A coiled-coil masking domain for selective activation of therapeutic antibodies von Trang, Vivian H., Zhang, Xinqun, Yumul, Roma C., Zeng, Weiping, Stone, Ivan J., Wo, Serena W., Dominguez, Melissa M., Cochran, Julia H., Simmons, Jessica K., Ryan, Maureen C., Lyon, Robert P., Senter, Peter D., Levengood, Matthew R.

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Reducing the antigen-independent toxicity of antibody-drug conjugates by minimizing their non-specific clearance through PEGylation von Simmons, Jessica K., Burke, Patrick J., Cochran, Julia H., Pittman, Paul G, Lyon, Robert P.

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Mouse Strains Influence Clearance and Efficacy of Antibody and Antibody-Drug Conjugate Via Fc-FcγR Interaction von Li, Fu, Ulrich, Michelle L, Shih, Vincent Feng-Sheng, Cochran, Julia H, Hunter, Joshua H, Westendorf, Lori, Neale, Jason, Benjamin, Dennis R

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Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody-Drug Conjugates von Neumann, Christopher S, Olivas, Kathleen C, Anderson, Martha E, Cochran, Julia H, Jin, Steven, Li, Fu, Loftus, Luke V, Meyer, David W, Neale, Jason, Nix, Jay C, Pittman, Paul G, Simmons, Jessica K, Ulrich, Michelle L, Waight, Andrew B, Wong, Abbie, Zaval, Margo C, Zeng, Weiping, Lyon, Robert P, Senter, Peter D

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Development of Novel Quaternary Ammonium Linkers for Antibody-Drug Conjugates von Burke, Patrick J, Hamilton, Joseph Z, Pires, Thomas A, Setter, Jocelyn R, Hunter, Joshua H, Cochran, Julia H, Waight, Andrew B, Gordon, Kristine A, Toki, Brian E, Emmerton, Kim K, Zeng, Weiping, Stone, Ivan J, Senter, Peter D, Lyon, Robert P, Jeffrey, Scott C

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The Methylene Alkoxy Carbamate Self-Immolative Unit: Utilization for the Targeted Delivery of Alcohol-Containing Payloads with Antibody-Drug Conjugates von Kolakowski, Robert V., Haelsig, Karl T., Emmerton, Kim K., Leiske, Chris I., Miyamoto, Jamie B., Cochran, Julia H., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C.

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SGN-CD228A Is an Investigational CD228-Directed Antibody-Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models von Mazahreh, Rebecca, Mason, Marsha L, Gosink, John J, Olson, Devra J, Thurman, Robert, Hale, Christopher, Westendorf, Lori, Pires, Thomas A, Leiske, Christopher I, Carlson, Markus, Nguyen, Liem T, Cochran, Julia H, Okeley, Nicole M, Yumul, Roma, Jin, Steven, Stone, Ivan J, Sahetya, Disha, Nesterova, Albina, Allred, Sean, Hensley, Kelly M, Hu, Rachael, Lawrence, Robert, Lewis, Timothy S, Sandall, Sharsti

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Development of Novel Antibody-Camptothecin Conjugates von Lyski, Ryan D, Bou, Lauren B, Lau, Uland Y, Meyer, David W, Cochran, Julia H, Okeley, Nicole M, Emmerton, Kim K, Zapata, Francisco, Simmons, Jessica K, Trueblood, Esther S, Ortiz, David J, Zaval, Margo C, Snead, Katie M, Jin, Steven, Farr, Lauren M, Ryan, Maureen C, Senter, Peter D, Jeffrey, Scott C

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Lactone Stabilization is Not a Necessary Feature for Antibody Conjugates of Camptothecins von Lau, Uland Y, Benoit, Lauren T, Stevens, Nicole S, Emmerton, Kim K, Zaval, Margo, Cochran, Julia H, Senter, Peter D

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Improving Antibody‐Tubulysin Conjugates through Linker Chemistry and Site‐Specific Conjugation von Hamilton, Joseph Z., Pires, Thomas A., Mitchell, Jamie A., Cochran, Julia H., Emmerton, Kim K., Zaval, Margo, Stone, Ivan J., Anderson, Martha E., Jin, Steven, Waight, Andrew B., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C., Burke, Patrick J.

