Sequential analysis of multistage hepatocarcinogenesis reveals that miR-100 and PLK1 dysregulation is an early event maintained along tumor progression von Petrelli, A, Perra, A, Schernhuber, K, Cargnelutti, M, Salvi, A, Migliore, C, Ghiso, E, Benetti, A, Barlati, S, Ledda-Columbano, G M, Portolani, N, De Petro, G, Columbano, A, Giordano, S

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S-14-03 Role of Nrf2 in chemical carcinogenesis von Columbano, A.

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Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells von Simbula, G, Columbano, A, Ledda-Columbano, G M, Sanna, L, Deidda, M, Diana, A, Pibiri, M

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Reactivation of thyroid hormone receptors in fully developed rat hepatocellular carcinomas causes their regression and prevents lung metastasis von Perra, A, Kowalik, M.A, Cabras, L, Puliga, E, Ledda-Columbano, G.M, Columbano, A

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Narrow-line Seyfert 1 galaxies: an amasing class of AGN von Tarchi, A., Castangia, P., Columbano, A., Panessa, F., Braatz, J. A.

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P0306 : Impairment of autophagy in the early stages of hepatocarcinogenesis von Kowalik, M.A, Perra, A, Falasca, L, Piacentini, M, Ledda-Columbano, G.M, Columbano, A

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Analysis of NRF2-KEAP1 Pathway and Metabolic Reprogramming in Two Distinct Models of Rat Liver Proliferation von Cabras, L, Orrù, C, Perra, A, Morandi, A, Ledda-Columbano, G.M, Columbano, A, Kowalik, M.A

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P59 YES-ASSOCIATED PROTEIN (YAP) IS REQUIRED FOR THE CLONAL EXPANSION OF PRENEOPLASTIC HEPATOCYTES AND OVAL CELL PROLIFERATION von Kowalik, M.A, Perra, A, Ghiso, E, Ledda-Columbano, G.M, Giordano, S, Columbano, A

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P0317 : Down-regulation of Hao2 is associated with the onset and development of hepatocellular carcinoma in rodents von Mattu, S, Perra, A, Menegon, S, Kowalik, M.A, Petrelli, A, Ledda-Columbano, G.M, Giordano, S, Columbano, A

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Induction of pancreatic acinar cell proliferation by thyroid hormone von Ledda-Columbano, G M, Perra, A, Pibiri, M, Molotzu, F, Columbano, A

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Metabolic Reprogramming toward Awarburg Phenotype Characterizes Early Phases of Hepatic Carcinogenesis von Kowalik, M.A, Guzzo, G, Morandi, A, Perra, A, Menegon, S, Masgras, I, Trevisan, E, Angioni, M.M, Fornari, F, Quagliata, L, Ledda-Columbano, G.M, Gramantieri, L, Terracciano, L, Giordano, S, Chiarugi, P, Rasola, A, Columbano, A

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P0397 : Nrf2 mutations are an early and frequent event in the development of rat hepatocellular carcinoma von Columbano, A, Giordano, S, Perra, A, Kowalik, M.A, Ledda-Columbano, G.M, Petrelli, A, Menegon, S, Quagliata, L, Terraciano, L, Zavattari, P

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Mitogenesis by ligands of nuclear receptors: an attractive model for the study of the molecular mechanisms implicated in liver growth von Columbano, A, Ledda-Columbano, G M

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The TRβ-selective agonist, GC-1, stimulates mitochondrial oxidative processes to a lesser extent than triiodothyronine von Venditti, P, Chiellini, G, Di Stefano, L, Napolitano, G, Zucchi, R, Columbano, A, Scanlan, T S, Di Meo, S

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234 ROLE OF YAP IN THE REGULATION OF XENOBIOTIC-INDUCED LIVER ENLARGEMENT AND HCC DEVELOPMENT von Kowalik, M.A, Saliba, C, Pibiri, M, Ledda-Columbano, G.M, Sarotto, I, Ghiso, E, Giordano, S, Columbano, A

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Triiodothyronine stimulates hepatocyte proliferation in two models of impaired liver regeneration von Columbano, A., Simbula, M., Pibiri, M., Perra, A., Deidda, M., Locker, J., Pisanu, A., Uccheddu, A., Ledda-Columbano, G. M.

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In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway von LEDDA-COLUMBANO, G. M, CURTO, M, COLUMBANO, A, PIGA, R, ZEDDA, A. I, MENEGAZZI, M, SARTORI, C, SHINOZUKA, H, BLUETHMANN, H, POLI, V, CILIBERTO, G

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Induction of hepatocyte proliferation by retinoic acid von Ledda-Columbano, G.M., Pibiri, M., Molotzu, F., Cossu, C., Sanna, L., Simbula, G., Perra, A., Columbano, A.

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216 MIR-100 IS DOWNREGULATED FROM EARLY STAGES OF HEPATOCARCINOGENESIS AND CORRELATES WITH OVEREXPRESSION OF ITS TARGET PLK1 von Petrelli, A, Perra, A, Schernhuber, K, Salvi, A, Migliore, C, Ghiso, E, Benetti, A, Ledda-Columbano, G.M, Barlati, S, Portolani, N, de Petro, G, Columbano, A, Giordano, S

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535 THYROID HORMONE RECEPTOR LIGANDS INDUCE REGRESSION OF RAT PRENEOPLASTIC LIVER LESIONS CAUSING THEIR REVERSION TO A DIFFERENTIATED PHENOTYPE von Perra, A, Kowalik, M.A, Pibiri, M, Ledda-Columbano, G.M, Columbano, A

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