Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy von Chuang, Chihyuan, Collibee, Scott, Ashcraft, Luke, Wang, Wenyue, Vander Wal, Mark, Wang, Xiaolin, Hwee, Darren T, Wu, Yangsong, Wang, Jingying, Chin, Eva R, Cremin, Peadar, Zamora, Jeanelle, Hartman, James, Schaletzky, Julia, Wehri, Eddie, Robertson, Laura A, Malik, Fady I, Morgan, Bradley P

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Discovery of Nelutroctiv (CK-136), a Selective Cardiac Troponin Activator for the Treatment of Cardiovascular Diseases Associated with Reduced Cardiac Contractility von Romero, Antonio, Ashcraft, Luke, Chandra, Aroop, DiMassa, Vincent, Cremin, Peadar, Collibee, Scott E., Chuang, Chihyuan, Hartman, James, Hwee, Darren T., St. Jean, David, Malinowski, Justin, DeBenedetto, Mikkel, Moebius, David, Payette, Joshua, Vargas, Richard, Yeoman, John, Motani, Alykhan, Reagan, Jeffrey, Malik, Fady I., Morgan, Bradley P.

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Cardiac Troponin Activator CK-963 Increases Cardiac Contractility in Rats von Collibee, Scott E., Romero, Antonio, Muci, Alexander R., Hwee, Darren T., Chuang, Chihyuan, Hartman, James J., Motani, Alykhan S., Ashcraft, Luke, DeRosier, Andre, Grillo, Mark, Lu, Qing, Malik, Fady I., Morgan, Bradley P.

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Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function von Collibee, Scott E, Bergnes, Gustave, Chuang, Chihyuan, Ashcraft, Luke, Gardina, Jeffrey, Garard, Marc, Jamison, Chris R, Lu, Kevin, Lu, Pu-Ping, Muci, Alexander, Romero, Antonio, Valkevich, Ellen, Wang, Wenyue, Warrington, Jeffrey, Yao, Bing, Durham, Nickie, Hartman, James, Marquez, Anna, Hinken, Aaron, Schaletzky, Julia, Xu, Donghong, Hwee, Darren T, Morgans, David, Malik, Fady I, Morgan, Bradley P

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Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases von Russell, Alan J, Hartman, James J, Hinken, Aaron C, Muci, Alexander R, Kawas, Raja, Driscoll, Lena, Godinez, Guillermo, Lee, Kenneth H, Marquez, David, Browne, William F, Chen, Michael M, Clarke, David, Collibee, Scott E, Garard, Marc, Hansen, Richard, Jia, Zhiheng, Lu, Pu-Ping, Rodriguez, Hector, Saikali, Khalil G, Schaletzky, Julia, Vijayakumar, Vipin, Albertus, Daniel L, Claflin, Dennis R, Morgans, David J, Morgan, Bradley P, Malik, Fady I

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Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator von Collibee, Scott E, Bergnes, Gustave, Muci, Alexander, Browne, William F, Garard, Marc, Hinken, Aaron C, Russell, Alan J, Suehiro, Ion, Hartman, James, Kawas, Raja, Lu, Pu-Ping, Lee, Kenneth H, Marquez, David, Tomlinson, Matthew, Xu, Donghong, Kennedy, Adam, Hwee, Darren, Schaletzky, Julia, Leung, Kwan, Malik, Fady I, Morgans, David J, Morgan, Bradley P

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Asymmetric Catalysis with Libraries of Palladium β-Turn Phosphine Complexes von Gilbertson, Scott R, Collibee, Scott E, Agarkov, Anton

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Discovery of Omecamtiv Mecarbil the First, Selective, Small Molecule Activator of Cardiac Myosin von Morgan, Bradley P, Muci, Alexander, Lu, Pu-Ping, Qian, Xiangping, Tochimoto, Todd, Smith, Whitney W, Garard, Marc, Kraynack, Erica, Collibee, Scott, Suehiro, Ion, Tomasi, Adam, Valdez, S. Corey, Wang, Wenyue, Jiang, Hong, Hartman, James, Rodriguez, Hector M, Kawas, Raja, Sylvester, Sheila, Elias, Kathleen A, Godinez, Guillermo, Lee, Kenneth, Anderson, Robert, Sueoka, Sandra, Xu, Donghong, Wang, Zhengping, Djordjevic, Nebojsa, Malik, Fady I, Morgans, David J