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SGN-35C: A Novel CD30-Directed Antibody-Drug Conjugate for the Treatment of Lymphomas von Hamblett, Kevin J., Cochran, Julia, Snead, Katie, Jin, Steven, Yumul, Roma, Simmons, Jessica, Stone, Ivan, Lyski, Ryan, Schrum, Jason P., Lim, Andrea R., Clarke, Astrid

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The Methylene Alkoxy Carbamate Self-Immolative Unit: Utilization for the Targeted Delivery of Alcohol-Containing Payloads with Antibody-Drug Conjugates von Kolakowski, Robert V., Haelsig, Karl T., Emmerton, Kim K., Leiske, Chris I., Miyamoto, Jamie B., Cochran, Julia H., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C.

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Abstract 2895: Characterization of payload release from a novel camptothecin drug-linker von Cochran, Julia H., Farr, Lauren, Lyski, Ryan, Senter, Peter D., Jeffrey, Scott C., Hengel, Shawna M., Okeley, Nicole M.

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Abstract 60: Reducing toxicity of antibody-drug conjugates through modulation of pharmacokinetics von Simmons, Jessica, Zapata, Francisco, Neff-Laford, Haley, Hunter, Joshua, Cochran, Julia, Burke, Patrick, Lyon, Robert P.

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Abstract 5581: Enfortumab vedotin, an anti-Nectin-4 ADC demonstrates bystander cell killing and immunogenic cell death anti-tumor activity mechanisms of action in urothelial cancer... von Liu, Bernard A., Olson, Devra, Snead, Katie, Gosink, John, Tenn, Elena-Marie, Zaval, Margo, Cao, Anthony, Sahetya, Disha, Nesterova, Albina, Hensley, Kelly, Cochran, Julia, Gardai, Shyra, Lewis, Timothy S.

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Abstract 3833: SEA-BCMA: A highly active enhanced antibody for multiple myeloma von Epps, Heather Van, Anderson, Martha, Yu, Changpu, Klussman, Kerry, Westendorf, Lori, Carosino, Chris, Manlove, Luke, Cochran, Julia, Neale, Jason, Benjamin, Dennis, Ryan, Maureen

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Abstract 750: Modular coiled-coil masking domains for tumor-specific antibody activation von Trang, Vivian H., Zhang, Xinqun, Dominguez, Melissa M., Zeng, Weiping, Cochran, Julia H., Stone, Ivan J., Senter, Peter D., Levengood, Matthew R.

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Abstract 5619: Additional mechanisms of action of SGN-CD48A in multiple myeloma and improved antitumor activity in combination with daratumumab von Olson, Devra J., Liu, Bernard A., Zaval, Margo, Cao, Anthony, Gurgel, Jesse, Cochran, Julia, Stevens, Nicole, Anderson, Martha, Lewis, Timothy S.

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Front Cover: Improving Antibody‐Tubulysin Conjugates through Linker Chemistry and Site‐Specific Conjugation (ChemMedChem 7/2021) von Hamilton, Joseph Z., Pires, Thomas A., Mitchell, Jamie A., Cochran, Julia H., Emmerton, Kim K., Zaval, Margo, Stone, Ivan J., Anderson, Martha E., Jin, Steven, Waight, Andrew B., Lyon, Robert P., Senter, Peter D., Jeffrey, Scott C., Burke, Patrick J.

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Abstract 1649: Impact of linker and conjugation site on tubulysin M ADC stability and in vivo activity von Burke, Patrick J., Hamilton, Joseph Z., Pires, Thomas A., Leiske, Christopher I., Cochran, Julia H., Setter, Jocelyn R., Emmerton, Kim K., Waight, Andrew B., Senter, Peter D., Lyon, Robert P., Jeffrey, Scott C.

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