Towards remote monitoring in pediatric care and clinical trials-Tolerability, repeatability and reference values of candidate digital endpoints derived from physical activity, hear... von Kruizinga, M. D., Heide, N. van der, Moll, A., Zhuparris, A., Yavuz, Y., Kam, M. L. de, Stuurman, F. E., Cohen, A. F., Driessen, G. J. A.

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Impact of (chemo)radiotherapy on immune cell composition and function in cervical cancer patients von van Meir, H., Nout, R. A., Welters, M. J. P., Loof, N. M., de Kam, M. L., van Ham, J. J., Samuels, S., Kenter, G. G., Cohen, A. F., Melief, C. J. M., Burggraaf, J., van Poelgeest, M. I. E., van der Burg, S. H.

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Establishing risk of human experimentation with drugs: lessons from TGN1412 von Kenter, MJH, Cohen, AF

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Effect of intrapulmonary tetrahydrocannabinol administration in humans von Zuurman, L., Roy, C., Schoemaker, RC, Hazekamp, A., den Hartigh, J., Bender, JCME, Verpoorte, R., Pinquier, JL, Cohen, AF, van Gerven, JMA

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Pharmacokinetics, pharmacodynamics and the pharmacokinetic/ pharmacodynamic relationship of zolpidem in healthy subjects von de Haas, SL, Schoemaker, RC, van Gerven, JMA, Hoever, P, Cohen, AF, Dingemanse, J

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Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects von Dumont, G. J. H., De Visser, S. J., Cohen, A. F., Van Gerven, J. M. A.

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Pharmacokinetics and systemic endocrine effects of the phyto‐oestrogen 8‐prenylnaringenin after single oral doses to postmenopausal women von Rad, M., Hümpel, M., Schaefer, O., Schoemaker, R. C., Schleuning, W‐D., Cohen, A. F., Burggraaf, J.

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Modelling of the concentration—effect relationship of THC on central nervous system parameters and heart rate — insight into its mechanisms of action and a tool for clinical resear... von Strougo, A., Zuurman, L., Roy, C., Pinquier, JL, van Gerven, JMA, Cohen, AF, Schoemaker, RC

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Re-engineering the European Union Clinical Trials Directive von Kenter, MJH, Cohen, AF

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The effects of the glycine reuptake inhibitor R213129 on the central nervous system and on scopolamine-induced impairments in psychomotor and cognitive function in healthy subjects von Liem-Moolenaar, M, Zoethout, RWM, de Boer, P, Schmidt, M, de Kam, ML, Cohen, AF, Franson, KL, van Gerven, JMA

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Inhibition of THC-induced effects on the central nervous system and heart rate by a novel CB1 receptor antagonist AVE1625 von Zuurman, L., Roy, C., Schoemaker, RC, Amatsaleh, A., Guimaeres, L., Pinquier, JL, Cohen, AF, van Gerven, JMA

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Psychomotor and cognitive effects of a single oral dose of talnetant (SB223412) in healthy volunteers compared with placebo or haloperidol von Liem-Moolenaar, M., Gray, FA, de Visser, SJ, Franson, KL, Schoemaker, RC, Schmitt, JAJ, Cohen, AF, van Gerven, JMA

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Biomarkers for the effects of benzodiazepines in healthy volunteers von De Visser, S. J., Van Der Post, J. P., De Waal, P. P., Cornet, F., Cohen, A. F., Van Gerven, J. M. A.

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Development of Novel, Value-Based, Digital Endpoints for Clinical Trials: A Structured Approach Toward Fit-for-Purpose Validation von Kruizinga, M. D., Stuurman, F. E., Exadaktylos, Doll, R. J., Stephenson, D. T., Groeneveld, G. J., Driessen, G. J. A., Cohen, A. F.

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The effects of a glycine reuptake inhibitor R231857 on the central nervous system and on scopolamine-induced impairments in cognitive and psychomotor function in healthy subjects von Liem-Moolenaar, M, Zoethout, RWM, de Boer, P, Schmidt, M, de Kam, ML, Cohen, AF, Franson, KL, van Gerven, JMA

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The central nervous system effects, pharmacokinetics and safety of the NAALADase‐inhibitor GPI 5693 von Van Der Post, J. P., De Visser, S. J., De Kam, M. L., Woelfler, M., Hilt, D. C., Vornov, J., Burak, E. S., Bortey, E., Slusher, B. S., Limsakun, T., Cohen, A. F., Van Gerven, J. M. A.

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The effects of a novel histamine-3 receptor inverse agonist on essential tremor in comparison to stable levels of alcohol von Zoethout, RWM, Iannone, R, Bloem, BR, Palcza, J, Murphy, G, Chodakewitz, J, Buntinx, A, Gottesdiener, K, Marsilio, S, Rosen, L, van Dyck, K, Louis, ED, Cohen, AF, Schoemaker, RC, Tokita, S, Sato, N, Koblan, KS, Hargreaves, RH, Renger, JJ, van Gerven, JMA

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The pharmacokinetic and pharmacodynamic effects of SL65.1498, a GABA-A 2,3 selective agonist, in comparison with lorazepam in healthy volunteers von de Haas, SL, Franson, KL, Schmitt, JAJ, Cohen, AF, Fau, JB, Dubruc, C, van Gerven, JMA

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Pharmacodynamics and Pharmacokinetics of the Novel Thrombopoietin Mimetic Peptide RWJ-800088 in Humans von Liem‐Moolenaar, M, Cerneus, D, Molloy, CJ, End, D, Brown, KH, Kam, ML, Cohen, AF, Hensbergen, Y, Burggraaf, J

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Pharmacodynamic and pharmacokinetic effects of the intravenously administered CB1 receptor agonist Org 28611 in healthy male volunteers von Zuurman, L, Passier, PCCM, de Kam, ML, Kleijn, HJ, Cohen, AF, van Gerven, JMA

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