Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia von Moujalled, Donia M., Pomilio, Giovanna, Ghiurau, Corina, Ivey, Adam, Salmon, Jessica, Rijal, Sewa, Macraild, Sarah, Zhang, Lan, Teh, Tse-Chieh, Tiong, Ing-Soo, Lan, Ping, Chanrion, Maia, Claperon, Audrey, Rocchetti, Francesca, Zichi, Adrien, Kraus-Berthier, Laurence, Wang, Youzhen, Halilovic, Ensar, Morris, Erick, Colland, Frédéric, Segal, David, Huang, David, Roberts, Andrew W., Maragno, Ana Leticia, Lessene, Guillaume, Geneste, Olivier, Wei, Andrew H.

Volltext

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling von Arimoto, Kei-ichiro, Löchte, Sara, Stoner, Samuel A, Burkart, Christoph, Zhang, Yue, Miyauchi, Sayuri, Wilmes, Stephan, Fan, Jun-Bao, Heinisch, Jürgen J, Li, Zhi, Yan, Ming, Pellegrini, Sandra, Colland, Frédéric, Piehler, Jacob, Zhang, Dong-Er

Volltext

Discovery of S64315, a Potent and Selective Mcl‑1 Inhibitor von Szlavik, Zoltan, Csekei, Marton, Paczal, Attila, Szabo, Zoltan B, Sipos, Szabolcs, Radics, Gabor, Proszenyak, Agnes, Balint, Balazs, Murray, James, Davidson, James, Chen, Ijen, Dokurno, Pawel, Surgenor, Allan E, Daniels, Zoe Marie, Hubbard, Roderick E, Le Toumelin-Braizat, Gaëtane, Claperon, Audrey, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Bruno, Alain, Chanrion, Maia, Colland, Frédéric, Maragno, Ana-Leticia, Demarles, Didier, Geneste, Olivier, Kotschy, Andras

Volltext

Targeting ubiquitin specific proteases for drug discovery von Daviet, Laurent, Colland, Frédéric

Volltext

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells von Colland, Frédéric, Formstecher, Etienne, Jacq, Xavier, Reverdy, Céline, Planquette, Cécile, Conrath, Susan, Trouplin, Virginie, Bianchi, Julie, Aushev, Vasily N, Camonis, Jacques, Calabrese, Alessandra, Borg-Capra, Catherine, Sippl, Wolfgang, Collura, Vincent, Boissy, Guillaume, Rain, Jean-Christophe, Guedat, Philippe, Delansorne, Rémi, Daviet, Laurent

Volltext

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP von Burgering, Boudewijn M.T, van der Horst, Armando, de Vries-Smits, Alida M.M, Brenkman, Arjan B, van Triest, Miranda H, van den Broek, Niels, Colland, Frédéric, Maurice, Madelon M

Volltext

Mst4 and Ezrin Induce Brush Borders Downstream of the Lkb1/Strad/Mo25 Polarization Complex von ten Klooster, Jean Paul, Jansen, Marnix, Yuan, Jin, Oorschot, Viola, Begthel, Harry, Di Giacomo, Valeria, Colland, Frédéric, de Koning, John, Maurice, Madelon M., Hornbeck, Peter, Clevers, Hans

Volltext

Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the IκB kinase subunit IKKα von Gouin, Edith, Adib-Conquy, Minou, Balestrino, Damien, Nahori, Marie-Anne, Villiers, Véronique, Colland, Frédéric, Dramsi, Shaynoor, Dussurget, Olivier, Cossart, Pascale

Volltext

TGIF Governs a Feed-Forward Network that Empowers Wnt Signaling to Drive Mammary Tumorigenesis von Zhang, Ming-Zhu, Ferrigno, Olivier, Wang, Zhe, Ohnishi, Mutsuko, Prunier, Céline, Levy, Laurence, Razzaque, Mohammed, Horne, Williams C., Romero, Damian, Tzivion, Guri, Colland, Frédéric, Baron, Roland, Atfi, Azeddine

