuel, Conde-Ceide, Susana, Alonso de Diego, Sergio A., López, Silvia, Martínez-Viturro, Carlos M., Tong, Han Min, Lavreysen, Hilde, Macdonald, Gregor J., Steckler, Thomas, Mackie, Claire, Bridges, Thomas M., Daniels, J. Scott, Niswender, Colleen M., Noetzel, Meredith J., Jones, Carrie K., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.

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Acyl dihydropyrazolo[1,5-a]pyrimidinones as metabotropic glutamate receptor 5 positive allosteric modulators von Malosh, Chrysa, Turlington, Mark, Bridges, Thomas M., Rook, Jerri M., Noetzel, Meredith J., Vinson, Paige N., Steckler, Thomas, Lavreysen, Hilde, Mackie, Claire, Bartolomé-Nebreda, José M., Conde-Ceide, Susana, Martínez-Viturro, Carlos M., Piedrafita, María, Sánchez-Casado, M. Rosa, Macdonald, Gregor J., Daniels, J. Scott, Jones, Carrie K., Niswender, Colleen M., Conn, P. Jeffrey, Lindsley, Craig W., Stauffer, Shaun R.

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Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5Modulation of NMDAR Currents von Rook, Jerri M, Xiang, Zixiu, Lv, Xiaohui, Ghoshal, Ayan, Dickerson, Jonathan W, Bridges, Thomas M, Johnson, Kari A, Foster, Daniel J, Gregory, Karen J, Vinson, Paige N, Thompson, Analisa D, Byun, Nellie, Collier, Rebekah L, Bubser, Michael, Nedelcovych, Michael T, Gould, Robert W, Stauffer, Shaun R, Daniels, J Scott, Niswender, Colleen M, Lavreysen, Hilde, Mackie, Claire, Conde-Ceide, Susana, Alcazar, Jesus, Bartolomé-Nebreda, José M, Macdonald, Gregor J, Talpos, John C, Steckler, Thomas, Jones, Carrie K, Lindsley, Craig W, Conn, P Jeffrey

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Biased mGlu 5 -Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu 5 Modulation of NMDAR Currents von Rook, Jerri M., Xiang, Zixiu, Lv, Xiaohui, Ghoshal, Ayan, Dickerson, Jonathan W., Bridges, Thomas M., Johnson, Kari A., Foster, Daniel J., Gregory, Karen J., Vinson, Paige N., Thompson, Analisa D., Byun, Nellie, Collier, Rebekah L., Bubser, Michael, Nedelcovych, Michael T., Gould, Robert W., Stauffer, Shaun R., Daniels, J. Scott, Niswender, Colleen M., Lavreysen, Hilde, Mackie, Claire, Conde-Ceide, Susana, Alcazar, Jesus, Bartolomé-Nebreda, José M., Macdonald, Gregor J., Talpos, John C., Steckler, Thomas, Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey

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Microwave-assisted, efficient and regioselective Pd-catalyzed C-phenylation of halopyrimidines von Ceide, Susana Conde, Montalban, Antonio Garrido

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