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Catalysis with Phosphine-Containing Amino Acids in Various “Turn” Motifs von Agarkov, Anton, Greenfield, Scott J, Ohishi, Takahiro, Collibee, Scott E, Gilbertson, Scott R

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A facile and convenient synthesis of functionalized ortho-nitrophenylboronic acids von Collibee, Scott E., Yu, Jiaxin

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BCl3- and TiCl4-Mediated Reductions of β-Hydroxy Ketones von Sarko, Christopher R, Collibee, Scott E, Knorr, Allison L, DiMare, Marcello

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Application of polymer-supported triphenyl phosphine in the palladium-catalyzed cyanation reaction under microwave conditions von Srivastava, Rajiv R., Collibee, Scott E.

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BICYCLIC PIPERAZINONES AND THERAPEUTIC USES THEREOF von KUROSAKI, Toshio, MAKINO, Takuya, HONJO, Eriko, EVANS, Chris, KOIZUMI, Yuka, COLLIBEE, Scott, MORGAN, Bradley P

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NAMPT MODULATORS von TOCHIMOTO, Todd, LU, Pu-Ping, GARCIA, Alfredo, ROMERO, Antonio, WANG, Wenyue, SHEN, Minxing, EVANS, Christopher, COLLIBEE, Scott E

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NAMPT MODULATORS von TOCHIMOTO, Todd, LU, Pu-Ping, GARCIA, Alfredo, ROMERO, Antonio, WANG, Wenyue, SHEN, Minxing, EVANS, Christopher, COLLIBEE, Scott E

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BICYCLIC 1,4-DIAZEPANONES AND THERAPEUTIC USES THEREOF von KUROSAKI, Toshio, MAKINO, Takuya, KOIZUMI, Yuka, YAMAKI, Susumu, KURIWAKI, Ikumi, HONJO, Eriko, EVANS, Chris, LU, Pu-Ping, TSUCHIYA, Kazuyuki, WANG, Wenyue, SEKIOKA, Ryuichi, COLLIBEE, Scott, MORGAN, Bradley P, YAMASAKI, Makoto, KATOH, Naoto

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Bicyclic 1,4-diazepanones and therapeutic uses thereof von Yamaki, Susumu, Katoh, Naoto, Kuriwaki, Ikumi, Koizumi, Yuka, Wang, Wenyue, Collibee, Scott, Yamasaki, Makoto, Makino, Takuya, Morgan, Bradley P, Tsuchiya, Kazuyuki, Sekioka, Ryuichi, Kurosaki, Toshio, Honjo, Eriko, Evans, Chris, Lu, Pu-Ping

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AMINO-PYRIMIDINE SKELETAL MUSCLE MODULATORS von QIAN, Xiangping, CHUANG, Chihyuan, YANG, Zhe, LU, Pu-Ping, ROMERO, Antonio, WARRINGTON, Jeffrey, COLLIBEE, Scott, MORGAN, Bradley P, MUCI, Alex R, BERGNES, Gustave

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SLOW SKELETAL TROPONIN ACTIVATORS von GARARD, Marc, TANAKA, Hiroaki, SATO, Shota, SAMI, Yuichi, ABE, Tomoaki, INAGAKI, Yusuke, IMADA, Sunao, ISHIDA, Junya, ISHIKAWA, Noriko, NEGORO, Kenji, OHNUKI, Kei, LU, Pu-Ping, COLLIBEE, Scott, KOGANEMARU, Yohei, YAMASAKI, Makoto, MORGAN, Bradley P, KAMIKUBO, Takashi

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SULFONAMIDE COMPOUNDS AS CARDIAC SARCOMERE ACTIVATORS von ASHCRAFT, Luke W, ZHANG, Hanmo, CHANDRA, Aroop, CHUANG, Chihyuan, JOHNSON, Michael, GONZALEZ, Felix, MUCI - DECEASED, Alex, ROMERO, Antonio, COLLIBEE, Scott, MORGAN, Bradley P, MOEBIUS, David, GARDINA, Jeffrey

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