Volltext

disintegrin and metalloproteinase ADAM12 contributes to TGF-β signaling through interaction with the type II receptor von Atfi, Azeddine, Dumont, Emmanuelle, Colland, Frédéric, Bonnier, Dominique, L'Helgoualc'h, Annie, Prunier, Céline, Ferrand, Nathalie, Clément, Bruno, Wewer, Ulla M, Théret, Nathalie

Volltext

Synthesis and Biological Evaluation of 9-Oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile Analogues as Potential Inhibitors of Deubiquitinating Enzymes von Colombo, Matteo, Vallese, Stefania, Peretto, Ilaria, Jacq, Xavier, Rain, Jean-Christophe, Colland, Frédéric, Guedat, Philippe

Volltext

Development of Inducible Systems To Engineer Conditional Mutants of Essential Genes of Helicobacter pylori von Boneca, Ivo G, Ecobichon, Chantal, Chaput, Catherine, Mathieu, Aurélie, Guadagnini, Stéphanie, Prévost, Marie-Christine, Colland, Frédéric, Labigne, Agnès, de Reuse, Hilde

Volltext

Functional proteomics mapping of a human signaling pathway von Colland, Frédéric, Jacq, Xavier, Trouplin, Virginie, Mougin, Christelle, Groizeleau, Caroline, Hamburger, Alexandre, Meil, Alain, Wojcik, Jérôme, Legrain, Pierre, Gauthier, Jean-Michel

Volltext

Patented small molecule inhibitors in the ubiquitin proteasome system von Guédat, Philippe, Colland, Frédéric

Volltext

Identification of PHRF1 as a Tumor Suppressor that Promotes the TGF-β Cytostatic Program through Selective Release of TGIF-Driven PML Inactivation von Ettahar, Asma, Ferrigno, Olivier, Zhang, Ming-Zhu, Ohnishi, Mutsuko, Ferrand, Nathalie, Prunier, Céline, Levy, Laurence, Bourgeade, Marie-Françoise, Bieche, Ivan, Romero, Damian G., Colland, Frédéric, Atfi, Azeddine

Volltext

Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase von Cholay, Michael, Reverdy, Céline, Benarous, Richard, Colland, Frédéric, Daviet, Laurent

Volltext

Characterization of the elongasome core PBP2 : MreC complex of Helicobacter pylori von El Ghachi, Meriem, Matteï, Pierre‐Jean, Ecobichon, Chantal, Martins, Alexandre, Hoos, Sylviane, Schmitt, Christine, Colland, Frédéric, Ebel, Christine, Prévost, Marie‐Christine, Gabel, Frank, England, Patrick, Dessen, Andréa, Boneca, Ivo G.

Volltext

ARHGAP10 is necessary for α-catenin recruitment at adherens junctions and for Listeria invasion von Cossart, Pascale, Sousa, Sandra, Cabanes, Didier, Archambaud, Cristel, Colland, Frédéric, Lemichez, Emmanuel, Popoff, Michel, Boisson-Dupuis, Stéphanie, Gouin, Edith, Lecuit, Marc, Legrain, Pierre

Volltext

Identification of PCTA, a TGIF antagonist that promotes PML function in TGF-β signalling von Faresse, Nourdine, Colland, Frédéric, Ferrand, Nathalie, Prunier, Céline, Bourgeade, Marie-Francoise, Atfi, Azeddine

Volltext

The Effect of Core Replacement on S64315, a Selective MCL‑1 Inhibitor, and Its Analogues von Sipos, Szabolcs, Bálint, Balázs, Szabó, Zoltán B, Ondi, Levente, Csékei, Márton, Szlávik, Zoltán, Proszenyák, Ágnes, Murray, James B, Davidson, James, Chen, Ijen, Dokurno, Pawel, Surgenor, Allan E, Pedder, Christopher, Hubbard, Roderick E, Maragno, Ana-Leticia, Chanrion, Maia, Colland, Frederic, Geneste, Olivier, Kotschy, András

Volltext